KEGG ORTHOLOGY: K11987

ORTHOLOGY: K11987

Entry

K11987                      KO

Symbol

PTGS2, COX2

Name

prostaglandin-endoperoxide synthase 2 [EC:1.14.99.1]

Pathway

map00590

Arachidonic acid metabolism

map01100

Metabolic pathways

map04064

NF-kappa B signaling pathway

map04148

Efferocytosis

map04370

VEGF signaling pathway

map04625

C-type lectin receptor signaling pathway

map04657

IL-17 signaling pathway

map04668

TNF signaling pathway

map04723

Retrograde endocannabinoid signaling

map04726

Serotonergic synapse

map04913

Ovarian steroidogenesis

map04921

Oxytocin signaling pathway

map04923

Regulation of lipolysis in adipocytes

map05010

Alzheimer disease

map05022

Pathways of neurodegeneration - multiple diseases

map05140

Leishmaniasis

map05163

Human cytomegalovirus infection

map05165

Human papillomavirus infection

map05167

Kaposi sarcoma-associated herpesvirus infection

map05200

Pathways in cancer

map05204

Chemical carcinogenesis - DNA adducts

map05206

MicroRNAs in cancer

map05222

Small cell lung cancer

Reaction

R00073

reduced acceptor:prostaglandin G2 oxidoreductase

R01590

arachidonate:oxygen oxidoreductase

Disease

H00017

Esophageal cancer

H00025

Penile cancer

H00046

Cholangiocarcinoma

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09103 Lipid metabolism
   00590 Arachidonic acid metabolism
    K11987  PTGS2, COX2; prostaglandin-endoperoxide synthase 2
09130 Environmental Information Processing
  09132 Signal transduction
   04370 VEGF signaling pathway
    K11987  PTGS2, COX2; prostaglandin-endoperoxide synthase 2
   04064 NF-kappa B signaling pathway
    K11987  PTGS2, COX2; prostaglandin-endoperoxide synthase 2
   04668 TNF signaling pathway
    K11987  PTGS2, COX2; prostaglandin-endoperoxide synthase 2
09140 Cellular Processes
  09141 Transport and catabolism
   04148 Efferocytosis
    K11987  PTGS2, COX2; prostaglandin-endoperoxide synthase 2
09150 Organismal Systems
  09151 Immune system
   04625 C-type lectin receptor signaling pathway
    K11987  PTGS2, COX2; prostaglandin-endoperoxide synthase 2
   04657 IL-17 signaling pathway
    K11987  PTGS2, COX2; prostaglandin-endoperoxide synthase 2
  09152 Endocrine system
   04923 Regulation of lipolysis in adipocytes
    K11987  PTGS2, COX2; prostaglandin-endoperoxide synthase 2
   04913 Ovarian steroidogenesis
    K11987  PTGS2, COX2; prostaglandin-endoperoxide synthase 2
   04921 Oxytocin signaling pathway
    K11987  PTGS2, COX2; prostaglandin-endoperoxide synthase 2
  09156 Nervous system
   04726 Serotonergic synapse
    K11987  PTGS2, COX2; prostaglandin-endoperoxide synthase 2
   04723 Retrograde endocannabinoid signaling
    K11987  PTGS2, COX2; prostaglandin-endoperoxide synthase 2
09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K11987  PTGS2, COX2; prostaglandin-endoperoxide synthase 2
   05206 MicroRNAs in cancer
    K11987  PTGS2, COX2; prostaglandin-endoperoxide synthase 2
   05204 Chemical carcinogenesis - DNA adducts
    K11987  PTGS2, COX2; prostaglandin-endoperoxide synthase 2
  09162 Cancer: specific types
   05222 Small cell lung cancer
    K11987  PTGS2, COX2; prostaglandin-endoperoxide synthase 2
  09172 Infectious disease: viral
   05163 Human cytomegalovirus infection
    K11987  PTGS2, COX2; prostaglandin-endoperoxide synthase 2
   05167 Kaposi sarcoma-associated herpesvirus infection
    K11987  PTGS2, COX2; prostaglandin-endoperoxide synthase 2
   05165 Human papillomavirus infection
    K11987  PTGS2, COX2; prostaglandin-endoperoxide synthase 2
  09174 Infectious disease: parasitic
   05140 Leishmaniasis
    K11987  PTGS2, COX2; prostaglandin-endoperoxide synthase 2
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    K11987  PTGS2, COX2; prostaglandin-endoperoxide synthase 2
   05022 Pathways of neurodegeneration - multiple diseases
    K11987  PTGS2, COX2; prostaglandin-endoperoxide synthase 2
Enzymes [BR:ko01000]
1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.99  Miscellaneous
    1.14.99.1  prostaglandin-endoperoxide synthase
     K11987  PTGS2, COX2; prostaglandin-endoperoxide synthase 2

Other DBs

GO:

0004666

Genes

HSA:	5743(PTGS2)

PTR:	469616(PTGS2)

PPS:	100985650(PTGS2)

GGO:	101146681(PTGS2)

PON:	100436566(PTGS2)

PPYG:

129013985(PTGS2)

NLE:	100591090(PTGS2)

HMH:	116457725(PTGS2)

SSYN:

129458621(PTGS2)

MCC:	716671(PTGS2)

MCF:	102143028(PTGS2)

MTHB:

126950108

MNI:	105484600(PTGS2)

CSAB:

103230420(PTGS2)

CATY:

105579902(PTGS2)

PANU:

101025796(PTGS2)

TGE:	112611851(PTGS2)

MLEU:

105553184(PTGS2)

RRO:	104664377(PTGS2)

RBB:	108523178(PTGS2)

TFN:	117074573(PTGS2)

PTEH:

111536921(PTGS2)

CANG:

105506149(PTGS2)

CJC:	100407639(PTGS2)

SBQ:	101027603(PTGS2)

CIMI:

108301379(PTGS2)

ANAN:

105711770(PTGS2)

CSYR:

103275362(PTGS2)

MMUR:

105855505(PTGS2)

LCAT:

123626853(PTGS2)

PCOQ:

105813187(PTGS2)

OGA:	100944482(PTGS2)

MMU:	19225(Ptgs2)

MCAL:

110288090 110288092 110288093 110292340

MPAH:

110315297 110321554(Ptgs2)

RNO:	29527(Ptgs2)

MCOC:

116070506(Ptgs2)

ANU:	117716475(Ptgs2)

MUN:	110553489(Ptgs2)

CGE:	100751220(Ptgs2)

MAUA:

101823908(Ptgs2)

PROB:

127223393(Ptgs2)

PLEU:

114696775(Ptgs2)

MORG:

121455411(Ptgs2)

MFOT:

126514187

AAMP:

119827843(Ptgs2)

NGI:	103726651(Ptgs2)

HGL:	101704771(Ptgs2)

CPOC:

100135607(Ptgs2)

CCAN:

109685138(Ptgs2)

DORD:

105989626(Ptgs2)

DSP:	122103768(Ptgs2)

PLOP:

125359010(Ptgs2)

NCAR:

124962420

MMMA:

107147540(Ptgs2)

OCU:	100009248(PTGS2)

OPI:	101536557(PTGS2)

TUP:	102478264(PTGS2)

GVR:	103592767(PTGS2)

CFA:	442942(PTGS2)

CLUD:

112648518(PTGS2)

VVP:	112921830(PTGS2)

VLG:	121497643(PTGS2)

NPO:	129505764(PTGS2)

AML:	100481615(PTGS2)

UMR:	103668648(PTGS2)

UAH:	113262761(PTGS2)

UAR:	123801412(PTGS2)

ELK:

111150791

LLV:

125086360

MPUF:

101688096(PTGS2)

MNP:	132025471(PTGS2)

MLK:	131814650(PTGS2)

NVS:	122918633(PTGS2)

ORO:	101375484(PTGS2)

EJU:	114222880(PTGS2)

ZCA:	113933515(PTGS2)

MLX:	118013715(PTGS2)

NSU:	110573976(PTGS2)

LWW:	102726761(PTGS2)

FCA:	100126581(PTGS2)

PYU:	121011859(PTGS2)

PCOO:

112857635(PTGS2)

PBG:	122475760(PTGS2)

PVIV:

125155837(PTGS2)

LRUF:

124510169

PTG:	102948685(PTGS2)

PPAD:

109253602(PTGS2)

PUC:

125925212

AJU:

106967086

HHV:	120248734(PTGS2)

BTA:	282023(PTGS2)

BOM:	102271174(PTGS2)

BIU:	109570734(PTGS2)

BBUB:

102416528(PTGS2)

BBIS:

104998056(PTGS2)

CHX:	100860905(PTGS2)

OAS:	443460(PTGS2)

BTAX:

128061601(PTGS2)

ODA:	120880449(PTGS2)

CCAD:

122452326(PTGS2)

MBEZ:

129551280(PTGS2)

SSC:	397590(PTGS2)

CFR:	102509586(PTGS2)

CBAI:

105083396(PTGS2)

CDK:	105099289(PTGS2)

VPC:	102536038(PTGS2)

BACU:

102999195(PTGS2)

BMUS:

118884708(PTGS2)

LVE:	103088613(PTGS2)

OOR:	101270299(PTGS2)

DLE:	111184673(PTGS2)

PCAD:

102982708(PTGS2)

PSIU:

116759534(PTGS2)

NASI:

112403598(PTGS2)

ECB:	791253(PTGS2)

EPZ:	103547078(PTGS2)

EAI:	106846783(PTGS2)

MYB:	102259598(PTGS2)

MYD:	102774808(PTGS2)

MMYO:

118673371(PTGS2)

MLF:	102423775(PTGS2)

MDT:	132221347(PTGS2)

PKL:	118721470(PTGS2)

EFUS:

103290037(PTGS2)

MNA:	107546245(PTGS2)

DRO:	112296707(PTGS2)

SHON:

118979157(PTGS2)

AJM:	119059729(PTGS2)

PDIC:

114511915(PTGS2)

PHAS:

123818377(PTGS2)

MMF:	118637857(PTGS2)

PPAM:

129081870(PTGS2)

HAI:	109379092(PTGS2)

RFQ:	117014281(PTGS2)

PALE:

102886561(PTGS2)

PGIG:

120617547(PTGS2)

PVP:	105295029(PTGS2)

RAY:	107521616(PTGS2)

MJV:	108406216(PTGS2)

TOD:	119241194(PTGS2)

SARA:

101543763(PTGS2)

SETR:

126013403(PTGS2)

LAV:	100666359(PTGS2)

TMU:

101345018

ETF:	101653785(PTGS2)

DNM:	101438934(PTGS2)

MDO:	100024802(PTGS2)

GAS:	123244793(PTGS2)

SHR:	100926756(PTGS2)

AFZ:

127562792

PCW:	110206875(PTGS2)

TVP:	118846778(PTGS2)

OAA:	100086096(PTGS2)

GGA:	396451(PTGS2)

PCOC:

116238667(PTGS2)

MGP:	100550092(PTGS2)

CJO:	107317330(PTGS2)

TPAI:

128072166(PTGS2)

LMUT:

125694021(PTGS2)

NMEL:

110402447(PTGS2)

APLA:

101790135(PTGS2)

ACYG:

106034056(PTGS2)

CATA:

118243264(PTGS2)

AFUL:

116491944(PTGS2)

TGU:	100221909(PTGS2)

LSR:	110467832(PTGS2)

SCAN:

103814802(PTGS2)

PMOA:

120510474(PTGS2)

OTC:	121344623(PTGS2)

PRUF:

121360112(PTGS2)

GFR:	102045242(PTGS2)

FAB:	101816125(PTGS2)

OMA:	130256418(PTGS2)

PHI:	102105209(PTGS2)

PMAJ:

107208209(PTGS2)

CCAE:

111932522(PTGS2)

CCW:	104693603(PTGS2)

CBRC:

103617153(PTGS2)

ETL:	114066906(PTGS2)

ZAB:	102075122(PTGS2)

ZLE:	135450937(PTGS2)

ACHL:

103807814(PTGS2)

SVG:	106857929(PTGS2)

MMEA:

130584975(PTGS2)

HRT:	120756852(PTGS2)

SATI:

136364697(PTGS2)

FPG:	101918755(PTGS2)

FCH:	102050356(PTGS2)

CCRI:

104155104(PTGS2)

NNT:	104399258(PTGS2)

SHAB:

115611588(PTGS2)

ACUN:

113483094(PTGS2)

TALA:

104357859(PTGS2)

ACHC:

115348714(PTGS2)

HALD:

104315621(PTGS2)

HLE:	104840027(PTGS2)

AGEN:

126042066

GCL:

127019322

CSTI:

104560519(PTGS2)

LDI:	104342355(PTGS2)

MNB:	103780859(PTGS2)

DPUB:

104309402(PTGS2)

AVIT:

104277910(PTGS2)

BRHI:

104490436(PTGS2)

EGZ:	104124553(PTGS2)

NNI:	104011302(PTGS2)

PCRI:

104037256(PTGS2)

PCAO:

104046206(PTGS2)

PADL:

103922182(PTGS2)

AFOR:

103895492(PTGS2)

FGA:	104082674(PTGS2)

GSTE:

104264982(PTGS2)

CLV:	102088650(PTGS2)

MUI:	104533596(PTGS2)

PGUU:

104466894(PTGS2)

PLET:

104627345(PTGS2)

EHS:	104508273(PTGS2)

CMAC:

104473824(PTGS2)

CUCA:

104063275(PTGS2)

TEO:	104380596(PTGS2)

BREG:

104632878(PTGS2)

OHA:	104326328(PTGS2)

ACAR:

104520827(PTGS2)

CPEA:

104388922(PTGS2)

CVF:	104285913(PTGS2)

RTD:	128914219(PTGS2)

AAM:

106486027

AROW:

112964578(PTGS2)

NPD:	112951111(PTGS2)

TGT:	104568282(PTGS2)

DNE:	112983769(PTGS2)

SCAM:

104142612(PTGS2)

ASN:	102369126(PTGS2)

AMJ:	106736995(PTGS2)

CPOO:

109307218(PTGS2)

GGN:	109286913(PTGS2)

PSS:	102459102(PTGS2)

CMY:	102934690(PTGS2)

CCAY:

125641698(PTGS2)

DCC:	119860729(PTGS2)

CPIC:

101941281(PTGS2)

TST:	117882058(PTGS2)

CABI:

116826611(PTGS2)

MRV:	120370233(PTGS2)

ACS:	100560130(ptgs2)

ASAO:

132774418(PTGS2)

PVT:	110079773(PTGS2)

SUND:

121930072(PTGS2)

PBI:	103063043(PTGS2)

PMUR:

107285158(PTGS2)

CTIG:

120308734(PTGS2)

TSR:	106542642(PTGS2)

PGUT:

117661093(PTGS2)

APRI:

131194108(PTGS2)

PTEX:

113438049(PTGS2)

NSS:	113413194(PTGS2)

VKO:	123027906(PTGS2)

PMUA:

114598627 114598628

PRAF:

128415341(PTGS2) 128415343

ZVI:	118089145 118089253

HCG:	128323529(PTGS2)

GJA:	107121970(PTGS2)

STOW:

125425043(PTGS2)

EMC:	129331394(PTGS2)

XLA:	108714508(ptgs2.L) 446781(ptgs2.S)

XTR:	595089(ptgs2)

NPR:	108798706(PTGS2)

RTEM:

120945540(PTGS2)

BBUF:

120979010(PTGS2)

BGAR:

122943666(PTGS2)

MUO:	115471946(PTGS2)

GSH:	117368073(PTGS2)

DRE:	246227(ptgs2a) 559020(ptgs2b)

SRX:	107718138 107722606 107726413 107732418

SANH:

107677761 107693741 107696154 107698381

SGH:	107553505 107589869 107594645 107599092

CCAR:

109071632(ptgs2) 109081129

CAUA:

113045805 113062963 113072624 113115972 113120750

CGIB:

127939042 127950607 127983392 128027375

PTET:

122325232(ptgs2b) 122360421(ptgs2a)

LROH:

127180465(ptgs2a) 127182997(ptgs2b)

OMC:	131524712(ptgs2a) 131527224(ptgs2b)

PPRM:

120483023(ptgs2a) 120493605(ptgs2b)

RKG:	130079414(ptgs2a) 130102976(ptgs2b)

MAMB:

125250692(ptgs2a) 125278201(ptgs2b)

CIDE:

127494950 127502124 127522420

CERY:

137002323(ptgs2a) 137018454(ptgs2b)

MASI:

127442703 127456664

TROS:

130553772(ptgs2a)

TDW:	130415487(ptgs2a) 130434102(ptgs2b)

MANU:

129430141(ptgs2b) 129442372(ptgs2a)

IPU:	108257974(ptgs2b) 108277762 108277763

IFU:	128600996(ptgs2b) 128620942

PHYP:

113539247 113546811

SMEO:

124377272(ptgs2b) 124394956(ptgs2a)

TFD:	113642216(ptgs2a) 113647522(ptgs2b)

TVC:	132843522(ptgs2b) 132858326(ptgs2a)

TRN:	134319943(ptgs2b) 134334075(ptgs2a)

AMEX:

103032345(ptgs2a) 103034574(ptgs2b)

CMAO:

118804707(ptgs2a) 118815279(ptgs2b)

EEE:	113585124 113588667

CHAR:

105910734(ptgs2b)

TRU:	101064817(ptgs2)

TFS:	130528701(ptgs2b)

TNG:	GSTEN00033631G001

LCO:	104921828(ptgs2)

NCC:	104955130(ptgs2)

TBEN:

117496002(ptgs2b)

CGOB:

115006753(ptgs2)

PGEO:

117445268(ptgs2b)

GACU:

117542427(ptgs2b)

EMAC:

134869349(ptgs2b)

ELY:	117254034(ptgs2b)

EFO:	125895446(ptgs2b)

PLEP:

121965412(ptgs2b)

SLUC:

116060361(ptgs2b)

ECRA:

117949850(ptgs2b)

ESP:	116694962(ptgs2)

PFLV:

114561193(ptgs2)

GAT:	120823991(ptgs2b)

PPUG:

119216828(ptgs2b)

AFB:	129094098(ptgs2b)

CLUM:

117729217(ptgs2b)

PSWI:

130194402

MSAM:

119900433(ptgs2b)

SCHU:

122877625(ptgs2b)

CUD:	121511973(ptgs2b)

ALAT:

119028658(ptgs2b)

MZE:	101472557(ptgs2)

ONL:	100698573(ptgs2)

OAU:	116335047(ptgs2b)

OLA:	100359365(ptgs2)

OML:	112150839(ptgs2b)

CSAI:

133458633(ptgs2b)

XMA:	102228898(ptgs2)

XCO:	114150821(ptgs2)

XHE:	116726213(ptgs2)

PRET:

103468244(ptgs2)

PFOR:

103137256(ptgs2)

PLAI:

106936158(ptgs2)

PMEI:

106913887(ptgs2)

GAF:	122838735(ptgs2b)

PPRL:

129371818(ptgs2b)

CVG:	107085952(ptgs2)

CTUL:

119787704(ptgs2b)

GMU:	124874136(ptgs2b)

NFU:	107392885(ptgs2)

KMR:	108238364(ptgs2b)

ALIM:

106516825(ptgs2)

NWH:	119430565(ptgs2b)

AOCE:

111585762(ptgs2)

MCEP:

125009483(ptgs2b)

CSEM:

103395284(ptgs2)

POV:	109636696(ptgs2)

SSEN:

122780440 122780441

HHIP:

117760688(ptgs2b)

HSP:	118121108(ptgs2b)

PPLT:

128447995(ptgs2b)

SMAU:

118318243(ptgs2b)

LCF:	108896773(ptgs2b)

SDU:	111219627(ptgs2)

SLAL:

111645378(ptgs2)

XGL:	120791019(ptgs2b)

HCQ:	109519080(ptgs2)

SSCV:

125968914

SBIA:

133503955(ptgs2b)

PEE:	133406766(ptgs2b)

PTAO:

133480604(ptgs2b)

BPEC:

110167945(ptgs2)

MALB:

109961724(ptgs2)

BSPL:

114853827(ptgs2b)

SJO:	128362004(ptgs2b)

SASA:

100136456(cox-2) 106560558 106583970 106599098

STRU:

115156784 115158768(ptgs2) 115169908 115192190

OTW:	112227066 112250956 112251388(ptgs2b) 112260348

OMY:	100136025(cox-2) 110508862 110521832 110523034(ptgs2b)

OGO:	123997083(ptgs2b) 124009489 124037149 124041979

ONE:	115103206 115114277 115118188 115145304

OKI:	109871539 109874966 109898162 109902882(ptgs2)

OKE:	118358889 118393998(ptgs2b) 118394539 118402246

SALP:

111956708 111971482 111975404(ptgs2) 111979383

SNH:	120020058(ptgs2a) 120051921 120055021 120055825

CCLU:

121534073(ptgs2b) 121535088 121539927 121580802(ptgs2a)

ELS:	105028801 105029082(ptgs2)

SFM:	108935147 108935314(ptgs2)

PKI:	111840107 111841020

AANG:

118224852(ptgs2b) 118230093(ptgs2a)

LOC:	102685668(ptgs2)

PSPA:

121327167 121330673

ARUT:

117413155(ptgs2b) 117416604

PSEX:

120514708

LCM:	102352257(PTGS2)

CMK:	103179983(ptgs2b)

RTP:	109933769(ptgs2b)

CPLA:

122554451(ptgs2b)

HOC:

132819043

LERI:

129701124(ptgs2b)

PMRN:

103091789 116944816

LRJ:	133354639 133354678

BFO:	118421716 118427666

BBEL:

109462019 109463842

CIN:	100183010 100183175

SCLV:

120331187 120340042 120348034 120348654 120348658

DPX:	DAPPUDRAFT_313427(COX)

DMK:

DPZ:

PVM:

PJA:

PCHN:

PMOO:

HAME:

PCLA:

CQD:

PTRU:

ESN:

MNZ:	135210707 135215625

HAZT:

108668991

LGI:	LOTGIDRAFT_139178

PVUL:

PCAN:

BGT:

GAE:

HRF:

HRJ:

CRG:	105337232 105344258

CANU:

128156383 128192945

CVN:	111123664 111127644

OED:

125678677

MYI:

110451344

PMAX:

117321998

MCAF:

127727666 127727667 127728071 127734097

MMER:

RPHI:

DPOL:

MAEA:

OBI:	106867682 106867683

OSN:	115225592 115225784

LJP:

135480457

DGT:

114537549

» show all

Reference

PMID:8473346

Authors

Jones DA, Carlton DP, McIntyre TM, Zimmerman GA, Prescott SM

Title

Molecular cloning of human prostaglandin endoperoxide synthase type II and demonstration of expression in response to cytokines.

Journal

J Biol Chem 268:9049-54 (1993)

Sequence

[hsa:5743]

Reference

PMID:16373578

Authors

Kim SF, Huri DA, Snyder SH

Title

Inducible nitric oxide synthase binds, S-nitrosylates, and activates cyclooxygenase-2.

Journal

Science 310:1966-70 (2005)
DOI:10.1126/science.1119407

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