Entry
Symbol
CAD
Name
carbamoyl-phosphate synthase / aspartate carbamoyltransferase / dihydroorotase [EC:
6.3.5.5 2.1.3.2 3.5.2.3 ]
Pathway
map00250 Alanine, aspartate and glutamate metabolism
map01110 Biosynthesis of secondary metabolites
Module
M00051 De novo pyrimidine biosynthesis, glutamine (+ PRPP) => UMP
Reaction
R00256 L-glutamine amidohydrolase
R00575 HCO3-:L-glutamine amido-ligase (ADP-forming, carbamate-phosphorylating)
R01395 ATP:carbamate phosphotransferase
R01397 carbamoyl-phosphate:L-aspartate carbamoyltransferase
R01993 (S)-dihydroorotate amidohydrolase
R10948 ATP:HCO3- phosphotransferase
Disease
H00606 Early infantile epileptic encephalopathy
Brite
KEGG Orthology (KO) [BR:ko00001 ]
09100 Metabolism
09104 Nucleotide metabolism
00240 Pyrimidine metabolism
K11540 CAD; carbamoyl-phosphate synthase / aspartate carbamoyltransferase / dihydroorotase
09105 Amino acid metabolism
00250 Alanine, aspartate and glutamate metabolism
K11540 CAD; carbamoyl-phosphate synthase / aspartate carbamoyltransferase / dihydroorotase
00220 Arginine biosynthesis
K11540 CAD; carbamoyl-phosphate synthase / aspartate carbamoyltransferase / dihydroorotase
09180 Brite Hierarchies
09181 Protein families: metabolism
01002 Peptidases and inhibitors
K11540 CAD; carbamoyl-phosphate synthase / aspartate carbamoyltransferase / dihydroorotase
Enzymes [BR:ko01000 ]
2. Transferases
2.1 Transferring one-carbon groups
2.1.3 Carboxy- and carbamoyltransferases
2.1.3.2 aspartate carbamoyltransferase
K11540 CAD; carbamoyl-phosphate synthase / aspartate carbamoyltransferase / dihydroorotase
3. Hydrolases
3.5 Acting on carbon-nitrogen bonds, other than peptide bonds
3.5.2 In cyclic amides
3.5.2.3 dihydroorotase
K11540 CAD; carbamoyl-phosphate synthase / aspartate carbamoyltransferase / dihydroorotase
6. Ligases
6.3 Forming carbon-nitrogen bonds
6.3.5 Carbon-nitrogen ligases with glutamine as amido-N-donor
6.3.5.5 carbamoyl-phosphate synthase (glutamine-hydrolysing)
K11540 CAD; carbamoyl-phosphate synthase / aspartate carbamoyltransferase / dihydroorotase
Peptidases and inhibitors [BR:ko01002 ]
Cysteine peptidases
Family C26: gamma-glutamyl hydrolase family
K11540 CAD; carbamoyl-phosphate synthase / aspartate carbamoyltransferase / dihydroorotase
Metallo peptidases
Family M38: beta-aspartyl dipeptidase family
K11540 CAD; carbamoyl-phosphate synthase / aspartate carbamoyltransferase / dihydroorotase
BRITE hierarchy
Other DBs
Genes
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Taxonomy UniProt
Reference
Authors
Iwahana H, Fujimura M, Ii S, Kondo M, Moritani M, Takahashi Y, Yamaoka T, Yoshimoto K, Itakura M
Title
Molecular cloning of a human cDNA encoding a trifunctional enzyme of carbamoyl-phosphate synthetase-aspartate transcarbamoylase-dihydroorotase in de Novo pyrimidine synthesis.
Journal
Sequence
Reference
Authors
Grande-Garcia A, Lallous N, Diaz-Tejada C, Ramon-Maiques S
Title
Structure, functional characterization, and evolution of the dihydroorotase domain of human CAD.
Journal
Sequence