KEGG   ORTHOLOGY: K10817
Entry
K10817                      KO                                     
Symbol
eryAI
Name
6-deoxyerythronolide-B synthase EryAI [EC:2.3.1.94]
Pathway
map00522  Biosynthesis of 12-, 14- and 16-membered macrolides
map01052  Type I polyketide structures
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
Module
M00774  Erythromycin biosynthesis, propanoyl-CoA + methylmalonyl-CoA => deoxyerythronolide B => erythromycin A/B
Reaction
R00918  propanoyl-CoA:(2S)-methylmalonyl-CoA malonyltransferase (cyclizing)
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   01052 Type I polyketide structures
    K10817  eryAI; 6-deoxyerythronolide-B synthase EryAI
   00522 Biosynthesis of 12-, 14- and 16-membered macrolides
    K10817  eryAI; 6-deoxyerythronolide-B synthase EryAI
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01004 Lipid biosynthesis proteins
    K10817  eryAI; 6-deoxyerythronolide-B synthase EryAI
   01008 Polyketide biosynthesis proteins
    K10817  eryAI; 6-deoxyerythronolide-B synthase EryAI
Enzymes [BR:ko01000]
 2. Transferases
  2.3  Acyltransferases
   2.3.1  Transferring groups other than aminoacyl groups
    2.3.1.94  6-deoxyerythronolide-B synthase
     K10817  eryAI; 6-deoxyerythronolide-B synthase EryAI
Lipid biosynthesis proteins [BR:ko01004]
 Polyketide synthase
  Modular PKS
   K10817  eryAI; 6-deoxyerythronolide-B synthase EryAI
Polyketide biosynthesis proteins [BR:ko01008]
 Polyketide synthase (PKS)
  Modular type I PKS
   cis-AT PKS
    Erythronolide PKS
     K10817  eryAI; 6-deoxyerythronolide-B synthase EryAI
Other DBs
GO: 0047879
Genes
SNR: SNOUR_10075
SGF: HEP81_07912
AER: AERYTH_15920
SEN: SACE_0721(eryAI)
AEY: CDG81_13185
AG: AAG13917(megAI)
Reference
PMID:1618327
  Authors
Caffrey P, Bevitt DJ, Staunton J, Leadlay PF
  Title
Identification of DEBS 1, DEBS 2 and DEBS 3, the multienzyme polypeptides of the erythromycin-producing polyketide synthase from Saccharopolyspora erythraea.
  Journal
FEBS Lett 304:225-8 (1992)
DOI:10.1016/0014-5793(92)80624-P
Reference
PMID:11851474
  Authors
Staunton J, Wilkinson B
  Title
Biosynthesis of Erythromycin and Rapamycin.
  Journal
Chem Rev 97:2611-2630 (1997)
DOI:10.1021/cr9600316

  All links  
Ontology (5)   
   KEGG BRITE (4)   
   GO (1)   
Pathway (9)   
   KEGG PATHWAY (8)   
   KEGG MODULE (1)   
Chemical reaction (9)   
   KEGG ENZYME (1)   
   KEGG REACTION (1)   
   KEGG RCLASS (7)   
Gene (7)   
   KEGG GENES (6)   
   OC (1)   
Literature (2)   
   PubMed (2)   
All databases (32)   

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