KEGG ORTHOLOGY: K10800

ORTHOLOGY: K10800

Entry

K10800                      KO

Symbol

SMUG1

Name

single-strand selective monofunctional uracil DNA glycosylase [EC:3.2.2.-]

Pathway

map03410

Base excision repair

Brite

KEGG Orthology (KO) [BR:ko00001]
09120 Genetic Information Processing
  09124 Replication and repair
   03410 Base excision repair
    K10800  SMUG1; single-strand selective monofunctional uracil DNA glycosylase
09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03400 DNA repair and recombination proteins
    K10800  SMUG1; single-strand selective monofunctional uracil DNA glycosylase
DNA repair and recombination proteins [BR:ko03400]
Eukaryotic type
  SSBR (single strand breaks repair)
   BER (base exicision repair)
    DNA glycosylases
     K10800  SMUG1; single-strand selective monofunctional uracil DNA glycosylase
Prokaryotic type
  SSBR (single strand breaks repair)
   BER (base exicision repair)
    DNA glycosylases
     K10800  SMUG1; single-strand selective monofunctional uracil DNA glycosylase

Other DBs

GO:

0017065

Genes

HSA:	23583(SMUG1)

PTR:	451953(SMUG1)

PPS:	100972534(SMUG1)

GGO:	101133114(SMUG1)

PON:	100449666(SMUG1)

PPYG:

129009464(SMUG1)

NLE:	100581848(SMUG1)

HMH:	116480975(SMUG1)

SSYN:

129465822(SMUG1)

MCC:	704743(SMUG1)

MCF:	101864789(SMUG1)

MTHB:

126931160

MNI:	105474231(SMUG1)

CSAB:

103238429(SMUG1)

CATY:

105580246(SMUG1)

PANU:

101026837(SMUG1)

TGE:	112635221(SMUG1)

MLEU:

105548547(SMUG1)

RRO:	104670568(SMUG1)

RBB:	108514631(SMUG1)

TFN:	117090002(SMUG1)

PTEH:

111541911(SMUG1)

CANG:

105503542(SMUG1)

CJC:	100414423(SMUG1)

SBQ:	101030615 101041059

CIMI:

108284906(SMUG1)

ANAN:

105715890(SMUG1)

MMUR:

105871113(SMUG1)

LCAT:

123639740(SMUG1) 123647601

PCOQ:

105818547(SMUG1)

OGA:	100946620(SMUG1) 105888383

MMU:	71726(Smug1)

MCAL:

110310372(Smug1)

MPAH:

110334824(Smug1)

RNO:	315344(Smug1)

MCOC:

116080764(Smug1)

ANU:	117719390(Smug1)

MUN:	110557605(Smug1)

CGE:	100770488(Smug1)

MAUA:

101841690(Smug1)

PROB:

127226160(Smug1)

PLEU:

114696609(Smug1)

MORG:

121459798(Smug1)

MFOT:

126491212

AAMP:

119823845(Smug1)

NGI:	103738845(Smug1)

HGL:	101709636(Smug1)

CPOC:

100724319(Smug1)

CCAN:

109686643(Smug1)

DORD:

105997915(Smug1)

DSP:	122124171(Smug1)

PLOP:

125363724(Smug1)

NCAR:

124983641

MMMA:

107148824(Smug1)

OCU:

100352573

OPI:	101528460(SMUG1)

TUP:	102487283(SMUG1)

GVR:

103593207

CFA:	486497(SMUG1)

CLUD:

112667156(SMUG1)

VVP:	112911277(SMUG1)

VLG:	121480246(SMUG1)

NPO:	129517330(SMUG1)

AML:	100478171(SMUG1)

UMR:	103675556(SMUG1)

UAH:	113257523(SMUG1)

UAR:	123794674(SMUG1)

ELK:

111157966

LLV:

125106622

MPUF:

101691858(SMUG1)

MNP:	132019750(SMUG1)

MLK:	131838666(SMUG1)

NVS:	122891727(SMUG1)

ORO:	101384531(SMUG1)

EJU:	114225866(SMUG1)

ZCA:	113922972(SMUG1)

MLX:	118008765(SMUG1)

NSU:	110577460(SMUG1)

LWW:	102737936(SMUG1)

FCA:	101091213(SMUG1)

PYU:	121038451(SMUG1)

PCOO:

112867210(SMUG1)

PBG:	122472414 122473520(SMUG1)

PVIV:

125171128(SMUG1)

LRUF:

124501769

PTG:	102964711(SMUG1)

PPAD:

109249237(SMUG1)

PUC:

125919139

AJU:

106989336

HHV:	120220042(SMUG1)

BTA:	539771(SMUG1)

BOM:	102272112(SMUG1)

BIU:	109559011(SMUG1)

BBUB:

102408448(SMUG1)

BBIS:

105001603(SMUG1)

CHX:	102189462(SMUG1)

OAS:	101107856(SMUG1)

BTAX:

128048847(SMUG1)

ODA:	120858326(SMUG1)

CCAD:

122427396(SMUG1) 122441698

MBEZ:

129535936(SMUG1)

SSC:	100153912(SMUG1)

CFR:	102514309(SMUG1)

CBAI:

105076383(SMUG1)

CDK:	105101010(SMUG1)

VPC:	102526104(SMUG1)

BACU:

102999722(SMUG1)

BMUS:

118902474(SMUG1)

LVE:	103077322(SMUG1)

OOR:	101278170(SMUG1)

DLE:	111173925(SMUG1)

PCAD:

102984087(SMUG1)

PSIU:

116760760(SMUG1)

NASI:

112394192(SMUG1)

ECB:	100064502(SMUG1)

EPZ:	103555871(SMUG1)

EAI:	106828178(SMUG1)

MYB:	102245321(SMUG1)

MYD:	102762705(SMUG1)

MMYO:

118651175(SMUG1)

MLF:	102433171(SMUG1)

MDT:	132227697(SMUG1)

PKL:	118729944(SMUG1)

EFUS:

103285364(SMUG1)

MNA:	107541077(SMUG1)

DRO:	112318633(SMUG1)

SHON:

118996074(SMUG1)

AJM:	119043537(SMUG1)

PDIC:

114513576(SMUG1)

PHAS:

123812424(SMUG1)

MMF:	118624331(SMUG1)

PPAM:

129084541(SMUG1)

HAI:	109391849(SMUG1)

RFQ:	117029221(SMUG1)

PALE:

102889610(SMUG1)

PGIG:

120602124(SMUG1)

PVP:	105302631(SMUG1)

RAY:	107509872(SMUG1)

MJV:	108408530(SMUG1)

TOD:	119248004(SMUG1)

SARA:

101547547(SMUG1)

SETR:

126022610(SMUG1)

LAV:	100664522(SMUG1)

TMU:

101356370

ETF:	101646864(SMUG1)

DNM:	101420571(SMUG1)

MDO:	100010844(SMUG1)

GAS:	123249978(SMUG1)

SHR:	100930371(SMUG1)

AFZ:

127539142

PCW:	110207027(SMUG1)

TVP:	118849727(SMUG1)

OAA:	100091274(SMUG1)

GGA:	431025(SMUG1)

PCOC:

116234961(SMUG1)

MGP:	104916790(SMUG1)

NMEL:

110392002(SMUG1)

CATA:

118261091(SMUG1)

AFUL:

116499849(SMUG1)

TGU:

115491507

OTC:	121335601(SMUG1)

PRUF:

121355307(SMUG1)

OMA:	130265832(SMUG1)

PHI:	102112707(SMUG1)

ZLE:	135459064(SMUG1)

MMEA:

130587428(SMUG1)

FPG:	101923215(SMUG1)

FCH:	102058712(SMUG1)

SHAB:

115618686(SMUG1)

ACHC:

115351303(SMUG1)

HLE:	104830265(SMUG1)

AGEN:

126036698

CSTI:

104560541(SMUG1)

LDI:	104350693(SMUG1)

NNI:	104019118(SMUG1)

CUCA:

104062901(SMUG1)

BREG:

104641216(SMUG1)

CVF:

104289250

RTD:	128903822(SMUG1)

ASN:	112547943(SMUG1)

AMJ:	102562687(SMUG1)

CMY:	102945286(SMUG1)

CCAY:

125627624(SMUG1)

DCC:	119846154(SMUG1)

CPIC:

101939143(SMUG1)

TST:	117889057(SMUG1)

CABI:

116828546(SMUG1)

MRV:	120391371(SMUG1)

ACS:	100551589(smug1)

ASAO:

132767683(SMUG1)

PVT:	110074441(SMUG1)

SUND:

121923649(SMUG1)

PBI:	103060135(SMUG1)

PMUR:

107289494(SMUG1)

CTIG:

120302338 120314465

TSR:	106556521(SMUG1)

PGUT:

117666462 132709211

APRI:

131193561(SMUG1)

PTEX:

113445529(SMUG1)

NSS:	113418420(SMUG1)

VKO:	123029904(SMUG1)

PMUA:

114593081(SMUG1)

PRAF:

128406264(SMUG1)

ZVI:	118076914(SMUG1)

HCG:	128345263(SMUG1)

GJA:	107122616(SMUG1) 107125367

STOW:

125427646(SMUG1)

EMC:	129346220(SMUG1)

XLA:	399139(smug1.L)

XTR:	100037877(smug1)

NPR:	108797145(SMUG1)

RTEM:

120929359(SMUG1)

BBUF:

120996120(SMUG1)

BGAR:

122932269(SMUG1)

MUO:	115466802(SMUG1)

GSH:	117356304(SMUG1)

DRE:	570901(smug1)

SRX:	107707359 107754564

SANH:

107660781 107687108

SGH:	107551321 107557534

CCAR:

109093347(smug1)

CAUA:

113069228(smug1)

CGIB:

127968151 128028586

PTET:

122353504(smug1)

LROH:

127161278(smug1)

OMC:	131549380(smug1)

PPRM:

120473437(smug1)

RKG:	130086257(smug1)

MAMB:

125263691(smug1)

CIDE:

127522929

CERY:

137021248(smug1)

MASI:

127425976

TROS:

130550015 130550016

TDW:	130410326(smug1)

MANU:

129427901(smug1)

IPU:

108255130

IFU:	128625371(smug1)

PHYP:

113538023(smug1)

SMEO:

124402009(smug1)

TFD:	113661982(smug1)

TVC:	132838325(smug1)

TRN:	134302120(smug1)

CMAO:

118799974(smug1)

EEE:	113572404(smug1)

CHAR:

105907196(smug1)

TRU:	101073400(smug1)

TFS:	130524523(smug1)

TNG:	GSTEN00012219G001

LCO:	104929056(smug1)

NCC:	104959846(smug1)

TBEN:

117489591(smug1)

CGOB:

115007763(smug1)

PGEO:

117447190(smug1)

GACU:

117554879(smug1)

EMAC:

134882341(smug1)

ELY:	117256500(smug1)

EFO:	125896344(smug1)

PLEP:

121951002(smug1)

SLUC:

116066015(smug1)

ECRA:

117942898(smug1)

ESP:	116687245(smug1)

PFLV:

114554386(smug1)

GAT:	120835336(smug1)

PPUG:

119194015(smug1)

AFB:	129105881(smug1)

CLUM:

117730801(smug1)

PSWI:

130207994(smug1)

MSAM:

119886778(smug1)

SCHU:

122888482(smug1)

CUD:	121507028(smug1)

ALAT:

119021961(smug1)

MZE:	101469528(smug1)

ONL:	100708508(smug1)

OAU:	116326618(smug1)

OLA:	101163811(smug1)

OML:	112145264(smug1)

CSAI:

133449435(smug1)

XMA:	102234867(smug1)

XCO:	114135068(smug1)

XHE:	116710065(smug1)

PRET:

103465337(smug1)

PFOR:

103147615(smug1)

PLAI:

106938342(smug1)

PMEI:

106907474(smug1)

GAF:	122834495(smug1)

PPRL:

129358509(smug1)

CVG:	107082067(smug1)

CTUL:

119785406(smug1)

GMU:	124856196(smug1)

NFU:	107385641(smug1)

KMR:	108235689(smug1)

ALIM:

106536731(smug1)

NWH:	119412851(smug1)

AOCE:

111587643(smug1)

MCEP:

125006074(smug1)

CSEM:

103386059(smug1)

POV:	109628914(smug1)

SSEN:

122768411(smug1)

HHIP:

117761716(smug1)

HSP:	118105296(smug1)

PPLT:

128453661(smug1)

SMAU:

118309729(smug1)

LCF:	108886426 108898951

SDU:	111221824(smug1)

SLAL:

111667702(smug1)

XGL:	120783049(smug1)

HCQ:	109522442(smug1)

SSCV:

125977552

SBIA:

133507828(smug1)

PEE:	133408744(smug1)

PTAO:

133483165(smug1)

BPEC:

110171273 110171312

MALB:

109956238(smug1)

BSPL:

114856343(smug1)

SJO:	128355851(smug1)

SASA:

106583296(smug1)

STRU:

115150482(smug1)

OTW:	112254684(smug1)

OMY:	110528210(smug1)

OGO:	124019462(smug1)

ONE:

115146060

OKI:	109875932(smug1)

OKE:	118400357(smug1)

SALP:

111970180(smug1)

SNH:	120064582(smug1)

CCLU:

121577540(smug1)

ELS:	105016984(smug1)

SFM:	108918353(smug1)

PKI:	111854609(smug1)

AANG:

118211383(smug1)

LOC:	102687687(smug1)

PSPA:

121308810(smug1)

ARUT:

117400999 117971639

PSEX:

120524881(smug1)

LCM:	102365320(SMUG1)

CMK:	103189317(smug1)

HOC:	132808919 132808982

LERI:

129715561(smug1)

PMRN:

116948667(SMUG1)

LRJ:	133349698(SMUG1)

BFO:

BBEL:

CIN:

SCLV:

SPU:	577235 764571

LPIC:

129256568 129257918

APLC:

110976035

ARUN:

117288299

AJC:	117116920 117116921

DME:	Dmel_CG5285(Smug)

DER:

6552325

DSE:

6616778

DSI:	Dsimw501_GD15165(Dsim_GD15165)

DYA:	Dyak_GE10117

DSR:

DPO:

DPE:

DMN:

DWI:

DGR:

DMO:	Dmoj_GI24772

DAZ:

DNV:

DHE:

CCAT:

BOD:

RZE:

AOQ:

TDA:	119662332 119680918 119683595

MDE:

101900036

SCAC:

106080596

LCQ:	111683782 111690409

LSQ:	119607434 119610769

GFS:

ECOE:

CLON:

HIS:

AGA:

ACOZ:

AARA:

AMER:

ASTE:

AFUN:

AMOU:

AALI:

AAG:

AALB:

ASUA:

CQU:	CpipJ_CPIJ002767

CPII:

CNS:

AME:

ACER:

ALAB:

ADR:

AFLR:

BIM:

BBIF:

BVK:

BVAN:

BTER:

BAFF:

BPYO:

BPAS:

FVI:

CCAL:

OBB:

MGEN:

NMEA:

CGIG:

SOC:

MPHA:

AEC:

ACEP:

PBAR:

VEM:

HST:

DQU:

CFO:

FEX:

LHU:	105678652(Smug)

PGC:

OBO:

PCF:

PFUC:

VPS:

VCRB:

VVE:

NVI:

CSOL:

TPRE:

LHT:

LBD:

MDL:

CGLO:

FAS:

DAM:

AGIF:

VCAN:

CCIN:

NPT:

NFB:

NLO:

NVG:

AROA:

TCA:

SOY:

AGRG:

ATD:

CSET:

AGB:

LDC:

DVV:

NVL:	108560960 108561552

APLN:

108739102

PPYR:

116160348 116175004

OTU:	111429244 111429245

BMOR:

BMAN:

MSEX:

BANY:

MJU:

NIQ:

VCD:

MCIX:

PMAC:

PPOT:

PXU:

PRAP:

PBX:

PNAP:

ZCE:

CCRC:

LSIN:

AAGE:

HAW:

HZE:

TNL:

SLIU:

OFU:

ATRA:

GMW:

PXY:

PGW:

LGLY:

CFEL:

API:

DNX:

RMD:

ACOO:

DVT:

BTAB:

DCI:

CLEC:

HHAL:

NLU:

HVI:

MQU:

PHU:	Phum_PHUM450440

FOC:

TPAL:

ZNE:

CSEC:

SGRE:

BROR:

IEL:

DPX:	DAPPUDRAFT_128395

DMK:

DPZ:

PVM:

PJA:

PMOO:

HAME:

PCLA:

CQD:

PTRU:

ESN:

MNZ:

HAZT:

108677285 108677286 108677293 108677295 108680084

EAF:

TCF:

PPOI:

DSV:

RSAN:

RMP:

CSCU:

CVS:	136972187 136989093

PTEP:

ABRU:

UDV:

SDM:

LPOL:

HRO:	HELRODRAFT_143241

LGI:	LOTGIDRAFT_156721

HRF:

HRJ:

OBI:

OSN:

NVE:

EPA:	110251711 110254505

ATEN:

ADF:

AMIL:

PDAM:

SPIS:

AQU:

PPP:	112286263 112288234 112292826

GSL:	Gasu_56260

CCP:	CHC_T00005047001

ACAN:

ACA1_287990

AFUS:

EYZ66_03735

TMB:	Thimo_1862

MAER:

DAI18_02240

LMIR:

NCTC12852_00381

POLL:

OEG81_02220

COF:	FOZ74_14530

OTK:	C6570_10445

ARES:

IWH25_03720

OTR:	OTERR_01090(smuG)

NIV:	JY500_18560

EBA:	ebA2814(smuG)

ABRE:

pbN1_17640

APET:

ToN1_26420

RBH:	B4966_14985

AZO:

azo3976

AOA:

dqs_4119

AZA:	AZKH_4546(smuG)

AZI:	AzCIB_4656

AZD:	CDA09_22830

AZR:	CJ010_24925

TMZ:	Tmz1t_4073

THU:	AC731_014840

THAU:

C4PIVTH_1256

TCL:

Tchl_1134

THK:	CCZ27_19850

TAK:	Tharo_3342

THAG:

CKCBHOJB_03562

AZQ:	G3580_19650

ACOM:

CEW83_13985

ATW:	C0099_15720

ZPA:	C3497_14325

FPHO:

SHINM1_020940(smuG1)

APP:	CAP2UW1_0682

HTL:

HPTL_1858

GME:

Gmet_0095

GPI:	GPICK_01310

GBZ:	JZM60_06700

GEO:

Geob_3733

GSB:	GSUB_09320

GHC:	L9S41_08300

DRT:

Dret_1331

DAT:	HRM2_39870(smuG)

DOV:	DSCO28_05950(smuG1)

DWD:	DSCW_08240(smuG1)

DALK:

DSCA_07900(smuG1)

DML:	Dmul_09120

SUR:	STAUR_1475

VIN:	AKJ08_0437

SAMY:

HOH:

NANN:

BSED:

PCAY:

BBAE:

OBT:	OPIT5_20500

CAA:

Caka_2399

CALG:

SH580_07835

RUFI:

K0V07_08780

PUO:	RZN69_02300

PPHT:

MTAR:

AMU:

AGL:

ABIW:

Abiwalacus_16940(smuG1)

AMAK:

J5W79_01380

ROO:	G5S37_09615

LUO:	HHL09_14020

LAMB:

KBB96_18790

LUI:	llg_07920(smuG1)

SOA:	G3M56_007085

VBA:	IMCC26134_06875

RBA:	RB10395(smuG1)

PIR:	VN12_10430

RUL:

UC8_09670

RML:	FF011L_19530

ROL:	CA51_17970

RUV:

EC9_16630

RCF:	Poly24_12230

AHEL:

Q31a_64380

RLC:	K227x_19710

SMAM:

SNEP:

AMOB:

BMEI:

CCOP:

PHM:	PSMK_04790

PBAP:

Pla133_46170

SSM:	Spirs_3799

SFC:	Spiaf_0462

SLR:	L21SP2_2842

SBU:	SpiBuddy_1940

SGP:	SpiGrapes_3015

SASS:

MUG09_10410

SCC:	Spico_0977

» show all

Reference

PMID:10074426

Authors

Haushalter KA, Todd Stukenberg MW, Kirschner MW, Verdine GL

Title

Identification of a new uracil-DNA glycosylase family by expression cloning using synthetic inhibitors.

Journal

Curr Biol 9:174-85 (1999)
DOI:10.1016/S0960-9822(99)80087-6

Sequence

[hsa:23583] [xla:399139]

Reference

PMID:12718543

Authors

Masaoka A, Matsubara M, Hasegawa R, Tanaka T, Kurisu S, Terato H, Ohyama Y, Karino N, Matsuda A, Ide H

Title

Mammalian 5-formyluracil-DNA glycosylase. 2. Role of SMUG1 uracil-DNA glycosylase in repair of 5-formyluracil and other oxidized and deaminated base lesions.

Journal

Biochemistry 42:5003-12 (2003)
DOI:10.1021/bi0273213

Sequence

[hsa:23583] [rno:315344]

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Ontology (3)   
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Pathway (2)   
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Gene (5585)   
   KEGG GENES (682)   
   KEGG MGENES (3682)   
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