KEGG   ORTHOLOGY: K11038
Entry
K11038                      KO                                     

Name
hlg, luk
Definition
leukocidin/hemolysin toxin family protein
Pathway
ko05150  Staphylococcus aureus infection
Brite
KEGG Orthology (KO) [BR:ko00001]
 09160 Human Diseases
  09171 Infectious disease: bacterial
   05150 Staphylococcus aureus infection
    K11038  hlg, luk; leukocidin/hemolysin toxin family protein
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   02000 Transporters
    K11038  hlg, luk; leukocidin/hemolysin toxin family protein
   02042 Bacterial toxins
    K11038  hlg, luk; leukocidin/hemolysin toxin family protein
Transporters [BR:ko02000]
 Other transporters
  Pores ion channels
   K11038  hlg, luk; leukocidin/hemolysin toxin family protein
Bacterial toxins [BR:ko02042]
 Type II toxins: Membrane damaging toxins
  Pore-forming toxins, Beta-pore-forming/Cholesterol-dependent
   K11038  hlg, luk; leukocidin/hemolysin toxin family protein
Other DBs
TC: 1.C.3.3 1.C.3.4
Genes
HCH: HCH_05158
HAHE: ENC22_07235
SAU: SA1637(lukD) SA1638(lukE) SA1812 SA1813 SA2207(hlgA) SA2208(hlgC) SA2209(hlgB)
SAV: SAV1819(lukD) SAV1820(lukE) SAV2004 SAV2005 SAV2419(hlgA) SAV2420(hlgC) SAV2421(hlgB)
SAW: SAHV_1804(lukD) SAHV_1805(lukE) SAHV_1990 SAHV_1991 SAHV_2403(hlgA) SAHV_2404(hlgC) SAHV_2405(hlgB)
SAH: SaurJH1_1904 SaurJH1_1905 SaurJH1_2099 SaurJH1_2100 SaurJH1_2493 SaurJH1_2494 SaurJH1_2495
SAJ: SaurJH9_1870 SaurJH9_1871 SaurJH9_2062 SaurJH9_2063 SaurJH9_2445 SaurJH9_2446 SaurJH9_2447
SAM: MW1378(lukF) MW1379(lukS) MW1767(lukD) MW1768(lukE) MW1941 MW1942 MW2342(hlgA) MW2343(hlgC) MW2344(hlgB)
SAS: SAS1748(hlgB) SAS1749(hlgA) SAS1924 SAS1925 SAS2310 SAS2311 SAS2312
SAR: SAR2107 SAR2108 SAR2509(hlgA) SAR2510(hlgC) SAR2511(hlgB)
SAC: SACOL1880(lukD) SACOL1881(lukE) SACOL2004 SACOL2006 SACOL2419(hlgA) SACOL2421(hlgC) SACOL2422(hlgB)
SAE: NWMN_1718(lukD) NWMN_1719(lukE) NWMN_1927(lukF) NWMN_1928(lukS) NWMN_2318(hlgA) NWMN_2319(hlgC) NWMN_2320(hlgB)
SAD: SAAV_1828(lukD) SAAV_1829(lukE) SAAV_2072 SAAV_2073 SAAV_2485(hlgA) SAAV_2486(hlgC) SAAV_2487(hlgB)
SUU: M013TW_1436(lukF-PV) M013TW_1437(lukS-PV) M013TW_1976(lukG) M013TW_1977(lukH) M013TW_2380(hlgA) M013TW_2382(hlgC) M013TW_2383(hlgB)
SAUE: RSAU_001674(lukD) RSAU_001675(lukE) RSAU_001837(lukG) RSAU_001838(lukH) RSAU_002258(hlgA) RSAU_002259(hlgC) RSAU_002260(hlgB)
SAUU: SA957_1377(lukF-PV) SA957_1378(lukS-PV) SA957_1864 SA957_1865 SA957_2252(hlgA) SA957_2254(hlgC) SA957_2255(hlgB)
SAUG: SA268_1381(lukF-PV) SA268_1382(lukS-PV) SA268_1936 SA268_1937 SA268_2325(hlgA) SA268_2327(hlgC) SA268_2328(hlgB)
SAUF: X998_1843(lukD) X998_1844 X998_1995(lukG) X998_1996(lukH) X998_2404(hlgA) X998_2406(hlgC) X998_2407(hlgB)
SAUC: CA347_2097(lukF) CA347_2098 CA347_2499(hlgA) CA347_2500(hlgC) CA347_2501(lukF)
SDT: SPSE_0990(lukF-I) SPSE_0991(lukS-I)
SDP: NCTC12225_01194(lukF-I) NCTC12225_01195(lukS-I)
MCAK: MCCS_01180(hlgB) MCCS_01190(hlgC)
VG: 1262726(PVL_26) 1262730(PVL_27) 1262954(phiPV83p62) 1262967(phiPV83p61) 14296837(LukS-PV) 14296842(LukF-PV) 14515443(lukS-PV) 14515446(lukF-PV) 22112714(lukS-PV) 22112715(lukF-PV) 4594537(LukF-PV) 4594538(LukS-PV) 5130983(ST3AORF021) 5525303(lukF-PV) 5525304(lukS-PV) 6965668(LukS-PV) 6965674(LukF-PV) 7967046(lukS-PV) 7967047(lukF-PV) 920148(lukF-PV) 920172(lukS-PV)
 » show all
Reference
  Authors
Barrio MB, Rainard P, Prevost G
  Title
LukM/LukF'-PV is the most active Staphylococcus aureus leukotoxin on bovine neutrophils.
  Journal
Microbes Infect 8:2068-74 (2006)
DOI:10.1016/j.micinf.2006.03.004
Reference
PMID:9781679
  Authors
Gravet A, Colin DA, Keller D, Girardot R, Monteil H, Prevost G
  Title
Characterization of a novel structural member, LukE-LukD, of the bi-component staphylococcal leucotoxins family.
  Journal
FEBS Lett 436:202-8 (1998)
DOI:10.1016/S0014-5793(98)01130-2
  Sequence
Reference
  Authors
Pedelacq JD, Maveyraud L, Prevost G, Baba-Moussa L, Gonzalez A, Courcelle E, Shepard W, Monteil H, Samama JP, Mourey L
  Title
The structure of a Staphylococcus aureus leucocidin component (LukF-PV) reveals the fold of the water-soluble species of a family of transmembrane pore-forming toxins.
  Journal
Structure 7:277-87 (1999)
DOI:10.1016/S0969-2126(99)80038-0
  Sequence

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