KEGG ORTHOLOGY: K10723

ORTHOLOGY: K10723

Entry

K10723                      KO

Symbol

SHD, CYP314A1

Name

ecdysone 20-monooxygenase [EC:1.14.99.22]

Pathway

map00981

Insect hormone biosynthesis

Reaction

R02374

ecdysone,hydrogen-donor:oxygen oxidoreductase (20-hydroxylating)

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   00981 Insect hormone biosynthesis
    K10723  SHD, CYP314A1; ecdysone 20-monooxygenase
09180 Brite Hierarchies
  09181 Protein families: metabolism
   00199 Cytochrome P450
    K10723  SHD, CYP314A1; ecdysone 20-monooxygenase
Enzymes [BR:ko01000]
1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.99  Miscellaneous
    1.14.99.22  ecdysone 20-monooxygenase
     K10723  SHD, CYP314A1; ecdysone 20-monooxygenase
Cytochrome P450 [BR:ko00199]
Cytochrome P450, animal type
  CYP314 family
   K10723  SHD, CYP314A1; ecdysone 20-monooxygenase

Other DBs

GO:

0004501

Genes

DME:	Dmel_CG13478(shd)

DER:

6545923

DSE:

6605674

DSI:	Dsimw501_GD14493(Dsim_GD14493)

DYA:	Dyak_GE22018

DSR:

DPO:

DPE:

DMN:

DWI:

DGR:

DMO:	Dmoj_GI11492

DAZ:

DNV:

DHE:

DVI:

CCAT:

BOD:

BDR:

RZE:

AOQ:

TDA:	119672901 119672949

MDE:

SCAC:

LCQ:

LSQ:

GFS:

ECOE:

CLON:

HIS:

AGA:

ACOZ:

AARA:

AMER:

ASTE:

AFUN:

AMOU:

AALI:

AAG:	110677901 5574128

AALB:

109413055 115261322

ASUA:

134219073

CQU:	CpipJ_CPIJ001380

CPII:

120426314

CNS:

116342612

BCOO:

119084419

AME:	411057(Cyp314a1)

ACER:

ALAB:

ADR:

AFLR:

BIM:

BBIF:

BVK:

BVAN:

BTER:

BAFF:

BPYO:

BPAS:

FVI:

CCAL:

OBB:

OLG:

MGEN:

NMEA:

CGIG:

SOC:

MPHA:

PBAR:

VEM:

HST:

DQU:

CFO:

FEX:

LHU:

PGC:

OBO:

PCF:

PFUC:

VPS:

VCRB:

VVE:

NVI:	100115247(CYP314A1)

CSOL:

TPRE:

LHT:

LBD:

MDL:

CGLO:

FAS:

DAM:

AGIF:

CINS:

VCAN:

CCIN:

DSM:

NPT:

NFB:

NLO:

NVG:

AROA:

TCA:	661451(Cyp314a1)

DPA:

SOY:

AGRG:

ATD:

CSET:

AGB:

LDC:

DVV:

NVL:

APLN:

PPYR:

OTU:

BMOR:

100127102(Cyp314a1)

BMAN:

114243638

MSEX:

115447334

DPL:	KGM_205009

BANY:

MJU:

NIQ:

VCD:

MCIX:

PMAC:

PPOT:

PXU:

PRAP:

PBX:

PNAP:

ZCE:

CCRC:

LSIN:

AAGE:

HAW:

HZE:

TNL:	113499203 113508193

SLIU:

OFU:

ATRA:

GMW:

PXY:

PGW:

LGLY:

CFEL:

API:	100165833 100167431

DNX:

AGS:

RMD:

ACOO:

DVT:

BTAB:

DCI:

CLEC:

HHAL:

NLU:

HVI:

MQU:

PHU:	Phum_PHUM213010

FOC:

TPAL:

ZNE:

CSEC:

SGRE:

BROR:

IEL:

FCD:

DPX:	DAPPUDRAFT_198743

DMK:

DPZ:

HAME:

LSM:

TCF:

DSV:

RSAN:

RMP:

VDE:

VJA:

TUT:

DPTE:

DFR:

CSCU:

PTEP:

ABRU:

UDV:

SDM:

LPOL:

Reference

PMID:14610274

Authors

Petryk A, Warren JT, Marques G, Jarcho MP, Gilbert LI, Kahler J, Parvy JP, Li Y, Dauphin-Villemant C, O'Connor MB

Title

Shade is the Drosophila P450 enzyme that mediates the hydroxylation of ecdysone to the steroid insect molting hormone 20-hydroxyecdysone.

Journal

Proc Natl Acad Sci U S A 100:13773-8 (2003)
DOI:10.1073/pnas.2336088100

Sequence

[dme:Dmel_CG13478]

All links

Ontology (4)   
   KEGG BRITE (3)   
   GO (1)   
Pathway (2)   
   KEGG PATHWAY (2)   
Chemical reaction (3)   
   KEGG ENZYME (1)   
   KEGG REACTION (1)   
   KEGG RCLASS (1)   
Gene (370)   
   KEGG GENES (190)   
   KEGG MGENES (3)   
   RefGene (175)   
   OC (2)   
Literature (1)   
   PubMed (1)   
All databases (380)   

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