KEGG ORTHOLOGY: K12040

ORTHOLOGY: K12040

Entry

K12040                      KO

Symbol

SLC9A3, NHE3

Name

solute carrier family 9 (sodium/hydrogen exchanger), member 3

Pathway

map04964

Proximal tubule bicarbonate reclamation

map04974

Protein digestion and absorption

map04976

Bile secretion

map04978

Mineral absorption

Disease

H01174

Congenital diarrhea

Brite

KEGG Orthology (KO) [BR:ko00001]
09150 Organismal Systems
  09154 Digestive system
   04976 Bile secretion
    K12040  SLC9A3, NHE3; solute carrier family 9 (sodium/hydrogen exchanger), member 3
   04974 Protein digestion and absorption
    K12040  SLC9A3, NHE3; solute carrier family 9 (sodium/hydrogen exchanger), member 3
   04978 Mineral absorption
    K12040  SLC9A3, NHE3; solute carrier family 9 (sodium/hydrogen exchanger), member 3
  09155 Excretory system
   04964 Proximal tubule bicarbonate reclamation
    K12040  SLC9A3, NHE3; solute carrier family 9 (sodium/hydrogen exchanger), member 3
09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   02000 Transporters
    K12040  SLC9A3, NHE3; solute carrier family 9 (sodium/hydrogen exchanger), member 3
Transporters [BR:ko02000]
Solute carrier family (SLC)
  SLC9: Na+/H+ exchanger
   K12040  SLC9A3, NHE3; solute carrier family 9 (sodium/hydrogen exchanger), member 3

Other DBs

GO:

0015385

TC:	2.A.36.1.2 2.A.36.1.6 2.A.36.1.10

Genes

HSA:	6550(SLC9A3)

PTR:	741885(SLC9A3)

PPS:	134730350(SLC9A3)

GGO:	101138939(SLC9A3) 115933183

PON:	100456947(SLC9A3)

PPYG:

129036511(SLC9A3)

NLE:	100594232(SLC9A3)

HMH:	116456802(SLC9A3)

SSYN:

129464749(SLC9A3)

MCC:	708641(SLC9A3)

MCF:	102131406(SLC9A3)

MTHB:

126957440

MNI:

105483376

CSAB:

103214902(SLC9A3)

CATY:

105586008(SLC9A3)

TGE:	112625891(SLC9A3)

MLEU:

105532416(SLC9A3)

RRO:	104654228(SLC9A3)

RBB:	108527214(SLC9A3)

TFN:	117064668(SLC9A3)

PTEH:

111527981(SLC9A3)

CANG:

105525304(SLC9A3)

CJC:	100398311(SLC9A3)

SBQ:	101035592(SLC9A3)

CIMI:

108297780(SLC9A3)

ANAN:

105732944(SLC9A3)

CSYR:

103275428(SLC9A3)

MMUR:

105876471(SLC9A3)

LCAT:

123648200(SLC9A3)

PCOQ:

105823060(SLC9A3)

OGA:	100963588(SLC9A3)

MMU:	105243(Slc9a3)

MCAL:

110308357(Slc9a3)

MPAH:

110329116(Slc9a3)

RNO:	24784(Slc9a3)

MCOC:

116083139(Slc9a3)

ANU:	117723757(Slc9a3)

MUN:	110545368(Slc9a3)

CGE:	100755928(Slc9a3)

MAUA:

101823513(Slc9a3)

PROB:

127220872(Slc9a3)

PLEU:

114696090(Slc9a3)

MORG:

121433707(Slc9a3)

MFOT:

126503786

AAMP:

119810410(Slc9a3)

NGI:	103749664(Slc9a3)

HGL:	101700748(Slc9a3)

CPOC:

100734952(Slc9a3)

CCAN:

109693454(Slc9a3)

DORD:

105983787(Slc9a3)

DSP:	122121030(Slc9a3)

PLOP:

125367436(Slc9a3)

NCAR:

124986704

MMMA:

107146353(Slc9a3)

OCU:	100009430(SLC9A3)

OPI:	101516872(SLC9A3)

TUP:	102495630(SLC9A3)

GVR:	103593892(SLC9A3)

CFA:	488073(SLC9A3)

CLUD:

112662740(SLC9A3)

VVP:	112935440(SLC9A3)

VLG:	121477513(SLC9A3)

NPO:	129498355(SLC9A3)

AML:	100484801(SLC9A3)

UMR:	103679269(SLC9A3)

UAH:	113260774(SLC9A3)

UAR:	123799111(SLC9A3)

ELK:

111153445

LLV:

125100209

MPUF:

101678425(SLC9A3)

MNP:	132028172(SLC9A3)

MLK:	131831517(SLC9A3)

NVS:	122896326(SLC9A3)

ORO:	101383717(SLC9A3)

EJU:	114198546(SLC9A3)

ZCA:	113928392(SLC9A3)

MLX:	118006164(SLC9A3)

NSU:	110577704(SLC9A3)

LWW:

102742907

FCA:	101082470(SLC9A3)

PYU:	121021775(SLC9A3)

PCOO:

112861701(SLC9A3)

PBG:	122495882(SLC9A3)

PVIV:

125159814(SLC9A3)

LRUF:

124508109

PTG:	102953119(SLC9A3)

PPAD:

109260200(SLC9A3)

PUC:

125934753

AJU:

106988571

HHV:	120235607(SLC9A3)

BTA:	407112(SLC9A3)

BOM:	102274000(SLC9A3)

BIU:	109575090(SLC9A3)

BBIS:

105000989(SLC9A3)

CHX:	102184475(SLC9A3)

OAS:	494437(SLC9A3)

BTAX:

128066142(SLC9A3)

ODA:	120879270(SLC9A3)

CCAD:

122454511(SLC9A3)

MBEZ:

129553410(SLC9A3)

SSC:	397358(SLC9A3)

CFR:	102504114(SLC9A3)

CBAI:

105081244(SLC9A3)

CDK:	105102198(SLC9A3)

VPC:	102537344(SLC9A3)

BACU:

103003544(SLC9A3)

BMUS:

118891862(SLC9A3)

LVE:	103089771(SLC9A3)

OOR:	101270215(SLC9A3)

DLE:	111178531(SLC9A3)

PCAD:

102988630(SLC9A3)

PSIU:

116752340(SLC9A3)

NASI:

112390891(SLC9A3)

ECB:	100034109(SLC9A3)

EPZ:	103560328(SLC9A3)

EAI:	106835892(SLC9A3)

MYB:	102239868(SLC9A3)

MYD:	102767673(SLC9A3)

MMYO:

118655903(SLC9A3)

MLF:	102419854(SLC9A3)

MDT:	132233625(SLC9A3)

PKL:	118703010(SLC9A3)

EFUS:

103305126(SLC9A3)

MNA:	107536701(SLC9A3)

DRO:	112321037(SLC9A3)

SHON:

118998644(SLC9A3)

AJM:	119043388(SLC9A3)

PDIC:

114513158(SLC9A3)

PHAS:

123824708(SLC9A3)

MMF:	118642685(SLC9A3)

PPAM:

129074555(SLC9A3)

HAI:	109371685(SLC9A3)

RFQ:	117024892(SLC9A3)

PALE:

102896551(SLC9A3)

PGIG:

120586314(SLC9A3)

PVP:	105301312(SLC9A3)

MJV:	108386941(SLC9A3)

TOD:	119260511(SLC9A3)

SARA:

101539829 101542104(SLC9A3)

SETR:

126000776(SLC9A3)

LAV:	100676853(SLC9A3)

TMU:

101343708

ETF:	101640633(SLC9A3)

DNM:	101416426(SLC9A3)

MDO:	100011473(SLC9A3)

GAS:	123237933(SLC9A3)

SHR:	100932576(SLC9A3)

AFZ:

127543581

PCW:	110207918(SLC9A3)

TVP:	118833489(SLC9A3)

OAA:	100092285(SLC9A3)

GGA:	420801(SLC9A3)

PCOC:

116238556(SLC9A3)

MGP:	100543455(SLC9A3)

CJO:	107309778(SLC9A3)

TPAI:

128087774(SLC9A3)

LMUT:

125691392(SLC9A3)

NMEL:

110394898(SLC9A3)

APLA:

101792043(SLC9A3)

ACYG:

106038375(SLC9A3)

CATA:

118249627(SLC9A3)

AFUL:

116486320(SLC9A3)

TGU:	100223153(SLC9A3)

LSR:	110475978(SLC9A3)

SCAN:

103819381(SLC9A3)

PMOA:

120503596(SLC9A3)

OTC:	121336222(SLC9A3)

PRUF:

121349266(SLC9A3)

GFR:	102044346(SLC9A3)

FAB:	101808327(SLC9A3)

OMA:	130249733(SLC9A3)

PHI:	102110840(SLC9A3)

PMAJ:

107200605(SLC9A3)

CCAE:

111923703(SLC9A3)

CCW:	104688875(SLC9A3)

CBRC:

103618681(SLC9A3)

ETL:	114063816(SLC9A3)

ZAB:	102070458(SLC9A3)

ZLE:	135443168(SLC9A3)

ACHL:

103800538(SLC9A3)

SVG:	106853858(SLC9A3)

MMEA:

130581125(SLC9A3)

HRT:	120753648(SLC9A3)

SATI:

136367264(SLC9A3)

FPG:	101913816(SLC9A3)

FCH:	102053997(SLC9A3)

CCRI:

104162016(SLC9A3)

NNT:	104406114(SLC9A3)

SHAB:

115617402(SLC9A3)

ACUN:

113476394(SLC9A3)

TALA:

104368760(SLC9A3)

ACHC:

115353152(SLC9A3)

HALD:

104324491(SLC9A3)

HLE:	104837611(SLC9A3)

AGEN:

126048557

GCL:

127013329

CSTI:

104556902(SLC9A3)

LDI:	104349183(SLC9A3)

MNB:	103780695(SLC9A3)

DPUB:

104308910(SLC9A3)

AVIT:

104278034(SLC9A3)

BRHI:

104496270(SLC9A3)

EGZ:	104125465(SLC9A3)

NNI:	104021779(SLC9A3)

PCRI:

104028607(SLC9A3)

PCAO:

104050281(SLC9A3)

PADL:

103917361(SLC9A3)

AFOR:

103907522(SLC9A3)

FGA:	104084126(SLC9A3)

GSTE:

104257801(SLC9A3)

CLV:	102097172(SLC9A3)

MUI:	104546417(SLC9A3)

PGUU:

104468617(SLC9A3)

PLET:

104626460(SLC9A3)

EHS:	104516317(SLC9A3)

CMAC:

104487077(SLC9A3)

CUCA:

104055750(SLC9A3)

TEO:	104371876(SLC9A3)

OHA:	104337972(SLC9A3)

ACAR:

104518354(SLC9A3)

CPEA:

104398272(SLC9A3)

CVF:	104295232(SLC9A3)

RTD:	128905442(SLC9A3)

AAM:	106492282(SLC9A3)

AROW:

112973468(SLC9A3)

NPD:	112947545(SLC9A3)

TGT:	104581168(SLC9A3)

DNE:	112987305(SLC9A3)

ASN:	102372043(SLC9A3)

AMJ:	102573212(SLC9A3)

CPOO:

109313243(SLC9A3)

GGN:	109291910(SLC9A3)

PSS:	102444577(SLC9A3)

CMY:	102945630(SLC9A3)

CCAY:

125631910(SLC9A3)

DCC:	119851256(SLC9A3)

CPIC:

101946408(SLC9A3)

TST:	117871575(SLC9A3)

CABI:

116816378(SLC9A3)

MRV:	120398985(SLC9A3)

ACS:	100567923(slc9a3)

ASAO:

132779648(SLC9A3)

PVT:	110090569(SLC9A3)

SUND:

121933617(SLC9A3)

PBI:	103054025(SLC9A3)

TSR:	106552719(SLC9A3)

PGUT:

117664915(SLC9A3)

APRI:

131198205(SLC9A3)

PTEX:

113450516(SLC9A3)

NSS:	113419090(SLC9A3)

VKO:	123017605(SLC9A3)

PMUA:

114582040(SLC9A3)

PRAF:

128399771(SLC9A3)

ZVI:	118094375(SLC9A3)

HCG:	128329575(SLC9A3)

GJA:	107115917(SLC9A3)

STOW:

125441345(SLC9A3)

EMC:	129337768(SLC9A3)

XLA:	108719058(slc9a3.L)

XTR:	100492870(slc9a3)

NPR:	108789032(SLC9A3)

RTEM:

120940523(SLC9A3)

BBUF:

121001880(SLC9A3)

BGAR:

122938881(SLC9A3)

MUO:	115474302(SLC9A3)

GSH:	117355186(SLC9A3)

DRE:	568258(slc9a3.1) 568314(slc9a3.2)

SRX:	107739592 107739626 107748719 107748744

SANH:

107656567 107656591 107693290 107693388

SGH:	107565571 107589455 107599576 107599577

CCAR:

109111882 109112356

CAUA:

113062341 113062342 113120145 113120146

CGIB:

127935874 127935875 127978722 127978872

PTET:

122323685(slc9a3.2) 122323686(slc9a3.1)

LROH:

127181682(slc9a3.2) 127181683(slc9a3.1)

OMC:	131526209(slc9a3.1) 131526229(slc9a3.2)

PPRM:

120483301(slc9a3.2) 120483740(slc9a3.1)

RKG:	130097389(slc9a3.2) 130097390(slc9a3.1)

MAMB:

125275317(slc9a3.1) 125275319(slc9a3.2)

CIDE:

127501525 127501526

CERY:

137037202(slc9a3.2) 137037545(slc9a3.1)

MASI:

127421525 127421576 127425073 127425080

TROS:

130567047(slc9a3.1) 130567397(slc9a3.2)

TDW:	130416059(slc9a3.2) 130416075(slc9a3.1)

MANU:

129455710(slc9a3.2) 129455712(slc9a3.1)

IPU:	108272766(slc9a3.1)

IFU:	128615790(slc9a3.1)

PHYP:

SMEO:

TFD:

TVC:

TRN:	134300956(slc9a3.2)

AMEX:

CMAO:

EEE:

CHAR:

TRU:	101071140(slc9a3)

TFS:	130518136(slc9a3.1)

TNG:	GSTEN00003672G001

LCO:	104928068(slc9a3)

TBEN:

117477935

CGOB:

115015628(slc9a3)

PGEO:

GACU:

EMAC:

ELY:

EFO:

PLEP:

SLUC:

116047174(slc9a3.1)

ECRA:

117957051

ESP:	116701800(slc9a3)

PFLV:

114567741(slc9a3)

GAT:	120826635(slc9a3.1)

PPUG:

119218886

AFB:

129097143

CLUM:

117739547(slc9a3.1)

PSWI:

130197206(slc9a3.1)

MSAM:

SCHU:

CUD:

ALAT:

MZE:	101473782 101474089 101474645

ONL:	100691637 100692172 100708352 100708625

OAU:	116315549 116318884(slc9a3.2) 116318885 116318886

OLA:	100529178(slc9a3)

OML:

CSAI:

XMA:

XCO:

XHE:

PRET:

PFOR:

103143487(slc9a3)

PLAI:

106946894

PMEI:

106927618(slc9a3)

GAF:

PPRL:

CVG:

CTUL:

GMU:	124878841 124879811

NFU:	107394886(slc9a3)

KMR:

108228835

ALIM:

106530104(slc9a3)

AOCE:

111586623(slc9a3)

MCEP:

125020272

CSEM:

103393986(slc9a3)

POV:

109640390

SSEN:

122786200

HHIP:

117770232(slc9a3.1)

HSP:	118124549(slc9a3.1)

PPLT:

128461732

SMAU:

118291615

LCF:

108899344

SDU:	111230512(slc9a3)

SLAL:

111661084(slc9a3)

XGL:

120786825

HCQ:	109513642 109513643

SSCV:

SBIA:

PEE:

PTAO:

BPEC:

110168850(slc9a3)

MALB:

109958671(slc9a3)

BSPL:

114865424(slc9a3.1)

SJO:

128373873

SASA:

106569766 106583044 106588241

STRU:

115150782 115176105

OTW:	112230021 112254426 112264937

OMY:	100136705(nhe3) 100301645(nhe3b) 110496081

OGO:	124012840 124031430 124043705

ONE:	115128271 115131809 115138169

OKI:	109891005 109903780 109908519

OKE:	118398331 118399182 118400158

SALP:

111955107 111955465 111969933

SNH:	120022386 120027327 120065611

CCLU:

121571382 121578659 121585534

ELS:	105028268(slc9a3)

SFM:	108933390(slc9a3)

PKI:	111834096(slc9a3)

AANG:

118233766(slc9a3.1)

LOC:	102687033 102687235(slc9a3)

PSPA:

121309200 121314870

ARUT:

117400010 117435359 117970933

PSEX:

120515639

LCM:	102347744(SLC9A3)

CMK:

103176226

RTP:	109921751 109931870

CPLA:

122564452 122564453

HOC:	132832320 132832336

LERI:

129706890

PMRN:

116944128 116954070

LRJ:	133350838 133355889

BFO:

CIN:

SCLV:

SPU:

LPIC:

APLC:

110978534 110984401 110986091

ARUN:

117305439

SKO:

100370587

DME:	Dmel_CG9256(Nhe2)

DER:

6548699

DSE:

6618240

DSI:	Dsimw501_GD24301(Dsim_GD24301)

DYA:	Dyak_GE12897

DAN:

DSR:

DPO:

DPE:

DMN:

DWI:

DGR:

DMO:	Dmoj_GI21064

DAZ:

DNV:

DHE:

DVI:

CCAT:

BOD:

BDR:

RZE:

AOQ:

TDA:

MDE:

SCAC:

LCQ:

LSQ:

GFS:

ECOE:

CLON:

HIS:

AGA:

ACOZ:

AARA:

AMER:

ASTE:

AFUN:

AMOU:

AALI:

AAG:

AALB:

ASUA:

CQU:	CpipJ_CPIJ009357

CPII:

CNS:

BCOO:

AME:

ACER:

ALAB:

ADR:

BIM:

BBIF:

BVK:

BVAN:

BTER:

BAFF:

BPYO:

BPAS:

CCAL:

OBB:

OLG:

MGEN:

NMEA:

CGIG:

SOC:

MPHA:

AEC:

ACEP:

PBAR:

VEM:

HST:

DQU:

CFO:

FEX:

LHU:	105676318(Nhe2)

PGC:

OBO:

PCF:

PFUC:

VPS:

VCRB:

VVE:

NVI:

CSOL:

TPRE:

LHT:

LBD:

MDL:

CGLO:

FAS:

DAM:

AGIF:

CINS:

VCAN:

CCIN:

DSM:

NPT:

NFB:

NLO:

NVG:

AROA:

TCA:

DPA:

SOY:

AGRG:

ATD:

CSET:

AGB:

LDC:

DVV:

APLN:

PPYR:

OTU:

BMOR:

BMAN:

MSEX:

DPL:	KGM_213550

BANY:

MJU:

NIQ:

VCD:

MCIX:

PMAC:

PPOT:

PXU:

PRAP:

PBX:

PNAP:

ZCE:

CCRC:

LSIN:

AAGE:

HAW:

HZE:

TNL:

SLIU:

OFU:

ATRA:

GMW:

PXY:

PGW:

LGLY:

CFEL:

CCRN:

BTAB:

DCI:	103513877 103516187

CLEC:

106667259

HHAL:

106689399(Nhe2)

NLU:

111054054

HVI:

124353580

MQU:

129004470

PHU:	Phum_PHUM467900

FOC:

113211445

TPAL:

117650429

ZNE:	110834034 110835424

CSEC:

SGRE:

BROR:

IEL:

FCD:	110842360 110856505

DPX:	DAPPUDRAFT_217278 DAPPUDRAFT_300379

DMK:

116932696

DPZ:	124312896 124312899 124348401 124349277

PVM:	113810734 113818806

PJA:

PCHN:

PMOO:

PCLA:

CQD:	128694861 128694866

PTRU:

ESN:

MNZ:

HAZT:

EAF:	111699427 111702721 111709267 111710798 111713914

LSM:

121130598

TCF:	131885383 131885388

PPOI:

119104177 119105534 119111061

DSV:

RSAN:

RMP:

VDE:

VJA:

TUT:	107360381 107362085

DPTE:

113794807

DFR:

124497772

CSCU:

111620583 111642254

CVS:	136970157 136979744

PTEP:

107439993 107448946 107452408

ABRU:

129958540 129971123

UDV:	129218777 129221161

SDM:

118182204

LPOL:

106458872 106461598 106463078 106478166

NAI:	NECAME_01826 NECAME_16109

TSP:

Tsp_11628

HRO:	HELRODRAFT_106963

PVUL:

PCAN:

GAE:

HRF:

HRJ:	124253200 124253207 124285988

CRG:

CANU:

CVN:

OED:

MYI:	110447473 110455817 110462655

PMAX:

MMER:

DPOL:

MAEA:

OSN:

LJP:	135475166 135479397

LAK:	106154270 106177722

OVI:	T265_01664 T265_01665 T265_01668 T265_01669 T265_01670

EGL:	EGR_04831 EGR_05807 EGR_05808 EGR_09019

LLON:

NVE:

EPA:

ATEN:

AMIL:

PDAM:

SPIS:

DGT:

HMG:

Reference

PMID:10666043

Authors

Praetorius J, Andreasen D, Jensen BL, Ainsworth MA, Friis UG, Johansen T

Title

NHE1, NHE2, and NHE3 contribute to regulation of intracellular pH in murine duodenal epithelial cells.

Journal

Am J Physiol Gastrointest Liver Physiol 278:G197-206 (2000)
DOI:10.1152/ajpgi.2000.278.2.G197

Sequence

[mmu:105243]

Reference

PMID:14758480

Authors

Bonnici B, Wagner CA

Title

Postnatal expression of transport proteins involved in acid-base transport in mouse kidney.

Journal

Pflugers Arch 448:16-28 (2004)
DOI:10.1007/s00424-003-1227-4

Reference

PMID:15994375

Authors

Choe KP, Kato A, Hirose S, Plata C, Sindic A, Romero MF, Claiborne JB, Evans DH

Title

NHE3 in an ancestral vertebrate: primary sequence, distribution, localization, and function in gills.

Journal

Am J Physiol Regul Integr Comp Physiol 289:R1520-34 (2005)
DOI:10.1152/ajpregu.00048.2005

Reference

PMID:15643048

Authors

Brett CL, Donowitz M, Rao R

Title

Evolutionary origins of eukaryotic sodium/proton exchangers.

Journal

Am J Physiol Cell Physiol 288:C223-39 (2005)
DOI:10.1152/ajpcell.00360.2004

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Ontology (6)   
   KEGG BRITE (2)   
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   TC (3)   
Pathway (8)   
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   KEGG DISEASE (1)   
Drug (2)   
   KEGG DRUG (2)   
Gene (2880)   
   KEGG GENES (745)   
   KEGG MGENES (361)   
   RefGene (1766)   
   OC (8)   
Literature (4)   
   PubMed (4)   
All databases (2901)   

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