ORTHOLOGY: K11411 Help
Entry
Symbol
SIRT1, SIR2L1
Name
NAD-dependent protein deacetylase sirtuin 1 [EC:
2.3.1.286 ]
Pathway
map00760 Nicotinate and nicotinamide metabolism
map04212 Longevity regulating pathway - worm
map04213 Longevity regulating pathway - multiple species
Reaction
Brite
KEGG Orthology (KO) [BR:ko00001 ]
09100 Metabolism
09108 Metabolism of cofactors and vitamins
00760 Nicotinate and nicotinamide metabolism
K11411 SIRT1, SIR2L1; NAD-dependent protein deacetylase sirtuin 1
09130 Environmental Information Processing
09132 Signal transduction
04310 Wnt signaling pathway
K11411 SIRT1, SIR2L1; NAD-dependent protein deacetylase sirtuin 1
04068 FoxO signaling pathway
K11411 SIRT1, SIR2L1; NAD-dependent protein deacetylase sirtuin 1
04152 AMPK signaling pathway
K11411 SIRT1, SIR2L1; NAD-dependent protein deacetylase sirtuin 1
09140 Cellular Processes
09141 Transport and catabolism
04148 Efferocytosis
K11411 SIRT1, SIR2L1; NAD-dependent protein deacetylase sirtuin 1
09143 Cell growth and death
04218 Cellular senescence
K11411 SIRT1, SIR2L1; NAD-dependent protein deacetylase sirtuin 1
09150 Organismal Systems
09152 Endocrine system
04922 Glucagon signaling pathway
K11411 SIRT1, SIR2L1; NAD-dependent protein deacetylase sirtuin 1
09149 Aging
04211 Longevity regulating pathway
K11411 SIRT1, SIR2L1; NAD-dependent protein deacetylase sirtuin 1
04212 Longevity regulating pathway - worm
K11411 SIRT1, SIR2L1; NAD-dependent protein deacetylase sirtuin 1
04213 Longevity regulating pathway - multiple species
K11411 SIRT1, SIR2L1; NAD-dependent protein deacetylase sirtuin 1
09160 Human Diseases
09161 Cancer: overview
05206 MicroRNAs in cancer
K11411 SIRT1, SIR2L1; NAD-dependent protein deacetylase sirtuin 1
09165 Substance dependence
05031 Amphetamine addiction
K11411 SIRT1, SIR2L1; NAD-dependent protein deacetylase sirtuin 1
09167 Endocrine and metabolic disease
04936 Alcoholic liver disease
K11411 SIRT1, SIR2L1; NAD-dependent protein deacetylase sirtuin 1
09180 Brite Hierarchies
09182 Protein families: genetic information processing
03036 Chromosome and associated proteins
K11411 SIRT1, SIR2L1; NAD-dependent protein deacetylase sirtuin 1
03029 Mitochondrial biogenesis
K11411 SIRT1, SIR2L1; NAD-dependent protein deacetylase sirtuin 1
Enzymes [BR:ko01000 ]
2. Transferases
2.3 Acyltransferases
2.3.1 Transferring groups other than aminoacyl groups
2.3.1.286 protein acetyllysine N-acetyltransferase
K11411 SIRT1, SIR2L1; NAD-dependent protein deacetylase sirtuin 1
Chromosome and associated proteins [BR:ko03036 ]
Eukaryotic type
Histone modification proteins
HDACs (histone deacetylases)
SIRTs (sirtuins, class III HDACs)
K11411 SIRT1, SIR2L1; NAD-dependent protein deacetylase sirtuin 1
Mitochondrial biogenesis [BR:ko03029 ]
Mitochondrial quality control factors
Regulator of mitochondrial biogenesis
Other regulator of mitochondrial biogenesis
K11411 SIRT1, SIR2L1; NAD-dependent protein deacetylase sirtuin 1
BRITE hierarchy
Other DBs
Genes
» show all
Taxonomy UniProt
Reference
Authors
Vaziri H, Dessain SK, Ng Eaton E, Imai SI, Frye RA, Pandita TK, Guarente L, Weinberg RA
Title
hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase.
Journal
Sequence
Reference
Authors
Li X, Zhang S, Blander G, Tse JG, Krieger M, Guarente L
Title
SIRT1 deacetylates and positively regulates the nuclear receptor LXR.
Journal
Sequence
Reference
Authors
Frye RA
Title
Characterization of five human cDNAs with homology to the yeast SIR2 gene: Sir2-like proteins (sirtuins) metabolize NAD and may have protein ADP-ribosyltransferase activity.
Journal
Sequence