KEGG   ORTHOLOGY: K12196
Entry
K12196                      KO                                     
Symbol
VPS4
Name
vacuolar protein-sorting-associated protein 4
Pathway
map03250  Viral life cycle - HIV-1
map04144  Endocytosis
map04217  Necroptosis
Disease
H02548  CIMDAG syndrome
Brite
KEGG Orthology (KO) [BR:ko00001]
 09120 Genetic Information Processing
  09125 Information processing in viruses
   03250 Viral life cycle - HIV-1
    K12196  VPS4; vacuolar protein-sorting-associated protein 4
 09140 Cellular Processes
  09141 Transport and catabolism
   04144 Endocytosis
    K12196  VPS4; vacuolar protein-sorting-associated protein 4
  09143 Cell growth and death
   04217 Necroptosis
    K12196  VPS4; vacuolar protein-sorting-associated protein 4
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking
    K12196  VPS4; vacuolar protein-sorting-associated protein 4
   03400 DNA repair and recombination proteins
    K12196  VPS4; vacuolar protein-sorting-associated protein 4
Membrane trafficking [BR:ko04131]
 Endosome - Lysosome transport
  Endosomal sorting complexes required for transport (ESCRT)
   ESCRT-III complex
    K12196  VPS4; vacuolar protein-sorting-associated protein 4
DNA repair and recombination proteins [BR:ko03400]
 Eukaryotic type
  Check point factors
   Other check point factors
    K12196  VPS4; vacuolar protein-sorting-associated protein 4
Genes
HSA: 27183(VPS4A) 9525(VPS4B)
PTR: 468565(VPS4B) 743569(VPS4A)
PPS: 100979126(VPS4A) 100985727(VPS4B)
GGO: 101137221(VPS4B) 109024872(VPS4A)
PON: 100173605(VPS4B) 100432461(VPS4A)
NLE: 100599923(VPS4B) 100600466(VPS4A)
MCC: 705277(VPS4A) 707614(VPS4B)
MCF: 102117132(VPS4A) 102137049(VPS4B)
CSAB: 103233218(VPS4A) 103244163(VPS4B)
CATY: 105581326(VPS4A) 105590008(VPS4B)
PANU: 100997079 101007665(VPS4A) 116271491(VPS4B)
TGE: 112611541(VPS4B) 112614435(VPS4A)
RRO: 104655887(VPS4A) 104682246(VPS4B)
RBB: 108514504 108526371(VPS4B)
TFN: 117087969(VPS4A) 117099757(VPS4B)
PTEH: 111528444(VPS4B) 111529744 111532310 111541401(VPS4A)
CJC: 100401960(VPS4A) 100409304(VPS4B)
SBQ: 101040109(VPS4B) 101040422(VPS4A)
CSYR: 103257383(VPS4B) 103272546(VPS4A)
MMUR: 105858965(VPS4A) 105876726(VPS4B)
OGA: 100947446(VPS4B) 100953004 100954094(VPS4A)
MMU: 116733(Vps4a) 20479(Vps4b)
MCAL: 110299445(Vps4b) 110300585(Vps4a)
MPAH: 110321353(Vps4b) 110337232(Vps4a)
RNO: 246772(Vps4a) 360834(Vps4b)
MCOC: 116070112(Vps4a) 116097347(Vps4b)
MUN: 110546079(Vps4a) 110557798(Vps4b)
CGE: 100752222(Vps4b) 100763128(Vps4a)
PLEU: 114683424(Vps4a) 114702807(Vps4b)
NGI: 103734774(Vps4a) 103740101(Vps4b)
HGL: 101702359(Vps4b) 101716007(Vps4a)
CPOC: 100724580(Vps4a) 100730380(Vps4b)
CCAN: 109693755(Vps4b) 109693768(Vps4a)
DORD: 105982948(Vps4a) 105987656(Vps4b)
DSP: 122119435(Vps4b) 122126191(Vps4a)
OCU: 100338152(VPS4B) 100340140(VPS4A)
OPI: 101517047(VPS4B) 101530528(VPS4A)
TUP: 102473200(VPS4B) 102490804(VPS4A)
CFA: 479674(VPS4A) 607306(VPS4B)
VVP: 112919309(VPS4B) 112929525(VPS4A)
VLG: 121481833(VPS4B) 121500326(VPS4A)
AML: 100478745(VPS4A) 100484849(VPS4B)
UMR: 103673616(VPS4A) 103675825(VPS4B)
UAH: 113252426(VPS4A) 113253497(VPS4B)
UAR: 123787456(VPS4B) 123803527(VPS4A)
MPUF: 101674867(VPS4B) 101682545 101685573(VPS4A)
ORO: 101372624(VPS4A) 101373051(VPS4B)
EJU: 114201661(VPS4A) 114208837(VPS4B)
ZCA: 113911395 113912801(VPS4B) 113935986(VPS4A)
MLX: 118004776(VPS4B) 118023625(VPS4A)
FCA: 101082613(VPS4A) 101083116(VPS4B)
PYU: 121009714(VPS4A) 121032834(VPS4B)
PBG: 122470837(VPS4B) 122494395(VPS4A)
PTG: 102950702(VPS4A) 102951832(VPS4B)
PPAD: 109270708(VPS4A) 109275620(VPS4B)
AJU: 106972439(VPS4A) 106985026(VPS4B)
HHV: 120223319(VPS4A) 120245031(VPS4B)
BTA: 539357(VPS4B) 618168(VPS4A)
BOM: 102268861(VPS4B) 102280491(VPS4A)
BIU: 109571987(VPS4A) 109577861(VPS4B)
BBUB: 102389981(VPS4B) 102395793(VPS4A)
CHX: 102182624(VPS4A) 102184021(VPS4B)
ODA: 120872692(VPS4A) 120880861(VPS4B)
CCAD: 122420299(VPS4A) 122425637(VPS4B) 122434805
SSC: 100625338(VPS4B) 100627841(VPS4A)
CFR: 102516856(VPS4A) 102524343(VPS4B)
CBAI: 105073900(VPS4B) 105074869(VPS4A)
CDK: 105088403(VPS4A) 105089002(VPS4B)
BACU: 103016217(VPS4B) 103019224(VPS4A)
LVE: 103071904(VPS4A) 103078021(VPS4B)
OOR: 101277421(VPS4B) 101289648(VPS4A)
DLE: 111179582(VPS4A) 111180197(VPS4B)
PCAD: 102976814(VPS4A) 102986996(VPS4B)
PSIU: 116738928(VPS4B) 116743580(VPS4A)
ECB: 100051010(VPS4B) 100067034(VPS4A)
EPZ: 103550770(VPS4B) 103563767(VPS4A)
EAI: 106822421(VPS4A) 106832881(VPS4B)
MYB: 102241816(VPS4B) 102247023(VPS4A)
MYD: 102763274(VPS4B) 102770465(VPS4A)
MMYO: 118662906(VPS4B) 118674441(VPS4A)
MLF: 102429502(VPS4A) 102432927(VPS4B)
MNA: 107527901(VPS4A) 107545445(VPS4B)
PKL: 118707341(VPS4B) 118720926(VPS4A)
HAI: 109390330(VPS4A) 109390786(VPS4B)
DRO: 112300607(VPS4A) 112322756(VPS4B)
SHON: 118979404(VPS4B) 118983801(VPS4A)
AJM: 119043160 119057574(VPS4B) 119061876(VPS4A)
PDIC: 114488087(VPS4A) 114506641(VPS4B)
PHAS: 123805801(VPS4A) 123826128(VPS4B)
MMF: 118618778(VPS4B) 118639229(VPS4A)
RFQ: 117011757(VPS4B) 117035556(VPS4A)
PALE: 102884816(VPS4A) 102896701(VPS4B)
PGIG: 120583522(VPS4B) 120593916(VPS4A)
PVP: 105292716(VPS4B) 105307198(VPS4A)
RAY: 107503919(VPS4B) 107520709(VPS4A)
MJV: 108385220(VPS4B) 108405296(VPS4A)
TOD: 119242992(VPS4B) 119249000(VPS4A)
SARA: 101543175(VPS4A) 101544665 101548980(VPS4B)
LAV: 100661089(VPS4A) 100674984(VPS4B)
DNM: 101416497(VPS4A) 101438946(VPS4B)
MDO: 100020119(VPS4A) 100024840(VPS4B)
GAS: 123233229(VPS4A) 123238272(VPS4B) 123255036
SHR: 100921038(VPS4A) 100934931(VPS4B)
PCW: 110210258(VPS4A) 110214708(VPS4B)
OAA: 100079283(VPS4A) 100084654(VPS4B)
GGA: 420901(VPS4B) 425637(VPS4A)
PCOC: 116226392(VPS4B) 116243687(VPS4A)
MGP: 100544703(VPS4B) 100547487(VPS4A)
CJO: 107309630(VPS4B) 107319482(VPS4A)
NMEL: 110394040(VPS4B) 110404406(VPS4A)
ACYG: 106039935(VPS4B)
AFUL: 116486040(VPS4B) 116486144 116494158(VPS4A)
TGU: 100221971(VPS4B) 100226302(VPS4A)
LSR: 110468817(VPS4A) 110470705(VPS4B)
SCAN: 103816909(VPS4A) 103819384(VPS4B)
PMOA: 120496237(VPS4A) 120508341(VPS4B)
OTC: 121333774(VPS4A) 121348361(VPS4B)
PRUF: 121358043(VPS4B) 121362479(VPS4A)
GFR: 102036378(VPS4B) 102040958(VPS4A)
FAB: 101818437(VPS4B) 101821669(VPS4A)
PHI: 102104733(VPS4A) 102112877(VPS4B)
PMAJ: 107200662(VPS4B) 107209941(VPS4A)
CCAE: 111934726(VPS4A) 111945646
CCW: 104691948(VPS4A) 104698160(VPS4B)
ETL: 114065313(VPS4B) 114067957(VPS4A)
ZAB: 102062220(VPS4B) 102071083(VPS4A)
FPG: 101912913(VPS4A) 101922591(VPS4B)
FCH: 102049796(VPS4A) 102054435(VPS4B)
CLV: 102086404(VPS4A) 102095537(VPS4B)
EGZ: 104122830(VPS4B) 104129689(VPS4A)
NNI: 104021918(VPS4B) 104023614
ACUN: 113476056(VPS4B)
TALA: 104364651(VPS4B) 116965629(VPS4A)
PADL: 103919234(VPS4B)
ACHC: 115346504(VPS4A) 115353001(VPS4B)
AAM: 106500225(VPS4B)
AROW: 112972769(VPS4B) 112975154(VPS4A)
NPD: 112943401(VPS4B) 112947512(VPS4A)
DNE: 112992489(VPS4B) 112994993(VPS4A)
ASN: 102369518(VPS4B) 102379209(VPS4A)
AMJ: 102560443(VPS4A) 102565218(VPS4B)
CPOO: 109310741(VPS4A) 109314900(VPS4B)
GGN: 109289364(VPS4A) 109300880(VPS4B)
PSS: 102447081(VPS4B) 102457115(VPS4A)
CMY: 102934928(VPS4A) 102947817(VPS4B)
CPIC: 101936643(VPS4B) 101950266(VPS4A)
TST: 117873084(VPS4B) 117886692(VPS4A)
CABI: 116819567(VPS4A) 116832015(VPS4B)
MRV: 120384841(VPS4A) 120399026(VPS4B)
ACS: 100559561(vps4a) 100559678(vps4b)
PVT: 110075420(VPS4B) 110076255(VPS4A)
SUND: 121927780(VPS4B) 121937462(VPS4A)
PBI: 103053086 103056985(VPS4A)
PMUR: 107283521(VPS4A) 107283583(VPS4B)
TSR: 106542957(VPS4B) 106555902(VPS4A)
PGUT: 117671060(VPS4A) 117674758(VPS4B)
VKO: 123021592(VPS4B) 123022319(VPS4A)
PMUA: 114600978(VPS4B) 114602082(VPS4A)
ZVI: 118086481(VPS4A) 118089881(VPS4B)
GJA: 107106530(VPS4A) 107108138(VPS4B)
XLA: 100381132(sntb2.S) 379801(vps4b.S) 444796(vps4b.L) 447546(vps4a.L)
XTR: 100158600(vps4a) 496572(vps4b)
NPR: 108787726(VPS4A) 108792579 108793660(VPS4B)
RTEM: 120922004(VPS4A) 120940637(VPS4B)
BBUF: 120980669(VPS4A) 121001176(VPS4B)
BGAR: 122920967(VPS4A) 122939019(VPS4B)
DRE: 393880(vps4b) 767670(vps4a)
IPU: 108267468(vps4b) 108268521(vps4a) 108270689
PHYP: 113527219 113540247(vps4b) 113546647(vps4a)
SMEO: 124386512(vps4a) 124387206(vps4b) 124391743
TRU: 101066795(vps4a) 101069250(vps4b) 101077130
LCO: 104918295(vps4b) 104919108 104937186(vps4a)
NCC: 104957654(vps4b) 104962690
ELY: 117253971 117262206(vps4a) 117264123(vps4b)
PLEP: 121949892(vps4a) 121951516(vps4b) 121963875
SLUC: 116040159(vps4a) 116046057(vps4b) 116058924
ECRA: 117948815(vps4a) 117950160 117954505(vps4b)
GAT: 120809252(vps4a) 120814872 120815678(vps4b)
PPUG: 119196115(vps4a) 119209463(vps4b) 119216202
MSAM: 119887536 119893311(vps4a) 119901047 119902075(vps4b)
CUD: 121511751 121514927(vps4a) 121520426(vps4b)
ONL: 100690436(vps4a) 100709926(vps4b) 100711005
OAU: 116312855(vps4a) 116316969(vps4b) 116331135
OLA: 101160844(vps4b) 101168949(vps4a) 101171319
OML: 112136919 112147589(vps4b) 112152805(vps4a)
XMA: 102223269(vps4a) 102223781(vps4b) 102227389
XCO: 114146157(vps4b) 114150828 114151056(vps4a)
XHE: 116721300(vps4b) 116726031 116735568(vps4a)
PRET: 103463808 103466308(vps4a) 103479576(vps4b)
PFOR: 103137085 103142423(vps4a) 103143024(vps4b) 103152541
GAF: 122835428(vps4a) 122838964 122841205(vps4b)
CTUL: 119772210 119784729(vps4a) 119795702(vps4b)
NFU: 107383940(vps4b) 107389286(vps4a) 107393420
KMR: 108239687(vps4b) 108243410 108246593(vps4a)
ALIM: 106534230(vps4b) 106536447(vps4a)
NWH: 119408035 119415070(vps4b) 119416185(vps4a)
CSEM: 103376678 103379733(vps4a) 103396179(vps4b)
LCF: 108879104 108883439(vps4b) 108901938(vps4a)
SDU: 111226315 111238826(vps4a) 111239006(vps4b)
SLAL: 111647764(vps4a) 111669109 111670491(vps4b)
XGL: 120790493 120793656(vps4a) 120799358(vps4b)
HCQ: 109521221(vps4b) 109532564
BPEC: 110154736 110157420(vps4b) 110169201(vps4a)
MALB: 109951860(vps4a) 109957619(vps4b) 109962068
SASA: 106560901 106569187(VPS4B) 106584355 106599662(VPS4B) 106613859(VPS4B)
ELS: 105018559(vps4a) 105018959(vps4b)
SFM: 108926621(vps4a) 108937480(vps4b)
PKI: 111845957(vps4b) 111851674 111851860(vps4a)
AANG: 118215068(vps4a) 118225301 118228533 118233080(vps4b)
LOC: 102685335(vps4b) 102691710(vps4a)
LCM: 102352172(VPS4A) 102367637
CMK: 103183186 103188095(vps4a)
RTP: 109924156 109930206(vps4b)
CIN: 100180144
DME: Dmel_CG6842(Vps4)
DER: 6550218
DSE: 6614802
DSI: Dsimw501_GD17375(Dsim_GD17375)
DAN: 6502121
DSR: 110184289
DPE: 113566509
DMN: 108155335
DWI: 6652836
DGR: 116805553
DAZ: 108619479
DNV: 115564235
DHE: 111602851
DVI: 6633690
CCAT: 101451106
BOD: 106618718
SCAC: 106088796
LCQ: 111685960
ACOZ: 120957480
AARA: 120906814
CPII: 120413337
CNS: 116343214
AME: 409756
ACER: 107997603
ALAB: 122710786
BIM: 100740675
BBIF: 117207692
BVK: 117236141
BVAN: 117153430
BTER: 100648278
BPYO: 122569461
CCAL: 108632380
OBB: 114882702
MGEN: 117221816
NMEA: 116430419
CGIG: 122395444
SOC: 105204870
MPHA: 105832709
AEC: 105150541
ACEP: 105623898
PBAR: 105426537
VEM: 105557626
HST: 105185614
DQU: 106744055
CFO: 105259410
FEX: 115232878
LHU: 105673553
PGC: 109860799
OBO: 105274636
PCF: 106792207
PFUC: 122518613
VPS: 122632056
NVI: 100118923
CSOL: 105365042
TPRE: 106659376
MDL: 103572757
CGLO: 123267572
FAS: 105264426
DAM: 107045280
AGIF: 122858360
CCIN: 107267977
TCA: 656502(Vsp4) 663681
BMOR: 100313493(Vps4)
BMAN: 114246489
MSEX: 115444289
BANY: 112051598
PMAC: 106718692
PPOT: 106106273
PXU: 106122564
PRAP: 111001147
ZCE: 119837249
HAW: 110375638
OFU: 114361191
API: 100159853
DNX: 107165365
AGS: 114126051
BTAB: 109044110
DCI: 103512383
NLU: 111051708
DMK: 116931820
PTRU: 123512448
EAF: 111717993
TUT: 107372083
DPTE: 113790342
DFR: 124491515
CSCU: 111629280
SDM: 118183222
CEL: CELE_Y34D9A.10(vps-4)
CBR: CBG_22083(Cbr-vps-4)
TSP: Tsp_05353
XEN: 124437849
HMG: 100197636(vps4a) 100197788
AQU: 100635058
ATH: AT1G08270 AT2G27600(SKD1)
CRB: 17889973
CPAP: 110817269
CIT: 102616626
TCC: 18590343
LJA: Lj0g3v0079279.1(Lj0g3v0079279.1) Lj3g3v1149140.1(Lj3g3v1149140.1) Lj3g3v2995710.1(Lj3g3v2995710.1)
FVE: 101313954
RCN: 112202386
PPER: 18773640
PMUM: 103328316
PAVI: 110763308
PDUL: 117630777
PXB: 103954219
CSV: 101218878
BVG: 104900334
SOE: 110785346
CQI: 110689619
DOSA: Os01t0141100-01(Os01g0141100) Os01t0141300-00(Os01g0141300) Os02t0159900-01(Os02g0159900)
OBR: 102710338
BDI: 100837561
SBI: 8073330
SITA: 101759619
SVS: 117857445
PHAI: 112893564
AOF: 109827237
ATR: 18438336
APRO: F751_4119
SCE: YPR173C(VPS4)
ERC: Ecym_2804
KMX: KLMA_70279(VPS4)
NCS: NCAS_0A15130(NCAS0A15130)
NDI: NDAI_0J00290(NDAI0J00290)
TPF: TPHA_0I03200(TPHA0I03200)
TBL: TBLA_0E00840(TBLA0E00840)
TDL: TDEL_0H00410(TDEL0H00410)
KAF: KAFR_0B00410(KAFR0B00410)
CAL: CAALFM_C503090WA(VPS4)
SLB: AWJ20_2567(VPS4)
BNN: FOA43_002680(VPS4)
BBRX: BRETT_001507(VPS4)
NCR: NCU06942
NTE: NEUTE1DRAFT66608(NEUTE1DRAFT_66608)
MGR: MGG_07916
SSCK: SPSK_04312
MAW: MAC_00205
CMT: CCM_00460
BFU: BCIN_02g08530(Bcvps4)
MBE: MBM_06758
ANI: AN3061.2
ANG: ANI_1_424144(An16g03010)
ALUC: AKAW2_70263S(VPS4)
ACHE: ACHE_20889S(VPS4)
APUU: APUU_30467A(VPS4)
ABE: ARB_01169
TVE: TRV_03256
PTE: PTT_16168
SPO: SPAC2G11.06(vps4)
CNE: CNI00460
CNB: CNBH0440
TASA: A1Q1_07863
MRR: Moror_507
ABP: AGABI1DRAFT115434(AGABI1DRAFT_115434)
ABV: AGABI2DRAFT215522(AGABI2DRAFT_215522)
MGL: MGL_0322
MRT: MRET_0981
DDI: DDB_G0284347(vps4)
DFA: DFA_00999(vps4)
EHI: EHI_118900(62.t00004)
PCB: PCHAS_132450(PC000115.02.0)
TAN: TA04080
TPV: TP03_0351
BBO: BBOV_II000190(18.m05996)
CPV: cgd1_3390
SMIN: v1.2.000679.t1(symbB.v1.2.000679.t1) v1.2.037660.t1(symbB.v1.2.037660.t1)
SPAR: SPRG_10874
SMR: Smar_1278
SID: M164_1295
SII: LD85_1424
SIH: SiH_1257
SIR: SiRe_1175
SIC: SiL_1171
AHO: Ahos_1335
NCT: NMSP_0535(vat_4)
NVN: NVIE_025520(cdvC)
BARC: AOA65_0114(vat_1)
LOKI: Lokiarch_37470(vat_4)
PSYT: DSAG12_03699(vat_4)
 » show all
Reference
  Authors
Scheuring S, Rohricht RA, Schoning-Burkhardt B, Beyer A, Muller S, Abts HF, Kohrer K
  Title
Mammalian cells express two VPS4 proteins both of which are involved in intracellular protein trafficking.
  Journal
J Mol Biol 312:469-80 (2001)
DOI:10.1006/jmbi.2001.4917
  Sequence
[hsa:9525 27183]

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