KEGG ORTHOLOGY: K12076

ORTHOLOGY: K12076

Entry

K12076                      KO

Symbol

DLG1

Name

disks large protein 1

Pathway

map04390

Hippo signaling pathway

map04391

Hippo signaling pathway - fly

map04530

Tight junction

map04660

T cell receptor signaling pathway

map05165

Human papillomavirus infection

map05166

Human T-cell leukemia virus 1 infection

map05203

Viral carcinogenesis

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04390 Hippo signaling pathway
    K12076  DLG1; disks large protein 1
   04391 Hippo signaling pathway - fly
    K12076  DLG1; disks large protein 1
09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04530 Tight junction
    K12076  DLG1; disks large protein 1
09150 Organismal Systems
  09151 Immune system
   04660 T cell receptor signaling pathway
    K12076  DLG1; disks large protein 1
09160 Human Diseases
  09161 Cancer: overview
   05203 Viral carcinogenesis
    K12076  DLG1; disks large protein 1
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    K12076  DLG1; disks large protein 1
   05165 Human papillomavirus infection
    K12076  DLG1; disks large protein 1
09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03036 Chromosome and associated proteins
    K12076  DLG1; disks large protein 1
Chromosome and associated proteins [BR:ko03036]
Eukaryotic type
  Centrosome formation proteins
   Other centrosome associated proteins
    K12076  DLG1; disks large protein 1

Genes

HSA:	1739(DLG1)

PTR:	460968(DLG1)

PPS:	100987596(DLG1)

GGO:	101132886(DLG1)

PON:	100444925(DLG1)

PPYG:

129032723(DLG1)

NLE:	100603856(DLG1)

HMH:	116480008(DLG1)

SSYN:

134733200(DLG1)

MCC:	709572(DLG1)

MCF:	102123600(DLG1)

MTHB:

126947952

MNI:	105470793(DLG1)

CSAB:

103241973(DLG1)

CATY:

105575147(DLG1)

PANU:

101017325(DLG1)

TGE:	112618689(DLG1)

MLEU:

105545916(DLG1)

RRO:	104676365(DLG1)

RBB:	108530521(DLG1)

TFN:	117084441(DLG1)

CANG:

105525518(DLG1)

CJC:	100401687(DLG1)

SBQ:	101032502(DLG1)

CIMI:

108300264(DLG1)

ANAN:

105705235(DLG1)

CSYR:

103276722(DLG1)

MMUR:

105879800(DLG1)

LCAT:

123630419(DLG1)

PCOQ:

105807991(DLG1)

OGA:	100941673(DLG1)

MMU:	13383(Dlg1)

MCAL:

110311707(Dlg1)

MPAH:

110329715(Dlg1)

RNO:	25252(Dlg1)

MCOC:

116085801(Dlg1)

ANU:	117718155(Dlg1)

MUN:	110553298(Dlg1)

CGE:	100774630(Dlg1)

MAUA:

101836528(Dlg1)

PROB:

127227052(Dlg1)

PLEU:

114710020(Dlg1)

MORG:

121461810(Dlg1)

MFOT:

126512159

AAMP:

119825325(Dlg1)

NGI:	103738531(Dlg1)

HGL:	101716409(Dlg1)

CCAN:

109699995

DORD:

105987886(Dlg1)

DSP:	122099335(Dlg1)

PLOP:

125351837(Dlg1)

NCAR:

124992640

MMMA:

107143219(Dlg1)

OCU:

100339253

OPI:	101519328(DLG1)

TUP:	102468222(DLG1)

GVR:

103601545

CFA:	488036(DLG1)

CLUD:

112676377(DLG1)

VVP:	112913543(DLG1)

VLG:	121486853(DLG1)

NPO:	129503650(DLG1)

AML:	100481489(DLG1)

UMR:	103678920(DLG1)

UAH:	113253232(DLG1)

UAR:	123802097(DLG1)

ELK:

111155042

LLV:

125102466

MPUF:

101672385(DLG1)

MNP:	132011914(DLG1)

MLK:	131824691(DLG1)

NVS:	122908825(DLG1)

ORO:	101363847(DLG1)

EJU:	114206958(DLG1)

ZCA:	113916566(DLG1)

MLX:	118006967(DLG1)

NSU:	110582548(DLG1)

LWW:	102742814(DLG1)

FCA:	101084051(DLG1)

PYU:	121036407(DLG1)

PCOO:

112849898(DLG1)

PBG:	122491584(DLG1)

PVIV:

125174900(DLG1)

LRUF:

124527049

PTG:	102971040(DLG1)

PPAD:

109266561(DLG1)

PUC:

125921053

AJU:

106976354

HHV:	120244365(DLG1)

BTA:	785291(DLG1)

BOM:	102284602(DLG1)

BIU:	109562672(DLG1)

BBUB:

102396861(DLG1)

BBIS:

104984563(DLG1)

CHX:	102178485(DLG1)

OAS:	101103028(DLG1)

BTAX:

128053795(DLG1)

ODA:	120870023(DLG1)

CCAD:

122444689(DLG1)

MBEZ:

129543789(DLG1)

SSC:	100157729(DLG1)

CFR:	102508504(DLG1)

CBAI:

105072377(DLG1)

CDK:	105101276(DLG1)

VPC:	102538971(DLG1)

BACU:

103001527(DLG1)

BMUS:

118894116(DLG1)

LVE:	103079722(DLG1)

OOR:	101270560(DLG1)

DLE:	111172354(DLG1)

PCAD:

102986766(DLG1)

PSIU:

116752867(DLG1)

NASI:

112404263(DLG1)

ECB:	100060094(DLG1)

EPZ:

103559183

EAI:	106848317(DLG1)

MYB:	102251241(DLG1)

MYD:	102771948(DLG1)

MMYO:

118677032(DLG1)

MLF:	102436423(DLG1)

MDT:	132230265(DLG1)

PKL:	118724613(DLG1)

EFUS:

103303537(DLG1)

MNA:	107527282(DLG1)

DRO:	112320513(DLG1)

SHON:

118980856(DLG1)

AJM:	119050862(DLG1)

PDIC:

114490980(DLG1)

PHAS:

123826784(DLG1)

MMF:	118617313(DLG1)

PPAM:

129071786(DLG1)

HAI:	109387512(DLG1)

RFQ:	117034744(DLG1)

PALE:

102887557(DLG1)

PGIG:

120592931(DLG1)

PVP:	105306273(DLG1)

RAY:	107505282(DLG1)

MJV:	108408003(DLG1)

TOD:	119257413(DLG1)

SARA:

101552433(DLG1)

SETR:

126012126(DLG1)

LAV:	100662117(DLG1)

TMU:

101353387

ETF:	101656004(DLG1)

DNM:	101446715(DLG1)

MDO:	100017371(DLG1)

GAS:	123242790(DLG1)

SHR:	100924037(DLG1)

AFZ:

127558287

PCW:	110193183(DLG1)

TVP:	118846114(DLG1)

OAA:	100082103(DLG1)

GGA:	424890(DLG1)

PCOC:

116230867(DLG1)

MGP:	100545279(DLG1)

CJO:	107318156(DLG1)

TPAI:

128082569(DLG1)

LMUT:

125697323(DLG1)

NMEL:

110397341(DLG1)

CATA:

118247040(DLG1)

AFUL:

116492728(DLG1)

TGU:	100220198(DLG1)

LSR:	110473916(DLG1)

SCAN:

103815402(DLG1)

PMOA:

120508544(DLG1)

OTC:	121341175(DLG1)

PRUF:

121357932(DLG1)

GFR:	102034754(DLG1)

FAB:	101813757(DLG1)

OMA:	130256769(DLG1)

PHI:	102113578(DLG1)

PMAJ:

107208781(DLG1)

CCAE:

111933478(DLG1)

CCW:	104693473(DLG1)

CBRC:

103624816(DLG1)

ETL:	114057579(DLG1)

ZAB:	102068932(DLG1)

ZLE:	135451921(DLG1)

ACHL:

103800472

SVG:	106862577(DLG1)

MMEA:

130580391(DLG1)

HRT:	120756916(DLG1)

SATI:

136365692(DLG1)

FPG:	101914926(DLG1)

FCH:	102052280(DLG1)

CCRI:

104159045(DLG1)

NNT:

104412132

SHAB:

115611598(DLG1)

ACUN:

113483502(DLG1)

TALA:

104366487(DLG1)

ACHC:

115346785(DLG1)

HALD:

104312483

HLE:	104832309(DLG1)

AGEN:

126039951

GCL:

127019892

CSTI:

104558845(DLG1)

LDI:	104347088(DLG1)

MNB:	103781660(DLG1)

DPUB:

104307656(DLG1)

AVIT:

104276867

BRHI:

104502200(DLG1)

EGZ:	104127125(DLG1)

NNI:	104015686(DLG1)

PCAO:

104046549

PADL:

103913851(DLG1)

AFOR:

103901510(DLG1)

FGA:

104071153

GSTE:

104251743(DLG1)

CLV:	102091278(DLG1)

MUI:

104543534

PGUU:

104464082

PLET:

104616654

EHS:	104510135(DLG1)

CMAC:

104478996

CUCA:

104063423(DLG1)

TEO:	104376637(DLG1)

BREG:

104642506(DLG1)

OHA:	104338755(DLG1)

ACAR:

104522935(DLG1)

CPEA:

104392330(DLG1)

CVF:	104284987(DLG1)

RTD:	128911798(DLG1)

AAM:	106485876(DLG1)

AROW:

112962134(DLG1)

NPD:	112947440(DLG1)

TGT:	104575035(DLG1)

DNE:	112981701(DLG1)

SCAM:

104153218(DLG1)

ASN:	102388205(DLG1)

AMJ:	102560983(DLG1)

GGN:	109288131(DLG1)

PSS:	102453762(DLG1)

CMY:	102946800(DLG1)

CCAY:

125642745(DLG1)

DCC:	119861796(DLG1)

CPIC:

101941940(DLG1)

TST:	117882505(DLG1)

CABI:

116828961(DLG1)

MRV:	120372183(DLG1)

ASAO:

132769759(DLG1)

PVT:

110087113

SUND:

121926572(DLG1)

PBI:	103061777(DLG1)

PMUR:

107291694(DLG1)

CTIG:

120307170(DLG1)

TSR:	106551581(DLG1)

PGUT:

117669846(DLG1)

APRI:

131200565(DLG1)

PTEX:

113450929(DLG1)

NSS:	113425174(DLG1)

VKO:	123018785(DLG1)

PMUA:

114598216(DLG1)

PRAF:

128414933(DLG1)

ZVI:	118094082(DLG1)

HCG:	128348775(DLG1)

GJA:	107125637(DLG1)

STOW:

125437662(DLG1)

EMC:	129332146(DLG1)

XLA:	108716985 108718075

XTR:	733937(dlg1)

NPR:	108795997(DLG1)

RTEM:

120936810(DLG1)

BBUF:

120997942(DLG1)

BGAR:

122935704(DLG1)

MUO:	115479146(DLG1)

GSH:	117366621(DLG1)

DRE:	114446(dlg1a) 497648(dlg1b)

SRX:	107705307 107709173 107728401 107738730

SANH:

107653521 107659037 107660320 107692362

SGH:	107550443(dlg1) 107564254 107591188

CCAR:

109079802 109084421 109097926

CAUA:

113045744 113050581 113065306 113099647 113115091

CGIB:

127950397 127959327 128015600 128022506

PTET:

122327566(dlg1b) 122347478(dlg1a)

LROH:

127167435(dlg1a) 127174633(dlg1b)

OMC:	131531621(dlg1b) 131541911(dlg1a)

PPRM:

120479903(dlg1b) 120493049(dlg1a)

RKG:	130091147(dlg1a) 130098005(dlg1b)

MAMB:

125271660(dlg1b) 125273946(dlg1a)

CIDE:

127506853 127513977

CERY:

137003697(dlg1b) 137010523(dlg1a)

MASI:

127441476 127442008 127445611 127448861

TROS:

130554427(dlg1b) 130557124(dlg1a)

TDW:	130418071(dlg1b) 130425195(dlg1a)

MANU:

129442560(dlg1b) 129450208(dlg1a)

IPU:	108271975(dlg1a) 108280564(dlg1b)

IFU:	128614989(dlg1a) 128624296(dlg1b)

PHYP:

113528380 113546395

SMEO:

124393258(dlg1a) 124402770(dlg1b)

TFD:	113642961(dlg1a) 113650086(dlg1b)

TVC:	132844335(dlg1a) 132844503(dlg1b)

TRN:	134302850(dlg1b) 134317256(dlg1a)

AMEX:

103021716(dlg1a) 103032064(dlg1b)

CMAO:

118796740(dlg1l) 118807994(dlg1)

EEE:	113579531 113590541(dlg1)

CHAR:

105899217(dlg1b) 105912929(dlg1a)

TRU:	101063550(dlg1) 101067056

TFS:	130529306 130538339

TNG:	GSTEN00011480G001

LCO:	104939045 104939120 104939266

NCC:	104946575(dlg1)

TBEN:

CGOB:

PGEO:

GACU:

EMAC:

134866235(dlg1b) 134869563

ELY:	117253444 117271975(dlg1l)

EFO:	125895515 125902869(dlg1b)

PLEP:

SLUC:

ECRA:

ESP:

PFLV:

114561748 114564775(dlg1)

GAT:	120814893 120824323

PPUG:

119209006(dlg1l) 119216778

AFB:	129089280(dlg1b) 129094992

CLUM:

117729574 117746426(dlg1l)

PSWI:

130190911(dlg1b) 130193617(dlg1a)

MSAM:

119900364 119902695

SCHU:

122878315 122886951(dlg1b)

CUD:	121512285 121519831(dlg1b)

ALAT:

119010645 119028594

MZE:	101468517 101473605(dlg1)

ONL:	100696554 100697840

OAU:	116314196 116336356

OLA:	101156681 101171070

OML:	112144252(dlg1l) 112150267

CSAI:

133452365 133458595

XMA:	102219363 102220044

XCO:	114145774 114150742

XHE:	116716460 116720928 116725863

PRET:

103460621 103463088(dlg1)

PFOR:

103129486(dlg1) 103156135

PLAI:

106938268(dlg1) 106952755

PMEI:

106921416 106925986(dlg1)

GAF:	122839051 122841666

PPRL:

129351696 129352684 129373265

CVG:	107102374 107102375 107103477(dlg1)

CTUL:

119772509 119773165 119785015

GMU:	124870533 124873635

NFU:	107383683 107392960(dlg1)

KMR:	108228900 108238416

ALIM:

106524105(dlg1) 106531552 106532721 106535784(dlg3)

NWH:	119415276 119430652

AOCE:

111568381(dlg1) 111580207

MCEP:

125009066 125010895

CSEM:

103396276(dlg1) 103396862

POV:	109636679(dlg1) 109645388

SSEN:

122772234 122780544

HHIP:

117760392 117778593(dlg1l)

HSP:	118117630(dlg1b) 118121252

PPLT:

128448322 128454666(dlg1b)

SMAU:

118310712 118317931

LCF:	108880076 108892296(dlg1b) 108902608

SDU:	111231758 111237413

SLAL:

111645407 111649806(dlg1)

XGL:	120790544 120799598

HCQ:	109512742 109518832

SSCV:

125976263 125985127

SBIA:

133503106 133510930(dlg1b)

PEE:	133406791 133411919(dlg1b)

PTAO:

133481290 133488881(dlg1b)

BPEC:

110164226 110165887

MALB:

109961757 109973980

BSPL:

114844622 114854238

SJO:	128362404 128369816

SASA:

106560582(dlg1) 106568684 106583961

STRU:

115156587 115158802 115192178

OTW:	112251094 112251651 112260258(dlg1b)

OMY:	110521846 110524815 110529990(dlg1l)

OGO:	123996580 124009355(dlg1b) 124037986

ONE:	115114090 115145287

OKI:	109875092 109897228 109903054

OKE:	118358901 118396031 118402290(dlg1b)

SALP:

111957243 111971430

SNH:	120055060 120055693

CCLU:

121534111 121534900(dlg1b) 121540404

ELS:	105011989 105023059

SFM:	108921599 108939922

PKI:	111858807 111860396

AANG:

118226472(dlg1) 118229263(dlg1l)

LOC:	102685881(dlg1)

PSPA:

121322890(dlg1b) 121327141

ARUT:

117417163 117423772

PSEX:

120532385(dlg1a)

LCM:	102359739(DLG1)

CMK:

103181252

CPLA:

122556067(dlg1b)

HOC:	132821831(dlg1b)

LERI:

PMRN:

LRJ:

BFO:

BBEL:

CIN:

SPU:

LPIC:

SKO:	100329000(SAP97)

DME:	Dmel_CG1725(dlg1)

DER:

6551603

DSE:

6617665

DSI:	Dsimw501_GD17020(Dsim_GD17020)

DYA:	Dyak_GE15932

DAN:

DSR:

DPO:

DPE:

DMN:

DWI:

DGR:

DMO:	Dmoj_GI15716

DAZ:

108619351

DNV:	108656458 115564664

DHE:

CCAT:

BOD:

BDR:

RZE:

AOQ:

TDA:

MDE:	101889331 101892219

SCAC:

LCQ:

LSQ:

GFS:

ECOE:

CLON:

HIS:

AGA:

ACOZ:

AARA:

AMER:

ASTE:

AFUN:

AMOU:

AALI:

AAG:

AALB:

ASUA:

CQU:	CpipJ_CPIJ009531

CPII:

CNS:

BCOO:

AME:

ACER:

ALAB:

ADR:

AFLR:

BIM:

BBIF:

BVK:	117236049 117238358

BVAN:

BTER:

BAFF:

BPYO:

BPAS:

FVI:

CCAL:

OBB:	114874846 114883068 114883076

OLG:

MGEN:

NMEA:

CGIG:

SOC:

MPHA:

AEC:

ACEP:

PBAR:

VEM:	105559395 105564557

HST:

DQU:

CFO:

FEX:

LHU:	105677469(dlg1)

PGC:

OBO:

PCF:

PFUC:

VPS:

VCRB:

VVE:

NVI:	100119218 100123718

CSOL:

TPRE:

LHT:

LBD:

MDL:

CGLO:

FAS:

DAM:

AGIF:

CINS:

VCAN:

CCIN:

DSM:

NPT:

NFB:

NLO:

NVG:

AROA:

TCA:

DPA:

SOY:

AGRG:

CSET:

AGB:

LDC:

DVV:

NVL:	108561152 108569963

APLN:

PPYR:

OTU:

BMOR:

BMAN:

MSEX:

DPL:	KGM_202075 KGM_214049

BANY:

112044894 112053715

MJU:	123867416 123869765

NIQ:	126768939 126771039

VCD:	124532110 124532420

MCIX:

123655336 123655941

PMAC:

106715022 106720699

PPOT:

106103598 106106606

PXU:	106116055 106126574

PRAP:

110994339 110996950

PBX:	123710603 123717564

PNAP:

ZCE:

CCRC:

LSIN:

AAGE:

HAW:	110370755 110383987

HZE:	124629570 124632086

TNL:	113497791 113500623

SLIU:

111348085 111355605

OFU:	114356612 114360087

ATRA:

106132407 106134666

GMW:	113512635 113515629

PXY:

105388463

PGW:	126368000 126369650

LGLY:

125224646 125241778

CFEL:

113373031 113373032

CCRN:

123294017

API:	100165774 100166812

DNX:	107164151 107165505

AGS:	114127821 114129934

RMD:	113548526 113560753

ACOO:

126834349 126835220

DVT:	126906153 126910518

BTAB:

CLEC:

HHAL:

NLU:

HVI:

MQU:	128988457 128991111

PHU:	Phum_PHUM577960

FOC:

TPAL:

ZNE:

CSEC:

SGRE:

BROR:

FCD:

DPX:	DAPPUDRAFT_214226

DMK:

DPZ:

PVM:

PJA:

PCHN:

PMOO:

HAME:

PCLA:

CQD:

PTRU:

ESN:	126993198 127007446

MNZ:

135198512

HAZT:

108670993

EAF:	111698640 111704513

LSM:	121117666 121125157

TCF:	131880139 131884614

PPOI:

119096361 119096697 119109156

ISC:

DSV:

RSAN:

VDE:

VJA:

DPTE:

CSCU:

CVS:	136989045(dlg1)

PTEP:

107439267 107440719

ABRU:

129962641 129968742

UDV:	129216806 129227577

SDM:

118184470

LPOL:

106460238 106465346 106472696 106478764

PMEO:

129600710

CEL:	CELE_C25F6.2(dlg-1)

CBR:	CBG_14691(Cbr-dlg-1)

CRQ:	GCK72_024430

NAI:	NECAME_08367

BMY:	BM_BM2372(Bma-dlg-1)

LOA:	LOAG_16975

TSP:

Tsp_08375

HRO:	HELRODRAFT_208518 HELRODRAFT_73781 HELRODRAFT_75327 HELRODRAFT_95514

PVUL:

PCAN:

BGT:

GAE:

HRF:

HRJ:

CRG:

CANU:

CVN:

OED:

MYI:

PMAX:

MCAF:

MMER:

RPHI:

DPOL:

MAEA:

OBI:

OSN:

LJP:

LAK:	106169289 106171195 106176764

SMM:	Smp_146240 Smp_170290

OVI:	T265_03670

EGL:

LLON:

NVE:

EPA:

ATEN:

ADF:

AMIL:

PDAM:

SPIS:

DGT:

XEN:

HMG:

HSY:

RES:

TAD:	TRIADDRAFT_63520

AQU:

100641739

SRE:	PTSG_12450

GTT:	GUITHDRAFT_132899

» show all

Reference

PMID:17187070

Authors

Round JL, Humphries LA, Tomassian T, Mittelstadt P, Zhang M, Miceli MC

Title

Scaffold protein Dlgh1 coordinates alternative p38 kinase activation, directing T cell receptor signals toward NFAT but not NF-kappaB transcription factors.

Journal

Nat Immunol 8:154-61 (2007)
DOI:10.1038/ni1422

Reference

PMID:8678991

Authors

Burgess DL, Rafael JA, Meisler MH, Chamberlain JS

Title

Dlgh1, a mouse homolog of the drosophila discs-large gene, is located on chromosome 16.

Journal

Mamm Genome 7:623-4 (1996)
DOI:10.1007/s003359900187

Sequence

[mmu:13383]

Reference

PMID:7937897

Authors

Lue RA, Marfatia SM, Branton D, Chishti AH

Title

Cloning and characterization of hdlg: the human homologue of the Drosophila discs large tumor suppressor binds to protein 4.1.

Journal

Proc Natl Acad Sci U S A 91:9818-22 (1994)
DOI:10.1073/pnas.91.21.9818

Sequence

[hsa:1739]

All links

Ontology (2)   
   KEGG BRITE (2)   
Pathway (14)   
   KEGG PATHWAY (14)   
Gene (3280)   
   KEGG GENES (850)   
   KEGG MGENES (383)   
   RefGene (2039)   
   OC (8)   
Literature (3)   
   PubMed (3)   
All databases (3299)   

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