KEGG ORTHOLOGY: K10713

ORTHOLOGY: K10713

Entry

K10713 KO

Name

fae

Definition

5,6,7,8-tetrahydromethanopterin hydro-lyase [EC:4.2.1.147]

Pathway

ko00680

Methane metabolism

ko01100

Metabolic pathways

ko01120

Microbial metabolism in diverse environments

ko01200

Carbon metabolism

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09102 Energy metabolism
   00680 Methane metabolism
    K10713  fae; 5,6,7,8-tetrahydromethanopterin hydro-lyase
Enzymes [BR:ko01000]
4. Lyases
  4.2  Carbon-oxygen lyases
   4.2.1  Hydro-lyases
    4.2.1.147  5,6,7,8-tetrahydromethanopterin hydro-lyase
     K10713  fae; 5,6,7,8-tetrahydromethanopterin hydro-lyase

Other DBs

RN:

R08058

COG:

COG1795

Genes

KMI:	VW41_19435

CNT:	JT31_16265

CEM:	LH23_01445

CEN:	LH86_01435

YPE:

YPK:

YPH:

YPA:

YPN:

YPM:

YPP:	YPDSF_1875

YPG:	YpAngola_A1721

YPZ:

YPZ3_2110

YPT:	A1122_13840

YPD:

YPD4_2151

YPX:

YPD8_2236

YPW:	CH59_2(fae)

YPJ:	CH55_148(fae)

YPV:	BZ15_1068(fae)

YPL:	CH46_2648(fae)

YPS:

YPTB2503

YPO:	BZ17_4134(fae)

YPI:	YpsIP31758_1542

YPY:

YPK_1651

YPB:

YPTS_2597

YPQ:	DJ40_4039(fae)

YPU:	BZ21_1799(fae)

YPR:	BZ20_3706(fae)

YPC:	BZ23_2084(fae)

YPF:	BZ19_1865(fae)

SPE:

Spro_2468

SFO:	Z042_11985

EAME:

GXP68_21270(fae)

DYE:	EO087_01975(fae)

PCQ:	PcP3B5_53090(fae)

PFN:	HZ99_00560

PMAN:

OU5_6013

PTV:	AA957_01335

PAZO:

AYR47_21265

PCZ:	PCL1606_37300

PSEM:

TO66_12085

PSOS:

POS17_3724

PANR:

A7J50_2664

PYM:	AK972_2518

PKE:	DLD99_16655(fae)

POJ:	PtoMrB4_31270

MCA:	MCA2778 MCA2866

METU:

GNH96_00505(fae) GNH96_03515(fae)

MMT:	Metme_0102 Metme_2268 Metme_2975

MDN:	JT25_013205 JT25_015530 JT25_019350 JT25_022600

MDH:	AYM39_06220 AYM39_08555 AYM39_18505

MKO:	MKLM6_1265 MKLM6_1781 MKLM6_3742

METL:

U737_02620(fae) U737_05120(fae) U737_11025(fae) U737_14805(fae)

MAH:	MEALZ_0850(fae2) MEALZ_1456(fae) MEALZ_2428(fae)

MBUR:

EQU24_09110(fae) EQU24_10305(fae) EQU24_13345(fae) EQU24_14320(fae)

MPSY:

CEK71_02655(fae) CEK71_20175(fae)

MMAI:

sS8_0613 sS8_3390 sS8_4382 sS8_4455 sS8_5134

MMOB:

F6R98_04980(fae) F6R98_15000(fae) F6R98_19005(fae)

MEJ:	Q7A_1764(fae) Q7A_1938(fae) Q7A_47(fae)

MEC:	Q7C_1775 Q7C_2566 Q7C_8

BLEP:

AL038_08760(fae) AL038_13645(fae)

NHL:

Nhal_3879

NWR:	E3U44_04660(fae)

TSY:	THSYN_31765 THSYN_32775

SEDS:

AAY24_01665

AMAH:

DLM_3633

RIN:	ACS15_3974(fae)

BUR:	Bcep18194_B2825

BCEN:

DM39_4730(fae)

BMK:	DM80_4395(fae)

BCEP:

APZ15_26560

BPYR:

ABD05_19745

BDF:	WI26_16315

BTEI:

WS51_00910

BSTL:

BBJ41_29385

BUG:	BC1001_3951 BC1001_4826

BGF:	BC1003_4670 BC1003_5452

BGD:	bgla_2g26440

BYI:	BYI23_B014430 BYI23_D012810 BYI23_D013000

BUE:	BRPE67_BCDS01420 BRPE67_DCDS01480 BRPE67_DCDS01680

BUQ:	AC233_22040 AC233_25905

BUM:	AXG89_19490

BUI:	AX768_29255

BXE:	Bxe_B2436(fae)

BXB:	DR64_4764(fae)

BPH:	Bphy_5474 Bphy_6487

BGE:	BC1002_3220

BPX:	BUPH_00535 BUPH_01391

BPY:	Bphyt_6933

BUZ:	AYM40_21715

BFN:	OI25_5387(fae)

BCAI:

K788_0000879 K788_0003216 K788_0008560

PSPW:

BJG93_19410

PARA:

BTO02_24110

PARB:

CJU94_31180(fae)

PHS:	C2L64_25890(fae) C2L64_32370(fae) C2L64_38280(fae)

PTER:

C2L65_22495(fae) C2L65_29025(fae) C2L65_34275(fae)

PGP:	CUJ91_21485(fae) CUJ91_30315(fae)

PCJ:	CUJ87_23435(fae) CUJ87_27745(fae)

PTS:	CUJ90_21415(fae) CUJ90_28055(fae)

PCAF:

DSC91_002948

PMEG:

FNZ07_05665(fae)

CABA:

SBC2_54700(fae)

BUO:	BRPE64_BCDS01560 BRPE64_DCDS00870 BRPE64_DCDS01190

RHG:	EXZ61_07325(fae)

VAP:	Vapar_3063 Vapar_3079

VPD:	VAPA_1c31280 VAPA_1c31430(fae)

MPT:	Mpe_A2612 Mpe_A2627

METP:

C1M51_15005(fae) C1M51_15080(fae)

CARE:

LT85_1433

LCH:	Lcho_3132 Lcho_3147

RGE:	RGE_40280(fae) RGE_40430

AON:	DEH84_18915(fae)

METR:

BSY238_1372(fae) BSY238_3289(fae)

MFA:	Mfla_1652 Mfla_2364 Mfla_2524 Mfla_2543

MMB:	Mmol_0024 Mmol_1253 Mmol_2056

MEH:	M301_0896 M301_1343 M301_1423 M301_2758

MEI:	Msip34_1495 Msip34_1496 Msip34_2416 Msip34_2608

MEP:	MPQ_1558 MPQ_1559 MPQ_2354 MPQ_2546

MBAC:

BN1209_1682

MEU:	ACJ67_01845 ACJ67_07775 ACJ67_12360

SPLB:

SFPGR_25950

AZA:	AZKH_p0238(fae) AZKH_p0270(fae)

AZD:	CDA09_11330(fae) CDA09_11535(fae)

THU:	AC731_004855 AC731_004925

THK:	CCZ27_13170(fae) CCZ27_13240(fae)

MCI:	Mesci_4263

MESW:

A9K65_023635

MESM:

EJ066_29735(fae)

PHT:	BLM14_23805 BLM14_29225

RGA:	RGR602_PC01571(fae)

XAU:	Xaut_0032 Xaut_1365 Xaut_1627

AZC:

AZC_0890

SNO:	Snov_0740 Snov_1050

STAR:

G3545_09615(fae) G3545_09875(fae)

LNE:	FZC33_09350(fae)

ANC:	GBB76_00705(fae) GBB76_01750(fae)

APRA:

G3A50_17700(fae)

MEA:	Mex_1p1339(fae) Mex_1p1766(fae) Mex_1p3356(fae)

MDI:	METDI2111(fae) METDI2518(fae) METDI3927(fae)

MEX:	Mext_1450 Mext_1834 Mext_3143

MCH:	Mchl_1725 Mchl_2169 Mchl_3465

MPO:	Mpop_1445 Mpop_1785 Mpop_3340

MZA:	B2G69_14880 B2G69_16830 B2G69_23280

MRD:	Mrad2831_0533 Mrad2831_2016 Mrad2831_4467

MET:	M446_4369 M446_5783

MNO:	Mnod_3403 Mnod_4915 Mnod_6007

MOR:	MOC_0688 MOC_2407 MOC_5126(fae)

META:

Y590_06750 Y590_08785 Y590_15320

MAQU:

Maq22A_1p31155(fae) Maq22A_c16490(fae)

MPHY:

MCBMB27_00110 MCBMB27_01618 MCBMB27_03977

MEE:	DA075_05745(fae) DA075_25935

METD:

C0214_08220(fae) C0214_10540(fae) C0214_17445 C0214_27315

METX:

A3862_04400 A3862_09065 A3862_20975 A3862_28285

METS:

DK389_14645(fae) DK389_20670(fae)

METI:

DK427_18460(fae) DK427_19030 DK427_23350(fae)

MMES:

MMSR116_16705(fae) MMSR116_21455 MMSR116_24175(fae)

MTEA:

DK419_01760 DK419_10810(fae)

MSL:	Msil_1799 Msil_2390

MTUN:

MTUNDRAET4_1948(fae) MTUNDRAET4_2726(fae) MTUNDRAET4_3737 MTUNDRAET4_4163

MLG:	CWB41_00705 CWB41_04145(fae) CWB41_06060(fae) CWB41_07900(fae)

HDN:	Hden_1474 Hden_1875 Hden_2126

HDT:	HYPDE_31273 HYPDE_33638

HMC:	HYPMC_1396(fae) HYPMC_1624(fae) HYPMC_2181(fae) HYPMC_3439

HNI:	W911_00020 W911_13190

FIL:	BN1229_v1_0583(fae) BN1229_v1_1275

FIY:	BN1229_v1_0585(fae) BN1229_v1_1273

MSC:	BN69_0705 BN69_1051(fae) BN69_1356(fae) BN69_1357

MBRY:

B1812_14735 B1812_14740 B1812_18000

MROS:

EHO51_09550(fae) EHO51_11440(fae) EHO51_13070(fae) EHO51_13075(fae)

MHEY:

H2LOC_003830(fae) H2LOC_003835(fae) H2LOC_014910(fae) H2LOC_019690

MPAR:

F7D14_05065(fae) F7D14_05070(fae) F7D14_07930(fae) F7D14_11835(fae) F7D14_12840(fae)

MTW:	CQW49_09280(fae) CQW49_13475(fae) CQW49_13480(fae)

PLEO:

OHA_1_02036(fae)

AALA:

IGS74_05765(fae)

MCG:	GL4_1783 GL4_3256

HDI:	HDIA_0174(fae_1) HDIA_2315(fae_2) HDIA_3044(fae_3)

METG:

HT051_03555(fae) HT051_10195(fae)

GBE:	GbCGDNIH1_0524 GbCGDNIH1_0770

GBH:	GbCGDNIH2_0524 GbCGDNIH2_0770

GBC:	GbCGDNIH3_0524 GbCGDNIH3_0770

GBS:	GbCGDNIH4_0524 GbCGDNIH4_0770

ALI:	AZOLI_p10696(fae1) AZOLI_p10865 AZOLI_p10886(fae2)

ABS:	AZOBR_p270080(fae)

ABQ:	ABAZ39_25485

ABF:	AMK58_22315

ATI:	AL072_27025

AZT:	TSH58p_01220(fae)

AZM:	DM194_17130(fae)

AOZ:	HUE56_08815(fae) HUE56_08905(fae)

SVL:	Strvi_4314

SRC:	M271_03745

SCLF:

BB341_29110

SMAL:

SMALA_7629

SNQ:	CP978_00965(fae)

SSPO:

DDQ41_05910(fae)

LXY:	O159_21150

MIX:	AB663_001784

MOY:	CVS54_02583(fae)

RLA:	Rhola_00000810

RPLA:

A4Z71_00360

CPHY:

B5808_02390

LTR:	EVS81_09120(fae)

LEB:	G7066_15115(fae)

MANT:

BHD05_05170

ARR:	ARUE_c06130

ARN:	CGK93_03385(fae)

AAU:

AMD:

AMN:

AMM:

AMZ:

LED:	BBK82_32490

ABAI:

IMCC26256_111856

RUB:	GBA63_16325(fae)

RBA:	RB10297(fae) RB9338(fae)

PSL:	Psta_2526 Psta_2658

PIR:	VN12_03550(fae_1) VN12_18235(fae_2)

RUL:	UC8_03170(fae_1) UC8_11080(fae_2)

MFF:	MFFC18_24490(fae_1) MFFC18_35380(fae_2)

ROL:	CA51_24730(fae)

AHEL:

Q31a_40200(fae)

LCRE:

Pla8534_42870(fae)

LPAV:

PLANPX_0556

AMUC:

Pan181_45480(fae)

PND:	Pla175_09770 Pla175_50940(fae)

PLM:	Plim_1285 Plim_3519

PEH:	Spb1_04510(fae_1) Spb1_19420(fae_2)

PBS:	Plabr_0087

PLS:	VT03_23680(fae_1) VT03_31915(fae_2)

PLH:	VT85_01025(fae_1) VT85_19960(fae_2)

FMR:	Fuma_01647(fae_1) Fuma_04816(fae_2)

GMR:	GmarT_10980(fae_1) GmarT_49910(fae_2)

GIM:	F1728_09275(fae) F1728_20510(fae)

BVO:	Pan97_44420(fae)

MRI:	Mal4_08490(fae)

SDYN:

Mal52_22840(fae_1) Mal52_35040(fae_2)

PLON:

Pla110_13110(fae)

GES:	VT84_01760(fae_1) VT84_22510(fae_2)

GOG:	C1280_14275(fae) C1280_25120(fae)

GMS:	SOIL9_33500 SOIL9_33510 SOIL9_75910

TIM:	GMBLW1_20440 GMBLW1_46820

LRS:	PX52LOC_00083 PX52LOC_07250(fae)

FTJ:	FTUN_3066 FTUN_8061

IPA:

Isop_1013

SACI:

Sinac_4606 Sinac_4954

PBOR:

BSF38_03483(fae_1) BSF38_04915(fae_2)

AGV:	OJF2_60590(fae_1) OJF2_74120(fae_2)

MOX:	DAMO_0454(fae)

MEW:	MSWAN_2043

METH:

MBMB1_1667

MFC:	BRM9_0918(fae)

MFI:	DSM1535_0886

MCUB:

MCBB_1971(fae-hps_3)

METO:

CIT02_09565(fae)

MKA:

MK1275

FPL:

Ferp_1735

GAH:

GAH_00673

MBA:	Mbar_A2060

MBY:	MSBRM_2444

MBW:	MSBRW_2677

MBAR:

MSBR2_2410

MBAK:

MSBR3_2463

MAC:

MA_3006

MVC:	MSVAZ_2649

MEK:	MSKOL_2653

MLS:	MSLAZ_1178

MSJ:	MSSAC_3267

MSZ:	MSSIH_1163

MSW:	MSSIT_1211

MTHR:

MSTHT_0003 MSTHT_0011

MTHE:

MSTHC_0717

MFZ:	AOB57_002495(fae)

MBU:

Mbur_0367

MMET:

MCMEM_1329

MZI:	HWN40_05490(fae)

MHZ:	Metho_1162

MCJ:	MCON_1033(faeA)

MHI:

Mhar_0339

MEM:	Memar_0975

MBG:	BN140_1906

MEMA:

MMAB1_2454(faeA)

RCI:	RCIX1876(fae)

IAG:

Igag_0274

» show all

Reference

PMID:11073907

Authors

Vorholt JA, Marx CJ, Lidstrom ME, Thauer RK

Title

Novel formaldehyde-activating enzyme in Methylobacterium extorquens AM1 required for growth on methanol.

Journal

J Bacteriol 182:6645-50 (2000)
DOI:10.1128/JB.182.23.6645-6650.2000

Sequence

[mea:Mex_1p1766]

Reference

PMID:16075199

Authors

Goenrich M, Thauer RK, Yurimoto H, Kato N

Title

Formaldehyde activating enzyme (Fae) and hexulose-6-phosphate synthase (Hps) in Methanosarcina barkeri: a possible function in ribose-5-phosphate biosynthesis.

Journal

Arch Microbiol 184:41-8 (2005)
DOI:10.1007/s00203-005-0008-1

All links

Ontology (3)   
   KEGG BRITE (2)   
   COG (1)   
Pathway (8)   
   KEGG PATHWAY (8)   
Chemical reaction (4)   
   KEGG ENZYME (1)   
   KEGG REACTION (1)   
   KEGG RCLASS (2)   
Gene (3444)   
   KEGG GENES (475)   
   KEGG MGENES (2641)   
   RefGene (319)   
   OC (9)   
Literature (2)   
   PubMed (2)   
All databases (3461)   

Download RDF

ORTHOLOGY: K13812

Entry

K13812 KO

Name

fae-hps

Definition

bifunctional enzyme Fae/Hps [EC:4.2.1.147 4.1.2.43]

Pathway

ko00030

Pentose phosphate pathway

ko00680

Methane metabolism

ko01100

Metabolic pathways

ko01120

Microbial metabolism in diverse environments

ko01200

Carbon metabolism

ko01230

Biosynthesis of amino acids

Module

M00345

Formaldehyde assimilation, ribulose monophosphate pathway

M00580

Pentose phosphate pathway, archaea, fructose 6P => ribose 5P

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09101 Carbohydrate metabolism
   00030 Pentose phosphate pathway
    K13812  fae-hps; bifunctional enzyme Fae/Hps
  09102 Energy metabolism
   00680 Methane metabolism
    K13812  fae-hps; bifunctional enzyme Fae/Hps
Enzymes [BR:ko01000]
4. Lyases
  4.1  Carbon-carbon lyases
   4.1.2  Aldehyde-lyases
    4.1.2.43  3-hexulose-6-phosphate synthase
     K13812  fae-hps; bifunctional enzyme Fae/Hps
  4.2  Carbon-oxygen lyases
   4.2.1  Hydro-lyases
    4.2.1.147  5,6,7,8-tetrahydromethanopterin hydro-lyase
     K13812  fae-hps; bifunctional enzyme Fae/Hps

Other DBs

RN:	R05338 R08058

COG:	COG1795 COG0269

Genes

MJA:

MJ_1447

MFE:	Mefer_1012

MVU:	Metvu_1176

MFS:	MFS40622_0906

MIF:	Metin_1286

MJH:	JH146_0570

MIG:	Metig_0664

MAE:

Maeo_0614

MOK:	Metok_1249

METF:

CFE53_04300

MTH:

MTH_1474

MMG:	MTBMA_c00570(fae_hps)

METC:

MTCT_1339

MWO:	MWSIV6_0011(fae-hps)

METE:

tca_01421(fae)

METZ:

METK:

MTHM:

MST:

METB:

MRU:

MSI:

MEB:

MMIL:

MEYE:

MOL:

MEL:	Metbo_0071

MEW:	MSWAN_0017

METH:

MBMB1_0009(fae-hps)

MFC:

BRM9_0060

MFI:	DSM1535_1378(fae-hps)

MCUB:

MCBB_0021(fae-hps_1)

MSUB:

BK009_09760

METN:

BK008_05430

METT:

CIT01_05685(fae)

METO:

CIT02_07030(fae)

MFV:

Mfer_0572

AFU:

AF_1305

AFG:	AFULGI_00014160

APO:	Arcpr_1052

AVE:	Arcve_1411

AST:	Asulf_01087

FPL:

Ferp_2129

GAC:

GACE_2158

GAH:

GAH_00575

MBA:	Mbar_A0935

MBY:	MSBRM_0067

MBW:	MSBRW_0061

MBAR:

MBAK:

MAC:

MMA:

MMAZ:

MMJ:	MSMAS_0037

MMAC:

MSMAC_0037

MVC:	MSVAZ_0074

MEK:	MSKOL_0070

MLS:	MSLAZ_0035

METM:

MSMTP_0040

MEF:	MSWH1_0036

MEQ:	MSWHS_0037

MSJ:	MSSAC_0046

MSZ:	MSSIH_0039

MSW:	MSSIT_0039

MTHR:

MSTHT_1787

MTHE:

MSTHC_1499

MHOR:

MSHOH_0037

MFZ:	AOB57_008160

MBU:	Mbur_1994(fae-hps)

MMET:

MCMEM_0222

MMH:

Mmah_0234

MHAZ:

BHR79_02340

MEV:	Metev_1698

MZH:	Mzhil_0262

MPY:

Mpsy_1425

MZI:	HWN40_01665

MHZ:	Metho_0261

MTP:

MCJ:

MHI:

MHU:

MLA:

MEM:	Memar_1085

MBG:	BN140_1075

MEMA:

MMAB1_1386(fae-hps)

MPI:

Mpet_0801

MBN:

Mboo_0772

MFO:	Metfor_2057

MPL:

Mpal_1036

MPD:	MCP_2904(fae_hps)

MEZ:	Mtc_0381(fae)

RCI:	RCIX775(fae-hps)

CCAI:

NAS2_0542

BARC:

AOA65_1083(faeB-hpsB)

BARB:

AOA66_1278

FLT:	Sv326_0214 Sv326_0884

LOKI:

Lokiarch_06870 Lokiarch_17920 Lokiarch_47420

PSYT:

DSAG12_03237(faeB-hpsB)

» show all

Reference

PMID:16237021

Authors

Grochowski LL, Xu H, White RH

Title

Ribose-5-phosphate biosynthesis in Methanocaldococcus jannaschii occurs in the absence of a pentose-phosphate pathway.

Journal

J Bacteriol 187:7382-9 (2005)
DOI:10.1128/JB.187.21.7382-7389.2005

Sequence

[mja:MJ_1447]

All links

Ontology (4)   
   KEGG BRITE (2)   
   COG (2)   
Pathway (14)   
   KEGG PATHWAY (12)   
   KEGG MODULE (2)   
Chemical reaction (8)   
   KEGG ENZYME (2)   
   KEGG REACTION (2)   
   KEGG RCLASS (4)   
Gene (179)   
   KEGG GENES (101)   
   KEGG MGENES (61)   
   RefGene (15)   
   OC (2)   
Literature (1)   
   PubMed (1)   
All databases (206)   

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ENZYME: 4.2.1.147

Entry

EC 4.2.1.147 Enzyme

Name

5,6,7,8-tetrahydromethanopterin hydro-lyase;
formaldehyde-activating enzyme

Class

Lyases;
Carbon-oxygen lyases;
Hydro-lyases

Sysname

5,6,7,8-tetrahydromethanopterin hydro-lyase (formaldehyde-adding, tetrahydromethanopterin-forming)

Reaction(IUBMB)

5,6,7,8-tetrahydromethanopterin + formaldehyde = 5,10-methylenetetrahydromethanopterin + H2O [RN:R08058]

Reaction(KEGG)

R08058

Substrate

5,6,7,8-tetrahydromethanopterin [CPD:C01217];
formaldehyde [CPD:C00067]

Product

5,10-methylenetetrahydromethanopterin [CPD:C04377];
H2O [CPD:C00001]

Comment

Found in methylotrophic bacteria and methanogenic archaea.

History

EC 4.2.1.147 created 2014

Pathway

ec00680

Methane metabolism

ec01100

Metabolic pathways

ec01120

Microbial metabolism in diverse environments

Orthology

K10713

5,6,7,8-tetrahydromethanopterin hydro-lyase

K13812

bifunctional enzyme Fae/Hps

Genes

KMI:	VW41_19435

CNT:	JT31_16265

CEM:	LH23_01445

CEN:	LH86_01435

YPE:

YPK:

YPH:

YPA:

YPN:

YPM:

YPP:	YPDSF_1875

YPG:	YpAngola_A1721

YPZ:

YPZ3_2110

YPT:	A1122_13840

YPD:

YPD4_2151

YPX:

YPD8_2236

YPW:	CH59_2(fae)

YPJ:	CH55_148(fae)

YPV:	BZ15_1068(fae)

YPL:	CH46_2648(fae)

YPS:

YPTB2503

YPO:	BZ17_4134(fae)

YPI:	YpsIP31758_1542

YPY:

YPK_1651

YPB:

YPTS_2597

YPQ:	DJ40_4039(fae)

YPU:	BZ21_1799(fae)

YPR:	BZ20_3706(fae)

YPC:	BZ23_2084(fae)

YPF:	BZ19_1865(fae)

SPE:

Spro_2468

SFO:	Z042_11985

EAME:

GXP68_21270(fae)

DYE:	EO087_01975(fae)

PCQ:	PcP3B5_53090(fae)

PFN:	HZ99_00560

PMAN:

OU5_6013

PTV:	AA957_01335

PAZO:

AYR47_21265

PCZ:	PCL1606_37300

PSEM:

TO66_12085

PSOS:

POS17_3724

PANR:

A7J50_2664

PYM:	AK972_2518

PKE:	DLD99_16655(fae)

POJ:	PtoMrB4_31270

MCA:	MCA2778 MCA2866

METU:

GNH96_00505(fae) GNH96_03515(fae)

MMT:	Metme_0102 Metme_2268 Metme_2975

MDN:	JT25_013205 JT25_015530 JT25_019350 JT25_022600

MDH:	AYM39_06220 AYM39_08555 AYM39_18505

MKO:	MKLM6_1265 MKLM6_1781 MKLM6_3742

METL:

U737_02620(fae) U737_05120(fae) U737_11025(fae) U737_14805(fae)

MAH:	MEALZ_0850(fae2) MEALZ_1456(fae) MEALZ_2428(fae)

MBUR:

EQU24_09110(fae) EQU24_10305(fae) EQU24_13345(fae) EQU24_14320(fae)

MPSY:

CEK71_02655(fae) CEK71_20175(fae)

MMAI:

sS8_0613 sS8_3390 sS8_4382 sS8_4455 sS8_5134

MMOB:

F6R98_04980(fae) F6R98_15000(fae) F6R98_19005(fae)

MEJ:	Q7A_1764(fae) Q7A_1938(fae) Q7A_47(fae)

MEC:	Q7C_1775 Q7C_2566 Q7C_8

BLEP:

AL038_08760(fae) AL038_13645(fae)

NHL:

Nhal_3879

NWR:	E3U44_04660(fae)

TSY:	THSYN_31765 THSYN_32775

SEDS:

AAY24_01665

AMAH:

DLM_3633

RIN:	ACS15_3974(fae)

BUR:	Bcep18194_B2825

BCEN:

DM39_4730(fae)

BMK:	DM80_4395(fae)

BCEP:

APZ15_26560

BPYR:

ABD05_19745

BDF:	WI26_16315

BTEI:

WS51_00910

BSTL:

BBJ41_29385

BUG:	BC1001_3951 BC1001_4826

BGF:	BC1003_4670 BC1003_5452

BGD:	bgla_2g26440

BYI:	BYI23_B014430 BYI23_D012810 BYI23_D013000

BUE:	BRPE67_BCDS01420 BRPE67_DCDS01480 BRPE67_DCDS01680

BUQ:	AC233_22040 AC233_25905

BUM:	AXG89_19490

BUI:	AX768_29255

BXE:	Bxe_B2436(fae)

BXB:	DR64_4764(fae)

BPH:	Bphy_5474 Bphy_6487

BGE:	BC1002_3220

BPX:	BUPH_00535 BUPH_01391

BPY:	Bphyt_6933

BUZ:	AYM40_21715

BFN:	OI25_5387(fae)

BCAI:

K788_0000879 K788_0003216 K788_0008560

PSPW:

BJG93_19410

PARA:

BTO02_24110

PARB:

CJU94_31180(fae)

PHS:	C2L64_25890(fae) C2L64_32370(fae) C2L64_38280(fae)

PTER:

C2L65_22495(fae) C2L65_29025(fae) C2L65_34275(fae)

PGP:	CUJ91_21485(fae) CUJ91_30315(fae)

PCJ:	CUJ87_23435(fae) CUJ87_27745(fae)

PTS:	CUJ90_21415(fae) CUJ90_28055(fae)

PCAF:

DSC91_002948

PMEG:

FNZ07_05665(fae)

CABA:

SBC2_54700(fae)

BUO:	BRPE64_BCDS01560 BRPE64_DCDS00870 BRPE64_DCDS01190

RHG:	EXZ61_07325(fae)

VAP:	Vapar_3063 Vapar_3079

VPD:	VAPA_1c31280 VAPA_1c31430(fae)

MPT:	Mpe_A2612 Mpe_A2627

METP:

C1M51_15005(fae) C1M51_15080(fae)

CARE:

LT85_1433

LCH:	Lcho_3132 Lcho_3147

RGE:	RGE_40280(fae) RGE_40430

AON:	DEH84_18915(fae)

METR:

BSY238_1372(fae) BSY238_3289(fae)

MFA:	Mfla_1652 Mfla_2364 Mfla_2524 Mfla_2543

MMB:	Mmol_0024 Mmol_1253 Mmol_2056

MEH:	M301_0896 M301_1343 M301_1423 M301_2758

MEI:	Msip34_1495 Msip34_1496 Msip34_2416 Msip34_2608

MEP:	MPQ_1558 MPQ_1559 MPQ_2354 MPQ_2546

MBAC:

BN1209_1682

MEU:	ACJ67_01845 ACJ67_07775 ACJ67_12360

SPLB:

SFPGR_25950

AZA:	AZKH_p0238(fae) AZKH_p0270(fae)

AZD:	CDA09_11330(fae) CDA09_11535(fae)

THU:	AC731_004855 AC731_004925

THK:	CCZ27_13170(fae) CCZ27_13240(fae)

MCI:	Mesci_4263

MESW:

A9K65_023635

MESM:

EJ066_29735(fae)

PHT:	BLM14_23805 BLM14_29225

RGA:	RGR602_PC01571(fae)

XAU:	Xaut_0032 Xaut_1365 Xaut_1627

AZC:

AZC_0890

SNO:	Snov_0740 Snov_1050

STAR:

G3545_09615(fae) G3545_09875(fae)

LNE:	FZC33_09350(fae)

ANC:	GBB76_00705(fae) GBB76_01750(fae)

APRA:

G3A50_17700(fae)

MEA:	Mex_1p1339(fae) Mex_1p1766(fae) Mex_1p3356(fae)

MDI:	METDI2111(fae) METDI2518(fae) METDI3927(fae)

MEX:	Mext_1450 Mext_1834 Mext_3143

MCH:	Mchl_1725 Mchl_2169 Mchl_3465

MPO:	Mpop_1445 Mpop_1785 Mpop_3340

MZA:	B2G69_14880 B2G69_16830 B2G69_23280

MRD:	Mrad2831_0533 Mrad2831_2016 Mrad2831_4467

MET:	M446_4369 M446_5783

MNO:	Mnod_3403 Mnod_4915 Mnod_6007

MOR:	MOC_0688 MOC_2407 MOC_5126(fae)

META:

Y590_06750 Y590_08785 Y590_15320

MAQU:

Maq22A_1p31155(fae) Maq22A_c16490(fae)

MPHY:

MCBMB27_00110 MCBMB27_01618 MCBMB27_03977

MEE:	DA075_05745(fae) DA075_25935

METD:

C0214_08220(fae) C0214_10540(fae) C0214_17445 C0214_27315

METX:

A3862_04400 A3862_09065 A3862_20975 A3862_28285

METS:

DK389_14645(fae) DK389_20670(fae)

METI:

DK427_18460(fae) DK427_19030 DK427_23350(fae)

MMES:

MMSR116_16705(fae) MMSR116_21455 MMSR116_24175(fae)

MTEA:

DK419_01760 DK419_10810(fae)

MSL:	Msil_1799 Msil_2390

MTUN:

MTUNDRAET4_1948(fae) MTUNDRAET4_2726(fae) MTUNDRAET4_3737 MTUNDRAET4_4163

MLG:	CWB41_00705 CWB41_04145(fae) CWB41_06060(fae) CWB41_07900(fae)

HDN:	Hden_1474 Hden_1875 Hden_2126

HDT:	HYPDE_31273 HYPDE_33638

HMC:	HYPMC_1396(fae) HYPMC_1624(fae) HYPMC_2181(fae) HYPMC_3439

HNI:	W911_00020 W911_13190

FIL:	BN1229_v1_0583(fae) BN1229_v1_1275

FIY:	BN1229_v1_0585(fae) BN1229_v1_1273

MSC:	BN69_0705 BN69_1051(fae) BN69_1356(fae) BN69_1357

MBRY:

B1812_14735 B1812_14740 B1812_18000

MROS:

EHO51_09550(fae) EHO51_11440(fae) EHO51_13070(fae) EHO51_13075(fae)

MHEY:

H2LOC_003830(fae) H2LOC_003835(fae) H2LOC_014910(fae) H2LOC_019690

MPAR:

F7D14_05065(fae) F7D14_05070(fae) F7D14_07930(fae) F7D14_11835(fae) F7D14_12840(fae)

MTW:	CQW49_09280(fae) CQW49_13475(fae) CQW49_13480(fae)

PLEO:

OHA_1_02036(fae)

AALA:

IGS74_05765(fae)

MCG:	GL4_1783 GL4_3256

HDI:	HDIA_0174(fae_1) HDIA_2315(fae_2) HDIA_3044(fae_3)

METG:

HT051_03555(fae) HT051_10195(fae)

GBE:	GbCGDNIH1_0524 GbCGDNIH1_0770

GBH:	GbCGDNIH2_0524 GbCGDNIH2_0770

GBC:	GbCGDNIH3_0524 GbCGDNIH3_0770

GBS:	GbCGDNIH4_0524 GbCGDNIH4_0770

ALI:	AZOLI_p10696(fae1) AZOLI_p10865 AZOLI_p10886(fae2)

ABS:	AZOBR_p270080(fae)

ABQ:	ABAZ39_25485

ABF:	AMK58_22315

ATI:	AL072_27025

AZT:	TSH58p_01220(fae)

AZM:	DM194_17130(fae)

AOZ:	HUE56_08815(fae) HUE56_08905(fae)

SVL:	Strvi_4314

SRC:	M271_03745

SCLF:

BB341_29110

SMAL:

SMALA_7629

SNQ:	CP978_00965(fae)

SSPO:

DDQ41_05910(fae)

LXY:	O159_21150

MIX:	AB663_001784

MOY:	CVS54_02583(fae)

RLA:	Rhola_00000810

RPLA:

A4Z71_00360

CPHY:

B5808_02390

LTR:	EVS81_09120(fae)

LEB:	G7066_15115(fae)

MANT:

BHD05_05170

ARR:	ARUE_c06130

ARN:	CGK93_03385(fae)

AAU:

AMD:

AMN:

AMM:

AMZ:

LED:	BBK82_32490

ABAI:

IMCC26256_111856

RUB:	GBA63_16325(fae)

RBA:	RB10297(fae) RB9338(fae)

PSL:	Psta_2526 Psta_2658

PIR:	VN12_03550(fae_1) VN12_18235(fae_2)

RUL:	UC8_03170(fae_1) UC8_11080(fae_2)

MFF:	MFFC18_24490(fae_1) MFFC18_35380(fae_2)

ROL:	CA51_24730(fae)

AHEL:

Q31a_40200(fae)

LCRE:

Pla8534_42870(fae)

LPAV:

PLANPX_0556

AMUC:

Pan181_45480(fae)

PND:	Pla175_09770 Pla175_50940(fae)

PLM:	Plim_1285 Plim_3519

PEH:	Spb1_04510(fae_1) Spb1_19420(fae_2)

PBS:	Plabr_0087

PLS:	VT03_23680(fae_1) VT03_31915(fae_2)

PLH:	VT85_01025(fae_1) VT85_19960(fae_2)

FMR:	Fuma_01647(fae_1) Fuma_04816(fae_2)

GMR:	GmarT_10980(fae_1) GmarT_49910(fae_2)

GIM:	F1728_09275(fae) F1728_20510(fae)

BVO:	Pan97_44420(fae)

MRI:	Mal4_08490(fae)

SDYN:

Mal52_22840(fae_1) Mal52_35040(fae_2)

PLON:

Pla110_13110(fae)

GES:	VT84_01760(fae_1) VT84_22510(fae_2)

GOG:	C1280_14275(fae) C1280_25120(fae)

GMS:	SOIL9_33500 SOIL9_33510 SOIL9_75910

TIM:	GMBLW1_20440 GMBLW1_46820

LRS:	PX52LOC_00083 PX52LOC_07250(fae)

FTJ:	FTUN_3066 FTUN_8061

IPA:

Isop_1013

SACI:

Sinac_4606 Sinac_4954

PBOR:

BSF38_03483(fae_1) BSF38_04915(fae_2)

AGV:	OJF2_60590(fae_1) OJF2_74120(fae_2)

MOX:	DAMO_0454(fae)

MJA:

MJ_1447

MFE:	Mefer_1012

MVU:	Metvu_1176

MFS:	MFS40622_0906

MIF:	Metin_1286

MJH:	JH146_0570

MIG:	Metig_0664

MAE:

Maeo_0614

MOK:	Metok_1249

METF:

CFE53_04300

MTH:

MTH_1474

MMG:	MTBMA_c00570(fae_hps)

METC:

MTCT_1339

MWO:	MWSIV6_0011(fae-hps)

METE:

tca_01421(fae)

METZ:

METK:

MTHM:

MST:

METB:

MRU:

MSI:

MEB:

MMIL:

MEYE:

MOL:

MEL:	Metbo_0071

MEW:	MSWAN_0017 MSWAN_2043

METH:

MBMB1_0009(fae-hps) MBMB1_1667

MFC:	BRM9_0060 BRM9_0918(fae)

MFI:	DSM1535_0886 DSM1535_1378(fae-hps)

MCUB:

MCBB_0021(fae-hps_1) MCBB_1971(fae-hps_3)

MSUB:

BK009_09760

METN:

BK008_05430

METT:

CIT01_05685(fae)

METO:

CIT02_07030(fae) CIT02_09565(fae)

MFV:

Mfer_0572

MKA:

MK1275

AFU:

AF_1305

AFG:	AFULGI_00014160

APO:	Arcpr_1052

AVE:	Arcve_1411

AST:	Asulf_01087

FPL:	Ferp_1735 Ferp_2129

GAC:

GACE_2158

GAH:	GAH_00575 GAH_00673

MBA:	Mbar_A0935 Mbar_A2060

MBY:	MSBRM_0067 MSBRM_2444

MBW:	MSBRW_0061 MSBRW_2677

MBAR:

MSBR2_2313 MSBR2_2410

MBAK:

MSBR3_2375 MSBR3_2463

MAC:	MA_3006 MA_4608

MMA:

MM_1279

MMAZ:

MmTuc01_1325

MMJ:	MSMAS_0037

MMAC:

MSMAC_0037

MVC:	MSVAZ_0074 MSVAZ_2649

MEK:	MSKOL_0070 MSKOL_2653

MLS:	MSLAZ_0035 MSLAZ_1178

METM:

MSMTP_0040

MEF:	MSWH1_0036

MEQ:	MSWHS_0037

MSJ:	MSSAC_0046 MSSAC_3267

MSZ:	MSSIH_0039 MSSIH_1163

MSW:	MSSIT_0039 MSSIT_1211

MTHR:

MSTHT_0003 MSTHT_0011 MSTHT_1787

MTHE:

MSTHC_0717 MSTHC_1499

MHOR:

MSHOH_0037

MFZ:	AOB57_002495(fae) AOB57_008160

MBU:	Mbur_0367 Mbur_1994(fae-hps)

MMET:

MCMEM_0222 MCMEM_1329

MMH:

Mmah_0234

MHAZ:

BHR79_02340

MEV:	Metev_1698

MZH:	Mzhil_0262

MPY:

Mpsy_1425

MZI:	HWN40_01665 HWN40_05490(fae)

MHZ:	Metho_0261 Metho_1162

MTP:

Mthe_0988

MCJ:	MCON_1033(faeA) MCON_1383

MHI:	Mhar_0019 Mhar_0339

MHU:

Mhun_1628

MLA:

Mlab_0996

MEM:	Memar_0975 Memar_1085

MBG:	BN140_1075 BN140_1906

MEMA:

MMAB1_1386(fae-hps) MMAB1_2454(faeA)

MPI:

Mpet_0801

MBN:

Mboo_0772

MFO:	Metfor_2057

MPL:

Mpal_1036

MPD:	MCP_2904(fae_hps)

MEZ:	Mtc_0381(fae)

RCI:	RCIX1876(fae) RCIX775(fae-hps)

IAG:

Igag_0274

CCAI:

NAS2_0542

BARC:

AOA65_1083(faeB-hpsB)

BARB:

AOA66_1278

FLT:	Sv326_0214 Sv326_0884

LOKI:

Lokiarch_06870 Lokiarch_17920 Lokiarch_47420

PSYT:

DSAG12_03237(faeB-hpsB)

» show all

Reference

1 [PMID:11073907]

Authors

Vorholt JA, Marx CJ, Lidstrom ME, Thauer RK

Title

Novel formaldehyde-activating enzyme in Methylobacterium extorquens AM1 required for growth on methanol.

Journal

J Bacteriol 182:6645-50 (2000)
DOI:10.1128/JB.182.23.6645-6650.2000

Sequence

[mea:Mex_1p1766]

Reference

2 [PMID:15632161]

Authors

Acharya P, Goenrich M, Hagemeier CH, Demmer U, Vorholt JA, Thauer RK, Ermler U

Title

How an enzyme binds the C1 carrier tetrahydromethanopterin. Structure of the tetrahydromethanopterin-dependent formaldehyde-activating enzyme (Fae) from Methylobacterium extorquens AM1.

Journal

J Biol Chem 280:13712-9 (2005)
DOI:10.1074/jbc.M412320200

Sequence

[mea:Mex_1p1766]

Other DBs

ExplorEnz - The Enzyme Database:

4.2.1.147

IUBMB Enzyme Nomenclature:

4.2.1.147

ExPASy - ENZYME nomenclature database:

4.2.1.147

BRENDA, the Enzyme Database:

4.2.1.147

REACTION: R08058

Entry

R08058 Reaction

Name

5,6,7,8-tetrahydromethanopterin hydro-lyase (formaldehyde-adding, 5,10-methylenetetrahydromethanopterin-forming)

Definition

5,6,7,8-Tetrahydromethanopterin + Formaldehyde <=> 5,10-Methylenetetrahydromethanopterin + H2O

Equation

C01217 + C00067 <=> C04377 + C00001

Reaction class

RC01583

C01217_C04377

RC01795

C00067_C04377

Enzyme

4.2.1.147

Pathway

rn00680

Methane metabolism

rn01100

Metabolic pathways

rn01120

Microbial metabolism in diverse environments

rn01200

Carbon metabolism

Orthology

K10713

5,6,7,8-tetrahydromethanopterin hydro-lyase [EC:4.2.1.147]

K13812

bifunctional enzyme Fae/Hps [EC:4.2.1.147 4.1.2.43]

Other DBs

RHEA:

24681

All links

Ontology (1)   
   KEGG BRITE (1)   
Pathway (8)   
   KEGG PATHWAY (8)   
Chemical substance (4)   
   KEGG COMPOUND (4)   
Chemical reaction (3)   
   KEGG ENZYME (1)   
   KEGG RCLASS (2)   
Gene (578)   
   KEGG ORTHOLOGY (2)   
   KEGG GENES (576)   
All databases (594)   

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