KEGG   ORTHOLOGY: K12252
Entry
K12252                      KO                                     

Name
aruH
Definition
arginine:pyruvate transaminase [EC:2.6.1.84]
Pathway
ko00330  Arginine and proline metabolism
ko01100  Metabolic pathways
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09105 Amino acid metabolism
   00330 Arginine and proline metabolism
    K12252  aruH; arginine:pyruvate transaminase
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01007 Amino acid related enzymes
    K12252  aruH; arginine:pyruvate transaminase
Enzymes [BR:ko01000]
 2. Transferases
  2.6  Transferring nitrogenous groups
   2.6.1  Transaminases
    2.6.1.84  arginine---pyruvate transaminase
     K12252  aruH; arginine:pyruvate transaminase
Amino acid related enzymes [BR:ko01007]
 Aminotransferase (transaminase)
  Class I
   K12252  aruH; arginine:pyruvate transaminase
Other DBs
RN: R08197
COG: COG0436
Genes
PAE: PA4976(aruH)
PAEV: N297_5148
PAEI: N296_5148
PAU: PA14_65770(aspC)
PAP: PSPA7_5709(aspC)
PAG: PLES_53641(aruH)
PAF: PAM18_5087(aruH)
PNC: NCGM2_0542(aspC)
PAEB: NCGM1900_5724(aspC)
PDK: PADK2_26370
PAEP: PA1S_26990
PAEM: U769_27255
PAEL: T223_27450
PAEU: BN889_05521(aruH)
PAEG: AI22_07005
PAEC: M802_5146
PAEO: M801_5013
PRE: PCA10_40340(aspC)
PCQ: PcP3B5_02230(aruH)
PPU: PP_3721(aruH)
PPF: Pput_2042
PPT: PPS_3189
PPB: PPUBIRD1_2041(aspC)
PPI: YSA_09437
PPX: T1E_1732(aspC)
PPUH: B479_15825
PPUT: L483_19365
PPUN: PP4_21010(aspC)
PPUD: DW66_3460
PMON: X969_15335
PMOT: X970_14980
PPRC: PFLCHA0_c27760(aspC2) PFLCHA0_c33840(aspC3)
PPRO: PPC_2762(aruH) PPC_3378
PEN: PSEEN3003(aspC)
PKC: PKB_0124(aspc1)
PSEC: CCOS191_2783(aruH)
PSOS: POS17_2711(aruH) POS17_3331
PSET: THL1_3997
PSIL: PMA3_15850
POJ: PtoMrB4_51000(aruH_2)
AAUS: EP12_18740
SAGA: M5M_04555
MICC: AUP74_01586(aruH_1) AUP74_02850(aruH_2)
MICT: FIU95_03540(aruH)
GAI: IMCC3135_11970(aruH_1)
CSA: Csal_0536
HEL: HELO_2764(aruH)
HBE: BEI_1553(aruH)
CHAE: CH06BL_12510(aruH)
BCEN: DM39_3804
BCT: GEM_4550
BPSL: WS57_08055
BXE: Bxe_B1173
BXB: DR64_6490
BFN: OI25_6931
CABA: SBC2_40600(aruH)
MLO: mlr1282
MHUA: MCHK_2912
MES: Meso_1479
AMIH: CO731_02952(aruH)
SME: SMc02262
SMX: SM11_chr0192(aspC)
SMEL: SM2011_c02262(aspC)
SMER: DU99_02980
SMD: Smed_0178
SFD: USDA257_c01790(aspC2)
SAME: SAMCFNEI73_Ch0558(aspC)
EAD: OV14_1495
NGL: RG1141_CH32880(aruH)
NEN: NCHU2750_30720(aruH)
RHT: NT26_2963(aspC)
SHZ: shn_00815
MMED: Mame_04622(aruH)
SIL: SPO2132(aspC-3) SPOA0066
RUT: FIU92_08160(aruH1) FIU92_13435(aruH2)
JAN: Jann_1956
RDE: RD1_3185(aspC)
RLI: RLO149_c024100(aspC)
PGD: Gal_03952
OAT: OAN307_c22570(aspC)
OAR: OA238_c22200(aspC)
OTM: OSB_16290(aruH)
LAQU: R2C4_03470
PTP: RCA23_c16670(aspC3)
MALG: MALG_01400
LABT: FIU93_14270(aruH)
SPSE: SULPSESMR1_01753(aruH)
RMM: ROSMUCSMR3_01198(aruH)
RID: RIdsm_02296(aruH)
ROH: FIU89_08135(aruH)
LVS: LOKVESSMR4R_02264(aruH)
AHT: ANTHELSMS3_03017(aruH)
ROT: FIV09_08090(aruH)
MALU: KU6B_22800
PAMO: BAR1_07280
PALW: PSAL_036520(aruH)
SECH: B18_10965
HTQ: FRZ44_30830(aruH)
HADH: FRZ61_16780(aruH)
 » show all
Reference
  Authors
Yang Z, Lu CD
  Title
Functional genomics enables identification of genes of the arginine transaminase pathway in Pseudomonas aeruginosa.
  Journal
J Bacteriol 189:3945-53 (2007)
DOI:10.1128/JB.00261-07
  Sequence
[pae:PA4976]

KEGG   ENZYME: 2.6.1.84
Entry
EC 2.6.1.84                 Enzyme                                 

Name
arginine---pyruvate transaminase;
arginine:pyruvate transaminase;
AruH;
ATase
Class
Transferases;
Transferring nitrogenous groups;
Transaminases
Sysname
L-arginine:pyruvate aminotransferase
Reaction(IUBMB)
L-arginine + pyruvate = 5-guanidino-2-oxopentanoate + L-alanine [RN:R08197]
Reaction(KEGG)
R08197
Substrate
L-arginine [CPD:C00062];
pyruvate [CPD:C00022]
Product
5-guanidino-2-oxopentanoate [CPD:C03771];
L-alanine [CPD:C00041]
Comment
A pyridoxal-phosphate protein. While L-arginine is the best substrate, the enzyme exhibits broad substrate specificity, with L-lysine, L-methionine, L-leucine, L-ornithine and L-glutamine also able to act as substrates, but more slowly. Pyruvate cannot be replaced by 2-oxoglutarate as amino-group acceptor. This is the first catalytic enzyme of the arginine transaminase pathway for L-arginine utilization in Pseudomonas aeruginosa. This pathway is only used when the major route of arginine catabolism, i.e. the arginine succinyltransferase pathway, is blocked.
History
EC 2.6.1.84 created 2007
Pathway
ec00330  Arginine and proline metabolism
ec01100  Metabolic pathways
Orthology
K12252  arginine:pyruvate transaminase
Genes
PAE: PA4976(aruH)
PAEV: N297_5148
PAEI: N296_5148
PAU: PA14_65770(aspC)
PAP: PSPA7_5709(aspC)
PAG: PLES_53641(aruH)
PAF: PAM18_5087(aruH)
PNC: NCGM2_0542(aspC)
PAEB: NCGM1900_5724(aspC)
PDK: PADK2_26370
PAEP: PA1S_26990
PAEM: U769_27255
PAEL: T223_27450
PAEU: BN889_05521(aruH)
PAEG: AI22_07005
PAEC: M802_5146
PAEO: M801_5013
PRE: PCA10_40340(aspC)
PCQ: PcP3B5_02230(aruH)
PPU: PP_3721(aruH)
PPF: Pput_2042
PPT: PPS_3189
PPB: PPUBIRD1_2041(aspC)
PPI: YSA_09437
PPX: T1E_1732(aspC)
PPUH: B479_15825
PPUT: L483_19365
PPUN: PP4_21010(aspC)
PPUD: DW66_3460
PMON: X969_15335
PMOT: X970_14980
PPRC: PFLCHA0_c27760(aspC2) PFLCHA0_c33840(aspC3)
PPRO: PPC_2762(aruH) PPC_3378
PEN: PSEEN3003(aspC)
PKC: PKB_0124(aspc1)
PSEC: CCOS191_2783(aruH)
PSOS: POS17_2711(aruH) POS17_3331
PSET: THL1_3997
PSIL: PMA3_15850
POJ: PtoMrB4_51000(aruH_2)
AAUS: EP12_18740
SAGA: M5M_04555
MICC: AUP74_01586(aruH_1) AUP74_02850(aruH_2)
MICT: FIU95_03540(aruH)
GAI: IMCC3135_11970(aruH_1)
CSA: Csal_0536
HEL: HELO_2764(aruH)
HBE: BEI_1553(aruH)
CHAE: CH06BL_12510(aruH)
BCEN: DM39_3804
BCT: GEM_4550
BPSL: WS57_08055
BXE: Bxe_B1173
BXB: DR64_6490
BFN: OI25_6931
CABA: SBC2_40600(aruH)
MLO: mlr1282
MHUA: MCHK_2912
MES: Meso_1479
AMIH: CO731_02952(aruH)
SME: SMc02262
SMX: SM11_chr0192(aspC)
SMEL: SM2011_c02262(aspC)
SMER: DU99_02980
SMD: Smed_0178
SFD: USDA257_c01790(aspC2)
SAME: SAMCFNEI73_Ch0558(aspC)
EAD: OV14_1495
NGL: RG1141_CH32880(aruH)
NEN: NCHU2750_30720(aruH)
RHT: NT26_2963(aspC)
SHZ: shn_00815
MMED: Mame_04622(aruH)
SIL: SPO2132(aspC-3) SPOA0066
RUT: FIU92_08160(aruH1) FIU92_13435(aruH2)
JAN: Jann_1956
RDE: RD1_3185(aspC)
RLI: RLO149_c024100(aspC)
PGD: Gal_03952
OAT: OAN307_c22570(aspC)
OAR: OA238_c22200(aspC)
OTM: OSB_16290(aruH)
LAQU: R2C4_03470
PTP: RCA23_c16670(aspC3)
MALG: MALG_01400
LABT: FIU93_14270(aruH)
SPSE: SULPSESMR1_01753(aruH)
RMM: ROSMUCSMR3_01198(aruH)
RID: RIdsm_02296(aruH)
ROH: FIU89_08135(aruH)
LVS: LOKVESSMR4R_02264(aruH)
AHT: ANTHELSMS3_03017(aruH)
ROT: FIV09_08090(aruH)
MALU: KU6B_22800
PAMO: BAR1_07280
PALW: PSAL_036520(aruH)
SECH: B18_10965
HTQ: FRZ44_30830(aruH)
HADH: FRZ61_16780(aruH)
 » show all
Reference
1  [PMID:17416668]
  Authors
Yang Z, Lu CD.
  Title
Characterization of an arginine:pyruvate transaminase in arginine catabolism of Pseudomonas aeruginosa PAO1.
  Journal
J Bacteriol 189:3954-9 (2007)
DOI:10.1128/JB.00262-07
  Sequence
[pae:PA4976]
Reference
2  [PMID:17416670]
  Authors
Yang Z, Lu CD
  Title
Functional genomics enables identification of genes of the arginine transaminase pathway in Pseudomonas aeruginosa.
  Journal
J Bacteriol 189:3945-53 (2007)
DOI:10.1128/JB.00261-07
  Sequence
[pae:PA4976]
Other DBs
ExplorEnz - The Enzyme Database: 2.6.1.84
IUBMB Enzyme Nomenclature: 2.6.1.84
ExPASy - ENZYME nomenclature database: 2.6.1.84
BRENDA, the Enzyme Database: 2.6.1.84

KEGG   REACTION: R08197
Entry
R08197                      Reaction                               

Name
L-arginine:pyruvate aminotransferase
Definition
L-Arginine + Pyruvate <=> 5-Guanidino-2-oxopentanoate + L-Alanine
Equation
Reaction class
RC00006  C00062_C03771
RC00008  C00022_C00041
Enzyme
Pathway
rn00330  Arginine and proline metabolism
rn01100  Metabolic pathways
Orthology
K12252  arginine:pyruvate transaminase [EC:2.6.1.84]
Other DBs
RHEA: 13836

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