KEGG   ORTHOLOGY: K11180Help
Entry
K11180                      KO                                     

Name
dsrA
Definition
dissimilatory sulfite reductase alpha subunit [EC:1.8.99.5]
Pathway
ko00633  Nitrotoluene degradation
ko00920  Sulfur metabolism
ko01100  Metabolic pathways
ko01120  Microbial metabolism in diverse environments
Module
M00596  Dissimilatory sulfate reduction, sulfate => H2S
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09102 Energy metabolism
   00920 Sulfur metabolism
    K11180  dsrA; dissimilatory sulfite reductase alpha subunit
  09111 Xenobiotics biodegradation and metabolism
   00633 Nitrotoluene degradation
    K11180  dsrA; dissimilatory sulfite reductase alpha subunit
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.8  Acting on a sulfur group of donors
   1.8.99  With unknown physiological acceptors
    1.8.99.5  dissimilatory sulfite reductase
     K11180  dsrA; dissimilatory sulfite reductase alpha subunit
BRITE hierarchy
Other DBs
RN: R00295 R00861 R08035
COG: COG2221
GO: 0018551
Genes
TIG: THII_0611
ALV: Alvin_1251(dsrA)
TVI: Thivi_0544
TMB: Thimo_0143
MPUR: MARPU_10915
TSY: THSYN_22545
AEH: Mlg_1653
HHA: Hhal_1951
HHK: HH1059_16540(dsrA-2)
TGR: Tgr7_2185
ACII: C4901_06765(dsrA)
TBN: TBH_C2462(dsrA)
RMA: Rmag_0870
VOK: COSY_0795(dsrA)
EBH: BSEPE_1261(dsrA)
ENM: EBS_1784(dsrA)
BBAG: E1O_03050
SHD: SUTH_01444(dsrA)
SLT: Slit_1686
SDR: SCD_n02074(dsrA) SCD_n02718(dsrA)
DVU: DVU0402(dsvA)
DVL: Dvul_2532
DVM: DvMF_1553
DDE: Dde_0526
DMA: DMR_03600
DHY: DESAM_20117(dsvA)
DGG: DGI_0691(dsrA)
DEF: CNY67_09565(dsrA) CNY67_15025(dsrA)
DTR: RSDT_0580(dsrA)
DFL: DFE_3070
DAS: Daes_2985
DPI: BN4_12627(dsrA)
PPRF: DPRO_1446(dsvA)
DBA: Dbac_0279
DRT: Dret_0244(dsrA)
DPS: DP0797
DSF: UWK_01633
DOL: Dole_2669
DML: Dmul_28180(dsrA)
DAL: Dalk_4301
DAT: HRM2_42400(dsrA2)
DTO: TOL2_C05570(dsrA)
SFU: Sfum_4042
DAX: FDQ92_05055(dsrA)
DBR: Deba_0960
RVA: Rvan_0600
BLAG: BLTE_30840(dsrA-2)
MAG: amb3367
MGY: MGMSRv2__3912(dsrA)
MGRY: MSR1_25020(dsvA)
MAGX: XM1_4244(dsrA)
MAGN: WV31_00295
MAGQ: MGMAQ_2110(dsrA)
MGM: Mmc1_2156
DSY: DSY0309(dsrA)
DHD: Dhaf_0252
DRM: Dred_3187
DAE: Dtox_0079
DAU: Daud_2201
CHY: CHY_2410(dsrA)
ADG: Adeg_2094
TACI: TDSAC_1343
CBAC: JI75_04660
CTE: CT0852(dsrA-1) CT2249(dsrA-2)
CPC: Cpar_0028
CCH: Cag_1956
CLI: Clim_0694
PVI: Cvib_0039
PLT: Plut_0036
PPH: Ppha_2321
PAA: Paes_0029
PROC: Ptc2401_00028(dsvA)
PROS: CHL67_00155(dsrA)
TYE: THEYE_A1994(dsrA)
CTHI: THC_0449
AFU: AF_0423
PIS: Pisl_0171
TNE: Tneu_0344
CMA: Cmaq_0853
TTN: TTX_0424(dsrA) TTX_0426(dsrA) TTX_1188(dsrA)
VDI: Vdis_2098
VMO: VMUT_0501
VG: 26673068(AV947_gp47)
 » show all
TaxonomyVtaxonomyKoalaUniProt
Reference
PMID:9695921
  Authors
Pott AS, Dahl C
  Title
Sirohaem sulfite reductase and other proteins encoded by genes at the dsr locus of Chromatium vinosum are involved in the oxidation of intracellular sulfur.
  Journal
Microbiology 144 ( Pt 7):1881-94 (1998)
DOI:10.1099/00221287-144-7-1881
  Sequence

KEGG   ORTHOLOGY: K11181Help
Entry
K11181                      KO                                     

Name
dsrB
Definition
dissimilatory sulfite reductase beta subunit [EC:1.8.99.5]
Pathway
ko00633  Nitrotoluene degradation
ko00920  Sulfur metabolism
ko01100  Metabolic pathways
ko01120  Microbial metabolism in diverse environments
Module
M00596  Dissimilatory sulfate reduction, sulfate => H2S
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09102 Energy metabolism
   00920 Sulfur metabolism
    K11181  dsrB; dissimilatory sulfite reductase beta subunit
  09111 Xenobiotics biodegradation and metabolism
   00633 Nitrotoluene degradation
    K11181  dsrB; dissimilatory sulfite reductase beta subunit
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.8  Acting on a sulfur group of donors
   1.8.99  With unknown physiological acceptors
    1.8.99.5  dissimilatory sulfite reductase
     K11181  dsrB; dissimilatory sulfite reductase beta subunit
BRITE hierarchy
Other DBs
RN: R00295 R00861 R08035
COG: COG2221
GO: 0018551
Genes
TIG: THII_0612
ALV: Alvin_1252(dsrB)
TVI: Thivi_0545
TMB: Thimo_0144
MPUR: MARPU_10910
TSY: THSYN_22540
AEH: Mlg_1654
HHA: Hhal_1952
HHK: HH1059_16550(dsrB-1)
TGR: Tgr7_2186
TNI: TVNIR_0859(dsrB_[H]) TVNIR_1767(dsvB_[H])
ACII: C4901_06770(dsrB)
TBN: TBH_C2461(dsrB)
RMA: Rmag_0869
VOK: COSY_0794(dsrB)
EBH: BSEPE_1260(dsrB)
ENM: EBS_1783(dsrB)
BBAG: E1O_03060
SHD: SUTH_01443(dsrB)
TBD: Tbd_2484
SLT: Slit_1685
SDR: SCD_n02717(dsrB)
DVU: DVU0403(dvsB)
DVL: Dvul_2531
DVM: DvMF_1554
DDE: Dde_0527
DMA: DMR_03610
DHY: DESAM_20116(dsvB)
DGG: DGI_0689(dsrB)
DEF: CNY67_09570(dsrB) CNY67_15020(dsrB)
DTR: RSDT_0579(dsrB)
DFL: DFE_3071
DAS: Daes_2984
DPI: BN4_12628(dsrB)
PPRF: DPRO_1445(dsvB)
DBA: Dbac_0280
DRT: Dret_0245(dsrB)
DPS: DP0798
DSF: UWK_01634
DOL: Dole_2670
DML: Dmul_28170(dsrB)
DAL: Dalk_4300
DAT: HRM2_42390(dsrB2)
DTO: TOL2_C05580(dsrB)
SFU: Sfum_4043
DAX: FDQ92_05050(dsrB)
DBR: Deba_0959
RVA: Rvan_0599
BLAG: BLTE_30830(dsrB-1)
MAG: amb3368
MGY: MGMSRv2__3911(dsrB)
MGRY: MSR1_25030(dsvB)
MAGX: XM1_4245(dsrB)
MAGN: WV31_00300
MAGQ: MGMAQ_2111(dsrB)
MGM: Mmc1_2157
DSY: DSY0310(dsrB)
DHD: Dhaf_0253
DRM: Dred_3186
DAE: Dtox_0080
DAU: Daud_2200
CHY: CHY_2409(dsrB)
ADG: Adeg_2093
TACI: TDSAC_1342
GPA: GPA_16680
CBAC: JI75_04655
CTE: CT0853(dsrB-1)
CPC: Cpar_0029
CCH: Cag_1955
CLI: Clim_0695
PVI: Cvib_0040
PLT: Plut_0037
PPH: Ppha_2320
PAA: Paes_0030
PROC: Ptc2401_00029(dsvB)
PROS: CHL67_00160(dsrB)
TYE: THEYE_A1995(dsrB)
CTHI: THC_0450
AFU: AF_0424
PIS: Pisl_0170
TNE: Tneu_0345
CMA: Cmaq_0854
TTN: TTX_0423(dsrA) TTX_0427(dsrA) TTX_1187(dsrB)
VDI: Vdis_2099
VMO: VMUT_0502
 » show all
TaxonomyKoalaUniProt
Reference
PMID:9695921
  Authors
Pott AS, Dahl C
  Title
Sirohaem sulfite reductase and other proteins encoded by genes at the dsr locus of Chromatium vinosum are involved in the oxidation of intracellular sulfur.
  Journal
Microbiology 144 ( Pt 7):1881-94 (1998)
DOI:10.1099/00221287-144-7-1881
  Sequence

KEGG   ENZYME: 1.8.99.5Help
Entry
EC 1.8.99.5                 Enzyme                                 

Name
dissimilatory sulfite reductase;
siroheme sulfite reductase;
hydrogen-sulfide:(acceptor) oxidoreductase (ambiguous);
DsrAB
Class
Oxidoreductases;
Acting on a sulfur group of donors;
With unknown physiological acceptors
BRITE hierarchy
Sysname
hydrogen-sulfide:[DsrC sulfur-carrier protein],acceptor oxidoreductase
Reaction(IUBMB)
(1) hydrogen sulfide + a [DsrC protein]-disulfide + 2 acceptor + 3 H2O = sulfite + a [DsrC protein]-dithiol + 2 reduced acceptor + 2 H+ (overall reaction) [RN:R00861];
(1a) hydrogen sulfide + a [DsrC protein]-disulfide = a [DsrC protein]-S-sulfanyl-L-cysteine;
(1b) a [DsrC protein]-S-sulfanyl-L-cysteine + 2 acceptor + 3 H2O = sulfite + a [DsrC protein]-dithiol + 2 reduced acceptor + 2 H+;
(2) a [DsrC protein]-S-sulfanyl-L-cysteine + 3 acceptor + 3 H2O = sulfite + a [DsrC protein]-disulfide + 3 reduced acceptor + 2 H+ (overall reaction);
(2a) a [DsrC protein]-S-sulfanyl-L-cysteine + 3 acceptor + 3 H2O = a [DsrC]-S-sulfo-L-cysteine + 3 reduced acceptor + H+;
(2b) a [DsrC]-S-sulfo-L-cysteine = sulfite + a [DsrC protein]-disulfide
Reaction(KEGG)
R00861;
(other) R00295 R08035
Show
Substrate
hydrogen sulfide [CPD:C00283];
[DsrC protein]-disulfide;
acceptor [CPD:C00028];
H2O [CPD:C00001];
[DsrC protein]-S-sulfanyl-L-cysteine;
[DsrC]-S-sulfo-L-cysteine
Product
sulfite [CPD:C00094];
[DsrC protein]-dithiol;
reduced acceptor [CPD:C00030];
H+ [CPD:C00080];
[DsrC protein]-S-sulfanyl-L-cysteine;
[DsrC protein]-disulfide;
[DsrC]-S-sulfo-L-cysteine
Comment
Contain siroheme. The enzyme is essential in prokaryotic sulfur-based energy metabolism, including sulfate/sulfite reducing organisms, sulfur-oxidizing bacteria, and organosulfonate reducers. In sulfur reducers it catalyses the reduction of sulfite to sulfide (reaction 1 in the right to left direction), while in sulfur oxidizers it catalyses the opposite reaction (reaction 2 in the left to right direction) [1]. The reaction involves the small protein DsrC, which is present in all the organisms that contain dissimilatory sulfite reductase. During the process an intramolecular disulfide bond is formed between two L-cysteine residues of DsrC. This disulfide can be reduced by a number of proteins including DsrK and TcmB [5]. This enzyme is different from EC 1.8.1.2, assimilatory sulfite reductase (NADPH), and EC 1.8.7.1, assimilatory sulfite reductase (ferredoxin), which are involved in sulfate assimilation.
History
EC 1.8.99.5 created 2015
Pathway
ec00633  Nitrotoluene degradation
ec00920  Sulfur metabolism
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K11180  dissimilatory sulfite reductase alpha subunit
K11181  dissimilatory sulfite reductase beta subunit
Genes
TIG: THII_0611 THII_0612
ALV: Alvin_1251(dsrA) Alvin_1252(dsrB)
TVI: Thivi_0544 Thivi_0545
TMB: Thimo_0143 Thimo_0144
MPUR: MARPU_10910 MARPU_10915
TSY: THSYN_22540 THSYN_22545
AEH: Mlg_1653 Mlg_1654
HHA: Hhal_1951 Hhal_1952
HHK: HH1059_16540(dsrA-2) HH1059_16550(dsrB-1)
TGR: Tgr7_2185 Tgr7_2186
TNI: TVNIR_0859(dsrB_[H]) TVNIR_0860 TVNIR_1766 TVNIR_1767(dsvB_[H])
ACII: C4901_06765(dsrA) C4901_06770(dsrB)
TBN: TBH_C2461(dsrB) TBH_C2462(dsrA)
VOK: COSY_0794(dsrB) COSY_0795(dsrA)
EBH: BSEPE_1260(dsrB) BSEPE_1261(dsrA)
ENM: EBS_1783(dsrB) EBS_1784(dsrA)
SHD: SUTH_01443(dsrB) SUTH_01444(dsrA)
SDR: SCD_n02074(dsrA) SCD_n02717(dsrB) SCD_n02718(dsrA)
DVU: DVU0402(dsvA) DVU0403(dvsB)
DHY: DESAM_20116(dsvB) DESAM_20117(dsvA)
DGG: DGI_0689(dsrB) DGI_0691(dsrA)
DEF: CNY67_09565(dsrA) CNY67_09570(dsrB) CNY67_15020(dsrB) CNY67_15025(dsrA)
DTR: RSDT_0579(dsrB) RSDT_0580(dsrA)
DPI: BN4_12627(dsrA) BN4_12628(dsrB)
PPRF: DPRO_1445(dsvB) DPRO_1446(dsvA)
DRT: Dret_0244(dsrA) Dret_0245(dsrB)
DML: Dmul_28170(dsrB) Dmul_28180(dsrA)
DAT: HRM2_42390(dsrB2) HRM2_42400(dsrA2)
DTO: TOL2_C05570(dsrA) TOL2_C05580(dsrB)
DAX: FDQ92_05050(dsrB) FDQ92_05055(dsrA)
BLAG: BLTE_30830(dsrB-1) BLTE_30840(dsrA-2)
MGY: MGMSRv2__3911(dsrB) MGMSRv2__3912(dsrA)
MGRY: MSR1_25020(dsvA) MSR1_25030(dsvB)
MAGX: XM1_4244(dsrA) XM1_4245(dsrB)
MAGQ: MGMAQ_2110(dsrA) MGMAQ_2111(dsrB)
DSY: DSY0309(dsrA) DSY0310(dsrB)
CHY: CHY_2409(dsrB) CHY_2410(dsrA)
CTE: CT0852(dsrA-1) CT0853(dsrB-1) CT2249(dsrA-2)
PROC: Ptc2401_00028(dsvA) Ptc2401_00029(dsvB)
PROS: CHL67_00155(dsrA) CHL67_00160(dsrB)
TYE: THEYE_A1994(dsrA) THEYE_A1995(dsrB)
TTN: TTX_0423(dsrA) TTX_0424(dsrA) TTX_0426(dsrA) TTX_0427(dsrA) TTX_1187(dsrB) TTX_1188(dsrA)
 » show all
Taxonomy
Reference
1
  Authors
Schedel, M., Vanselow, M. and Trueper, H. G.
  Title
Siroheme sulfite reductase from Chromatium vinosum. Purification and investigation of some of its molecular and catalytic properties.
  Journal
Arch Microbiol 121:29-36 (1979)
Reference
2  [PMID:7338517]
  Authors
Seki Y, Sogawa N, Ishimoto M
  Title
Siroheme as an active catalyst in sulfite reduction.
  Journal
J Biochem 90:1487-92 (1981)
Reference
3  [PMID:9695921]
  Authors
Pott AS, Dahl C.
  Title
Sirohaem sulfite reductase and other proteins encoded by genes at the dsr locus of Chromatium vinosum are involved in the oxidation of intracellular sulfur.
  Journal
Microbiology 144 ( Pt 7):1881-94 (1998)
DOI:10.1099/00221287-144-7-1881
  Sequence
Reference
4  [PMID:18829451]
  Authors
Oliveira TF, Vonrhein C, Matias PM, Venceslau SS, Pereira IA, Archer M
  Title
The crystal structure of Desulfovibrio vulgaris dissimilatory sulfite reductase bound to DsrC provides novel insights into the mechanism of sulfate respiration.
  Journal
J Biol Chem 283:34141-9 (2008)
DOI:10.1074/jbc.M805643200
Reference
5  [PMID:24662917]
  Authors
Venceslau SS, Stockdreher Y, Dahl C, Pereira IA
  Title
The "bacterial heterodisulfide" DsrC is a key protein in dissimilatory sulfur metabolism.
  Journal
Biochim Biophys Acta 1837:1148-64 (2014)
DOI:10.1016/j.bbabio.2014.03.007
Other DBs
ExplorEnz - The Enzyme Database: 1.8.99.5
IUBMB Enzyme Nomenclature: 1.8.99.5
ExPASy - ENZYME nomenclature database: 1.8.99.5
BRENDA, the Enzyme Database: 1.8.99.5
CAS: 37256-51-2

KEGG   REACTION: R00295Help
Entry
R00295                      Reaction                               

Name
trithionate: (acceptor) oxidoreductase
Definition
Trithionate + HO- + Acceptor + 2 H2O <=> Reduced acceptor + 3 HSO3-
Equation
Enzyme
Pathway
rn00920  Sulfur metabolism
rn01100  Metabolic pathways
rn01120  Microbial metabolism in diverse environments
Orthology
K11180  dissimilatory sulfite reductase alpha subunit [EC:1.8.99.5]
K11181  dissimilatory sulfite reductase beta subunit [EC:1.8.99.5]
Other DBs
RHEA: 13212

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