KEGG   ORTHOLOGY: K11778
Entry
K11778                      KO                                     
Symbol
DHDDS, RER2, SRT1
Name
ditrans,polycis-polyprenyl diphosphate synthase [EC:2.5.1.87]
Pathway
map00900  Terpenoid backbone biosynthesis
map01110  Biosynthesis of secondary metabolites
Disease
H00118  Congenital disorders of glycosylation type I
H00527  Retinitis pigmentosa
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   00900 Terpenoid backbone biosynthesis
    K11778  DHDDS, RER2, SRT1; ditrans,polycis-polyprenyl diphosphate synthase
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01006 Prenyltransferases
    K11778  DHDDS, RER2, SRT1; ditrans,polycis-polyprenyl diphosphate synthase
Enzymes [BR:ko01000]
 2. Transferases
  2.5  Transferring alkyl or aryl groups, other than methyl groups
   2.5.1  Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
    2.5.1.87  ditrans,polycis-polyprenyl diphosphate synthase [(2E,6E)-farnesyl diphosphate specific]
     K11778  DHDDS, RER2, SRT1; ditrans,polycis-polyprenyl diphosphate synthase
Prenyltransferases [BR:ko01006]
 Terpene biosynthesis
  Prenyl diphosphate synthase
   K11778  DHDDS, RER2, SRT1; ditrans,polycis-polyprenyl diphosphate synthase
Other DBs
RN: R05556
COG: COG0020
GO: 0045547
Genes
HSA: 79947(DHDDS)
PTR: 456662(DHDDS)
PPS: 100972313(DHDDS)
GGO: 101125977(DHDDS)
PON: 100171948(DHDDS)
NLE: 100603801(DHDDS)
MCC: 714635(DHDDS)
MCF: 101926129(DHDDS)
MTHB: 126955525
CSAB: 103225956(DHDDS)
CATY: 105594928(DHDDS)
PANU: 101018010(DHDDS)
TGE: 112612226(DHDDS)
RRO: 104675752(DHDDS)
RBB: 108518187(DHDDS)
TFN: 117093059(DHDDS)
PTEH: 111547650(DHDDS)
CJC: 100405741(DHDDS)
SBQ: 101046544(DHDDS)
CSYR: 103275644(DHDDS)
MMUR: 105863487(DHDDS)
LCAT: 123634358(DHDDS)
OGA: 100964101(DHDDS)
MMU: 67422(Dhdds)
MCAL: 110293104(Dhdds)
MPAH: 110323123(Dhdds)
RNO: 298541(Dhdds)
MCOC: 116096800(Dhdds)
MUN: 110552313(Dhdds)
CGE: 100767025(Dhdds)
MAUA: 101830353(Dhdds)
PLEU: 114705935(Dhdds)
MORG: 121448690(Dhdds)
MFOT: 126507863
AAMP: 119816342(Dhdds)
NGI: 103737115(Dhdds)
HGL: 101711794(Dhdds)
CPOC: 100729457(Dhdds)
CCAN: 109683062(Dhdds)
DORD: 106000289(Dhdds)
DSP: 122115276(Dhdds)
NCAR: 124963602
OCU: 100358963
OPI: 101519382(DHDDS)
TUP: 102482449(DHDDS)
GVR: 103601751(DHDDS)
CFA: 612157(DHDDS)
CLUD: 112659848(DHDDS)
VVP: 112931674(DHDDS)
VLG: 121483910 121497290(DHDDS)
AML: 100463534(DHDDS)
UMR: 103666770(DHDDS)
UAH: 113268456(DHDDS)
UAR: 123782171(DHDDS)
ELK: 111154780
LLV: 125097776
MPUF: 101677040(DHDDS)
ORO: 101375137(DHDDS)
EJU: 114217004(DHDDS)
ZCA: 113927644(DHDDS)
MLX: 118019837(DHDDS)
NSU: 110574789(DHDDS)
LWW: 102743512
FCA: 101085905(DHDDS)
PYU: 121023782(DHDDS)
PBG: 122480126(DHDDS)
LRUF: 124514994
PTG: 102966133(DHDDS)
PPAD: 109256774(DHDDS)
AJU: 106977611(DHDDS)
HHV: 120231115(DHDDS)
BTA: 523264(DHDDS)
BOM: 102271246(DHDDS)
BIU: 109573388(DHDDS)
BBUB: 102394454(DHDDS)
BBIS: 104981153(DHDDS)
CHX: 102169144(DHDDS)
OAS: 101110654(DHDDS)
ODA: 120855065(DHDDS)
CCAD: 122426053(DHDDS)
SSC: 100524683(DHDDS)
CFR: 102518547(DHDDS)
CBAI: 105063462(DHDDS)
CDK: 105100689(DHDDS)
VPC: 102526646(DHDDS)
BACU: 102998703(DHDDS)
LVE: 103088197(DHDDS)
OOR: 101277244(DHDDS)
DLE: 111163358(DHDDS)
PCAD: 102994453(DHDDS)
PSIU: 116751965(DHDDS)
ECB: 100057242(DHDDS)
EPZ: 103550540(DHDDS)
EAI: 106839917(DHDDS)
MYB: 102238802(DHDDS)
MYD: 102758520(DHDDS)
MMYO: 118675383(DHDDS)
MLF: 102426125(DHDDS)
MNA: 107539928(DHDDS)
PKL: 118722646(DHDDS)
HAI: 109386757(DHDDS)
DRO: 112299245(DHDDS)
SHON: 118977726(DHDDS)
AJM: 119042235(DHDDS)
PDIC: 114496546(DHDDS)
PHAS: 123832126(DHDDS)
MMF: 118627001(DHDDS)
RFQ: 117026641(DHDDS)
PALE: 102891420(DHDDS)
PGIG: 120596223(DHDDS)
PVP: 105290493(DHDDS)
RAY: 107503570(DHDDS)
MJV: 108399008
TOD: 119235225(DHDDS)
SARA: 101555358(DHDDS)
LAV: 100675778(DHDDS)
TMU: 101345368
ETF: 101660462(DHDDS)
DNM: 101438872(DHDDS)
MDO: 100012356(DHDDS)
GAS: 123240384(DHDDS)
SHR: 100922631(DHDDS)
PCW: 110206127(DHDDS)
OAA: 100083017(DHDDS)
PCOC: 116230152(DHDDS)
MGP: 100541233(DHDDS)
CJO: 107324014(DHDDS)
NMEL: 110387387(DHDDS)
APLA: 101804205(DHDDS)
ACYG: 106047921(DHDDS)
AFUL: 116498093(DHDDS)
TGU: 100230447(DHDDS)
LSR: 110472863(DHDDS)
SCAN: 103823525(DHDDS)
PMOA: 120513868(DHDDS)
OTC: 121342946(DHDDS)
PRUF: 121351232(DHDDS)
GFR: 102038851(DHDDS)
FAB: 101816671(DHDDS)
PHI: 102105638(DHDDS)
PMAJ: 107214256(DHDDS)
CCAE: 111939089(DHDDS)
CBRC: 103616809(DHDDS)
ETL: 114068054(DHDDS)
ZAB: 102067218(DHDDS)
ACHL: 103797236(DHDDS)
FPG: 101919832(DHDDS)
FCH: 102049798(DHDDS)
CLV: 102098335(DHDDS)
EGZ: 104134887(DHDDS)
NNI: 104017719(DHDDS)
PLET: 104628104(DHDDS)
PCRI: 104035049(DHDDS)
PCAO: 104048704(DHDDS)
ACUN: 113488396(DHDDS)
TALA: 104356396(DHDDS)
PADL: 103925863(DHDDS)
AFOR: 103896363(DHDDS)
ACHC: 115351740(DHDDS)
HALD: 104313640(DHDDS)
HLE: 104837185(DHDDS)
AGEN: 126046899
GCL: 127025074
CCRI: 104156188(DHDDS)
CSTI: 104551104(DHDDS)
EHS: 104507373(DHDDS)
CMAC: 104474540(DHDDS)
MUI: 104534471(DHDDS)
FGA: 104070830(DHDDS)
GSTE: 104255718(DHDDS)
LDI: 104350755(DHDDS)
MNB: 103773862(DHDDS)
OHA: 104337492(DHDDS)
NNT: 104400440(DHDDS)
DPUB: 104307400(DHDDS)
PGUU: 104459292(DHDDS)
ACAR: 104518822(DHDDS)
CPEA: 104394121(DHDDS)
AVIT: 104278300(DHDDS)
CVF: 104283932(DHDDS)
CUCA: 104061510(DHDDS)
TEO: 104375508(DHDDS)
BRHI: 104487991(DHDDS)
AAM: 106485593(DHDDS)
AROW: 112964395(DHDDS)
NPD: 112950737(DHDDS)
TGT: 104568616(DHDDS)
DNE: 112982017(DHDDS)
SCAM: 104148984(DHDDS)
ASN: 102374803(DHDDS)
AMJ: 102557872(DHDDS)
CPOO: 109318636(DHDDS)
GGN: 109294177(DHDDS)
PSS: 102444519(DHDDS)
CMY: 102941423(DHDDS)
CPIC: 101949942(DHDDS)
TST: 117868277(DHDDS)
CABI: 116837973(DHDDS)
MRV: 120389198(DHDDS)
ACS: 100552810(dhdds)
PVT: 110086158(DHDDS)
SUND: 121916196(DHDDS)
PBI: 103067643(DHDDS)
PMUR: 107293795(DHDDS)
CTIG: 120304078(DHDDS)
TSR: 106547071(DHDDS)
PGUT: 117663404(DHDDS)
VKO: 123025918(DHDDS)
PMUA: 114601527(DHDDS)
ZVI: 118086686(DHDDS)
GJA: 107110426(DHDDS)
STOW: 125435119(DHDDS)
XLA: 379162(dhdds.S) 398626(dhdds.L)
XTR: 100135207(dhdds)
NPR: 108800534(DHDDS)
RTEM: 120927377(DHDDS)
BBUF: 120995201(DHDDS)
DRE: 406468(dhdds)
SRX: 107707633(dhdds) 107719311
SGH: 107552517(dhdds) 107564097
PPRM: 120491110(dhdds)
MAMB: 125243779(dhdds)
IPU: 108256361(dhdds)
PHYP: 113533089(dhdds)
SMEO: 124375571(dhdds)
TFD: 113647218(dhdds)
AMEX: 103040074(dhdds)
EEE: 113583554(dhdds)
TRU: 101067613(dhdds)
LCO: 104924709(dhdds)
NCC: 104959484
CGOB: 115020889(dhdds)
ELY: 117265390(dhdds)
EFO: 125893634(dhdds)
PLEP: 121946383(dhdds)
SLUC: 116060719(dhdds)
ECRA: 117946814(dhdds)
ESP: 116690469(dhdds)
PFLV: 114557143(dhdds)
GAT: 120809966(dhdds)
PPUG: 119197743(dhdds)
MSAM: 119897246(dhdds)
CUD: 121513084(dhdds)
ALAT: 119005973(dhdds)
MZE: 101465746(dhdds)
ONL: 100705873(dhdds)
OAU: 116320957(dhdds)
OLA: 101156768(dhdds)
OML: 112144063(dhdds)
XMA: 102232893(dhdds)
XCO: 114141550(dhdds)
XHE: 116717224(dhdds)
PRET: 103477772(dhdds)
PFOR: 103139284(dhdds)
PLAI: 106944613(dhdds)
PMEI: 106916561(dhdds)
GAF: 122830615(dhdds)
CVG: 107082951(dhdds)
CTUL: 119777455(dhdds)
GMU: 124865923(dhdds)
NFU: 107379325(dhdds)
KMR: 108240318(dhdds)
ALIM: 106532228(dhdds)
NWH: 119409902(dhdds)
AOCE: 111578588(dhdds)
MCEP: 125016995(dhdds)
CSEM: 103388088(dhdds)
POV: 109632991(dhdds)
SSEN: 122774181(dhdds)
HHIP: 117777432(dhdds)
HSP: 118113380(dhdds)
LCF: 108899452
SDU: 111235772(dhdds)
SLAL: 111651765(dhdds)
XGL: 120783603(dhdds)
HCQ: 109515435(dhdds)
BPEC: 110174299(dhdds)
MALB: 109954705(dhdds)
BSPL: 114843356(dhdds)
OTW: 112223049 112246185(dhdds)
OMY: 100286813(dhdds) 110488805
OGO: 123997619 124005430(dhdds)
SNH: 120031439 120048345(dhdds)
CCLU: 121585988(dhdds)
ELS: 105028368(dhdds)
SFM: 108919101(dhdds)
PKI: 111844563(dhdds)
AANG: 118206594(dhdds)
LOC: 102687219(dhdds)
PSPA: 121303250(dhdds)
PSEX: 120517441(dhdds)
LCM: 102361662(DHDDS)
CMK: 103179564(dhdds)
RTP: 109937745(dhdds)
BFO: 118415667
BBEL: 109487387
CIN: 100179261
SPU: 591381
APLC: 110974411
AJC: 117103925
SKO: 100375715
DME: Dmel_CG10778(CG10778)
DER: 6551609
DSE: 6620258
DSI: Dsimw501_GD16139(Dsim_GD16139)
DAN: 6503683
DSR: 110184809
DPO: 4815413
DPE: 6600428
DMN: 108153958
DWI: 6644774
DGR: 6565695
DAZ: 108618390
DNV: 108655954
DHE: 111602838
DVI: 6631360
CCAT: 101451117
BOD: 106618336
RZE: 108360510
MDE: 101899706
SCAC: 106093376
LCQ: 111674513
LSQ: 119601535
HIS: 119660001
ACOZ: 120947645
AARA: 120908499
ASTE: 118505520
AAG: 5567376
AALB: 109426183
CPII: 120419308
CNS: 116339445
AME: 551358
ACER: 108003208
ALAB: 122718435
BIM: 100747096
BBIF: 117210816
BVK: 117235769
BVAN: 117162807
BTER: 100652219
BPYO: 122573888
CCAL: 108626907
OBB: 114875046
MGEN: 117228396
NMEA: 116424715
CGIG: 122403706
ACEP: 105619665
PBAR: 105429911
DQU: 106743998
CFO: 105258120
FEX: 115245817
LHU: 105679126
PGC: 109860006
OBO: 105276969
PCF: 106793556
PFUC: 122525877
VPS: 122632817
NVI: 100122811
CSOL: 105363743
MDL: 103569336
CGLO: 123262128
FAS: 105270819
DAM: 107040974
AGIF: 122857831
CINS: 118070757
LHT: 122511102
CCIN: 107269781
TCA: 661474
DPA: 109536787
SOY: 115879364
ATD: 109603363
AGB: 108915067
LDC: 111514189
APLN: 108736510
PPYR: 116178393
OTU: 111427237
BMOR: 732991(Dhdds)
BMAN: 114241813
MSEX: 115453111
BANY: 112055282
NIQ: 126781860
PMAC: 106715662
PPOT: 106103414
PXU: 106113456
PRAP: 110996230
PBX: 123710937
PNAP: 125059223
ZCE: 119833485
CCRC: 123691656
HAW: 110377390
HZE: 124632816
TNL: 113507305
SLIU: 111358432
OFU: 114366339
PXY: 105386183
CFEL: 113382923
DNX: 107163442
BTAB: 109042179
DCI: 103513917
CLEC: 106661118
HHAL: 106677342
NLU: 111055578
TPAL: 117652901
ZNE: 110838943
CSEC: 111866076
DMK: 116925770
DPZ: 124342436
PVM: 113800507
PJA: 122247807
PCHN: 125038834
HAME: 121863865
PCLA: 123772284
PTRU: 123511697
EAF: 111717985
LSM: 121114520
VDE: 111251001
VJA: 111266563
TUT: 107362638
DPTE: 113790149
DFR: 124494827
CSCU: 111614013
PTEP: 107448745
SDM: 118187810
CEL: CELE_T01G1.4(T01G1.4)
BMY: BM_BM5483(Bm5483)
TSP: Tsp_03385
PCAN: 112565857
BGT: 106078714
GAE: 121372222
HRF: 124116326
HRJ: 124288845
CRG: 105317193
MYI: 110456448
PMAX: 117327186
MMER: 123551612
OBI: 106875357
OSN: 115222973
LAK: 106155728
EGL: EGR_09410
NVE: 5510461
EPA: 110251744
ATEN: 116301992
ADF: 107338445
AMIL: 114958441
PDAM: 113671882
SPIS: 111333576
DGT: 114536433
XEN: 124443088
HMG: 101238202
AQU: 100633152
ATH: AT1G11755(LEW1) AT2G17570(cPT1) AT2G23400 AT2G23410(CPT) AT5G58770(cPT4) AT5G58780(cPT5) AT5G58782(cPT6) AT5G58784 AT5G60500(cPT8) AT5G60510(cPT9)
LJA: Lj0g3v0314369.1(Lj0g3v0314369.1) Lj0g3v0326269.1(Lj0g3v0326269.1) Lj0g3v0326269.3(Lj0g3v0326269.3) Lj1g3v0131170.1(Lj1g3v0131170.1)
DOSA: Os01t0857200-01(Os01g0857200) Os02t0197700-01(Os02g0197700) Os03t0197000-01(Os03g0197000) Os06t0167400-01(Os06g0167400) Os07t0607700-01(Os07g0607700)
APRO: F751_3077
SCE: YBR002C(RER2) YMR101C(SRT1)
KMX: KLMA_30092(SRT1) KLMA_60115(RER2)
NCS: NCAS_0E01380(NCAS0E01380) NCAS_0F01440(NCAS0F01440)
NDI: NDAI_0G01550(NDAI0G01550) NDAI_0H02320(NDAI0H02320)
TPF: TPHA_0A04470(TPHA0A04470) TPHA_0G02950(TPHA0G02950)
TBL: TBLA_0B08960(TBLA0B08960) TBLA_0F00550(TBLA0F00550)
TDL: TDEL_0A02280(TDEL0A02280) TDEL_0D04190(TDEL0D04190)
KAF: KAFR_0A00610(KAFR0A00610) KAFR_0F02540(KAFR0F02540)
KNG: KNAG_0E02410(KNAG0E02410) KNAG_0J01170(KNAG0J01170)
SLB: AWJ20_395(RER2)
NCR: NCU03460
NTE: NEUTE1DRAFT84674(NEUTE1DRAFT_84674)
MGR: MGG_12110
SSCK: SPSK_09391
MAW: MAC_02906
MAJ: MAA_01682
BFU: BCIN_05g03890(Bcrer2)
MBE: MBM_04118
ANI: AN5600.2
ANG: ANI_1_1896184(An04g05250)
ALUC: AKAW2_51499S(RER2)
ACHE: ACHE_10569A(RER2)
APUU: APUU_40959S(RER2)
PTE: PTT_19071
CNE: CND03430
CNB: CNBD2910
TASA: A1Q1_02236
ABP: AGABI1DRAFT110974(AGABI1DRAFT_110974)
ABV: AGABI2DRAFT190174(AGABI2DRAFT_190174)
SCM: SCHCO_02607928(SCHCODRAFT_02607928)
MGL: MGL_1818
MRT: MRET_1995
DFA: DFA_08567
TAN: TA04455
TPV: TP03_0421
 » show all
Reference
  Authors
Jones J, Viswanathan K, Krag SS, Betenbaugh MJ
  Title
Polyprenyl lipid synthesis in mammalian cells expressing human cis-prenyl transferase.
  Journal
Biochem Biophys Res Commun 331:379-83 (2005)
DOI:10.1016/j.bbrc.2005.03.181
Reference
PMID:9858571
  Authors
Sato M, Sato K, Nishikawa S, Hirata A, Kato J, Nakano A
  Title
The yeast RER2 gene, identified by endoplasmic reticulum protein localization mutations, encodes cis-prenyltransferase, a key enzyme in dolichol synthesis.
  Journal
Mol Cell Biol 19:471-83 (1999)
DOI:10.1128/MCB.19.1.471
  Sequence
Reference
  Authors
Oh SK, Han KH, Ryu SB, Kang H
  Title
Molecular cloning, expression, and functional analysis of a cis-prenyltransferase from Arabidopsis thaliana. Implications in rubber biosynthesis.
  Journal
J Biol Chem 275:18482-8 (2000)
DOI:10.1074/jbc.M002000200
  Sequence
[ath:AT2G23410]
Reference
  Authors
Cunillera N, Arro M, Fores O, Manzano D, Ferrer A
  Title
Characterization of dehydrodolichyl diphosphate synthase of Arabidopsis thaliana, a key enzyme in dolichol biosynthesis.
  Journal
FEBS Lett 477:170-4 (2000)
DOI:10.1016/S0014-5793(00)01798-1
  Sequence
[ath:AT2G23410]
Reference
  Authors
Zhang H, Ohyama K, Boudet J, Chen Z, Yang J, Zhang M, Muranaka T, Maurel C, Zhu JK, Gong Z
  Title
Dolichol biosynthesis and its effects on the unfolded protein response and abiotic stress resistance in Arabidopsis.
  Journal
Plant Cell 20:1879-98 (2008)
DOI:10.1105/tpc.108.061150

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