ORTHOLOGY: K11778 Help
Entry
Symbol
DHDDS, RER2, SRT1
Name
ditrans,polycis-polyprenyl diphosphate synthase [EC:
2.5.1.87 ]
Pathway
map00900 Terpenoid backbone biosynthesis
map01110 Biosynthesis of secondary metabolites
Reaction
R05556 (2E,6E)-farnesyl-diphosphate:isopentenyl-diphosphate cistransferase (adding 10-55 isopentenyl units)
Disease
H00118 Congenital disorders of glycosylation type I
Brite
KEGG Orthology (KO) [BR:ko00001 ]
09100 Metabolism
09109 Metabolism of terpenoids and polyketides
00900 Terpenoid backbone biosynthesis
K11778 DHDDS, RER2, SRT1; ditrans,polycis-polyprenyl diphosphate synthase
09180 Brite Hierarchies
09181 Protein families: metabolism
01006 Prenyltransferases
K11778 DHDDS, RER2, SRT1; ditrans,polycis-polyprenyl diphosphate synthase
Enzymes [BR:ko01000 ]
2. Transferases
2.5 Transferring alkyl or aryl groups, other than methyl groups
2.5.1 Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
2.5.1.87 ditrans,polycis-polyprenyl diphosphate synthase [(2E,6E)-farnesyl diphosphate specific]
K11778 DHDDS, RER2, SRT1; ditrans,polycis-polyprenyl diphosphate synthase
Prenyltransferases [BR:ko01006 ]
Terpene biosynthesis
Prenyl diphosphate synthase
K11778 DHDDS, RER2, SRT1; ditrans,polycis-polyprenyl diphosphate synthase
BRITE hierarchy
Other DBs
Genes
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Taxonomy UniProt
Reference
Authors
Jones J, Viswanathan K, Krag SS, Betenbaugh MJ
Title
Polyprenyl lipid synthesis in mammalian cells expressing human cis-prenyl transferase.
Journal
Reference
Authors
Sato M, Sato K, Nishikawa S, Hirata A, Kato J, Nakano A
Title
The yeast RER2 gene, identified by endoplasmic reticulum protein localization mutations, encodes cis-prenyltransferase, a key enzyme in dolichol synthesis.
Journal
Sequence
Reference
Authors
Oh SK, Han KH, Ryu SB, Kang H
Title
Molecular cloning, expression, and functional analysis of a cis-prenyltransferase from Arabidopsis thaliana. Implications in rubber biosynthesis.
Journal
Sequence
Reference
Authors
Cunillera N, Arro M, Fores O, Manzano D, Ferrer A
Title
Characterization of dehydrodolichyl diphosphate synthase of Arabidopsis thaliana, a key enzyme in dolichol biosynthesis.
Journal
Sequence
Reference
Authors
Zhang H, Ohyama K, Boudet J, Chen Z, Yang J, Zhang M, Muranaka T, Maurel C, Zhu JK, Gong Z
Title
Dolichol biosynthesis and its effects on the unfolded protein response and abiotic stress resistance in Arabidopsis.
Journal