KEGG   ORTHOLOGY: K11220
Entry
K11220                      KO                                     
Symbol
STAT1
Name
signal transducer and activator of transcription 1
Pathway
map04062  Chemokine signaling pathway
map04217  Necroptosis
map04380  Osteoclast differentiation
map04620  Toll-like receptor signaling pathway
map04621  NOD-like receptor signaling pathway
map04625  C-type lectin receptor signaling pathway
map04630  JAK-STAT signaling pathway
map04658  Th1 and Th2 cell differentiation
map04659  Th17 cell differentiation
map04917  Prolactin signaling pathway
map04919  Thyroid hormone signaling pathway
map04933  AGE-RAGE signaling pathway in diabetic complications
map04935  Growth hormone synthesis, secretion and action
map05140  Leishmaniasis
map05145  Toxoplasmosis
map05152  Tuberculosis
map05160  Hepatitis C
map05161  Hepatitis B
map05162  Measles
map05164  Influenza A
map05165  Human papillomavirus infection
map05167  Kaposi sarcoma-associated herpesvirus infection
map05168  Herpes simplex virus 1 infection
map05169  Epstein-Barr virus infection
map05171  Coronavirus disease - COVID-19
map05200  Pathways in cancer
map05212  Pancreatic cancer
map05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
map05321  Inflammatory bowel disease
Disease
H00089  IFN-gamma/IL-12 axis
H01109  Chronic mucocutaneous candidiasis
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04630 JAK-STAT signaling pathway
    K11220  STAT1; signal transducer and activator of transcription 1
 09140 Cellular Processes
  09143 Cell growth and death
   04217 Necroptosis
    K11220  STAT1; signal transducer and activator of transcription 1
 09150 Organismal Systems
  09151 Immune system
   04620 Toll-like receptor signaling pathway
    K11220  STAT1; signal transducer and activator of transcription 1
   04621 NOD-like receptor signaling pathway
    K11220  STAT1; signal transducer and activator of transcription 1
   04625 C-type lectin receptor signaling pathway
    K11220  STAT1; signal transducer and activator of transcription 1
   04658 Th1 and Th2 cell differentiation
    K11220  STAT1; signal transducer and activator of transcription 1
   04659 Th17 cell differentiation
    K11220  STAT1; signal transducer and activator of transcription 1
   04062 Chemokine signaling pathway
    K11220  STAT1; signal transducer and activator of transcription 1
  09152 Endocrine system
   04917 Prolactin signaling pathway
    K11220  STAT1; signal transducer and activator of transcription 1
   04935 Growth hormone synthesis, secretion and action
    K11220  STAT1; signal transducer and activator of transcription 1
   04919 Thyroid hormone signaling pathway
    K11220  STAT1; signal transducer and activator of transcription 1
  09158 Development and regeneration
   04380 Osteoclast differentiation
    K11220  STAT1; signal transducer and activator of transcription 1
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K11220  STAT1; signal transducer and activator of transcription 1
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    K11220  STAT1; signal transducer and activator of transcription 1
  09162 Cancer: specific types
   05212 Pancreatic cancer
    K11220  STAT1; signal transducer and activator of transcription 1
  09172 Infectious disease: viral
   05161 Hepatitis B
    K11220  STAT1; signal transducer and activator of transcription 1
   05160 Hepatitis C
    K11220  STAT1; signal transducer and activator of transcription 1
   05171 Coronavirus disease - COVID-19
    K11220  STAT1; signal transducer and activator of transcription 1
   05164 Influenza A
    K11220  STAT1; signal transducer and activator of transcription 1
   05162 Measles
    K11220  STAT1; signal transducer and activator of transcription 1
   05168 Herpes simplex virus 1 infection
    K11220  STAT1; signal transducer and activator of transcription 1
   05167 Kaposi sarcoma-associated herpesvirus infection
    K11220  STAT1; signal transducer and activator of transcription 1
   05169 Epstein-Barr virus infection
    K11220  STAT1; signal transducer and activator of transcription 1
   05165 Human papillomavirus infection
    K11220  STAT1; signal transducer and activator of transcription 1
  09171 Infectious disease: bacterial
   05152 Tuberculosis
    K11220  STAT1; signal transducer and activator of transcription 1
  09174 Infectious disease: parasitic
   05145 Toxoplasmosis
    K11220  STAT1; signal transducer and activator of transcription 1
   05140 Leishmaniasis
    K11220  STAT1; signal transducer and activator of transcription 1
  09163 Immune disease
   05321 Inflammatory bowel disease
    K11220  STAT1; signal transducer and activator of transcription 1
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    K11220  STAT1; signal transducer and activator of transcription 1
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03000 Transcription factors
    K11220  STAT1; signal transducer and activator of transcription 1
Transcription factors [BR:ko03000]
 Eukaryotic type
  beta-Scaffold factors with minor groove contacts
   STAT
    K11220  STAT1; signal transducer and activator of transcription 1
Genes
HSA: 6772(STAT1)
PTR: 459834(STAT1)
PPS: 100971620(STAT1)
GGO: 101131770(STAT1)
PON: 100173683(STAT1)
PPYG: 129031864(STAT1)
NLE: 100596344(STAT1)
HMH: 116810529(STAT1)
SSYN: 129488190(STAT1)
MCC: 693650(STAT1)
MCF: 101925134(STAT1)
MTHB: 126932637
MNI: 105468204(STAT1)
CSAB: 103217529(STAT1)
CATY: 105579958(STAT1)
PANU: 101005886(STAT1)
TGE: 112635950(STAT1)
MLEU: 105535217(STAT1)
RRO: 104675282(STAT1)
RBB: 108527866(STAT1)
TFN: 117094713(STAT1)
PTEH: 111546340(STAT1)
CANG: 105507777(STAT1)
CJC: 100401630(STAT1)
SBQ: 101030811(STAT1)
CIMI: 108284049(STAT1)
ANAN: 105710132(STAT1)
CSYR: 103256404(STAT1)
MMUR: 105877906(STAT1)
LCAT: 123643619(STAT1)
PCOQ: 105813290(STAT1)
OGA: 100956762(STAT1)
MMU: 20846(Stat1)
MCAL: 110304843(Stat1)
MPAH: 110321139(Stat1)
RNO: 25124(Stat1)
MCOC: 116088407(Stat1)
ANU: 117705244(Stat1)
MUN: 110552020(Stat1)
CGE: 100755609(Stat1)
MAUA: 101827798(Stat1)
PROB: 127226208(Stat1)
PLEU: 114705035(Stat1)
MFOT: 126511873
AAMP: 119803912(Stat1)
NGI: 103736156(Stat1)
HGL: 101718902(Stat1)
CPOC: 100724708(Stat1)
CCAN: 109679865 109682738(Stat1)
DORD: 105995197(Stat1)
DSP: 122115055(Stat1)
PLOP: 125350458(Stat1)
NCAR: 124979200
MMMA: 107138551(Stat1)
OPI: 101525476(STAT1)
TUP: 102476590(STAT1)
GVR: 103588074(STAT1)
CFA: 488449(STAT1)
CLUD: 112656324(STAT1)
VVP: 112922923(STAT1)
VLG: 121480638(STAT1)
NPO: 129522804(STAT1)
AML: 100474026(STAT1)
UMR: 103659933(STAT1)
UAH: 113250654(STAT1)
UAR: 123798145(STAT1)
ELK: 111144592
LLV: 125095018
MPUF: 101686596(STAT1)
MNP: 132013398(STAT1)
MLK: 131827656(STAT1)
NVS: 122902129(STAT1)
ORO: 101378785(STAT1)
EJU: 114223921(STAT1)
ZCA: 113919574(STAT1)
MLX: 118012204(STAT1)
NSU: 110592138(STAT1)
LWW: 102731818(STAT1)
FCA: 101084561(STAT1)
PYU: 121030838(STAT1)
PCOO: 112869860(STAT1)
PBG: 122481579(STAT1)
PVIV: 125173414(STAT1)
LRUF: 124515343
PTG: 102953174(STAT1)
PPAD: 109274693(STAT1)
PUC: 125911435
AJU: 106979712
HHV: 120233455(STAT1)
BTA: 510814(STAT1)
BOM: 102283508(STAT1)
BIU: 109568771(STAT1)
BBUB: 102415500(STAT1)
BBIS: 105003595(STAT1)
CHX: 102189170(STAT1)
OAS: 100307049(STAT1)
BTAX: 128071221(STAT1)
ODA: 120854684(STAT1)
CCAD: 122426277(STAT1)
MBEZ: 129537915(STAT1)
SSC: 396655(STAT1)
CFR: 102509999(STAT1)
CBAI: 105063982(STAT1)
CDK: 105088783(STAT1)
VPC: 102544679(STAT1)
BACU: 103013781
BMUS: 118898022(STAT1)
LVE: 103069117
OOR: 101272458(STAT1)
DLE: 111171663(STAT1)
PCAD: 102977655(STAT1)
PSIU: 116757187(STAT1)
NASI: 112392137(STAT1)
ECB: 100069633(STAT1)
EPZ: 103548655(STAT1)
EAI: 106828796(STAT1)
MYB: 102243651(STAT1)
MYD: 102757059(STAT1)
MMYO: 118661220(STAT1)
MLF: 102424662(STAT1)
MDT: 132238061(STAT1)
PKL: 118709492(STAT1)
EFUS: 103290572(STAT1)
MNA: 107540521(STAT1)
DRO: 112307780(STAT1)
SHON: 118985299(STAT1)
AJM: 119062093(STAT1)
PDIC: 114494120(STAT1)
PHAS: 123816523(STAT1)
MMF: 118625659(STAT1)
PPAM: 129065467(STAT1)
HAI: 109393276(STAT1)
RFQ: 117025725(STAT1)
PALE: 102886603(STAT1)
PGIG: 120587473(STAT1)
PVP: 105289309(STAT1)
RAY: 107519182(STAT1)
MJV: 108400080(STAT1)
TOD: 119256041(STAT1)
SARA: 101554357(STAT1)
SETR: 126009005(STAT1)
LAV: 100668424(STAT1)
TMU: 101357916
ETF: 101650838(STAT1)
DNM: 101436399(STAT1)
MDO: 100028917(STAT1)
GAS: 123242151(STAT1)
SHR: 105749862(STAT1)
AFZ: 127554459
PCW: 110213248(STAT1)
TVP: 118836098(STAT1)
OAA: 100087266(STAT1)
GGA: 424044(STAT1)
PCOC: 116235961(STAT1)
MGP: 100544816(STAT1)
CJO: 107316322(STAT1)
TPAI: 128077102(STAT1)
LMUT: 125697226(STAT1)
NMEL: 110399457(STAT1)
APLA: 101795022(STAT1)
ACYG: 106039967(STAT1)
CATA: 118261546(STAT1)
AFUL: 116490500(STAT1)
TGU: 100221342(STAT1)
LSR: 110471109(STAT1)
SCAN: 103814539(STAT1)
PMOA: 120511477(STAT1)
OTC: 121335389(STAT1)
PRUF: 121364380(STAT1)
GFR: 102036007(STAT1)
FAB: 101811260(STAT1)
OMA: 130255273(STAT1)
PHI: 102100816(STAT1)
PMAJ: 107207405(STAT1)
CCAE: 111931930(STAT1)
CCW: 104693738(STAT1)
CBRC: 103612443(STAT1)
ETL: 114057449(STAT1)
ZAB: 102075199(STAT1)
ZLE: 135450153(STAT1)
ACHL: 103800628(STAT1)
SVG: 106855910(STAT1)
MMEA: 130578196(STAT1)
HRT: 120755497(STAT1)
SATI: 136363364(STAT1)
FPG: 101922205(STAT1)
FCH: 102054689(STAT1)
CCRI: 104167043(STAT1)
NNT: 104413420(STAT1)
SHAB: 115608872(STAT1)
ACUN: 113482458(STAT1)
TALA: 104362790(STAT1)
ACHC: 115342511(STAT1)
HALD: 104324347(STAT1)
HLE: 104829588(STAT1)
AGEN: 126042725
GCL: 127018115
CSTI: 104560273(STAT1)
LDI: 104351582(STAT1)
DPUB: 104309847(STAT1)
BRHI: 104491544(STAT1)
EGZ: 104130544(STAT1)
NNI: 104014274(STAT1)
PCRI: 104024447(STAT1)
PCAO: 104041888(STAT1)
PADL: 103925472(STAT1)
AFOR: 103897147(STAT1)
FGA: 104077124(STAT1)
GSTE: 104259693(STAT1)
CLV: 102098106(STAT1)
MUI: 104544870
PGUU: 104457917(STAT1)
PLET: 104619945(STAT1)
EHS: 104508311(STAT1)
CMAC: 104485862(STAT1)
CUCA: 104058327(STAT1)
TEO: 104381035(STAT1)
BREG: 104643105(STAT1)
OHA: 104328394(STAT1)
ACAR: 104525996(STAT1)
CPEA: 104386613(STAT1)
CVF: 104290959(STAT1)
RTD: 128913182(STAT1)
AAM: 106492439(STAT1)
AROW: 112978333(STAT1)
NPD: 112954430(STAT1)
TGT: 104565536(STAT1)
DNE: 112982588(STAT1)
SCAM: 104143404(STAT1)
ASN: 102374439(STAT1)
AMJ: 102571738(STAT1)
CPOO: 109323031(STAT1)
GGN: 109301851(STAT1)
PSS: 102462741(STAT1)
CMY: 102934663(STAT1)
CCAY: 125644935(STAT1)
DCC: 119863823(STAT1)
CPIC: 101931440(STAT1)
TST: 117884619(STAT1)
CABI: 116815204(STAT1)
MRV: 120374631(STAT1)
ACS: 100558595(stat1)
ASAO: 132778013(STAT1)
PVT: 110083952(STAT1)
SUND: 121935257(STAT1)
PBI: 103060112(STAT1)
PMUR: 107289220(STAT1)
CTIG: 120298332(STAT1)
TSR: 106537889(STAT1)
PGUT: 117672712(STAT1)
APRI: 131201014(STAT1)
PTEX: 113433994(STAT1)
NSS: 113412400(STAT1)
VKO: 123021819(STAT1)
PMUA: 114607449(STAT1)
PRAF: 128399344(STAT1)
ZVI: 118095191(STAT1)
HCG: 128335373(STAT1)
EMC: 129323801(STAT1)
XLA: 108703082(stat1.S) 398324(stat1.L)
XTR: 780397(stat1)
NPR: 108798858(STAT1)
RTEM: 120943691(STAT1)
BBUF: 121008988(STAT1)
BGAR: 122945284(STAT1)
MUO: 115473779(STAT1)
GSH: 117360731(STAT1)
DRE: 30768(stat1a) 368481(stat1b)
PTET: 122327842(stat1a) 122351700(stat1b)
LROH: 127153806(stat1a) 127170576(stat1b) 127170859
OMC: 131531449(stat1a)
PPRM: 120477609 120477802(stat1b) 120486276(stat1a)
RKG: 130072558(stat1b) 130072594 130100395(stat1a)
MAMB: 125254061(stat1a) 125270612(stat1b)
CERY: 137027661(stat1a)
TROS: 130549106(stat1a) 130555682(stat1b)
TDW: 130427429(stat1b) 130430030(stat1a)
MANU: 129452652 129454249(stat1a)
IPU: 108259490(stat1a) 108266311(stat1b)
IFU: 128602760(stat1a) 128608451(stat1b)
TFD: 113651885(stat1a) 113657095(stat1b) 113661254 113661265
TVC: 132838889(stat1a) 132850464 132850466(stat1b)
TRN: 134304237(stat1a) 134324528
AMEX: 103028874(stat1a) 103031000(stat1b)
CMAO: 118801704(stat1a) 118809414 118821121(stat1b)
EEE: 113581352(stat1) 113586831
TRU: 101068828(stat1) 101079646
TFS: 130522341(stat1a) 130523302
NCC: 104949635
TBEN: 117469171 117485957(stat1b) 117499191(stat1a)
PGEO: 117441669(stat1a) 117466574
GACU: 117549497 117549793(stat1a)
EMAC: 134861047(stat1a) 134867158
ELY: 117249488 117250238(stat1a)
EFO: 125884694(stat1a) 125899274
SLUC: 116043142(stat1b) 116053691(stat1a)
ECRA: 117939468(stat1a) 117953178
ESP: 116674022(stat1) 116698329
GAT: 120826627(stat1a) 120834093
PPUG: 119220035(stat1a)
AFB: 129104815 129111532(stat1a)
CLUM: 117741800(stat1a)
SCHU: 122871839(stat1a) 122885811
CUD: 121506226(stat1a) 121522933
ALAT: 119015223(stat1a) 119025600
MZE: 101476764(stat1) 101486905
ONL: 100696359(stat1) 100709564
OAU: 116309467 116317095(stat1a)
OML: 112154777 112156680(stat1a)
CSAI: 133425311(stat1a)
PRET: 103457785(stat1) 103460709
PFOR: 103130104(stat1) 103130271
PLAI: 106942383(stat1) 106951655
PMEI: 106907676 106909973(stat1)
GAF: 122827058(stat1a) 122840006
PPRL: 129356612(stat1a)
CVG: 107080778 107092284(stat1)
CTUL: 119792770
GMU: 124861925(stat1a) 124870924
NFU: 107384662(stat1) 107397172
KMR: 108229342(stat1a) 108250770
ALIM: 106531438(stat1)
NWH: 119419796 119428888(stat1a)
MCEP: 125000988(stat1a) 125017356
CSEM: 103389515(stat1) 103392403
SSEN: 122758564 122763091(stat1a)
HHIP: 117754943 117774286(stat1a)
SDU: 111218101 111222701(stat1)
XGL: 120798154(stat1a) 120801616
HCQ: 109517578 109520194(stat1)
SSCV: 125988268
SBIA: 133505793(stat1a)
PEE: 133402577(stat1a)
PTAO: 133478909(stat1a)
MALB: 109955685(stat1)
BSPL: 114845713(stat1a) 114846801
SJO: 128354436(stat1a) 128367733
SASA: 100136558(STAT1) 106586142
OMY: 100136755(stat1-1) 100137016(stat1-2) 110501544(stat1b) 110520020 110527523
PKI: 111842948 111845415(stat1)
LOC: 102685821(stat1)
PSEX: 120522445
LCM: 102353760(STAT1)
CMK: 103176541
RTP: 109920367
PMRN: 116938726(STAT1)
LRJ: 133345932(STAT1)
 » show all
Reference
PMID:1502203
  Authors
Schindler C, Fu XY, Improta T, Aebersold R, Darnell JE Jr
  Title
Proteins of transcription factor ISGF-3: one gene encodes the 91-and 84-kDa ISGF-3 proteins that are activated by interferon alpha.
  Journal
Proc Natl Acad Sci U S A 89:7836-9 (1992)
DOI:10.1073/pnas.89.16.7836
  Sequence
[hsa:6772]

KEGG   ORTHOLOGY: K11221
Entry
K11221                      KO                                     
Symbol
STAT2
Name
signal transducer and activator of transcription 2
Pathway
map04062  Chemokine signaling pathway
map04217  Necroptosis
map04380  Osteoclast differentiation
map04620  Toll-like receptor signaling pathway
map04621  NOD-like receptor signaling pathway
map04625  C-type lectin receptor signaling pathway
map04630  JAK-STAT signaling pathway
map05160  Hepatitis C
map05161  Hepatitis B
map05162  Measles
map05164  Influenza A
map05165  Human papillomavirus infection
map05167  Kaposi sarcoma-associated herpesvirus infection
map05168  Herpes simplex virus 1 infection
map05169  Epstein-Barr virus infection
map05171  Coronavirus disease - COVID-19
map05200  Pathways in cancer
Disease
H00840  Pseudo-TORCH syndrome
H02525  Disorders of innate immunity
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04630 JAK-STAT signaling pathway
    K11221  STAT2; signal transducer and activator of transcription 2
 09140 Cellular Processes
  09143 Cell growth and death
   04217 Necroptosis
    K11221  STAT2; signal transducer and activator of transcription 2
 09150 Organismal Systems
  09151 Immune system
   04620 Toll-like receptor signaling pathway
    K11221  STAT2; signal transducer and activator of transcription 2
   04621 NOD-like receptor signaling pathway
    K11221  STAT2; signal transducer and activator of transcription 2
   04625 C-type lectin receptor signaling pathway
    K11221  STAT2; signal transducer and activator of transcription 2
   04062 Chemokine signaling pathway
    K11221  STAT2; signal transducer and activator of transcription 2
  09158 Development and regeneration
   04380 Osteoclast differentiation
    K11221  STAT2; signal transducer and activator of transcription 2
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K11221  STAT2; signal transducer and activator of transcription 2
  09172 Infectious disease: viral
   05161 Hepatitis B
    K11221  STAT2; signal transducer and activator of transcription 2
   05160 Hepatitis C
    K11221  STAT2; signal transducer and activator of transcription 2
   05171 Coronavirus disease - COVID-19
    K11221  STAT2; signal transducer and activator of transcription 2
   05164 Influenza A
    K11221  STAT2; signal transducer and activator of transcription 2
   05162 Measles
    K11221  STAT2; signal transducer and activator of transcription 2
   05168 Herpes simplex virus 1 infection
    K11221  STAT2; signal transducer and activator of transcription 2
   05167 Kaposi sarcoma-associated herpesvirus infection
    K11221  STAT2; signal transducer and activator of transcription 2
   05169 Epstein-Barr virus infection
    K11221  STAT2; signal transducer and activator of transcription 2
   05165 Human papillomavirus infection
    K11221  STAT2; signal transducer and activator of transcription 2
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03000 Transcription factors
    K11221  STAT2; signal transducer and activator of transcription 2
Transcription factors [BR:ko03000]
 Eukaryotic type
  beta-Scaffold factors with minor groove contacts
   STAT
    K11221  STAT2; signal transducer and activator of transcription 2
Genes
HSA: 6773(STAT2)
PTR: 451996(STAT2)
PPS: 100972085(STAT2)
GGO: 101146695(STAT2)
PON: 100452011(STAT2)
PPYG: 129010795(STAT2)
NLE: 100585171(STAT2)
HMH: 116480910(STAT2)
SSYN: 129465186(STAT2)
MCC: 712694(STAT2)
MCF: 102133020(STAT2)
MTHB: 126931203
MNI: 105474140(STAT2)
CSAB: 103238525(STAT2)
CATY: 105587295(STAT2)
PANU: 101011342(STAT2)
TGE: 112634334(STAT2)
MLEU: 105529948(STAT2)
RRO: 104673676(STAT2)
RBB: 108516059(STAT2)
TFN: 117089929(STAT2)
PTEH: 111541846(STAT2)
CANG: 105500610(STAT2)
CJC: 100393190(STAT2)
SBQ: 101029836(STAT2)
CIMI: 108309779(STAT2)
ANAN: 105715955(STAT2)
CSYR: 103258295
MMUR: 105865362(STAT2)
LCAT: 123639648(STAT2)
PCOQ: 105817095(STAT2)
OGA: 100944401(STAT2)
MMU: 20847(Stat2)
MCAL: 110302854(Stat2)
MPAH: 110326622(Stat2)
RNO: 288774(Stat2)
MCOC: 116076236(Stat2)
ANU: 117696619(Stat2)
MUN: 110559388(Stat2)
CGE: 100764772(Stat2)
MAUA: 101830537(Stat2)
PROB: 127215637(Stat2)
PLEU: 114681747(Stat2)
MORG: 121462696(Stat2)
MFOT: 126491990
AAMP: 119803231(Stat2)
NGI: 103746519(Stat2)
HGL: 101707295(Stat2)
CPOC: 100719719(Stat2)
CCAN: 109686120(Stat2)
DORD: 105990116(Stat2)
DSP: 122124118(Stat2)
PLOP: 125362786(Stat2)
NCAR: 124983364
MMMA: 107140168(Stat2)
OPI: 101536685(STAT2)
TUP: 102477989(STAT2)
GVR: 103594016(STAT2)
CFA: 481111(STAT2)
CLUD: 112678012(STAT2)
VVP: 112922378(STAT2)
VLG: 121491356(STAT2)
NPO: 129511791(STAT2)
AML: 100472167(STAT2)
UMR: 103656206(STAT2)
UAH: 113256419(STAT2)
UAR: 123787247(STAT2)
ELK: 111160141
LLV: 125106747
MPUF: 101690720(STAT2)
MNP: 132019801(STAT2)
MLK: 131838598(STAT2)
NVS: 122891158(STAT2)
ORO: 101368050(STAT2)
EJU: 114214932(STAT2)
ZCA: 113922098(STAT2)
MLX: 118008707(STAT2)
NSU: 110577818(STAT2)
LWW: 102739614(STAT2)
FCA: 101099224(STAT2)
PYU: 121040920(STAT2)
PCOO: 112863559(STAT2)
PBG: 122473765(STAT2)
PVIV: 125170213(STAT2)
LRUF: 124501367
PTG: 102967399(STAT2)
PPAD: 109270329(STAT2)
PUC: 125920249
AJU: 106986878
HHV: 120219936(STAT2)
BTA: 511023(STAT2)
BOM: 102277710(STAT2)
BIU: 109559357(STAT2)
BBUB: 102414314(STAT2)
BBIS: 104988072(STAT2)
CHX: 102190301(STAT2)
OAS: 101108211(STAT2)
BTAX: 128047300(STAT2)
ODA: 120857446(STAT2)
CCAD: 122427313(STAT2)
MBEZ: 129537127(STAT2)
SSC: 396923(STAT2)
CFR: 102510903(STAT2)
CBAI: 105075886(STAT2)
CDK: 105086362(STAT2)
VPC: 102545696(STAT2)
BACU: 103000458(STAT2)
BMUS: 118901552(STAT2)
LVE: 103081732(STAT2)
OOR: 101281591(STAT2)
DLE: 111173869(STAT2)
PCAD: 102981574(STAT2)
PSIU: 116760219(STAT2)
NASI: 112394097(STAT2)
ECB: 100052513(STAT2)
EPZ: 103557548(STAT2)
EAI: 106832955(STAT2)
MYB: 102240965(STAT2)
MYD: 102766233(STAT2)
MMYO: 118651142(STAT2)
MLF: 102430852(STAT2)
MDT: 132227766(STAT2)
PKL: 118729130(STAT2)
EFUS: 103292429(STAT2)
MNA: 107546189(STAT2)
DRO: 112319116(STAT2)
SHON: 118975851(STAT2)
AJM: 119040310(STAT2)
PDIC: 114513273(STAT2)
PHAS: 123812791(STAT2)
MMF: 118623876(STAT2)
PPAM: 129075775(STAT2)
HAI: 109396910(STAT2)
RFQ: 117028885(STAT2)
PALE: 102879640(STAT2)
PGIG: 120604905(STAT2)
PVP: 105302576(STAT2)
RAY: 107521231(STAT2)
MJV: 108402236(STAT2)
TOD: 119248061(STAT2)
SARA: 101550386(STAT2)
SETR: 126022154(STAT2)
LAV: 100656374(STAT2)
TMU: 101348948
ETF: 101661602(STAT2)
DNM: 101423495(STAT2)
GAS: 123250724(STAT2)
SHR: 100933167(STAT2)
AFZ: 127564177
PCW: 110210934(STAT2)
TVP: 118849960(STAT2)
OAA: 100087549(STAT2)
GGA: 100858732(STAT2)
PCOC: 116239827(STAT2)
MGP: 104916177(STAT2)
CJO: 107325845(STAT2)
TPAI: 128071944(STAT2)
LMUT: 125685612(STAT2)
NMEL: 110389141(STAT2)
APLA: 119714613(STAT2)
ACYG: 125181336(STAT2)
CATA: 118260153(STAT2)
AFUL: 116499942(STAT2)
TGU: 105760310
LSR: 110477089(STAT2)
OTC: 121337502(STAT2)
PRUF: 121358943(STAT2)
FAB: 101821433
OMA: 130265681(STAT2)
PHI: 102112270(STAT2)
ETL: 114070775(STAT2)
ZLE: 135459115(STAT2)
SVG: 106863158(STAT2)
HRT: 120764444(STAT2)
SATI: 136372778(STAT2)
FPG: 101912561(STAT2)
FCH: 106630923(STAT2)
SHAB: 115618700(STAT2)
TALA: 116963079(STAT2)
ACHC: 115351351(STAT2)
HLE: 104830351(STAT2)
AGEN: 126046516
AFOR: 103899559
RTD: 128903206(STAT2)
AROW: 112974309(STAT2)
NPD: 112955622(STAT2)
DNE: 112996983(STAT2)
ASN: 106721797(STAT2)
AMJ: 102574603(STAT2)
CPOO: 109322912(STAT2)
GGN: 109295410(STAT2)
CMY: 102932386(STAT2)
CCAY: 125627841(STAT2)
DCC: 119845671(STAT2)
CPIC: 101944167(STAT2)
CABI: 116827740(STAT2)
MRV: 120391254(STAT2)
ACS: 103277767(stat2)
ASAO: 132768316(STAT2)
PVT: 110074594(STAT2)
SUND: 121921484(STAT2)
PBI: 103065958(STAT2)
PMUR: 107290900(STAT2)
CTIG: 120305466(STAT2)
TSR: 106544441(STAT2)
PGUT: 117662768(STAT2)
APRI: 131191430(STAT2)
PTEX: 113447314(STAT2)
NSS: 113420192(STAT2)
VKO: 123019034(STAT2)
PMUA: 114586539(STAT2)
PRAF: 128406900(STAT2)
ZVI: 118079505(STAT2)
HCG: 128345788(STAT2)
GJA: 107126172(STAT2)
STOW: 125430031(STAT2)
EMC: 129328133(STAT2)
XLA: 108708573(stat2.L) 108709841(stat2.S)
XTR: 100170174(stat2)
NPR: 108791510
RTEM: 120929512(STAT2)
BBUF: 120996012(STAT2)
BGAR: 122930988(STAT2)
MUO: 115465885(STAT2)
GSH: 117358070(STAT2)
DRE: 565200(stat2)
CCAR: 109081275
PTET: 122347498(stat2)
LROH: 127166603(stat2)
OMC: 131542395(stat2)
PPRM: 120491376(stat2)
RKG: 130087560(stat2)
MAMB: 125273698(stat2)
CIDE: 127513816
CERY: 137011712(stat2)
TROS: 130556375(stat2)
TDW: 130424265(stat2)
MANU: 129450296(stat2)
IPU: 108272207(stat2)
IFU: 128614774(stat2)
PHYP: 113545874
SMEO: 124399142(stat2)
TFD: 113660522(stat2)
TVC: 132844152(stat2)
TRN: 134317205(stat2)
AMEX: 103021407(stat2)
CMAO: 118808245(stat2)
EEE: 113567990
CHAR: 105897943(stat2)
TRU: 101071462
TFS: 130524302(stat2)
LCO: 104931961
NCC: 104966838
TBEN: 117489454(stat2)
CGOB: 115007853
PGEO: 117446139(stat2)
GACU: 117551086(stat2)
EMAC: 134883587(stat2)
ELY: 117257067(stat2)
EFO: 125892992(stat2)
PLEP: 121955727(stat2)
SLUC: 116065448(stat2)
ECRA: 117943306(stat2)
ESP: 116688367
PFLV: 114553646
GAT: 120835023(stat2)
PPUG: 119229650(stat2)
AFB: 129106335(stat2)
CLUM: 117730251(stat2)
PSWI: 130207963(stat2)
MSAM: 119886144(stat2)
SCHU: 122867140(stat2)
CUD: 121506826(stat2)
ALAT: 119020489(stat2)
MZE: 101479682
ONL: 100701534
OAU: 116336550(stat2)
OLA: 101173855
OML: 112144620(stat2)
CSAI: 133448749(stat2)
XMA: 102236235
XCO: 114135114
XHE: 116710640
PRET: 103465382
PFOR: 103147660(stat2) 103147661
PLAI: 106954437
GAF: 122834731(stat2)
PPRL: 129357678(stat2)
CVG: 107082130
CTUL: 119776668(stat2)
GMU: 124856810(stat2)
NFU: 107385678
KMR: 108235753(stat2)
ALIM: 106518034(stat2)
NWH: 119411927(stat2)
AOCE: 111566617
MCEP: 125006679(stat2)
CSEM: 103385958
POV: 109629253
SSEN: 122768157(stat2)
HHIP: 117761297(stat2)
HSP: 118105504(stat2)
PPLT: 128447619(stat2)
SMAU: 118309014(stat2)
LCF: 108881447(stat2)
SDU: 111221460
SLAL: 111667811
XGL: 120807379(stat2)
HCQ: 109522346
SSCV: 125977770
SBIA: 133507561(stat2)
PEE: 133409336(stat2)
PTAO: 133483313(stat2)
BPEC: 110168365
MALB: 109956049
BSPL: 114855222(stat2)
SJO: 128355051(stat2)
SASA: 100270812(stat2)
STRU: 115207827
OTW: 112217577(stat2)
OMY: 110494323(stat2)
OGO: 124002667(stat2)
ONE: 115143174
OKI: 109895769
OKE: 118388565(stat2)
SALP: 111966796
SNH: 120061182(stat2)
CCLU: 121575263(stat2)
ELS: 105017162
SFM: 108918442
PKI: 111854344
AANG: 118210889(stat2)
LOC: 102698942
PSPA: 121309023(stat2)
PSEX: 120524824(stat2)
LCM: 102355078(STAT2)
CMK: 103191066
 » show all
Reference
PMID:1502204
  Authors
Fu XY, Schindler C, Improta T, Aebersold R, Darnell JE Jr
  Title
The proteins of ISGF-3, the interferon alpha-induced transcriptional activator, define a gene family involved in signal transduction.
  Journal
Proc Natl Acad Sci U S A 89:7840-3 (1992)
DOI:10.1073/pnas.89.16.7840
  Sequence
[hsa:6773]

KEGG   ORTHOLOGY: K11224
Entry
K11224                      KO                                     
Symbol
STAT5B
Name
signal transducer and activator of transcription 5B
Pathway
map04012  ErbB signaling pathway
map04062  Chemokine signaling pathway
map04217  Necroptosis
map04630  JAK-STAT signaling pathway
map04658  Th1 and Th2 cell differentiation
map04659  Th17 cell differentiation
map04917  Prolactin signaling pathway
map04933  AGE-RAGE signaling pathway in diabetic complications
map04935  Growth hormone synthesis, secretion and action
map05161  Hepatitis B
map05162  Measles
map05166  Human T-cell leukemia virus 1 infection
map05200  Pathways in cancer
map05203  Viral carcinogenesis
map05207  Chemical carcinogenesis - receptor activation
map05220  Chronic myeloid leukemia
map05221  Acute myeloid leukemia
map05223  Non-small cell lung cancer
Disease
H00931  Growth hormone insensitivity with immunodeficiency
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    K11224  STAT5B; signal transducer and activator of transcription 5B
   04630 JAK-STAT signaling pathway
    K11224  STAT5B; signal transducer and activator of transcription 5B
 09140 Cellular Processes
  09143 Cell growth and death
   04217 Necroptosis
    K11224  STAT5B; signal transducer and activator of transcription 5B
 09150 Organismal Systems
  09151 Immune system
   04658 Th1 and Th2 cell differentiation
    K11224  STAT5B; signal transducer and activator of transcription 5B
   04659 Th17 cell differentiation
    K11224  STAT5B; signal transducer and activator of transcription 5B
   04062 Chemokine signaling pathway
    K11224  STAT5B; signal transducer and activator of transcription 5B
  09152 Endocrine system
   04917 Prolactin signaling pathway
    K11224  STAT5B; signal transducer and activator of transcription 5B
   04935 Growth hormone synthesis, secretion and action
    K11224  STAT5B; signal transducer and activator of transcription 5B
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K11224  STAT5B; signal transducer and activator of transcription 5B
   05207 Chemical carcinogenesis - receptor activation
    K11224  STAT5B; signal transducer and activator of transcription 5B
   05203 Viral carcinogenesis
    K11224  STAT5B; signal transducer and activator of transcription 5B
  09162 Cancer: specific types
   05221 Acute myeloid leukemia
    K11224  STAT5B; signal transducer and activator of transcription 5B
   05220 Chronic myeloid leukemia
    K11224  STAT5B; signal transducer and activator of transcription 5B
   05223 Non-small cell lung cancer
    K11224  STAT5B; signal transducer and activator of transcription 5B
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    K11224  STAT5B; signal transducer and activator of transcription 5B
   05161 Hepatitis B
    K11224  STAT5B; signal transducer and activator of transcription 5B
   05162 Measles
    K11224  STAT5B; signal transducer and activator of transcription 5B
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    K11224  STAT5B; signal transducer and activator of transcription 5B
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03000 Transcription factors
    K11224  STAT5B; signal transducer and activator of transcription 5B
Transcription factors [BR:ko03000]
 Eukaryotic type
  beta-Scaffold factors with minor groove contacts
   STAT
    K11224  STAT5B; signal transducer and activator of transcription 5B
Genes
HSA: 6777(STAT5B)
PTR: 454679(STAT5B)
PPS: 100989105
GGO: 101128930
PON: 100462537(STAT5B)
PPYG: 129017272(STAT5B)
NLE: 100602489
HMH: 116474861(STAT5B)
SSYN: 129469974(STAT5B)
MCC: 709760(STAT5B)
MCF: 102127060(STAT5B)
MTHB: 126938430
MNI: 105472124
CSAB: 103243413(STAT5B)
CATY: 105579668(STAT5B)
PANU: 101000002(STAT5B)
TGE: 112610116(STAT5B)
MLEU: 105553080
RRO: 104680321
RBB: 108518352
TFN: 117066965
PTEH: 111537374(STAT5B)
CANG: 105503146
CJC: 100388552(STAT5B)
SBQ: 101043203(STAT5B)
CIMI: 108289827
ANAN: 105711172
CSYR: 103276756
MMUR: 105859420(STAT5B)
LCAT: 123620957(STAT5B)
PCOQ: 105820211
OGA: 100955743
MMU: 20851(Stat5b)
MCAL: 110306026(Stat5b)
MPAH: 110331105(Stat5b)
RNO: 25126(Stat5b)
MCOC: 116078734(Stat5b)
ANU: 117710053
MUN: 110550889
CGE: 100750571
MAUA: 101835654(Stat5b)
PROB: 127216001(Stat5b)
PLEU: 114682785
MORG: 121442319(Stat5b)
MFOT: 126510303
AAMP: 119811038
NGI: 103735893(Stat5b)
HGL: 101722721(Stat5b)
CPOC: 100716532(Stat5b)
CCAN: 109692057
DORD: 106002556(Stat5b)
DSP: 122100261
PLOP: 125365131(Stat5b)
NCAR: 124979870
MMMA: 107150572
OCU: 100348267
OPI: 101518842
TUP: 102492323(STAT5B)
GVR: 103595352
CFA: 490969(STAT5B)
CLUD: 112655520
VVP: 112910740(STAT5B)
VLG: 121472926(STAT5B)
NPO: 129508314
AML: 100479246
UMR: 103672570
UAH: 113265424
UAR: 123781849(STAT5B)
ELK: 111151253
LLV: 125087045
MPUF: 101692423(STAT5B)
MNP: 132004115
MLK: 131815766
NVS: 122906198
ORO: 101372217(STAT5B)
EJU: 114201399(STAT5B)
ZCA: 113939349(STAT5B)
MLX: 118024913(STAT5B)
NSU: 110573273
LWW: 102749665
FCA: 101090663(STAT5B)
PYU: 121045021(STAT5B)
PBG: 122485599(STAT5B)
PVIV: 125158439
LRUF: 124522246
PTG: 102972489(STAT5B)
PPAD: 109258541
PUC: 125926542
AJU: 106972565
HHV: 120248396(STAT5B)
BTA: 282376(STAT5B)
BOM: 102283211(STAT5B)
BIU: 109573773(STAT5B)
BBUB: 102400858
BBIS: 104990788
CHX: 102176415(STAT5B)
OAS: 101122961(STAT5B)
BTAX: 128064838(STAT5B)
ODA: 120867075
CCAD: 122441627
MBEZ: 129544423(STAT5B)
SSC: 397340(STAT5B)
CFR: 102511001(STAT5B)
CBAI: 105080118(STAT5B)
CDK: 105090456
VPC: 102538126
BMUS: 118887531(STAT5B)
LVE: 103082258(STAT5B)
OOR: 101280265(STAT5B)
DLE: 111166483
PCAD: 102994339(STAT5B)
PSIU: 116745059(STAT5B)
NASI: 112399174
ECB: 100052954
EPZ: 103550391
EAI: 106826362(STAT5B)
MYB: 102241062(STAT5B)
MMYO: 118671504
MLF: 102424720
MDT: 132218652(STAT5B)
PKL: 118726604
EFUS: 103293235(STAT5B)
MNA: 107528845
DRO: 112298560(STAT5B)
SHON: 118977990
AJM: 119037510
PDIC: 114502991(STAT5B)
PHAS: 123816875(STAT5B)
MMF: 118634401(STAT5B)
PPAM: 129086955
RFQ: 117014073(STAT5B)
PALE: 102884882
PGIG: 120611100
PVP: 105306336
RAY: 107513822(STAT5B)
MJV: 108388330
TOD: 119232882(STAT5B)
SARA: 101552185(STAT5B)
SETR: 126016963
LAV: 100669299(STAT5B)
TMU: 101354148
ETF: 101661010
DNM: 101419007(STAT5B)
MDO: 100011470(STAT5B)
GAS: 123245349
SHR: 100920307(STAT5B)
AFZ: 127560124
PCW: 110198412
TVP: 118845877
OAA: 100092915(STAT5B)
GGA: 395556(STAT5B)
PCOC: 116233608
MGP: 100546986
CJO: 107325190
TPAI: 128089013
LMUT: 125684570
NMEL: 110388528(STAT5B)
APLA: 101790203
ACYG: 106047991
CATA: 118259130
AFUL: 116498619
TGU: 100222731
LSR: 110471843
SCAN: 103821589
PMOA: 120496657
OTC: 121347621
PRUF: 121351183
GFR: 102036670(STAT5B)
FAB: 101808879(STAT5B)
OMA: 130263959
PHI: 102101483
PMAJ: 107215121
CCAE: 111939998
CCW: 104697815
CBRC: 103620455
ETL: 114063604
ZAB: 102066095
ZLE: 135458505
ACHL: 103804418
SVG: 106858640
MMEA: 130581463
HRT: 120763830
SATI: 136372157
FPG: 101918263(STAT5B)
FCH: 102053699
SHAB: 115617591
TALA: 116960729
ACHC: 115344699
HLE: 104842943
AGEN: 126038674
CSTI: 104560387
DPUB: 104309595
EGZ: 104135093
NNI: 104009926
AFOR: 103902253
CLV: 102098622
CUCA: 104054405
CPEA: 104385702
RTD: 128919233
AROW: 112968721
NPD: 112951852
TGT: 104571860
ASN: 102380420
AMJ: 102575674(STAT5B)
CPOO: 109320364
GGN: 109289127
CPIC: 101932204
TST: 117870579
CABI: 116820372
ACS: 100566752(stat5b)
ASAO: 132778223
PVT: 110074911
SUND: 121933099
PBI: 103049078
CTIG: 120309721
TSR: 106541154
PGUT: 117664595
APRI: 131198341
PTEX: 113442826
NSS: 113413518
VKO: 123030656
PMUA: 114583662
PRAF: 128399404
ZVI: 118094191
HCG: 128331647
GJA: 107111494
STOW: 125444644
EMC: 129338434
XLA: 399176(stat5b.L) 414637(stat5b.S)
XTR: 100495240(stat5b)
NPR: 108788932
RTEM: 120918206
BBUF: 121005428
BGAR: 122941072
MUO: 115481497
GSH: 117347194
DRE: 369197(stat5a) 445474(stat5b)
PTET: 122341745(stat5a) 122355458(stat5b)
LROH: 127155590(stat5a) 127174202(stat5b)
OMC: 131551083(stat5b)
PPRM: 120488720(stat5b) 120489715(stat5a)
RKG: 130071201(stat5a) 130087385(stat5b)
MAMB: 125255293(stat5b) 125279545(stat5a)
CERY: 137007419(stat5b)
TROS: 130568732(stat5b)
TDW: 130426023(stat5a) 130438645(stat5b)
MANU: 129420458(stat5b) 129436250(stat5a)
IPU: 108273804(stat5b) 108279147(stat5a)
IFU: 128601883(stat5a) 128616839(stat5b)
SMEO: 124388956(stat5b) 124396761(stat5a)
TFD: 113652201(stat5a) 113662164(stat5b)
TVC: 132840904(stat5b)
TRN: 134300169(stat5a) 134322030(stat5b)
AMEX: 103033010(stat5a) 103042656(stat5b)
CMAO: 118809132(stat5b) 118821461(stat5a)
CHAR: 105890767(stat5a) 105910183
TRU: 101071345
TFS: 130514621(stat5a)
TBEN: 117473486 117493483(stat5a)
PGEO: 117450919(stat5a) 117465138
GACU: 117548821(stat5a) 117560317
EMAC: 134870424 134877780(stat5a)
ELY: 117247445 117268498(stat5a)
EFO: 125879354(stat5a) 125880992
PLEP: 121956090(stat5a) 121958483
SLUC: 116059636(stat5a) 116067487
ECRA: 117936750 117958410(stat5a)
GAT: 120819248 120828238(stat5a)
PPUG: 119212799 119220165(stat5a)
AFB: 129093133 129098136(stat5a)
CLUM: 117734568(stat5a) 117748445
PSWI: 130188240(stat5a) 130203278
MSAM: 119892306(stat5a) 119916364
SCHU: 122867482 122869589(stat5a)
CUD: 121528063 121529468(stat5a)
ALAT: 119009634 119013365(stat5a)
OAU: 116312472(stat5a) 116320031
OML: 112146942(stat5a) 112162336
CSAI: 133419839 133422721(stat5a)
GAF: 122821445(stat5a) 122823242
PPRL: 129352275 129373719(stat5a)
CTUL: 119778879(stat5a) 119796116
KMR: 108243804(stat5a) 108245177
NWH: 119421910(stat5a) 119424214
MCEP: 124997980(stat5a) 125022426
SSEN: 122759289 122785610(stat5a)
HHIP: 117752427 117766855(stat5a)
HSP: 118100442 118122878(stat5a)
PPLT: 128426633 128458886(stat5a)
SMAU: 118287490 118289301(stat5a)
XGL: 120785048(stat5a) 120794630
SBIA: 133495970
PEE: 133415493(stat5a) 133418105
PTAO: 133469605
BSPL: 114845404 114860995(stat5a)
SJO: 128378374(stat5a) 128381015
PKI: 111856018
AANG: 118220791(stat5a)
LOC: 102697320(stat5b)
ARUT: 117433413 117435028(stat5a)
PSEX: 120518105(stat5a)
LCM: 102348150(STAT5B) 102350580(STAT6)
CMK: 103189177(stat5a)
RTP: 109924857 109929795(stat5a)
CPLA: 122539852(stat5a) 122543209
HOC: 132805836 132830987(stat5a)
LERI: 129710260(stat5a) 129714703
CIN: 778770(stat-b) 778907
SPU: 576433
ARUN: 117288577
AJC: 117120872
SKO: 100313741
DME: Dmel_CG4257(Stat92E)
DER: 6553695
DSE: 6619260
DSI: Dsimw501_GD20060(Dsim_GD20060)
DSR: 110188679
DPO: 6897369
DPE: 6588035
DMN: 108155914
DGR: 6569826
DAZ: 108615391
DNV: 108653502
DVI: 6629898
TDA: 119685678
MDE: 101895093
SCAC: 106096271
LCQ: 111679071
LSQ: 119609107
CLON: 129609511
HIS: 119652245
AALI: 118462907
AAG: 5572256
AALB: 109422192
ASUA: 134207693
AME: 413742
ACER: 108001157
ALAB: 122712845
ADR: 102673881
AFLR: 100864112
BIM: 100743540
BBIF: 117209933
BVK: 117230840
BVAN: 117166453
BTER: 100647789
BAFF: 126924528
BPYO: 122576024
BPAS: 132911729
FVI: 122536235
CCAL: 108630675
OBB: 114873069
OLG: 117610430
MGEN: 117219619
NMEA: 116431444
CGIG: 122394871
SOC: 105193817
MPHA: 105832515
AEC: 105148183
ACEP: 105624336
PBAR: 105433521
VEM: 105563878
HST: 105184844
DQU: 106749703
CFO: 105254529
FEX: 115240525
LHU: 105672556(Stat92E)
PGC: 109854643
OBO: 105281780
PCF: 106789625
PFUC: 122513482
VPS: 122636943
VCRB: 124430937
VVE: 124957094
NVI: 100121885
CSOL: 105361759
TPRE: 106651566
LHT: 122509003
LBD: 127288127
MDL: 103580774
CGLO: 123263507
FAS: 105266810
DAM: 107040670
AGIF: 122848525
CINS: 118067250
VCAN: 122419562
CCIN: 107275017
DSM: 124413078
NPT: 124221560
NFB: 124184852
NLO: 107227203
NVG: 124307088
AROA: 105693409
TCA: 657965(Stat)
DPA: 109540291
SOY: 115875164
AGRG: 126746020
ATD: 109594135
CSET: 123312582
AGB: 108914584
LDC: 111509439
NVL: 108559383
APLN: 108732879
PPYR: 116170388
OTU: 111415033
BMOR: 100302627(Stat)
BMAN: 114244414
MSEX: 115451759
BANY: 112051221
MJU: 123879668
NIQ: 126779907
PPOT: 106107473
PXU: 106126003
PRAP: 110992522
PBX: 123715650
PNAP: 125061300
ZCE: 119838494
CCRC: 123704742
LSIN: 126975029
AAGE: 121736540
HAW: 110381656
HZE: 124644398
TNL: 113509063
SLIU: 111359030
OFU: 114354585
ATRA: 106132869
GMW: 113513772
PXY: 105396563
PGW: 126379405
LGLY: 125239563
CFEL: 113369752
CCRN: 123290948
API: 100161101
DVT: 126908329
BTAB: 109041216
DCI: 103509325
HHAL: 106683428(Stat92E)
NLU: 111049728
HVI: 124353062
MQU: 128992970
FOC: 113201738
ZNE: 110830516
CSEC: 111869855
SGRE: 126267038
BROR: 134535922
IEL: 124163999
DPZ: 124320263
PVM: 113830023
PJA: 122265890
PCHN: 125040688
PCLA: 123758708
CQD: 128701161
PTRU: 123508992
ESN: 126983902
MNZ: 135219184
PPOI: 119111901
ISC: 8053058
DSV: 119456101
RMP: 119171954
CSCU: 111623415
CVS: 136968410(Stat92E)
ABRU: 129989007
UDV: 129226409
SDM: 118189820
LPOL: 106463512
PMEO: 129588506
CEL: CELE_Y51H4A.17(sta-1)
CBR: CBG_13675(Cbr-sta-1)
BMY: BM_BM6729(Bma-sta-1)
TSP: Tsp_04456
GAE: 121370464
CANU: 128180799
MCAF: 127728683
DPOL: 127859291
MAEA: 128233517
OSN: 115220884
LJP: 135462026
ADF: 107338381
AMIL: 114964117
SPIS: 111328363
XEN: 124437962
HMG: 100206878
RES: 135682336
AQU: 100641588
 » show all
Reference
PMID:8732682
  Authors
Silva CM, Lu H, Day RN
  Title
Characterization and cloning of STAT5 from IM-9 cells and its activation by growth hormone.
  Journal
Mol Endocrinol 10:508-18 (1996)
DOI:10.1210/mend.10.5.8732682
  Sequence
[hsa:6777]

KEGG   ORTHOLOGY: K04692
Entry
K04692                      KO                                     
Symbol
STAT3
Name
signal transducer and activator of transcription 3
Pathway
map01521  EGFR tyrosine kinase inhibitor resistance
map04062  Chemokine signaling pathway
map04066  HIF-1 signaling pathway
map04068  FoxO signaling pathway
map04217  Necroptosis
map04550  Signaling pathways regulating pluripotency of stem cells
map04630  JAK-STAT signaling pathway
map04659  Th17 cell differentiation
map04917  Prolactin signaling pathway
map04920  Adipocytokine signaling pathway
map04931  Insulin resistance
map04933  AGE-RAGE signaling pathway in diabetic complications
map04935  Growth hormone synthesis, secretion and action
map05145  Toxoplasmosis
map05160  Hepatitis C
map05161  Hepatitis B
map05162  Measles
map05163  Human cytomegalovirus infection
map05167  Kaposi sarcoma-associated herpesvirus infection
map05169  Epstein-Barr virus infection
map05171  Coronavirus disease - COVID-19
map05200  Pathways in cancer
map05203  Viral carcinogenesis
map05205  Proteoglycans in cancer
map05206  MicroRNAs in cancer
map05207  Chemical carcinogenesis - receptor activation
map05212  Pancreatic cancer
map05221  Acute myeloid leukemia
map05223  Non-small cell lung cancer
map05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
map05321  Inflammatory bowel disease
map05417  Lipid and atherosclerosis
Disease
H00016  Oral cancer
H00107  Other well-defined immunodeficiency syndromes
H01968  Hyper-IgE syndrome
H02540  Infantile-onset multisystem autoimmune disease
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04630 JAK-STAT signaling pathway
    K04692  STAT3; signal transducer and activator of transcription 3
   04066 HIF-1 signaling pathway
    K04692  STAT3; signal transducer and activator of transcription 3
   04068 FoxO signaling pathway
    K04692  STAT3; signal transducer and activator of transcription 3
 09140 Cellular Processes
  09143 Cell growth and death
   04217 Necroptosis
    K04692  STAT3; signal transducer and activator of transcription 3
  09144 Cellular community - eukaryotes
   04550 Signaling pathways regulating pluripotency of stem cells
    K04692  STAT3; signal transducer and activator of transcription 3
 09150 Organismal Systems
  09151 Immune system
   04659 Th17 cell differentiation
    K04692  STAT3; signal transducer and activator of transcription 3
   04062 Chemokine signaling pathway
    K04692  STAT3; signal transducer and activator of transcription 3
  09152 Endocrine system
   04920 Adipocytokine signaling pathway
    K04692  STAT3; signal transducer and activator of transcription 3
   04917 Prolactin signaling pathway
    K04692  STAT3; signal transducer and activator of transcription 3
   04935 Growth hormone synthesis, secretion and action
    K04692  STAT3; signal transducer and activator of transcription 3
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K04692  STAT3; signal transducer and activator of transcription 3
   05206 MicroRNAs in cancer
    K04692  STAT3; signal transducer and activator of transcription 3
   05205 Proteoglycans in cancer
    K04692  STAT3; signal transducer and activator of transcription 3
   05207 Chemical carcinogenesis - receptor activation
    K04692  STAT3; signal transducer and activator of transcription 3
   05203 Viral carcinogenesis
    K04692  STAT3; signal transducer and activator of transcription 3
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    K04692  STAT3; signal transducer and activator of transcription 3
  09162 Cancer: specific types
   05212 Pancreatic cancer
    K04692  STAT3; signal transducer and activator of transcription 3
   05221 Acute myeloid leukemia
    K04692  STAT3; signal transducer and activator of transcription 3
   05223 Non-small cell lung cancer
    K04692  STAT3; signal transducer and activator of transcription 3
  09172 Infectious disease: viral
   05161 Hepatitis B
    K04692  STAT3; signal transducer and activator of transcription 3
   05160 Hepatitis C
    K04692  STAT3; signal transducer and activator of transcription 3
   05171 Coronavirus disease - COVID-19
    K04692  STAT3; signal transducer and activator of transcription 3
   05162 Measles
    K04692  STAT3; signal transducer and activator of transcription 3
   05163 Human cytomegalovirus infection
    K04692  STAT3; signal transducer and activator of transcription 3
   05167 Kaposi sarcoma-associated herpesvirus infection
    K04692  STAT3; signal transducer and activator of transcription 3
   05169 Epstein-Barr virus infection
    K04692  STAT3; signal transducer and activator of transcription 3
  09174 Infectious disease: parasitic
   05145 Toxoplasmosis
    K04692  STAT3; signal transducer and activator of transcription 3
  09163 Immune disease
   05321 Inflammatory bowel disease
    K04692  STAT3; signal transducer and activator of transcription 3
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    K04692  STAT3; signal transducer and activator of transcription 3
  09167 Endocrine and metabolic disease
   04931 Insulin resistance
    K04692  STAT3; signal transducer and activator of transcription 3
   04933 AGE-RAGE signaling pathway in diabetic complications
    K04692  STAT3; signal transducer and activator of transcription 3
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    K04692  STAT3; signal transducer and activator of transcription 3
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03000 Transcription factors
    K04692  STAT3; signal transducer and activator of transcription 3
Transcription factors [BR:ko03000]
 Eukaryotic type
  beta-Scaffold factors with minor groove contacts
   STAT
    K04692  STAT3; signal transducer and activator of transcription 3
Genes
HSA: 6774(STAT3)
PTR: 454682(STAT3)
PPS: 100987766(STAT3)
GGO: 101135038(STAT3)
PON: 100171541(STAT3)
PPYG: 129017274(STAT3)
NLE: 100598877(STAT3)
HMH: 116474863(STAT3)
SSYN: 129469416(STAT3)
MCC: 574128(STAT3)
MCF: 102118402(STAT3)
MTHB: 126938424
MNI: 105472413(STAT3)
CSAB: 103243410(STAT3)
CATY: 105579724(STAT3)
PANU: 100998929(STAT3)
TGE: 112608953(STAT3)
MLEU: 105552958(STAT3)
RRO: 104680286(STAT3)
RBB: 108518318(STAT3)
TFN: 117066962(STAT3)
PTEH: 111537369
CANG: 105503009(STAT3)
CJC: 100389282(STAT3)
SBQ: 101049662(STAT3)
CIMI: 108289826(STAT3)
ANAN: 105711264(STAT3)
MMUR: 105859419(STAT3)
LCAT: 123620960(STAT3)
PCOQ: 105820249(STAT3)
OGA: 100958469(STAT3)
MMU: 20848(Stat3)
MCAL: 110306201(Stat3)
MPAH: 110332765(Stat3)
RNO: 25125(Stat3)
MCOC: 116076801(Stat3)
ANU: 117710477(Stat3)
MUN: 110550916(Stat3)
CGE: 100755865(Stat3)
MAUA: 101834358(Stat3)
PROB: 127216384(Stat3)
PLEU: 114682786(Stat3)
MORG: 121442318(Stat3)
MFOT: 126510305
AAMP: 119811206(Stat3)
NGI: 103735896(Stat3)
HGL: 101721899(Stat3)
CPOC: 100717084(Stat3)
CCAN: 109687324(Stat3)
DORD: 106003143(Stat3)
DSP: 122103310(Stat3)
PLOP: 125366353(Stat3)
NCAR: 124978933
MMMA: 107150570(Stat3)
OCU: 100348778
OPI: 101528287(STAT3)
TUP: 102492738(STAT3)
GVR: 103595356
CFA: 490967(STAT3)
CLUD: 112654961(STAT3)
VVP: 112910741(STAT3)
VLG: 121473042(STAT3)
NPO: 129506479(STAT3)
AML: 100469938(STAT3)
UMR: 103672573(STAT3)
UAH: 113265422(STAT3)
UAR: 123781851(STAT3)
ELK: 111151241
LLV: 125086956
MPUF: 101690716(STAT3)
MNP: 132004114(STAT3)
MLK: 131816590(STAT3)
NVS: 122906196(STAT3)
ORO: 101373587(STAT3)
EJU: 114201341(STAT3)
ZCA: 113939486(STAT3)
MLX: 118024910(STAT3)
NSU: 110573316(STAT3)
LWW: 102748936
FCA: 101095698(STAT3)
PYU: 121045024(STAT3)
PCOO: 112853996(STAT3)
PBG: 122485601(STAT3)
PVIV: 125158440(STAT3)
LRUF: 124522098
PTG: 102957987(STAT3)
PPAD: 109258518(STAT3)
PUC: 125926571
AJU: 106972608
HHV: 120248434(STAT3)
BTA: 508541(STAT3)
BOM: 102282282(STAT3)
BIU: 109573817(STAT3)
BBUB: 102414888(STAT3)
BBIS: 104990441(STAT3)
CHX: 102186154(STAT3)
OAS: 100294659(STAT3)
BTAX: 128065049(STAT3)
ODA: 120867076(STAT3)
CCAD: 122441604(STAT3)
MBEZ: 129544425(STAT3) 129549901
SSC: 733648(STAT3)
CFR: 102520228(STAT3)
CBAI: 105080116(STAT3)
CDK: 105090458(STAT3)
VPC: 102541847(STAT3)
BACU: 102997405 103008157(STAT3)
BMUS: 118887532(STAT3)
LVE: 103086495(STAT3)
OOR: 101281369(STAT3)
DLE: 111166491(STAT3)
PCAD: 102976764(STAT3)
PSIU: 116745657(STAT3)
NASI: 112399936(STAT3)
ECB: 100034011(STAT3)
EPZ: 103550364(STAT3)
EAI: 106826327(STAT3)
MYB: 102239853(STAT3)
MYD: 102752037(STAT3)
MMYO: 118671501(STAT3)
MLF: 102422489(STAT3)
MDT: 132218651(STAT3)
PKL: 118726602(STAT3)
EFUS: 103293093(STAT3)
MNA: 107528938(STAT3)
DRO: 112298562(STAT3)
SHON: 118978208(STAT3)
AJM: 119052142(STAT3)
PDIC: 114502756(STAT3)
PHAS: 123816770(STAT3)
MMF: 118634787(STAT3)
PPAM: 129086937(STAT3)
HAI: 109395763(STAT3)
RFQ: 117013100(STAT3)
PALE: 102884374(STAT3)
PGIG: 120611101(STAT3)
PVP: 105306294(STAT3)
RAY: 107513823(STAT3)
MJV: 108386068(STAT3)
TOD: 119232887(STAT3)
SARA: 101552896(STAT3)
SETR: 126020260(STAT3)
LAV: 100669583(STAT3)
TMU: 101342651
ETF: 101656698(STAT3)
DNM: 101444225(STAT3)
MDO: 100011382(STAT3)
GAS: 123246960(STAT3)
SHR: 100933581(STAT3)
AFZ: 127560120
PCW: 110198372(STAT3)
TVP: 118846384(STAT3)
OAA: 100087932(STAT3)
GGA: 420027(STAT3)
PCOC: 116233607(STAT3)
MGP: 100547142(STAT3)
CJO: 107325206(STAT3)
TPAI: 128089012(STAT3)
LMUT: 125684568(STAT3)
NMEL: 110388615(STAT3)
APLA: 101790010(STAT3)
ACYG: 106048026(STAT3)
CATA: 118259131(STAT3)
AFUL: 116498455(STAT3)
TGU: 100219856(STAT3)
LSR: 110471842(STAT3)
SCAN: 103821588(STAT3)
PMOA: 120496658(STAT3)
OTC: 121347603(STAT3)
PRUF: 121351062(STAT3)
GFR: 102036392(STAT3)
FAB: 101809631(STAT3)
OMA: 130263961(STAT3)
PHI: 102101801(STAT3)
PMAJ: 107215123(STAT3)
CCAE: 111939944(STAT3)
CCW: 104697761(STAT3)
CBRC: 103620736(STAT3)
ETL: 114063626(STAT3)
ZAB: 102062617(STAT3)
ZLE: 135458364(STAT3)
ACHL: 103797727(STAT3)
SVG: 106858641(STAT3)
MMEA: 130581462(STAT3)
HRT: 120763700(STAT3)
SATI: 136372158(STAT3)
FPG: 101917971(STAT3)
FCH: 102053408(STAT3)
CCRI: 104165667(STAT3)
SHAB: 115617605(STAT3)
ACUN: 113489073(STAT3)
TALA: 104360535(STAT3)
ACHC: 115344660(STAT3)
HALD: 104314723(STAT3)
HLE: 104842944(STAT3)
AGEN: 126038238
CSTI: 104563631(STAT3)
MNB: 103772403(STAT3)
DPUB: 104309596(STAT3)
BRHI: 104496281(STAT3)
EGZ: 104134824(STAT3)
NNI: 104009927(STAT3)
PCRI: 104027156(STAT3)
PCAO: 104049907(STAT3)
PADL: 103920524(STAT3)
AFOR: 103901821(STAT3)
FGA: 104075266
GSTE: 104262038(STAT3)
CLV: 102090191(STAT3)
MUI: 104541265(STAT3)
PGUU: 104464868(STAT3)
PLET: 104619955(STAT3)
CMAC: 104476015(STAT3)
CUCA: 104054404(STAT3)
TEO: 104372776(STAT3)
BREG: 104635697(STAT3)
OHA: 104332240(STAT3)
ACAR: 104522705(STAT3)
CPEA: 104385656(STAT3)
CVF: 104296000(STAT3)
RTD: 128919143(STAT3)
AAM: 106491102(STAT3)
AROW: 112968719(STAT3)
NPD: 112951799(STAT3)
TGT: 104571861(STAT3)
DNE: 112993847(STAT3)
SCAM: 104143581(STAT3)
ASN: 102381312(STAT3)
AMJ: 102575901(STAT3)
CPOO: 109320366(STAT3)
GGN: 109289716(STAT3)
PSS: 102460388(STAT3)
CMY: 102932633(STAT3)
CCAY: 125626679(STAT3)
DCC: 119848948(STAT3)
CPIC: 101952372(STAT3)
CABI: 116820371(STAT3)
MRV: 120392259(STAT3)
ACS: 100566559(stat3)
ASAO: 132778220(STAT3)
PVT: 110074829(STAT3)
SUND: 121933338(STAT3)
PBI: 103059982(STAT3)
PMUR: 107282651(STAT3)
CTIG: 120309722(STAT3)
TSR: 106541153(STAT3)
PGUT: 117664596(STAT3)
APRI: 131198342(STAT3)
PTEX: 113442956(STAT3)
NSS: 113413521(STAT3)
VKO: 123030484(STAT3)
PMUA: 114581554(STAT3)
PRAF: 128399426(STAT3)
ZVI: 118095339(STAT3)
HCG: 128329793(STAT3)
GJA: 107111493(STAT3)
STOW: 125444653(STAT3)
EMC: 129338257(STAT3)
XLA: 108702458 379264(stat3.2.L) 779100(stat3.1.L)
XTR: 100498278(stat3.1) 100498547(stat3.2)
NPR: 108792989(STAT3)
RTEM: 120918747(STAT3)
BBUF: 121003130(STAT3)
BGAR: 122942396(STAT3)
MUO: 115482291(STAT3)
GSH: 117347191(STAT3)
DRE: 30767(stat3)
SGH: 107560746(stat3) 107567623
PTET: 122341743(stat3)
LROH: 127155558(stat3)
OMC: 131536411(stat3)
PPRM: 120489714(stat3)
RKG: 130071199(stat3)
MAMB: 125279525(stat3)
CIDE: 127510137
CERY: 137017486(stat3)
TROS: 130561427(stat3)
TDW: 130426022(stat3)
MANU: 129436249(stat3)
IPU: 100304658
IFU: 128601899(stat3)
PHYP: 113528081(stat3)
SMEO: 124396762(stat3)
TFD: 113641145(stat3)
TVC: 132861476(stat3)
TRN: 134300168(stat3)
AMEX: 103033344(stat3)
CMAO: 118821460(stat3)
EEE: 113589971(stat3)
CHAR: 105890768(stat3)
TRU: 101070968(stat3)
TFS: 130514622(stat3)
LCO: 104925957(stat3)
TBEN: 117493484(stat3)
CGOB: 115012238(stat3)
PGEO: 117450920(stat3)
GACU: 117548409(stat3)
EMAC: 134877781(stat3)
ELY: 117268499(stat3)
EFO: 125879355(stat3)
PLEP: 121956091(stat3)
SLUC: 116059637(stat3)
ECRA: 117958415(stat3)
ESP: 116702317(stat3)
PFLV: 114569512(stat3)
GAT: 120828237(stat3)
PPUG: 119220174(stat3)
AFB: 129098137(stat3)
CLUM: 117734569(stat3)
PSWI: 130188242(stat3)
MSAM: 119892323(stat3)
SCHU: 122869591(stat3)
CUD: 121529469(stat3)
ALAT: 119013366(stat3)
MZE: 101480689(stat3)
ONL: 100692602(stat3)
OAU: 116312473(stat3)
OLA: 100049477(stat3)
OML: 112146943(stat3)
CSAI: 133422719(stat3)
XMA: 102226045(stat3)
XCO: 114160261(stat3)
XHE: 116735280(stat3)
PRET: 103469403(stat3)
PFOR: 103142203(stat3) 103142204
PLAI: 106963656(stat3)
PMEI: 106904928 106931289(stat3)
GAF: 122821446(stat3)
PPRL: 129373718(stat3)
CVG: 107091797(stat3)
CTUL: 119778878(stat3)
NFU: 107378443(stat3)
KMR: 108243798(stat3)
ALIM: 106528099(stat3)
NWH: 119421911(stat3)
AOCE: 111576401(stat3)
MCEP: 124997983(stat3)
CSEM: 103393170(stat3)
POV: 109634199(stat3)
SSEN: 122785609(stat3)
HHIP: 117766856(stat3)
HSP: 118122879(stat3)
PPLT: 128458887(stat3)
SMAU: 118289302(stat3)
LCF: 108901193
SDU: 111217480(stat3)
SLAL: 111660433(stat3)
XGL: 120785053(stat3)
HCQ: 109513792(stat3)
SSCV: 125983822
SBIA: 133514559(stat3)
PEE: 133415491(stat3)
PTAO: 133465411(stat3)
BPEC: 110159498(stat3)
MALB: 109964187(stat3)
BSPL: 114860996(stat3)
SJO: 128378375(stat3)
OMY: 100136756(rbtstat3) 110538194
ELS: 105013350(stat3)
PKI: 111842512(stat3) 111856019
AANG: 118216486 118220792(stat3)
LOC: 102697118(stat3)
PSEX: 120517701(stat3)
LCM: 102365345(STAT3)
CMK: 103189176(stat3)
RTP: 109928447
CPLA: 122539855(stat3)
HOC: 132830988(stat3)
LERI: 129710261(stat3)
PMRN: 116945023
LRJ: 133345387
 » show all
Reference
  Authors
Tsai YT, Su YH, Fang SS, Huang TN, Qiu Y, Jou YS, Shih HM, Kung HJ, Chen RH
  Title
Etk, a Btk family tyrosine kinase, mediates cellular transformation by linking Src to STAT3 activation.
  Journal
Mol Cell Biol 20:2043-54 (2000)
DOI:10.1128/MCB.20.6.2043-2054.2000
  Sequence
[hsa:6774]
Reference
PMID:7512451
  Authors
Akira S, Nishio Y, Inoue M, Wang XJ, Wei S, Matsusaka T, Yoshida K, Sudo T, Naruto M, Kishimoto T
  Title
Molecular cloning of APRF, a novel IFN-stimulated gene factor 3 p91-related transcription factor involved in the gp130-mediated signaling pathway.
  Journal
Cell 77:63-71 (1994)
DOI:10.1016/0092-8674(94)90235-6
  Sequence
[hsa:6774]

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