KEGG   ORTHOLOGY: K11646
Entry
K11646                      KO                                     

Name
K11646
Definition
3-dehydroquinate synthase II [EC:1.4.1.24]
Pathway
ko00400  Phenylalanine, tyrosine and tryptophan biosynthesis
ko01100  Metabolic pathways
ko01110  Biosynthesis of secondary metabolites
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09105 Amino acid metabolism
   00400 Phenylalanine, tyrosine and tryptophan biosynthesis
    K11646  K11646; 3-dehydroquinate synthase II
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.4  Acting on the CH-NH2 group of donors
   1.4.1  With NAD+ or NADP+ as acceptor
    1.4.1.24  3-dehydroquinate synthase II
     K11646  K11646; 3-dehydroquinate synthase II
Other DBs
RN: R08569
COG: COG1465
Genes
GHL: GM160_10825
BUG: BC1001_PA6183
DEL: DelCs14_2367
DVU: DVU0461
DVM: DvMF_1750
DVG: Deval_0422
DDE: Dde_3488
DDS: Ddes_0337
DDN: DND132_3202
DMA: DMR_05360
DGG: DGI_0593
DTR: RSDT_0005(aroB)
DFL: DFE_3006
DAS: Daes_0955
DPI: BN4_11437
PPRF: DPRO_2849
DBA: Dbac_2808
DRT: Dret_0115
SFU: Sfum_2724
AXL: AXY_21120
AAE: aq_1922
HTH: HTH_1199
TAL: Thal_0223
TTK: TST_1081
MJA: MJ_1249
MMP: MMP0006
MMD: GYY_00030
MMAK: MMKA1_00060(aroB)
MMAO: MMOS7_00060(aroB)
MMAD: MMJJ_10950(griH)
MAE: Maeo_1164
MVO: Mvol_1425
MTH: MTH_580
MMG: MTBMA_c09610(aroB)
METC: MTCT_0504
MWO: MWSIV6_0940(aroB')
METE: tca_00549(griH)
MST: Msp_0090
MRU: mru_0998(aroB)
MSI: Msm_0055
MEB: Abm4_0655(aroB)
MMIL: sm9_1017(aroB2)
MEYE: TL18_05335
MOL: YLM1_0541
METH: MBMB1_1071
MFC: BRM9_1273(aroB)
MCUB: MCBB_0940(aroB')
MFV: Mfer_0601
MKA: MK1408
AFU: AF_0229
FPL: Ferp_2249
GAC: GACE_1229
GAH: GAH_01752
MEAR: Mpt1_c10440(aroB')
MARC: AR505_0509
MBAR: MSBR2_2306
MBAK: MSBR3_2365
MAC: MA_4592
MMA: MM_1272
MMAC: MSMAC_0044
METM: MSMTP_0059
MTHR: MSTHT_1781
MTHE: MSTHC_1505
MHOR: MSHOH_0049
MBU: Mbur_2000
MMET: MCMEM_0228
MMH: Mmah_0240
MPY: Mpsy_1419
MTP: Mthe_0539
MCJ: MCON_1239(aroB)
MHI: Mhar_0787
MHU: Mhun_1034
MLA: Mlab_1653
MEMA: MMAB1_2642
MPI: Mpet_2704
MBN: Mboo_1559
MPL: Mpal_2609
MPD: MCP_1668
MEZ: Mtc_1382(aroB)
RCI: RRC152(aroB)
HAL: VNG_0310C
HSL: OE_1475F(aroB)
HHB: Hhub_1456(aroB)
HALH: HTSR_1438(aroB)
HHSR: HSR6_1510(aroB)
HSU: HLASF_0625(aroB)
HSF: HLASA_0621(aroB)
HMA: rrnAC1879(aroB)
HHI: HAH_2395(aroB)
NPH: NP_2238A(aroB)
NMO: Nmlp_1201(aroB)
HUT: Huta_1180
HTI: HTIA_1102
HMU: Hmuk_3035
HALL: LC1Hm_2380
HWA: HQ_1155A(aroB)
HWC: Hqrw_1192(aroB)
HVO: HVO_0792(aroB)
HME: HFX_0757
HLA: Hlac_1277
HTU: Htur_0813
NMG: Nmag_2808(aroB)
NAT: NJ7G_4142
SALI: L593_01230
NMR: Nmar_0552
NID: NPIRD3C_1722(aroB)
NIN: NADRNF5_1626(aroB)
NCT: NMSP_1119(aroB')
NGA: Ngar_c16220(aroB)
NVN: NVIE_005840(aroB)
NEV: NTE_01959
TAA: NMY3_02543(griH)
NFN: NFRAN_0127(aroB)
NCV: NCAV_0389(aroB)
NBV: T478_0479
NDV: NDEV_0553(aroB)
KCR: Kcr_1100
BARB: AOA66_0831(aroB')
CCAI: NAS2_0560
LOKI: Lokiarch_16770(aroB')
 » show all
Reference
  Authors
White RH
  Title
L-Aspartate semialdehyde and a 6-deoxy-5-ketohexose 1-phosphate are the precursors to the aromatic amino acids in Methanocaldococcus jannaschii.
  Journal
Biochemistry 43:7618-27 (2004)
DOI:10.1021/bi0495127
  Sequence
[mja:MJ_1249]

KEGG   ENZYME: 1.4.1.24
Entry
EC 1.4.1.24                 Enzyme                                 

Name
3-dehydroquinate synthase II;
DHQ synthase II;
MJ1249 (gene name);
aroB' (gene name)
Class
Oxidoreductases;
Acting on the CH-NH2 group of donors;
With NAD+ or NADP+ as acceptor
Sysname
2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate:NAD+ oxidoreductase (deaminating)
Reaction(IUBMB)
2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate + H2O + NAD+ = 3-dehydroquinate + NH3 + NADH + H+ [RN:R08569]
Reaction(KEGG)
R08569
Substrate
2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate;
H2O [CPD:C00001];
NAD+ [CPD:C00003]
Product
3-dehydroquinate [CPD:C00944];
NH3 [CPD:C00014];
NADH [CPD:C00004];
H+ [CPD:C00080]
Comment
The enzyme, which was isolated from the archaeon Methanocaldococcus jannaschii, plays a key role in an alternative pathway for the biosynthesis of 3-dehydroquinate (DHQ), an intermediate of the canonical pathway for the biosynthesis of aromatic amino acids. The enzyme catalyses a two-step reaction - an oxidative deamination, followed by cyclization.
History
EC 1.4.1.24 created 2012
Pathway
ec00400  Phenylalanine, tyrosine and tryptophan biosynthesis
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K11646  3-dehydroquinate synthase II
Genes
GHL: GM160_10825
BUG: BC1001_PA6183
DEL: DelCs14_2367
DVU: DVU0461
DVM: DvMF_1750
DVG: Deval_0422
DDE: Dde_3488
DDS: Ddes_0337
DDN: DND132_3202
DMA: DMR_05360
DGG: DGI_0593
DTR: RSDT_0005(aroB)
DFL: DFE_3006
DAS: Daes_0955
DPI: BN4_11437
PPRF: DPRO_2849
DBA: Dbac_2808
DRT: Dret_0115
SFU: Sfum_2724
AXL: AXY_21120
AAE: aq_1922
HTH: HTH_1199
TAL: Thal_0223
TTK: TST_1081
MJA: MJ_1249
MMP: MMP0006
MMD: GYY_00030
MMAK: MMKA1_00060(aroB)
MMAO: MMOS7_00060(aroB)
MMAD: MMJJ_10950(griH)
MAE: Maeo_1164
MVO: Mvol_1425
MTH: MTH_580
MMG: MTBMA_c09610(aroB)
METC: MTCT_0504
MWO: MWSIV6_0940(aroB')
METE: tca_00549(griH)
MST: Msp_0090
MRU: mru_0998(aroB)
MSI: Msm_0055
MEB: Abm4_0655(aroB)
MMIL: sm9_1017(aroB2)
MEYE: TL18_05335
MOL: YLM1_0541
METH: MBMB1_1071
MFC: BRM9_1273(aroB)
MCUB: MCBB_0940(aroB')
MFV: Mfer_0601
MKA: MK1408
AFU: AF_0229
FPL: Ferp_2249
GAC: GACE_1229
GAH: GAH_01752
MEAR: Mpt1_c10440(aroB')
MARC: AR505_0509
MBAR: MSBR2_2306
MBAK: MSBR3_2365
MAC: MA_4592
MMA: MM_1272
MMAC: MSMAC_0044
METM: MSMTP_0059
MTHR: MSTHT_1781
MTHE: MSTHC_1505
MHOR: MSHOH_0049
MBU: Mbur_2000
MMET: MCMEM_0228
MMH: Mmah_0240
MPY: Mpsy_1419
MTP: Mthe_0539
MCJ: MCON_1239(aroB)
MHI: Mhar_0787
MHU: Mhun_1034
MLA: Mlab_1653
MEMA: MMAB1_2642
MPI: Mpet_2704
MBN: Mboo_1559
MPL: Mpal_2609
MPD: MCP_1668
MEZ: Mtc_1382(aroB)
RCI: RRC152(aroB)
HAL: VNG_0310C
HSL: OE_1475F(aroB)
HHB: Hhub_1456(aroB)
HALH: HTSR_1438(aroB)
HHSR: HSR6_1510(aroB)
HSU: HLASF_0625(aroB)
HSF: HLASA_0621(aroB)
HMA: rrnAC1879(aroB)
HHI: HAH_2395(aroB)
NPH: NP_2238A(aroB)
NMO: Nmlp_1201(aroB)
HUT: Huta_1180
HTI: HTIA_1102
HMU: Hmuk_3035
HALL: LC1Hm_2380
HWA: HQ_1155A(aroB)
HWC: Hqrw_1192(aroB)
HVO: HVO_0792(aroB)
HME: HFX_0757
HLA: Hlac_1277
HTU: Htur_0813
NMG: Nmag_2808(aroB)
NAT: NJ7G_4142
SALI: L593_01230
NMR: Nmar_0552
NID: NPIRD3C_1722(aroB)
NIN: NADRNF5_1626(aroB)
NCT: NMSP_1119(aroB')
NGA: Ngar_c16220(aroB)
NVN: NVIE_005840(aroB)
NEV: NTE_01959
TAA: NMY3_02543(griH)
NFN: NFRAN_0127(aroB)
NCV: NCAV_0389(aroB)
NBV: T478_0479
NDV: NDEV_0553(aroB)
KCR: Kcr_1100
BARB: AOA66_0831(aroB')
CCAI: NAS2_0560
LOKI: Lokiarch_16770(aroB')
 » show all
Reference
1  [PMID:15182204]
  Authors
White RH.
  Title
L-Aspartate semialdehyde and a 6-deoxy-5-ketohexose 1-phosphate are the precursors to the aromatic amino acids in Methanocaldococcus jannaschii.
  Journal
Biochemistry 43:7618-27 (2004)
DOI:10.1021/bi0495127
  Sequence
[mja:MJ_1249]
Other DBs
ExplorEnz - The Enzyme Database: 1.4.1.24
IUBMB Enzyme Nomenclature: 1.4.1.24
ExPASy - ENZYME nomenclature database: 1.4.1.24
BRENDA, the Enzyme Database: 1.4.1.24

KEGG   REACTION: R08569
Entry
R08569                      Reaction                               

Name
2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate:NAD+ oxidoreductase (deaminating)
Definition
2-Amino-3,7-dideoxy-D-threo-hept-6-ulosonic acid + H2O + NAD+ <=> 3-Dehydroquinate + Ammonia + NADH + H+
Equation
Comment
two-step reaction (oxidative deamination, cyclization)
possibly intermediate (3,7-dideoxy-D-threo-hept-2,6-diulosonic acid)
Reaction class
RC00001  C00003_C00004
RC02302  C00944_C16850
Enzyme
Pathway
rn00400  Phenylalanine, tyrosine and tryptophan biosynthesis
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Orthology
K11646  3-dehydroquinate synthase II [EC:1.4.1.24]
Reference
1  [PMID:15182204]
  Authors
White RH.
  Title
L-Aspartate semialdehyde and a 6-deoxy-5-ketohexose 1-phosphate are the precursors to the aromatic amino acids in Methanocaldococcus jannaschii.
  Journal
Biochemistry 43:7618-27 (2004)
DOI:10.1021/bi0495127
Other DBs
RHEA: 25959

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