KEGG   ORTHOLOGY: K11781
Entry
K11781                      KO                                     

Name
cofH
Definition
5-amino-6-(D-ribitylamino)uracil---L-tyrosine 4-hydroxyphenyl transferase [EC:2.5.1.147]
Pathway
ko00680  Methane metabolism
ko01100  Metabolic pathways
ko01120  Microbial metabolism in diverse environments
ko01240  Biosynthesis of cofactors
Module
M00378  F420 biosynthesis
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09102 Energy metabolism
   00680 Methane metabolism
    K11781  cofH; 5-amino-6-(D-ribitylamino)uracil---L-tyrosine 4-hydroxyphenyl transferase
Enzymes [BR:ko01000]
 2. Transferases
  2.5  Transferring alkyl or aryl groups, other than methyl groups
   2.5.1  Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
    2.5.1.147  5-amino-6-(D-ribitylamino)uracil---L-tyrosine 4-hydroxyphenyl transferase
     K11781  cofH; 5-amino-6-(D-ribitylamino)uracil---L-tyrosine 4-hydroxyphenyl transferase
Other DBs
RN: R12161
COG: COG1060
GO: 0044689
Genes
MARS: A8C75_03570
BBEV: BBEV_1717(fbiC)
BSE: Bsel_1864
MTY: MTOK_03530
GBR: Gbro_3326
GPO: GPOL_c31240(fbiC2)
GOR: KTR9_3365
GTA: BCM27_17085
GRU: GCWB2_17305(mqnE)
GOM: D7316_05361(fbiC_1)
KRA: Krad_3629
SYN: sll1659
SYZ: MYO_12520
SYY: SYNGTS_0250(cofH)
SYT: SYNGTI_0250(cofH)
SYS: SYNPCCN_0250(cofH)
SYQ: SYNPCCP_0250(cofH)
SYC: syc0843_c
TEL: tlr1597(cofG)
THN: NK55_04740(cofH)
THEC: FFX45_05945(cofH)
CYI: CBM981_0450(cofH)
LET: O77CONTIG1_00551(mqnE)
HHG: XM38_009170(cofH)
THEU: HPC62_14945(cofH)
GEE: GM3708_16
MAR: MAE_44400
MPK: VL20_2553
CYL: AA637_02275(cofH)
ENN: FRE64_08190(cofH)
CYT: cce_4539
TER: Tery_2116
ARP: NIES39_L02990(cofH)
OXY: HCG48_14355(cofH)
LFS: HFV01_04975(cofH)
GVI: glr0776(cofG)
GLJ: GKIL_2220(cofH)
ANA: alr4129
NSH: GXM_01176
NED: HUN01_31190(cofH)
AVA: Ava_0775
NAZ: Aazo_0194
ANB: ANA_C11401(cofH)
ANN: EH233_04440(cofH)
CALH: IJ00_17760
NSP: BMF81_01996(cofH)
DOU: BMF77_01492(fbiC_1)
DFS: HGD76_10455(cofH)
CCUR: IAR63_12380(cofH)
TOQ: HCG51_15175(cofH)
CTHE: Chro_1933
MJA: MJ_1431
MMP: MMP0056(cofH) MMP0057(cofH)
MMAK: MMKA1_00580(cofH) MMKA1_00590(cofH)
MMAO: MMOS7_00820(cofH) MMOS7_00830(cofH)
MMAD: MMJJ_10390(mqnE_1) MMJJ_10400(mqnE_2)
MAE: Maeo_0750
MVO: Mvol_1375
METF: CFE53_02480(cofH)
MTH: MTH_820
MMG: MTBMA_c12170(cofH)
METC: MTCT_0736
MWO: MWSIV6_1196(cofH)
METE: tca_00787(fbiC_1)
METK: FVF72_07445(cofH)
MTHM: FZP57_05680(cofH)
MST: Msp_0392(cofH)
METB: AW729_05100(cofH)
MRU: mru_1266(cofH)
MSI: Msm_0079
MEB: Abm4_0772(cofH)
MMIL: sm9_0991(cofH)
MEYE: TL18_05430(cofH)
MOL: YLM1_0639
METH: MBMB1_0707(cofH1) MBMB1_1031(cofH3)
MFC: BRM9_1217(cofH1) BRM9_1488(cofH2)
MFI: DSM1535_1898(cofH1) DSM1535_2180(cofH3)
MCUB: MCBB_0164(cofH_1) MCBB_0722(cofH_3)
METT: CIT01_01905(cofH) CIT01_08975(cofH)
METO: CIT02_01855(cofH) CIT02_03225(cofH)
MFV: Mfer_0690
MKA: MK0897(thiH_1)
AFU: AF_0798
FPL: Ferp_0003
GAC: GACE_2059
GAH: GAH_00663
MFZ: AOB57_001355(cofH) AOB57_001360(cofH)
MZI: HWN40_09685(cofH)
MTP: Mthe_0284
MCJ: MCON_3335(cofH)
MHI: Mhar_0763
MLA: Mlab_0123
MBG: BN140_0224(cofH1) BN140_1481(cofH3)
MEMA: MMAB1_0286(cofH) MMAB1_1902(cofH)
MPD: MCP_2456(cofH-1) MCP_2457(cofH-2)
MEZ: Mtc_0997(cofH-1) Mtc_0998(cofH-2)
RCI: RCIX459(cofH-2) RCIX460(cofH-1)
HAL: VNG_1938C
HSL: OE_3723R(cofH)
HHB: Hhub_3265(cofH)
HALH: HTSR_1968(cofH)
HHSR: HSR6_2043(cofH)
SALR: FQU85_06460(cofH)
HALR: EFA46_002145(cofH)
HMA: rrnAC3278
HHI: HAH_0519(cofH)
HALJ: G9465_17525(cofH)
NPH: NP_2394A(cofH)
NMO: Nmlp_3320(cofH)
HUT: Huta_1308
HTI: HTIA_1198
HALA: Hrd1104_08980(cofH)
HMU: Hmuk_1418
HALZ: E5139_10245(cofH)
HALL: LC1Hm_0634(cofH)
HRR: HZS55_04965(cofH)
HPEL: HZS54_05045(cofH)
HLT: I7X12_07290(cofH)
HWA: HQ_3127A(cofH)
HWC: Hqrw_3668(cofH)
HVO: HVO_2198(cofH)
HME: HFX_2254(thiH)
HALE: G3A49_14430(cofH)
HAER: DU502_15190(cofH)
HRA: EI982_15065(cofH)
HALM: FCF25_02470(cofH)
HLA: Hlac_2018
HALB: EKH57_14575(cofH)
HEZZ: EO776_10065(cofH)
HALQ: Hrr1229_009800(cofH)
HALN: B4589_007640(cofH)
HALG: HUG10_09405(cofH)
HALU: HUG12_06420(cofH)
HDF: AArcSl_2517(cofH)
HTU: Htur_0645
HALY: HYG82_19890(cofH)
NMG: Nmag_2637(cofH)
NAT: NJ7G_3947
NVR: FEJ81_14745(cofH) FEJ81_22750(cofH)
NPL: FGF80_13885(cofH)
SALI: L593_13865
NAS: GCU68_09425(cofH)
NMR: Nmar_0592
NID: NPIRD3C_1666(cofH)
NIN: NADRNF5_1569(cofH)
NIW: Nisw_01900(cofH)
NCL: C5F47_06150(cofH)
NOX: C5F49_05910(cofH)
NUE: C5F50_04480(cofH)
NCT: NMSP_1084(cofH_2)
NIC: DSQ20_03190(cofH)
NGA: Ngar_c12350(cofH1)
NVN: NVIE_011280(cofH1)
NEV: NTE_02502
TAA: NMY3_02529(mqnE_1)
NFN: NFRAN_0113(cofH)
NCV: NCAV_0880(cofH)
NDV: NDEV_0671(cofH)
CCAI: NAS2_0578
 » show all
Reference
  Authors
Philmus B, Decamps L, Berteau O, Begley TP
  Title
Biosynthetic versatility and coordinated action of 5'-deoxyadenosyl radicals in deazaflavin biosynthesis.
  Journal
J Am Chem Soc 137:5406-13 (2015)
DOI:10.1021/ja513287k
  Sequence
Reference
  Authors
Graham DE, Xu H, White RH
  Title
Identification of the 7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase required for coenzyme F(420) biosynthesis.
  Journal
Arch Microbiol 180:455-64 (2003)
DOI:10.1007/s00203-003-0614-8
  Sequence
[mja:MJ_1431]

KEGG   ORTHOLOGY: K11779
Entry
K11779                      KO                                     

Name
fbiC
Definition
FO synthase [EC:2.5.1.147 4.3.1.32]
Pathway
ko00680  Methane metabolism
ko01100  Metabolic pathways
ko01120  Microbial metabolism in diverse environments
ko01240  Biosynthesis of cofactors
Module
M00378  F420 biosynthesis
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09102 Energy metabolism
   00680 Methane metabolism
    K11779  fbiC; FO synthase
Enzymes [BR:ko01000]
 2. Transferases
  2.5  Transferring alkyl or aryl groups, other than methyl groups
   2.5.1  Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
    2.5.1.147  5-amino-6-(D-ribitylamino)uracil---L-tyrosine 4-hydroxyphenyl transferase
     K11779  fbiC; FO synthase
 4. Lyases
  4.3  Carbon-nitrogen lyases
   4.3.1  Ammonia-lyases
    4.3.1.32  7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase
     K11779  fbiC; FO synthase
Other DBs
RN: R12161 R12162
COG: COG1060
GO: 0044689
Genes
CPS: CPS_4048 CPS_4049
EBA: p2A350
HOH: Hoch_0059
RPB: RPB_4423
OCA: OCAR_5007
PZU: PHZ_c2536
PDE: Pden_1114 Pden_1115
SWI: Swit_0717
KHA: IFJ82_10850(cofH)
BSE: Bsel_1865
MTU: Rv1173(fbiC)
MTV: RVBD_1173
MTC: MT1210
MRA: MRA_1184(fbiC)
MTG: MRGA327_07395(fbiC)
MTUR: CFBS_1252(fbiC)
MTO: MTCTRI2_1205(fbiC)
MTD: UDA_1173(fbiC)
MTN: ERDMAN_1316(fbiC)
MTJ: J112_06345(fbiC)
MTUE: J114_06345(fbiC)
MTX: M943_06155(fbiC)
MTUL: TBHG_01157
MTUT: HKBT1_1250(fbiC)
MTUU: HKBT2_1256(fbiC)
MTQ: HKBS1_1254(fbiC)
MBO: BQ2027_MB1206(fbiC)
MBB: BCG_1236(fbiC)
MBT: JTY_1209(fbiC)
MBM: BCGMEX_1208(fbiC)
MBX: BCGT_1005
MAF: MAF_11920(fbiC)
MMIC: RN08_1318
MCE: MCAN_11841(fbiC)
MCQ: BN44_11312(fbiC)
MCV: BN43_30241(fbiC)
MCX: BN42_21039(fbiC)
MCZ: BN45_30234(fbiC)
MLE: ML1492(fbiC)
MLB: MLBr01492
MPA: MAP_2611c
MAO: MAP4_1207
MAVI: RC58_05980(fbiC)
MAVU: RE97_05975(fbiC)
MAV: MAV_1312
MIT: OCO_12230
MIA: OCU_12190
MID: MIP_01953
MYO: OEM_12380
MCHI: AN480_07165(fbiC)
MMAL: CKJ54_05940(fbiC)
MLP: MLM_1243
MUL: MUL_1020(fbiC)
MMC: Mmcs_4032
MKM: Mkms_4107
MJL: Mjls_4262
MMI: MMAR_4279(fbiC)
MMAE: MMARE11_40940(fbiC)
MMM: W7S_05970(fbiC)
MLI: MULP_04464(fbiC)
MKN: MKAN_07265(fbiC)
MYV: G155_22255(fbiC)
MYE: AB431_23285(fbiC)
MHAD: B586_07415(fbiC)
MDX: BTO20_08855(fbiC)
MSHG: MSG_03833(fbiC)
MFJ: MFLOJ_48330(fbiC)
MXE: MYXE_14930(fbiC)
MNV: MNVI_05210(fbiC)
MPAG: C0J29_23420(fbiC)
MNM: MNVM_06740(fbiC)
MSG: MSMEI_4998(fbiC)
MSB: LJ00_25350(fbiC)
MSN: LI99_25355(fbiC)
MSH: LI98_25360(fbiC)
MVA: Mvan_4533
MGI: Mflv_2167
MNE: D174_20945(fbiC)
MYN: MyAD_20555(fbiC)
MGO: AFA91_14910(fbiC)
MPHL: MPHLCCUG_04074(mqnE)
MVQ: MYVA_4308(fbiC)
MLL: B1R94_06840(fbiC)
MHAS: MHAS_02879(fbiC)
MDU: MDUV_01960(fbiC)
MCHT: MCHIJ_26390(fbiC)
MDR: MDOR_28370(fbiC)
MMAG: MMAD_41900(fbiC)
MMOR: MMOR_20550(fbiC)
MFX: MFAL_38670(fbiC)
MAIC: MAIC_42080(fbiC)
MIJ: MINS_37690(fbiC)
MALV: MALV_49400(fbiC)
MPSC: MPSYJ_23260(fbiC)
MAB: MAB_1319
MMV: MYCMA_0695(fbiC)
MABB: MASS_1319(fbiC)
MIZ: BAB75_07105(fbiC)
MSTE: MSTE_01287
MSAO: MYCSP_05810(fbiC)
MSAL: DSM43276_01185(mqnE)
MJD: JDM601_1161(fbiC)
MTER: 4434518_01112(fbiC)
MMIN: MMIN_27930(fbiC)
MHIB: MHIB_06830(fbiC)
MKR: MKOR_00500(fbiC)
NFA: NFA_47520
NCY: NOCYR_4499(fbiC)
NBR: O3I_035915(fbiC)
NNO: NONO_c64550(fbiC)
NSL: BOX37_25530(fbiC)
NSR: NS506_01897(fbiC)
NTP: CRH09_33525(fbiC)
NOZ: DMB37_14595(fbiC)
RER: RER_41830(fbiC)
REY: O5Y_19555(fbiC)
REB: XU06_19700(fbiC)
ROP: ROP_60060(fbiC)
REQ: REQ_14170
RPY: Y013_22830(fbiC)
RHB: NY08_5017
RAV: AAT18_08315(fbiC)
RFA: A3L23_03076(fbiC)
RHW: BFN03_02640(fbiC)
RHS: A3Q41_00251(fbiC)
RRZ: CS378_23345(fbiC)
RHU: A3Q40_02330(fbiC)
RQI: C1M55_20650(fbiC)
RHQ: IM25_12240(fbiC)
RHOD: AOT96_01090(fbiC)
RBY: CEJ39_09030(fbiC)
GIT: C6V83_14745(fbiC)
SCO: SCO4429(fbiC)
SALB: XNR_2222
SMA: SAVERM_3794(cofG)
SGR: SGR_4235
SGB: WQO_14275(fbiC)
SCB: SCAB_52181(fbiC)
SCT: SCAT_2338(fbiC)
SFA: Sfla_3633
SBH: SBI_06333(fbiC)
SHY: SHJG_4710
SVE: SVEN_3084
SDV: BN159_5026(fbiC)
SALS: SLNWT_4334
STRP: F750_3084
SFI: SFUL_2886
SCI: B446_16865(fbiC)
SRC: M271_20760(fbiC) M271_38995(fbiC)
SALU: DC74_3703
SALL: SAZ_19675(fbiC)
SLV: SLIV_16290(fbiC)
SGU: SGLAU_14900(fbiC)
SVT: SVTN_16080(fbiC)
STRE: GZL_05186
SCW: TU94_14370(fbiC)
SLD: T261_4807
SLC: SL103_02830(fbiC)
STRM: M444_15375(fbiC)
STRC: AA958_12800(fbiC)
SAMB: SAM23877_3304(fbiC)
SPRI: SPRI_4317
SCZ: ABE83_21500(fbiC)
SCX: AS200_26105(fbiC)
SRW: TUE45_04323(mqnE_1)
STRF: ASR50_19115(fbiC)
SLE: sle_40200(sle_40200)
SRN: A4G23_02305(mqnE_1)
SPAV: Spa2297_14305(fbiC)
STRT: A8713_13345(fbiC)
SCLF: BB341_11230(fbiC)
SGS: AVL59_44175(fbiC)
STSI: A4E84_17315(fbiC)
SNR: SNOUR_23810(fbiC)
SPLU: LK06_018940(fbiC)
STRD: NI25_22395(fbiC)
SNW: BBN63_19680(fbiC)
SAUO: BV401_26765(fbiC) BV401_35045(fbiC)
SSIA: A7J05_20325(fbiC)
SVU: B1H20_13635(fbiC)
SPUN: BFF78_24080(fbiC)
SGV: B1H19_17935(fbiC)
SLAU: SLA_3135
SALF: SMD44_03660(fbiC)
SALJ: SMD11_3959(fbiC)
SLX: SLAV_16495(mqnE2)
STRO: STRMOE7_16995(fbiC)
SFK: KY5_3501c
SNZ: DC008_14780(fbiC)
SGE: DWG14_04813(fbiC)
SRJ: SRO_4209
SLK: SLUN_16960(fbiC)
SDX: C4B68_22925(fbiC)
SAST: CD934_19070(fbiC)
STIR: DDW44_12900(fbiC)
SGZ: C0216_28065(fbiC)
SHAW: CEB94_17765(fbiC)
SSPO: DDQ41_12865(fbiC)
KSK: KSE_45370(fbiC)
KAB: B7C62_13575(fbiC)
KAU: B6264_08870(fbiC)
NDK: I601_0314(mqnE)
NBE: Back2_26860(fbiC)
PSIM: KR76_06880
KFL: Kfla_6490
TFU: Tfu_2519
NDA: Ndas_3771
NAL: B005_0949(cofG)
NGV: CDO52_24260(fbiC)
STRR: EKD16_20105(mqnE)
TCU: Tcur_4075
SRO: Sros_1376
NOA: BKM31_38790(fbiC)
TBI: Tbis_0746
FAL: FRAAL1263
ACE: Acel_0769
GOB: Gobs_1483
BSD: BLASA_1295(fbiC)
MMAR: MODMU_1466(fbiC)
SEN: SACE_6594
AMD: AMED_6904(fbiC)
AMN: RAM_35420(fbiC)
AMM: AMES_6798(fbiC)
AMZ: B737_6798(fbiC)
AOI: AORI_1815(fbiC)
AJA: AJAP_30405(fbiC)
AMQ: AMETH_5642(fbiC)
AMYC: CU254_27985(fbiC)
AMYB: BKN51_01275(fbiC)
AORI: SD37_32150(fbiC)
ACTI: UA75_18405
ACAD: UA74_17915
AHG: AHOG_15900(mqnE)
ACTA: C1701_18075(fbiC)
ALO: CRK57346
SAQ: Sare_0888
MIL: ML5_1202
MTUA: CSH63_19720(fbiC)
MSAG: GCM10017556_35230(fbiC)
VMA: VAB18032_09475(fbiC)
PLAB: C6361_20395(fbiC)
PLAT: C6W10_23365(fbiC)
CAI: Caci_8766
AEY: CDG81_19075(fbiC)
RXY: Rxyl_0975
TRO: trd_A0899(cofH)
 » show all
Reference
  Authors
Choi KP, Kendrick N, Daniels L
  Title
Demonstration that fbiC is required by Mycobacterium bovis BCG for coenzyme F(420) and FO biosynthesis.
  Journal
J Bacteriol 184:2420-8 (2002)
DOI:10.1128/JB.184.9.2420-2428.2002
  Sequence

KEGG   ENZYME: 2.5.1.147
Entry
EC 2.5.1.147                Enzyme                                 

Name
5-amino-6-(D-ribitylamino)uracil---L-tyrosine 4-hydroxyphenyl transferase;
cofH (gene name);
cbiF (gene name) (ambiguous)
Class
Transferases;
Transferring alkyl or aryl groups, other than methyl groups;
Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
Sysname
5-amino-6-(D-ribitylamino)uracil:L-tyrosine, 4-hydroxyphenyl transferase
Reaction(IUBMB)
5-amino-6-(D-ribitylamino)uracil + L-tyrosine + S-adenosyl-L-methionine = 5-amino-5-(4-hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil + 2-iminoacetate + L-methionine + 5'-deoxyadenosine [RN:R12161]
Reaction(KEGG)
R12161
Substrate
5-amino-6-(D-ribitylamino)uracil [CPD:C04732];
L-tyrosine [CPD:C00082];
S-adenosyl-L-methionine [CPD:C00019]
Product
5-amino-5-(4-hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil [CPD:C21971];
2-iminoacetate [CPD:C15809];
L-methionine [CPD:C00073];
5'-deoxyadenosine [CPD:C05198]
Comment
The enzyme is involved in the production of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (FO), the precursor of the redox cofactor coenzyme F420, which is found in methanogens and in various actinobacteria. FO is also produced by some cyanobacteria and eukaryotes. The enzyme, which forms a complex with EC 4.3.1.32, 7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase, is a radical SAM enzyme that uses the 5'-deoxyadenosyl radical to initiate the reaction.
History
EC 2.5.1.147 created 2010 as EC 2.5.1.77, part transferred 2018 to EC 2.5.1.147
Pathway
ec00680  Methane metabolism
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K11779  FO synthase
K11781  5-amino-6-(D-ribitylamino)uracil---L-tyrosine 4-hydroxyphenyl transferase
Genes
CPS: CPS_4048 CPS_4049
MARS: A8C75_03570
EBA: p2A350
HOH: Hoch_0059
RPB: RPB_4423
OCA: OCAR_5007
PZU: PHZ_c2536
PDE: Pden_1114 Pden_1115
SWI: Swit_0717
KHA: IFJ82_10850(cofH)
BBEV: BBEV_1717(fbiC)
MTU: Rv1173(fbiC)
MTV: RVBD_1173
MTC: MT1210
MRA: MRA_1184(fbiC)
MTG: MRGA327_07395(fbiC)
MTUR: CFBS_1252(fbiC)
MTO: MTCTRI2_1205(fbiC)
MTD: UDA_1173(fbiC)
MTN: ERDMAN_1316(fbiC)
MTJ: J112_06345(fbiC)
MTUE: J114_06345(fbiC)
MTX: M943_06155(fbiC)
MTUL: TBHG_01157
MTUT: HKBT1_1250(fbiC)
MTUU: HKBT2_1256(fbiC)
MTQ: HKBS1_1254(fbiC)
MBO: BQ2027_MB1206(fbiC)
MBB: BCG_1236(fbiC)
MBT: JTY_1209(fbiC)
MBM: BCGMEX_1208(fbiC)
MBX: BCGT_1005
MAF: MAF_11920(fbiC)
MMIC: RN08_1318
MCE: MCAN_11841(fbiC)
MCQ: BN44_11312(fbiC)
MCV: BN43_30241(fbiC)
MCX: BN42_21039(fbiC)
MCZ: BN45_30234(fbiC)
MLE: ML1492(fbiC)
MLB: MLBr01492
MPA: MAP_2611c
MAO: MAP4_1207
MAVI: RC58_05980(fbiC)
MAVU: RE97_05975(fbiC)
MAV: MAV_1312
MIT: OCO_12230
MIA: OCU_12190
MID: MIP_01953
MYO: OEM_12380
MCHI: AN480_07165(fbiC)
MMAL: CKJ54_05940(fbiC)
MLP: MLM_1243
MUL: MUL_1020(fbiC)
MMC: Mmcs_4032
MKM: Mkms_4107
MJL: Mjls_4262
MMI: MMAR_4279(fbiC)
MMAE: MMARE11_40940(fbiC)
MMM: W7S_05970(fbiC)
MLI: MULP_04464(fbiC)
MKN: MKAN_07265(fbiC)
MYV: G155_22255(fbiC)
MYE: AB431_23285(fbiC)
MHAD: B586_07415(fbiC)
MDX: BTO20_08855(fbiC)
MSHG: MSG_03833(fbiC)
MFJ: MFLOJ_48330(fbiC)
MXE: MYXE_14930(fbiC)
MNV: MNVI_05210(fbiC)
MPAG: C0J29_23420(fbiC)
MNM: MNVM_06740(fbiC)
MSG: MSMEI_4998(fbiC)
MSB: LJ00_25350(fbiC)
MSN: LI99_25355(fbiC)
MSH: LI98_25360(fbiC)
MVA: Mvan_4533
MGI: Mflv_2167
MNE: D174_20945(fbiC)
MYN: MyAD_20555(fbiC)
MGO: AFA91_14910(fbiC)
MPHL: MPHLCCUG_04074(mqnE)
MVQ: MYVA_4308(fbiC)
MLL: B1R94_06840(fbiC)
MHAS: MHAS_02879(fbiC)
MDU: MDUV_01960(fbiC)
MCHT: MCHIJ_26390(fbiC)
MDR: MDOR_28370(fbiC)
MMAG: MMAD_41900(fbiC)
MMOR: MMOR_20550(fbiC)
MFX: MFAL_38670(fbiC)
MAIC: MAIC_42080(fbiC)
MIJ: MINS_37690(fbiC)
MALV: MALV_49400(fbiC)
MPSC: MPSYJ_23260(fbiC)
MAB: MAB_1319
MMV: MYCMA_0695(fbiC)
MABB: MASS_1319(fbiC)
MIZ: BAB75_07105(fbiC)
MSTE: MSTE_01287
MSAO: MYCSP_05810(fbiC)
MSAL: DSM43276_01185(mqnE)
MJD: JDM601_1161(fbiC)
MTER: 4434518_01112(fbiC)
MMIN: MMIN_27930(fbiC)
MHIB: MHIB_06830(fbiC)
MKR: MKOR_00500(fbiC)
NFA: NFA_47520
NCY: NOCYR_4499(fbiC)
NBR: O3I_035915(fbiC)
NNO: NONO_c64550(fbiC)
NSL: BOX37_25530(fbiC)
NSR: NS506_01897(fbiC)
NTP: CRH09_33525(fbiC)
NOZ: DMB37_14595(fbiC)
RER: RER_41830(fbiC)
REY: O5Y_19555(fbiC)
REB: XU06_19700(fbiC)
ROP: ROP_60060(fbiC)
REQ: REQ_14170
RPY: Y013_22830(fbiC)
RHB: NY08_5017
RAV: AAT18_08315(fbiC)
RFA: A3L23_03076(fbiC)
RHW: BFN03_02640(fbiC)
RHS: A3Q41_00251(fbiC)
RRZ: CS378_23345(fbiC)
RHU: A3Q40_02330(fbiC)
RQI: C1M55_20650(fbiC)
RHQ: IM25_12240(fbiC)
RHOD: AOT96_01090(fbiC)
RBY: CEJ39_09030(fbiC)
GBR: Gbro_3326
GPO: GPOL_c31240(fbiC2)
GOR: KTR9_3365
GIT: C6V83_14745(fbiC)
GRU: GCWB2_17305(mqnE)
GOM: D7316_05361(fbiC_1)
SCO: SCO4429(fbiC)
SALB: XNR_2222
SMA: SAVERM_3794(cofG)
SGR: SGR_4235
SGB: WQO_14275(fbiC)
SCB: SCAB_52181(fbiC)
SCT: SCAT_2338(fbiC)
SFA: Sfla_3633
SBH: SBI_06333(fbiC)
SHY: SHJG_4710
SVE: SVEN_3084
SDV: BN159_5026(fbiC)
SALS: SLNWT_4334
STRP: F750_3084
SFI: SFUL_2886
SCI: B446_16865(fbiC)
SRC: M271_20760(fbiC) M271_38995(fbiC)
SALU: DC74_3703
SALL: SAZ_19675(fbiC)
SLV: SLIV_16290(fbiC)
SGU: SGLAU_14900(fbiC)
SVT: SVTN_16080(fbiC)
STRE: GZL_05186
SCW: TU94_14370(fbiC)
SLD: T261_4807
SLC: SL103_02830(fbiC)
STRM: M444_15375(fbiC)
STRC: AA958_12800(fbiC)
SAMB: SAM23877_3304(fbiC)
SPRI: SPRI_4317
SCZ: ABE83_21500(fbiC)
SCX: AS200_26105(fbiC)
SRW: TUE45_04323(mqnE_1)
STRF: ASR50_19115(fbiC)
SLE: sle_40200(sle_40200)
SRN: A4G23_02305(mqnE_1)
SPAV: Spa2297_14305(fbiC)
STRT: A8713_13345(fbiC)
SCLF: BB341_11230(fbiC)
SGS: AVL59_44175(fbiC)
STSI: A4E84_17315(fbiC)
SNR: SNOUR_23810(fbiC)
SPLU: LK06_018940(fbiC)
STRD: NI25_22395(fbiC)
SNW: BBN63_19680(fbiC)
SAUO: BV401_26765(fbiC) BV401_35045(fbiC)
SSIA: A7J05_20325(fbiC)
SVU: B1H20_13635(fbiC)
SPUN: BFF78_24080(fbiC)
SGV: B1H19_17935(fbiC)
SLAU: SLA_3135
SALF: SMD44_03660(fbiC)
SALJ: SMD11_3959(fbiC)
SLX: SLAV_16495(mqnE2)
STRO: STRMOE7_16995(fbiC)
SFK: KY5_3501c
SNZ: DC008_14780(fbiC)
SGE: DWG14_04813(fbiC)
SRJ: SRO_4209
SLK: SLUN_16960(fbiC)
SDX: C4B68_22925(fbiC)
SAST: CD934_19070(fbiC)
STIR: DDW44_12900(fbiC)
SGZ: C0216_28065(fbiC)
SHAW: CEB94_17765(fbiC)
SSPO: DDQ41_12865(fbiC)
KSK: KSE_45370(fbiC)
KAB: B7C62_13575(fbiC)
KAU: B6264_08870(fbiC)
NDK: I601_0314(mqnE)
NBE: Back2_26860(fbiC)
PSIM: KR76_06880
KFL: Kfla_6490
TFU: Tfu_2519
NDA: Ndas_3771
NAL: B005_0949(cofG)
NGV: CDO52_24260(fbiC)
STRR: EKD16_20105(mqnE)
TCU: Tcur_4075
SRO: Sros_1376
NOA: BKM31_38790(fbiC)
TBI: Tbis_0746
FAL: FRAAL1263
ACE: Acel_0769
GOB: Gobs_1483
BSD: BLASA_1295(fbiC)
MMAR: MODMU_1466(fbiC)
KRA: Krad_3629
SEN: SACE_6594
AMD: AMED_6904(fbiC)
AMN: RAM_35420(fbiC)
AMM: AMES_6798(fbiC)
AMZ: B737_6798(fbiC)
AOI: AORI_1815(fbiC)
AJA: AJAP_30405(fbiC)
AMQ: AMETH_5642(fbiC)
AMYC: CU254_27985(fbiC)
AMYB: BKN51_01275(fbiC)
AORI: SD37_32150(fbiC)
ACTI: UA75_18405
ACAD: UA74_17915
AHG: AHOG_15900(mqnE)
ACTA: C1701_18075(fbiC)
ALO: CRK57346
SAQ: Sare_0888
MIL: ML5_1202
MTUA: CSH63_19720(fbiC)
MSAG: GCM10017556_35230(fbiC)
VMA: VAB18032_09475(fbiC)
PLAB: C6361_20395(fbiC)
PLAT: C6W10_23365(fbiC)
CAI: Caci_8766
AEY: CDG81_19075(fbiC)
RXY: Rxyl_0975
SYN: sll1659
SYZ: MYO_12520
SYY: SYNGTS_0250(cofH)
SYT: SYNGTI_0250(cofH)
SYS: SYNPCCN_0250(cofH)
SYQ: SYNPCCP_0250(cofH)
SYC: syc0843_c
TEL: tlr1597(cofG)
THN: NK55_04740(cofH)
THEC: FFX45_05945(cofH)
CYI: CBM981_0450(cofH)
LET: O77CONTIG1_00551(mqnE)
HHG: XM38_009170(cofH)
THEU: HPC62_14945(cofH)
GEE: GM3708_16
MAR: MAE_44400
MPK: VL20_2553
CYL: AA637_02275(cofH)
ENN: FRE64_08190(cofH)
CYT: cce_4539
TER: Tery_2116
ARP: NIES39_L02990(cofH)
OXY: HCG48_14355(cofH)
LFS: HFV01_04975(cofH)
GVI: glr0776(cofG)
GLJ: GKIL_2220(cofH)
ANA: alr4129
NSH: GXM_01176
NED: HUN01_31190(cofH)
AVA: Ava_0775
NAZ: Aazo_0194
ANB: ANA_C11401(cofH)
ANN: EH233_04440(cofH)
CALH: IJ00_17760
NSP: BMF81_01996(cofH)
DOU: BMF77_01492(fbiC_1)
DFS: HGD76_10455(cofH)
CCUR: IAR63_12380(cofH)
TOQ: HCG51_15175(cofH)
CTHE: Chro_1933
TRO: trd_A0899(cofH)
MJA: MJ_1431
MMP: MMP0056(cofH) MMP0057(cofH)
MMAK: MMKA1_00580(cofH) MMKA1_00590(cofH)
MMAO: MMOS7_00820(cofH) MMOS7_00830(cofH)
MMAD: MMJJ_10390(mqnE_1) MMJJ_10400(mqnE_2)
MAE: Maeo_0750
MVO: Mvol_1375
METF: CFE53_02480(cofH)
MTH: MTH_820
MMG: MTBMA_c12170(cofH)
METC: MTCT_0736
MWO: MWSIV6_1196(cofH)
METE: tca_00787(fbiC_1)
METK: FVF72_07445(cofH)
MTHM: FZP57_05680(cofH)
MST: Msp_0392(cofH)
METB: AW729_05100(cofH)
MRU: mru_1266(cofH)
MSI: Msm_0079
MEB: Abm4_0772(cofH)
MMIL: sm9_0991(cofH)
MEYE: TL18_05430(cofH)
MOL: YLM1_0639
METH: MBMB1_0707(cofH1) MBMB1_1031(cofH3)
MFC: BRM9_1217(cofH1) BRM9_1488(cofH2)
MFI: DSM1535_1898(cofH1) DSM1535_2180(cofH3)
MCUB: MCBB_0164(cofH_1) MCBB_0722(cofH_3)
METT: CIT01_01905(cofH) CIT01_08975(cofH)
METO: CIT02_01855(cofH) CIT02_03225(cofH)
MFV: Mfer_0690
MKA: MK0897(thiH_1)
AFU: AF_0798
FPL: Ferp_0003
GAC: GACE_2059
GAH: GAH_00663
MFZ: AOB57_001355(cofH) AOB57_001360(cofH)
MZI: HWN40_09685(cofH)
MTP: Mthe_0284
MCJ: MCON_3335(cofH)
MHI: Mhar_0763
MLA: Mlab_0123
MBG: BN140_0224(cofH1) BN140_1481(cofH3)
MEMA: MMAB1_0286(cofH) MMAB1_1902(cofH)
MPD: MCP_2456(cofH-1) MCP_2457(cofH-2)
MEZ: Mtc_0997(cofH-1) Mtc_0998(cofH-2)
RCI: RCIX459(cofH-2) RCIX460(cofH-1)
HAL: VNG_1938C
HSL: OE_3723R(cofH)
HHB: Hhub_3265(cofH)
HALH: HTSR_1968(cofH)
HHSR: HSR6_2043(cofH)
SALR: FQU85_06460(cofH)
HALR: EFA46_002145(cofH)
HMA: rrnAC3278
HHI: HAH_0519(cofH)
HALJ: G9465_17525(cofH)
NPH: NP_2394A(cofH)
NMO: Nmlp_3320(cofH)
HUT: Huta_1308
HTI: HTIA_1198
HALA: Hrd1104_08980(cofH)
HMU: Hmuk_1418
HALZ: E5139_10245(cofH)
HALL: LC1Hm_0634(cofH)
HRR: HZS55_04965(cofH)
HPEL: HZS54_05045(cofH)
HLT: I7X12_07290(cofH)
HWA: HQ_3127A(cofH)
HWC: Hqrw_3668(cofH)
HVO: HVO_2198(cofH)
HME: HFX_2254(thiH)
HALE: G3A49_14430(cofH)
HAER: DU502_15190(cofH)
HRA: EI982_15065(cofH)
HALM: FCF25_02470(cofH)
HLA: Hlac_2018
HALB: EKH57_14575(cofH)
HEZZ: EO776_10065(cofH)
HALQ: Hrr1229_009800(cofH)
HALN: B4589_007640(cofH)
HALG: HUG10_09405(cofH)
HALU: HUG12_06420(cofH)
HDF: AArcSl_2517(cofH)
HTU: Htur_0645
HALY: HYG82_19890(cofH)
NMG: Nmag_2637(cofH)
NAT: NJ7G_3947
NVR: FEJ81_14745(cofH) FEJ81_22750(cofH)
NPL: FGF80_13885(cofH)
SALI: L593_13865
NAS: GCU68_09425(cofH)
NMR: Nmar_0592
NID: NPIRD3C_1666(cofH)
NIN: NADRNF5_1569(cofH)
NIW: Nisw_01900(cofH)
NCL: C5F47_06150(cofH)
NOX: C5F49_05910(cofH)
NUE: C5F50_04480(cofH)
NCT: NMSP_1084(cofH_2)
NIC: DSQ20_03190(cofH)
NGA: Ngar_c12350(cofH1)
NVN: NVIE_011280(cofH1)
NEV: NTE_02502
TAA: NMY3_02529(mqnE_1)
NFN: NFRAN_0113(cofH)
NCV: NCAV_0880(cofH)
NDV: NDEV_0671(cofH)
CCAI: NAS2_0578
 » show all
Reference
1  [PMID:23072415]
  Authors
Decamps L, Philmus B, Benjdia A, White R, Begley TP, Berteau O
  Title
Biosynthesis of F0, precursor of the F420 cofactor, requires a unique two radical-SAM domain enzyme and tyrosine as substrate.
  Journal
J Am Chem Soc 134:18173-6 (2012)
DOI:10.1021/ja307762b
Reference
2  [PMID:25781338]
  Authors
Philmus B, Decamps L, Berteau O, Begley TP
  Title
Biosynthetic versatility and coordinated action of 5'-deoxyadenosyl radicals in deazaflavin biosynthesis.
  Journal
J Am Chem Soc 137:5406-13 (2015)
DOI:10.1021/ja513287k
Other DBs
ExplorEnz - The Enzyme Database: 2.5.1.147
IUBMB Enzyme Nomenclature: 2.5.1.147
ExPASy - ENZYME nomenclature database: 2.5.1.147
BRENDA, the Enzyme Database: 2.5.1.147

KEGG   REACTION: R12161
Entry
R12161                      Reaction                               

Name
5-amino-6-(D-ribitylamino)uracil:L-tyrosine 4-hydroxybenzyltransferase
Definition
5-Amino-6-(1-D-ribitylamino)uracil + L-Tyrosine + S-Adenosyl-L-methionine <=> 5-Amino-5-(4-hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil + Iminoglycine + L-Methionine + 5'-Deoxyadenosine
Equation
Reaction class
RC03095  C00082_C15809
RC03532  C04732_C21971
Enzyme
Pathway
rn00680  Methane metabolism
rn01100  Metabolic pathways
rn01120  Microbial metabolism in diverse environments
rn01240  Biosynthesis of cofactors
Module
M00378  F420 biosynthesis
Orthology
K11779  FO synthase [EC:2.5.1.147 4.3.1.32]
K11781  5-amino-6-(D-ribitylamino)uracil---L-tyrosine 4-hydroxyphenyl transferase [EC:2.5.1.147]

DBGET integrated database retrieval system