KEGG ORTHOLOGY: K10652

ORTHOLOGY: K10652

Entry

K10652                      KO

Symbol

TRIM25, EFP

Name

tripartite motif-containing protein 25 [EC:2.3.2.27]

Pathway

map04064

NF-kappa B signaling pathway

map04622

RIG-I-like receptor signaling pathway

map05164

Influenza A

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04064 NF-kappa B signaling pathway
    K10652  TRIM25, EFP; tripartite motif-containing protein 25
09150 Organismal Systems
  09151 Immune system
   04622 RIG-I-like receptor signaling pathway
    K10652  TRIM25, EFP; tripartite motif-containing protein 25
09160 Human Diseases
  09172 Infectious disease: viral
   05164 Influenza A
    K10652  TRIM25, EFP; tripartite motif-containing protein 25
09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04121 Ubiquitin system
    K10652  TRIM25, EFP; tripartite motif-containing protein 25
Enzymes [BR:ko01000]
2. Transferases
  2.3  Acyltransferases
   2.3.2  Aminoacyltransferases
    2.3.2.27  RING-type E3 ubiquitin transferase
     K10652  TRIM25, EFP; tripartite motif-containing protein 25
Ubiquitin system [BR:ko04121]
Ubiquitin ligases (E3)
  Single Ring-finger type E3
   TRIM/RBCC proteins
    K10652  TRIM25, EFP; tripartite motif-containing protein 25

Genes

HSA:	7706(TRIM25)

PTR:	455146(TRIM25)

PPS:	100971009(TRIM25)

GGO:	101151068(TRIM25)

PON:	100440167(TRIM25)

PPYG:

129018409(TRIM25)

NLE:	100599729(TRIM25)

HMH:	116474384(TRIM25)

SSYN:

129470723(TRIM25)

MCC:	712588(TRIM25)

MCF:	102117091(TRIM25)

MTHB:

126939380

MNI:	105476789(TRIM25)

CSAB:

103242879(TRIM25)

CATY:

105583291(TRIM25)

PANU:

101000930(TRIM25)

TGE:	112609722(TRIM25)

MLEU:

105539108(TRIM25)

RRO:	104675987(TRIM25)

RBB:	108530313(TRIM25)

TFN:	117067272(TRIM25)

PTEH:

111537612(TRIM25)

CANG:

105520125(TRIM25)

CJC:	100392057(TRIM25)

SBQ:	101039932 101050878(TRIM25)

CIMI:

108309394 108311417(TRIM25)

ANAN:

105722784(TRIM25)

CSYR:

103274575(TRIM25) 103275943

MMUR:

105860532(TRIM25) 105878919

LCAT:

123620452(TRIM25) 123621205

PCOQ:

105827504(TRIM25)

OGA:	100959876(TRIM25)

MMU:	217069(Trim25) 432613(Trim80)

MCAL:

110305277 110305541(Trim25)

MPAH:

110332510(Trim25) 110332642

RNO:	287824(Trim80) 494338(Trim25)

MCOC:

116076852(Trim25) 116078783

ANU:	117711101(Trim25) 117711612

MUN:	110547707 110555547(Trim25)

CGE:	100765402(Trim25) 100771249

MAUA:

101823174 101836813(Trim25)

PROB:

127221113 127228214(Trim25)

PLEU:

114699246(Trim25) 114707096

MORG:

121436060 121456220(Trim25)

MFOT:

126500297 126510276

AAMP:

119811084 119811844(Trim25)

HGL:	101710143(Trim25)

CPOC:

100720319 100727761

CCAN:

109696712(Trim25)

DORD:

106001010(Trim25) 106001398

DSP:	122103233(Trim25) 122128359

PLOP:

125344881 125365642(Trim25) 125366303

NCAR:

124978851 124978919

MMMA:

107150419(Trim25) 107157869

OCU:	100343500 100347704

OPI:	101521573(TRIM25) 101526185

TUP:	102491192(TRIM25) 102500384

GVR:	103597060(TRIM25)

CFA:	483307(TRIM80) 491103(TRIM25)

CLUD:

112655097(TRIM25) 112672787

VVP:	112917903(TRIM25) 112920660

VLG:	121472860(TRIM25) 121474024

NPO:	129501553 129511860(TRIM25)

AML:	100477320 100480984(TRIM25)

UMR:	103665935 103667472(TRIM25)

UAH:	113244653 113268845(TRIM25)

UAR:	123776945(TRIM25) 123803184

ELK:	111151515 111160466

LLV:	125086614 125087211

MPUF:

101678535(TRIM25) 101690340

MNP:	132004376(TRIM25)

MLK:	131815698(TRIM25) 131816686

NVS:	122906549(TRIM25) 122907534

ORO:	101364706(TRIM25) 101379565

EJU:	114200709(TRIM25) 114216111

ZCA:	113939158(TRIM25) 113939850

MLX:	118024287 118024720(TRIM25)

NSU:	110572446 110592865(TRIM25)

LWW:	102749328(TRIM25)

FCA:	101084663(TRIM25) 101093474

PYU:	121017898 121044747(TRIM25)

PCOO:

112855572(TRIM25)

PBG:	122485344(TRIM25) 122485883

PVIV:

125151669(TRIM25) 125152137

LRUF:

124512826 124513206

PTG:	102949419(TRIM25)

PPAD:

109247230(TRIM25) 109276952

PUC:	125926376 125926744

AJU:	106987791 106989931

HHV:	120228272 120237736(TRIM25)

BTA:	510923(TRIM25) 526787

BOM:	102273846 102277633(TRIM25)

BIU:	109573354 109573862(TRIM25)

BBUB:

102403751(TRIM25)

BBIS:

104997970(TRIM25) 105000543

CHX:	102181625(TRIM25) 108638216

OAS:	101122710 101122873(TRIM25)

BTAX:

128065473 128065641(TRIM25)

ODA:	120866497(TRIM25) 120866537

CCAD:

122424684 122451024(TRIM25)

MBEZ:

129538964(TRIM25) 129544739

SSC:	100622285(TRIM25)

CFR:	102506352 102516528(TRIM25)

CBAI:

105065806 105065887(TRIM25)

CDK:	105097789(TRIM25) 105104662

VPC:	102525345(TRIM25) 102529539

BACU:

103015462(TRIM25)

BMUS:

118886716(TRIM25)

LVE:	103090776(TRIM25)

OOR:	101287056(TRIM25)

DLE:	111163657(TRIM25)

PCAD:

102980110 102991542(TRIM25)

PSIU:

116745291(TRIM25)

NASI:

112408047(TRIM25)

ECB:	100060051 100146440 100147035(TRIM25)

EPZ:	103546322(TRIM25) 103546609

EAI:	106830285 106837979 106843847

MYB:	102252032(TRIM25)

MYD:	102773217(TRIM25)

MMYO:

118671596 118671744(TRIM25)

MLF:	102439259(TRIM25)

MDT:	132218395(TRIM25) 132219330

PKL:	118704430 118728033(TRIM25)

EFUS:

103291807(TRIM25) 103298405

MNA:	107532719(TRIM25)

DRO:	112316562(TRIM25)

SHON:

118980784(TRIM25)

AJM:	119062650(TRIM25)

PDIC:

114502762(TRIM25)

PHAS:

123817736(TRIM25)

MMF:	118633808(TRIM25)

PPAM:

129080166(TRIM25)

HAI:	109379737(TRIM25) 109383630

RFQ:	117013032(TRIM25)

PALE:

102879209(TRIM25) 102880256

PGIG:

120600359 120620785(TRIM25)

PVP:	105293421 105295372(TRIM25)

RAY:	107503772 107515788(TRIM25)

MJV:	108387798 108404932(TRIM25)

TOD:	119230789(TRIM25) 119231639

SARA:

101556886(TRIM25)

SETR:

125996498(TRIM25)

LAV:	100665415(TRIM25) 100674177

TMU:	101344128 101354577

ETF:	101654193(TRIM25) 101662463

DNM:	101410922 101436200(TRIM25)

MDO:	100013883(TRIM25) 100027651

GAS:	123244298 123244361(TRIM25)

SHR:	100928651(TRIM25) 100930100

AFZ:	127560014 127560486

PCW:	110212085(TRIM25) 110219242

TVP:	118846130(TRIM25) 118848689

OAA:	103168929(TRIM25)

GGA:	417401(TRIM25)

PCOC:

116232420(TRIM25)

MGP:	100548159(TRIM25)

CJO:	107322062(TRIM25)

TPAI:

128083287(TRIM25)

LMUT:

125702085(TRIM25)

NMEL:

110407231(TRIM25)

APLA:

101791574(TRIM25)

ACYG:

106034683(TRIM25)

CATA:

118253948(TRIM25)

AFUL:

116496420(TRIM25)

TGU:	100221651(TRIM25)

LSR:	110484633(TRIM25)

SCAN:

103819976(TRIM25)

PMOA:

120505668(TRIM25)

OTC:	121338285(TRIM25)

PRUF:

121363436(TRIM25)

GFR:	102040965(TRIM25)

FAB:	101815485(TRIM25)

OMA:	130260479(TRIM25)

PHI:	102100676(TRIM25)

PMAJ:

107212286(TRIM25)

CCAE:

111937562(TRIM25)

CCW:	104694263(TRIM25)

CBRC:

103619099

ETL:	114056855(TRIM25)

ZAB:

102071779

ZLE:	135455574(TRIM25)

ACHL:

103803473(TRIM25)

SVG:	106854285(TRIM25)

MMEA:

130575134(TRIM25)

HRT:	120760906(TRIM25)

SATI:

136369522(TRIM25)

FPG:	101923333(TRIM25)

FCH:	102057184(TRIM25)

CCRI:

104159793(TRIM25)

NNT:	104401245(TRIM25)

SHAB:

115616857(TRIM25)

ACUN:

113486950

TALA:

104368616(TRIM25)

ACHC:

115341221(TRIM25)

HALD:

104317711(TRIM25)

HLE:	104838742(TRIM25)

AGEN:

126043406

GCL:

127023979

CSTI:

104552900(TRIM25)

LDI:	104353896(TRIM25)

MNB:

103774788

DPUB:

104310128(TRIM25)

AVIT:

104276235(TRIM25)

BRHI:

104493060(TRIM25)

EGZ:	104123746(TRIM25)

NNI:	104014381(TRIM25)

PCRI:

104033672(TRIM25)

PCAO:

104042399(TRIM25)

PADL:

103916739(TRIM25)

AFOR:

103905915(TRIM25)

FGA:	104077946(TRIM25)

GSTE:

104262071(TRIM25)

CLV:	102084896(TRIM25)

MUI:	104543797(TRIM25)

PGUU:

104467689(TRIM25)

PLET:

104615960(TRIM25)

EHS:	104509407(TRIM25)

CMAC:

104484178(TRIM25)

CUCA:

104061995

TEO:	104371273(TRIM25)

BREG:

104632871(TRIM25)

OHA:	104332967(TRIM25)

ACAR:

104527460(TRIM25)

CPEA:

104393291(TRIM25)

CVF:	104282162(TRIM25)

RTD:	128917856(TRIM25)

AAM:	106493109(TRIM25)

AROW:

112966963(TRIM25)

NPD:	112953663(TRIM25)

TGT:	104565796(TRIM25)

DNE:

112982578

SCAM:

104146817(TRIM25)

ASN:	102370282(TRIM25) 112549333

AMJ:	102558244(TRIM25) 109284796

CPOO:

109314999(TRIM25) 109315238

GGN:	109296137 109297385(TRIM25)

PSS:	102460037(TRIM25) 102461130

CMY:	102940179 102947648(TRIM25)

CCAY:

125621258 125621730

DCC:	119842782 119842995

CPIC:

101946714(TRIM25) 101953724

TST:	117887286(TRIM25) 117887622

CABI:

116832285 116839594(TRIM25)

MRV:	120383375 120383383(TRIM25)

ACS:	100558661 100567794(trim25)

ASAO:

132765551 132768258(TRIM25)

PVT:	110074006(TRIM25) 110085801

SUND:

121922044 121922936

PBI:	103056401(TRIM25) 103058854

PMUR:

107286662 107287038(TRIM25)

CTIG:

120307774 120308085(TRIM25)

TSR:	106539650(TRIM25) 106552301(SLC16A5)

PGUT:

117660524 117662832(TRIM25) 132710992

APRI:

131191371(TRIM25) 131191417

PTEX:

113437125 113443092

NSS:	113412053 113420752(TRIM25)

VKO:	123019285 123035598

PMUA:

114587320 114590592

PRAF:

128407144(TRIM25) 128407456

ZVI:

118079567

HCG:	128345597(TRIM25) 128345972

GJA:	107110010 107124591(TRIM25)

STOW:

125427854 125429353(TRIM25)

EMC:	129327558 129346069

XLA:	108701227(trim25.L) 108701816 108702868(trim25.S)

XTR:

NPR:

RTEM:

BBUF:

MUO:	115473433(TRIM25) 115473562

GSH:	117367473(TRIM25) 117367907

DRE:	393144(trim25)

SRX:	107709224 107710025 107710280(trim25)

SANH:

107669536 107696950 107701197 107704618

SGH:	107553309 107558908 107591924(trim25)

CCAR:

109061809 109092324(trim25)

CAUA:

113040916 113050692 113094069 113098250

CGIB:

127945088 127959251 128011649 128015484

PTET:

122328862 122347250(trim25)

LROH:

127154559 127166529(trim25)

OMC:	131531590 131542204(trim25)

PPRM:

120473943 120480416(trim25)

RKG:	130081197(trim25) 130104218

MAMB:

125261018 125272922(trim25)

CIDE:

127505458 127514858

CERY:

137009757 137011615(trim25)

MASI:

127420038 127445747 127449004

TROS:

130571204(trim25) 130571775

TDW:	130409311 130410518(trim25)

MANU:

129431485 129439432(trim25)

IPU:	108272901(trim25)

IFU:	128615490(trim25)

PHYP:

113523690

SMEO:

124385205(trim25)

TFD:	113656871 113656873 125141225

TVC:	132845042(trim25)

TRN:	134316855(trim25) 134326373

AMEX:

103043961(trim25)

CMAO:

118808603(trim25) 118822551

EEE:	113578865(trim25) 113587083

CHAR:

105892289(trim25)

TRU:	101076539 105419963

TFS:	130527307(trim25) 130530409

LCO:	104919267 104921549(trim25)

NCC:

TBEN:

CGOB:

PGEO:

GACU:

117532892 117562526(trim25)

EMAC:

134864430 134866330

ELY:	117255355(trim25) 117257929

EFO:	125886547(trim25) 125891454

PLEP:

121941948(trim25) 121963830

SLUC:

116039606 116040751

ECRA:

117947305 117956246

ESP:	116692373 116694554

PFLV:

114558934 114564136

GAT:	120825012(trim25) 120829427

PPUG:

119217685

AFB:	129096480 129100413

CLUM:

117729354(trim25) 117732967

PSWI:

130190398(trim25) 130200017

MSAM:

119899731(trim25)

SCHU:

122872559 122872611 122883487

CUD:	121508492(trim25) 121517939

ALAT:

119004274(trim25) 119023291

MZE:	101470747 101473205

ONL:	100711119 102082729

OAU:	116311214 116331528(trim25)

OLA:	101157185 101159915

OML:	112157158 112158744

CSAI:

133446657 133456577

XMA:	102231777 111606171

XCO:	114143849 114144906

XHE:	116720301 116725987

PRET:

103463631(trim25) 103466864

PFOR:

103133107 103152546

PLAI:

106962911 106965189

PMEI:

106906933 106932298

GAF:	122830150(trim25) 122833236

PPRL:

129366798(trim25) 129371597

CVG:	107085477 107096642

CTUL:

119789757 119790210

GMU:	124868323(trim25) 124873062

NFU:	107380604 107391327

KMR:	108233045 108248218(trim25)

ALIM:

106522375 106524353(trim25)

NWH:	119417174 119423043

AOCE:

111575035 111582073

MCEP:

124997232 125004086(trim25)

CSEM:

103384232(trim25) 103384748

POV:	109627514(trim25) 109630476

SSEN:

122761814(trim25) 122776762

HHIP:

117764586 117770915 117770927

HSP:	118111579 118120048

PPLT:

128436812(trim25) 128442923

SMAU:

118312069(trim25) 118317360

LCF:	108882661 108884561(trim25)

SDU:	111217945 111230688

SLAL:

111655263 111655475

XGL:	120800158(trim25) 120804389

HCQ:	109511802 109527299(trim25)

SSCV:

125968751 125988750

SBIA:

133490824 133506583(trim25)

PEE:	133400184 133404272(trim25)

PTAO:

133475449 133476530(trim25)

BPEC:

110157976 110173813(trim25)

MALB:

109956820

BSPL:

114856182(trim25) 114859471

SJO:	128357166 128367873

SASA:

106564896 106566893 106588405 106590355 106590357

STRU:

115168169 115178139 115195543 115195544 115208610

OTW:	112221990 112227753 112227754 112230338 112245830

OMY:	110485965(trim25) 110489722 110492209 110493686

OGO:	124004232 124015766 124039601 124045086

ONE:	115101654 115103821 115130176 115130177 115142612

OKI:	109865709 109869619 109889467 109899301 109900159

OKE:	118359809 118364970 118370596 118389202 127919882

SALP:

111953171 111953591 111953592 111956399 111972532 111976252

SNH:	120032587 120037707 120050350 120050624 120061576 120065725

CCLU:

121533144 121546682 121569201 121569202

ELS:	105021554 105022776

SFM:	108939227 108940175(trim25)

PKI:	111833577 111855145

AANG:

118207581 118220170

LOC:	102683646 102689412

PSPA:

121295724 121296035 121298032 121299672 121299673 121300200

ARUT:

117395027 117423023 117424591 117426251 117434063 117964433

PSEX:

120517121(trim25)

LCM:	102356133(TRIM25) 102356589

CMK:	103190742(trim25)

RTP:

109922057

CPLA:

122562326

HOC:	132827685 132827886(trim25)

LERI:

129708485(trim25)

LRJ:

133339139

» show all

Reference

PMID:8248217

Authors

Inoue S, Orimo A, Hosoi T, Kondo S, Toyoshima H, Kondo T, Ikegami A, Ouchi Y, Orimo H, Muramatsu M

Title

Genomic binding-site cloning reveals an estrogen-responsive gene that encodes a RING finger protein.

Journal

Proc Natl Acad Sci U S A 90:11117-21 (1993)
DOI:10.1073/pnas.90.23.11117

Sequence

[hsa:7706]

Reference

PMID:18248090

Authors

Uchil PD, Quinlan BD, Chan WT, Luna JM, Mothes W

Title

TRIM E3 ligases interfere with early and late stages of the retroviral life cycle.

Journal

PLoS Pathog 4:e16 (2008)
DOI:10.1371/journal.ppat.0040016

Sequence

[hsa:7706]

Reference

PMID:17392790

Authors

Gack MU, Shin YC, Joo CH, Urano T, Liang C, Sun L, Takeuchi O, Akira S, Chen Z, Inoue S, Jung JU

Title

TRIM25 RING-finger E3 ubiquitin ligase is essential for RIG-I-mediated antiviral activity.

Journal

Nature 446:916-920 (2007)
DOI:10.1038/nature05732

Sequence

[hsa:7706]

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Ontology (3)   
   KEGG BRITE (3)   
Pathway (6)   
   KEGG PATHWAY (6)   
Chemical reaction (1)   
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Gene (857)   
   KEGG GENES (689)   
   KEGG MGENES (104)   
   RefGene (54)   
   OC (10)   
Literature (3)   
   PubMed (3)   
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