| Entry |
|
|---|
| Name |
diamine oxidase;
amine oxidase (ambiguous);
amine oxidase (copper-containing) (ambiguous);
CAO (ambiguous);
Cu-containing amine oxidase (ambiguous);
copper amine oxidase (ambiguous);
diamine oxidase (ambiguous);
diamino oxhydrase (ambiguous);
histaminase;
histamine deaminase (incorrect);
semicarbazide-sensitive amine oxidase (incorrect);
SSAO (incorrect)
|
|---|
| Class |
Oxidoreductases;
Acting on the CH-NH2 group of donors;
With oxygen as acceptor
|
|---|
| Sysname |
histamine:oxygen oxidoreductase (deaminating)
|
|---|
| Reaction(IUBMB) |
histamine + H2O + O2 = (imidazol-4-yl)acetaldehyde + NH3 + H2O2 [RN: R02150]
|
|---|
| Reaction(KEGG) |
|
|---|
| Substrate |
|
|---|
| Product |
(imidazol-4-yl)acetaldehyde;
NH3 [CPD: C00014];
H2O2 [CPD: C00027]
|
|---|
| Comment |
A group of enzymes that oxidize diamines, such as histamine, and also some primary monoamines but have little or no activity towards secondary and tertiary amines. They are copper quinoproteins (2,4,5-trihydroxyphenylalanine quinone) and, like EC 1.4.3.21 (primary-amine oxidase) but unlike EC 1.4.3.4 (monoamine oxidase), they are sensitive to inhibition by carbonyl-group reagents, such as semicarbazide.
|
|---|
| History |
EC 1.4.3.22 created 2007 (EC 1.4.3.6 created 1961, part-incorporated 2008)
|
|---|
| Pathway |
| ec00330 | Arginine and proline metabolism |
|
|---|
| Orthology |
|
|---|
| Genes |
» show all
|
|---|
| Reference |
1 |
|---|
| Authors |
Zeller, E.A. |
|---|
| Title |
Diamine oxidases. |
|---|
| Journal |
In: Boyer, P.D., Lardy, H. and Myrback, K. (Eds.), The Enzymes, 2nd ed., vol. 8, Academic Press, New York, 1963, p. 313-335. |
|---|
| Reference |
|
|---|
| Authors |
Crabbe MJ, Waight RD, Bardsley WG, Barker RW, Kelly ID, Knowles PF. |
|---|
| Title |
Human placental diamine oxidase. Improved purification and characterization of a copper- and manganese-containing amine oxidase with novel substrate specificity. |
|---|
| Journal |
|
|---|
| Reference |
|
|---|
| Authors |
Chassande O, Renard S, Barbry P, Lazdunski M |
|---|
| Title |
The human gene for diamine oxidase, an amiloride binding protein. Molecular cloning, sequencing, and characterization of the promoter. |
|---|
| Journal |
J Biol Chem 269:14484-9 (1994) |
|---|
| Sequence |
|
|---|
| Reference |
|
|---|
| Authors |
Houen G. |
|---|
| Title |
Mammalian Cu-containing amine oxidases (CAOs): new methods of analysis, structural relationships, and possible functions. |
|---|
| Journal |
APMIS Suppl 96:1-46 (1999) |
|---|
| Reference |
|
|---|
| Authors |
Elmore BO, Bollinger JA, Dooley DM. |
|---|
| Title |
Human kidney diamine oxidase: heterologous expression, purification, and characterization. |
|---|
| Journal |
|
|---|
| Other DBs |
| ExplorEnz - The Enzyme Database: | 1.4.3.22 |
| ExPASy - ENZYME nomenclature database: | 1.4.3.22 |
|
|---|
