KEGG   ORTHOLOGY: K10621
Entry
K10621                      KO                                     

Name
cmtC, dhbA
Definition
2,3-dihydroxy-p-cumate/2,3-dihydroxybenzoate 3,4-dioxygenase [EC:1.13.11.- 1.13.11.14]
Pathway
ko00362  Benzoate degradation
ko00622  Xylene degradation
ko01100  Metabolic pathways
ko01120  Microbial metabolism in diverse environments
ko01220  Degradation of aromatic compounds
Module
M00539  Cumate degradation, p-cumate => 2-oxopent-4-enoate + 2-methylpropanoate
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09111 Xenobiotics biodegradation and metabolism
   00362 Benzoate degradation
    K10621  cmtC, dhbA; 2,3-dihydroxy-p-cumate/2,3-dihydroxybenzoate 3,4-dioxygenase
   00622 Xylene degradation
    K10621  cmtC, dhbA; 2,3-dihydroxy-p-cumate/2,3-dihydroxybenzoate 3,4-dioxygenase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.13  Acting on single donors with incorporation of molecular oxygen (oxygenases)
   1.13.11  With incorporation of two atoms of oxygen
    1.13.11.14  2,3-dihydroxybenzoate 3,4-dioxygenase
     K10621  cmtC, dhbA; 2,3-dihydroxy-p-cumate/2,3-dihydroxybenzoate 3,4-dioxygenase
    1.13.11.-  
     K10621  cmtC, dhbA; 2,3-dihydroxy-p-cumate/2,3-dihydroxybenzoate 3,4-dioxygenase
Other DBs
RN: R01507 R05248
GO: 0018571 0045133
Genes
RBD: ALSL_1089
PPSE: BN5_3609
PPF: Pput_2896
PPX: T1E_4250
PMON: X969_10855
PMOT: X970_10510
ALR: DS731_01400
SPOI: IMCC21906_02719
ZAL: AZF00_03845 AZF00_17835
KIM: G3T16_05395
CYQ: Q91_1899
RSO: RSp0888(cmtC)
RSE: F504_4329(cmtC)
BXE: Bxe_A3554
BXB: DR64_1253
PPNO: DA70_13210
PPNM: LV28_17490
PPUL: RO07_11595
PSPU: NA29_07510
PAPI: SG18_11920
VPD: VAPA_1c22790(cmtC)
HPSE: HPF_01755(nsaC)
JAG: GJA_239
SMAZ: LH19_27430
SWI: Swit_1756
SPHD: HY78_16805
SPHB: EP837_03056(dmpB)
SPHR: BSY17_3120
TMO: TMO_b0428 TMO_b0429(bphC)
MIT: OCO_14770
MIA: OCU_15210
MJL: Mjls_4210
RRT: 4535765_00190(xylE_1) 4535765_00360(xylE_2)
SBH: SBI_01530
PAUT: Pdca_37820
AG: AFN52421(dhbA)
 » show all
Reference
PMID:8631713
  Authors
Eaton RW.
  Title
p-Cumate catabolic pathway in Pseudomonas putida Fl: cloning and characterization of DNA carrying the cmt operon.
  Journal
J Bacteriol 178:1351-62 (1996)
DOI:10.1128/JB.178.5.1351-1362.1996
  Sequence
[ppf:Pput_2896]
Reference
  Authors
Marin M, Plumeier I, Pieper DH
  Title
Degradation of 2,3-dihydroxybenzoate by a novel meta-cleavage pathway.
  Journal
J Bacteriol 194:3851-60 (2012)
DOI:10.1128/JB.00430-12
  Sequence

KEGG   ENZYME: 1.13.11.14
Entry
EC 1.13.11.14               Enzyme                                 

Name
2,3-dihydroxybenzoate 3,4-dioxygenase;
o-pyrocatechuate oxygenase;
2,3-dihydroxybenzoate 1,2-dioxygenase;
2,3-dihydroxybenzoic oxygenase;
2,3-dihydroxybenzoate oxygenase;
2,3-dihydroxybenzoate:oxygen 3,4-oxidoreductase (decyclizing)
Class
Oxidoreductases;
Acting on single donors with incorporation of molecular oxygen (oxygenases);
With incorporation of two atoms of oxygen
Sysname
2,3-dihydroxybenzoate:oxygen 3,4-oxidoreductase (ring-opening)
Reaction(IUBMB)
2,3-dihydroxybenzoate + O2 = 3-carboxy-2-hydroxymuconate semialdehyde [RN:R01507]
Reaction(KEGG)
R01507
Substrate
2,3-dihydroxybenzoate [CPD:C00196];
O2 [CPD:C00007]
Product
3-carboxy-2-hydroxymuconate semialdehyde [CPD:C04480]
History
EC 1.13.11.14 created 1972, modified 1976
Pathway
ec00362  Benzoate degradation
ec01120  Microbial metabolism in diverse environments
Orthology
K10621  2,3-dihydroxy-p-cumate/2,3-dihydroxybenzoate 3,4-dioxygenase
Genes
RBD: ALSL_1089
PPSE: BN5_3609
PPF: Pput_2896
PPX: T1E_4250
PMON: X969_10855
PMOT: X970_10510
ALR: DS731_01400
SPOI: IMCC21906_02719
ZAL: AZF00_03845 AZF00_17835
KIM: G3T16_05395
CYQ: Q91_1899
RSO: RSp0888(cmtC)
RSE: F504_4329(cmtC)
BXE: Bxe_A3554
BXB: DR64_1253
PPNO: DA70_13210
PPNM: LV28_17490
PPUL: RO07_11595
PSPU: NA29_07510
PAPI: SG18_11920
VPD: VAPA_1c22790(cmtC)
HPSE: HPF_01755(nsaC)
JAG: GJA_239
SMAZ: LH19_27430
SWI: Swit_1756
SPHD: HY78_16805
SPHB: EP837_03056(dmpB)
SPHR: BSY17_3120
TMO: TMO_b0428 TMO_b0429(bphC)
MIT: OCO_14770
MIA: OCU_15210
MJL: Mjls_4210
RRT: 4535765_00190(xylE_1) 4535765_00360(xylE_2)
SBH: SBI_01530
PAUT: Pdca_37820
 » show all
Reference
1
  Authors
Ribbons, D.W.
  Title
Bacterial oxidation of 2,3-dihydroxybenzoic acid - a new oxygenase.
  Journal
Biochem J 99:30 (1966)
Other DBs
ExplorEnz - The Enzyme Database: 1.13.11.14
IUBMB Enzyme Nomenclature: 1.13.11.14
ExPASy - ENZYME nomenclature database: 1.13.11.14
BRENDA, the Enzyme Database: 1.13.11.14
CAS: 9032-31-9

KEGG   REACTION: R01507
Entry
R01507                      Reaction                               

Name
2,3-dihydroxybenzoate:oxygen 3,4-oxidoreductase (decyclizing)
Definition
2,3-Dihydroxybenzoate + Oxygen <=> 3-Carboxy-2-hydroxymuconate semialdehyde
Equation
Reaction class
RC00387  C00196_C04480
Enzyme
Pathway
rn00362  Benzoate degradation
rn01120  Microbial metabolism in diverse environments
Orthology
K10621  2,3-dihydroxy-p-cumate/2,3-dihydroxybenzoate 3,4-dioxygenase [EC:1.13.11.- 1.13.11.14]
Other DBs
RHEA: 18480

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