KEGG   ORTHOLOGY: K11592
Entry
K11592                      KO                                     

Name
DICER1, DCR1
Definition
endoribonuclease Dicer [EC:3.1.26.-]
Pathway
ko05206  MicroRNAs in cancer
Disease
H01102  Pituitary adenomas
H01431  Cushing syndrome
Brite
KEGG Orthology (KO) [BR:ko00001]
 09160 Human Diseases
  09161 Cancer: overview
   05206 MicroRNAs in cancer
    K11592  DICER1, DCR1; endoribonuclease Dicer
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03036 Chromosome and associated proteins
    K11592  DICER1, DCR1; endoribonuclease Dicer
Enzymes [BR:ko01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.26  Endoribonucleases producing 5'-phosphomonoesters
    3.1.26.-  
     K11592  DICER1, DCR1; endoribonuclease Dicer
Chromosome and associated proteins [BR:ko03036]
 Eukaryotic type
  Gene silencing
   RISC (RNA-induced silencing complex)
    K11592  DICER1, DCR1; endoribonuclease Dicer
   microRNA pathway
    RISC loading complex
     K11592  DICER1, DCR1; endoribonuclease Dicer
Genes
HSA: 23405(DICER1)
PTR: 453137(DICER1)
PPS: 100995969(DICER1)
GGO: 101124693(DICER1)
PON: 100462160(DICER1)
NLE: 100589247(DICER1)
MCC: 702516(DICER1)
MCF: 102145214(DICER1)
CSAB: 103229626(DICER1)
RRO: 104654495(DICER1)
RBB: 108519134(DICER1)
CJC: 100398032(DICER1)
SBQ: 101041115(DICER1)
MMU: 192119(Dicer1)
MCAL: 110306463(Dicer1)
MPAH: 110324857(Dicer1)
RNO: 299284(Dicer1)
MUN: 110554379(Dicer1)
CGE: 100689239(Dicer1)
NGI: 103737725(Dicer1)
HGL: 101721048(Dicer1)
CCAN: 109698296(Dicer1)
OCU: 100357967(DICER1)
TUP: 102492546(DICER1)
CFA: 480426(DICER1)
VVP: 112907368(DICER1)
AML: 100479669(DICER1)
UMR: 103669722(DICER1)
UAH: 113267305(DICER1)
ORO: 101367606(DICER1)
ELK: 111148507
FCA: 101089449(DICER1)
PTG: 102963060(DICER1)
PPAD: 109274517(DICER1)
AJU: 106977463(DICER1)
BTA: 337871(DICER1)
BOM: 102270004(DICER1)
BIU: 109575356(DICER1)
BBUB: 102412807(DICER1)
CHX: 102175335(DICER1)
OAS: 101120020(DICER1)
SSC: 100505387(DICER1)
CFR: 102504410(DICER1)
CDK: 105095547(DICER1)
BACU: 102997781(DICER1)
LVE: 103084469(DICER1)
OOR: 101276130(DICER1)
DLE: 111176117(DICER1)
PCAD: 102977906(DICER1)
ECB: 100065648(DICER1)
EPZ: 103560738(DICER1)
EAI: 106832636(DICER1)
MYB: 102242366(DICER1)
MYD: 102769530(DICER1)
MNA: 107528078(DICER1)
HAI: 109382752(DICER1)
DRO: 112311150(DICER1)
PALE: 102894874(DICER1)
RAY: 107504891 107516357(DICER1)
MJV: 108387601(DICER1)
LAV: 100673369(DICER1)
TMU: 101346225
MDO: 100019289(DICER1)
SHR: 100918678(DICER1)
PCW: 110220889(DICER1)
OAA: 100079488(DICER1)
GGA: 423437(DICER1)
MGP: 100542530(DICER1)
CJO: 107315212(DICER1)
NMEL: 110402006(DICER1)
APLA: 101804383(DICER1)
ACYG: 106036343(DICER1)
TGU: 100227750(DICER1)
LSR: 110481192(DICER1)
SCAN: 103826446(DICER1)
GFR: 102041895(DICER1)
FAB: 101810874(DICER1)
PHI: 102102861(DICER1)
PMAJ: 107205627(DICER1)
CCAE: 111929550 111929845(DICER1)
CCW: 104686266(DICER1)
ETL: 114061897(DICER1)
FPG: 101923494(DICER1)
FCH: 102054571(DICER1)
CLV: 102090844(DICER1)
EGZ: 104127796(DICER1)
NNI: 104014803(DICER1)
ACUN: 113480445(DICER1)
PADL: 103923941(DICER1)
AAM: 106482944(DICER1)
ASN: 102369388(DICER1)
AMJ: 102560197(DICER1)
PSS: 102458079(DICER1)
CMY: 102934423(DICER1)
CPIC: 101934083(DICER1)
ACS: 100561007(dicer1)
PVT: 110088625(DICER1)
PBI: 103065054(DICER1)
PMUR: 107290203(DICER1)
TSR: 106544730(DICER1)
PMUA: 114590590(DICER1)
GJA: 107114749(DICER1)
XLA: 100316917(dicer1.S) 108698734(dicer1.L)
XTR: 100170154(dicer1)
NPR: 108789403(DICER1)
DRE: 324724(dicer1)
SRX: 107717084(dicer1) 107750873
IPU: 108270458(dicer1)
PHYP: 113534031(dicer1)
AMEX: 103033221(dicer1)
EEE: 113586245(dicer1)
TRU: 101069410
LCO: 104930836(dicer1)
MZE: 101472685(dicer1)
ONL: 100706888
OLA: 101164359(dicer1)
XMA: 102228023(dicer1)
XCO: 114134101(dicer1)
PRET: 103458963(dicer1)
CVG: 107097528(dicer1)
NFU: 107395773(dicer1)
KMR: 108245054(dicer1)
ALIM: 106519969(dicer1)
AOCE: 111581527(dicer1)
CSEM: 103384345(dicer1)
POV: 109639553(dicer1)
LCF: 108897896(dicer1)
SDU: 111225724(dicer1)
SLAL: 111645496(dicer1)
HCQ: 109515890(dicer1)
BPEC: 110165493(dicer1)
MALB: 109959678(dicer1)
ELS: 105015530(dicer1)
SFM: 108919612(dicer1)
PKI: 111834506(dicer1)
LCM: 102354179(DICER1)
CMK: 103190526(dicer1)
RTP: 109930774(dicer1)
BFO: 118416511
CIN: 100181362
SPU: 586001
APLC: 110982529
SKO: 100369641
DME: Dmel_CG4792(Dcr-1)
DER: 6554795
DSE: 6621093
DSI: Dsimw501_GD18429(Dsim_Dcr-1)
DAN: 6501066
DVI: 6630057
MDE: 101896691
LCQ: 111676130
AME: 552127(Dcr-1) 726766
TCA: 657440(Dcr-1) 658023(Dcr-2)
BMOR: 100499206(dcr-2) 119629098
PMAC: 106714069
CEL: CELE_K12H4.8(dcr-1)
CBR: CBG22974(Cbr-dcr-1)
BMY: Bm1_45410
PCAN: 112570328
CRG: 105336850
MYI: 110446500
OBI: 106877164
LAK: 106173323
ATH: AT1G01040(DCL1) AT3G03300(DCL2) AT3G43920(DCL3) AT5G20320(DCL4)
LJA: Lj0g3v0041629.1(Lj0g3v0041629.1) Lj0g3v0041629.2(Lj0g3v0041629.2) Lj1g3v1788430.1(Lj1g3v1788430.1) Lj1g3v5061000.1(Lj1g3v5061000.1) Lj2g3v0866690.1(Lj2g3v0866690.1)
SLY: 101055595(DCL4) 101247679(DCL2c) 101247976(DCL2d) 101254304(DCL2a) 101256737(DCL2b) 101260085(DCL1) 101265460(DCL3)
DOSA: Os01t0909200-01(Os01g0909200) Os03t0583900-01(Os03g0583900) Os04t0509300-01(Os04g0509300) Os10t0485600-00(Os10g0485600)
ATS: 109736585(LOC109736585) 109749372(LOC109749372) 109750274(LOC109750274) 109761477(LOC109761477) 109767952(LOC109767952)
CRE: CHLREDRAFT_173928(DCL1)
APRO: F751_5138
NCR: NCU08270(dcl-1)
NTE: NEUTE1DRAFT60268(NEUTE1DRAFT_60268)
MGR: MGG_01541
SSCK: SPSK_02925
NHE: NECHADRAFT_95309(DCL2101)
MAW: MAC_00265
MAJ: MAA_08201
CMT: CCM_09257
BFU: BCIN_12g06230(BcdcL1)
MBE: MBM_04322
ANG: ANI_1_360164(An18g02950)
CIM: CIMG_13589(CIMG09182)
PBL: PAAG_11489(PAAG_02421)
PBN: PADG_11946(PADG_05567)
ABE: ARB_04359
TVE: TRV_03185
PTE: PTT_06534
ZTR: MYCGRDRAFT_47983(DCL2401)
SPO: SPCC188.13c(dcr1)
TASA: A1Q1_05439
ABP: AGABI1DRAFT125544(AGABI1DRAFT_125544) AGABI1DRAFT128037(AGABI1DRAFT_128037) AGABI1DRAFT77978(AGABI1DRAFT_77978)
ABV: AGABI2DRAFT202619(AGABI2DRAFT_202619) AGABI2DRAFT209093(AGABI2DRAFT_209093) AGABI2DRAFT64825(AGABI2DRAFT_64825)
SPAR: SPRG_00195
 » show all
Reference
  Authors
Zhang H, Kolb FA, Jaskiewicz L, Westhof E, Filipowicz W
  Title
Single processing center models for human Dicer and bacterial RNase III.
  Journal
Cell 118:57-68 (2004)
DOI:10.1016/j.cell.2004.06.017
  Sequence
[hsa:23405]
Reference
  Authors
Provost P, Silverstein RA, Dishart D, Walfridsson J, Djupedal I, Kniola B, Wright A, Samuelsson B, Radmark O, Ekwall K
  Title
Dicer is required for chromosome segregation and gene silencing in fission yeast cells.
  Journal
Proc Natl Acad Sci U S A 99:16648-53 (2002)
DOI:10.1073/pnas.212633199
  Sequence

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