KEGG   ORTHOLOGY: K12253
Entry
K12253                      KO                                     

Name
aruI
Definition
5-guanidino-2-oxopentanoate decarboxylase [EC:4.1.1.75]
Pathway
ko00330  Arginine and proline metabolism
ko01100  Metabolic pathways
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09105 Amino acid metabolism
   00330 Arginine and proline metabolism
    K12253  aruI; 5-guanidino-2-oxopentanoate decarboxylase
Enzymes [BR:ko01000]
 4. Lyases
  4.1  Carbon-carbon lyases
   4.1.1  Carboxy-lyases
    4.1.1.75  5-guanidino-2-oxopentanoate decarboxylase
     K12253  aruI; 5-guanidino-2-oxopentanoate decarboxylase
Other DBs
RN: R03178
COG: COG0028
GO: 0047435
Genes
PAE: PA4977(aruI)
PAEV: N297_5149
PAEI: N296_5149
PAU: PA14_65795
PAP: PSPA7_5710
PAG: PLES_53651(aruI)
PNC: NCGM2_0541
PAEB: NCGM1900_5725
PDK: PADK2_26375
PSG: G655_26230
PAEP: PA1S_26995
PAEM: U769_27260
PAEL: T223_27455
PAEG: AI22_07000
PAEC: M802_5147
PAEO: M801_5014
PCQ: PcP3B5_02220(aruI_1)
PPU: PP_3723(aruI)
PPF: Pput_2040
PPT: PPS_3191
PPI: YSA_09434
PPX: T1E_1730
PPUH: B479_15835
PPUT: L483_19375
PPUN: PP4_20990
PPUD: DW66_3462
PMON: X969_15345
PMOT: X970_14990
PFL: PFL_2714
PPRC: PFLCHA0_c27750(ilvB1)
PPRO: PPC_2761(aruI)
PMAN: OU5_1976
PKC: PKB_0123
PSEM: TO66_13285
PSOS: POS17_2710(aruI)
PANR: A7J50_2200
PSET: THL1_3998
POJ: PtoMrB4_51010(aruI)
MICC: AUP74_02851(aruI_1)
SHZ: shn_17240
RUT: FIU92_05590(ilvG)
RDE: RD1_1943(ilvB)
OTM: OSB_09640(aruI)
SPSE: SULPSESMR1_00851(aruI)
RMM: ROSMUCSMR3_00989(aruI)
RID: RIdsm_03467(aruI)
ROH: FIU89_06845(aruI)
AHT: ANTHELSMS3_04191(aruI)
MALU: KU6B_35330(aruI)
PAMO: BAR1_13645
SECH: B18_10960
SPHT: K426_15955
HTQ: FRZ44_22350(aruI)
HADH: FRZ61_24760(aruI)
BTS: Btus_2445
TMR: Tmar_0213
MOY: CVS54_03500(aruI)
KRH: KRH_21370
KVR: CIB50_0000905(aruI)
MPH: MLP_52890
PSIM: KR76_17655
TCU: Tcur_0450
NML: Namu_2951
GOB: Gobs_3087
AMQ: AMETH_5699(ilvB)
AMYY: YIM_01385(aruI1)
PDX: Psed_4489
CWO: Cwoe_4926
TRO: trd_0363
TLI: Tlie_1792
MOX: DAMO_0156
 » show all
Reference
  Authors
Yang Z, Lu CD
  Title
Functional genomics enables identification of genes of the arginine transaminase pathway in Pseudomonas aeruginosa.
  Journal
J Bacteriol 189:3945-53 (2007)
DOI:10.1128/JB.00261-07
  Sequence
[pae:PA4977]

KEGG   ENZYME: 4.1.1.75
Entry
EC 4.1.1.75                 Enzyme                                 

Name
5-guanidino-2-oxopentanoate decarboxylase;
alpha-ketoarginine decarboxylase;
2-oxo-5-guanidinopentanoate carboxy-lyase
Class
Lyases;
Carbon-carbon lyases;
Carboxy-lyases
Sysname
5-guanidino-2-oxopentanoate carboxy-lyase (4-guanidinobutanal-forming)
Reaction(IUBMB)
5-guanidino-2-oxopentanoate = 4-guanidinobutanal + CO2 [RN:R03178]
Reaction(KEGG)
R03178
Substrate
5-guanidino-2-oxopentanoate [CPD:C03771]
Product
4-guanidinobutanal [CPD:C02647];
CO2 [CPD:C00011]
Comment
Enzyme activity is dependent on the presence of thiamine diphosphate and a divalent cation.
History
EC 4.1.1.75 created 1999
Pathway
ec00330  Arginine and proline metabolism
ec01100  Metabolic pathways
Orthology
K12253  5-guanidino-2-oxopentanoate decarboxylase
Genes
PAE: PA4977(aruI)
PAEV: N297_5149
PAEI: N296_5149
PAU: PA14_65795
PAP: PSPA7_5710
PAG: PLES_53651(aruI)
PNC: NCGM2_0541
PAEB: NCGM1900_5725
PDK: PADK2_26375
PSG: G655_26230
PAEP: PA1S_26995
PAEM: U769_27260
PAEL: T223_27455
PAEG: AI22_07000
PAEC: M802_5147
PAEO: M801_5014
PCQ: PcP3B5_02220(aruI_1)
PPU: PP_3723(aruI)
PPF: Pput_2040
PPT: PPS_3191
PPI: YSA_09434
PPX: T1E_1730
PPUH: B479_15835
PPUT: L483_19375
PPUN: PP4_20990
PPUD: DW66_3462
PMON: X969_15345
PMOT: X970_14990
PFL: PFL_2714
PPRC: PFLCHA0_c27750(ilvB1)
PPRO: PPC_2761(aruI)
PMAN: OU5_1976
PKC: PKB_0123
PSEM: TO66_13285
PSOS: POS17_2710(aruI)
PANR: A7J50_2200
PSET: THL1_3998
POJ: PtoMrB4_51010(aruI)
MICC: AUP74_02851(aruI_1)
SHZ: shn_17240
RUT: FIU92_05590(ilvG)
RDE: RD1_1943(ilvB)
OTM: OSB_09640(aruI)
SPSE: SULPSESMR1_00851(aruI)
RMM: ROSMUCSMR3_00989(aruI)
RID: RIdsm_03467(aruI)
ROH: FIU89_06845(aruI)
AHT: ANTHELSMS3_04191(aruI)
MALU: KU6B_35330(aruI)
PAMO: BAR1_13645
SECH: B18_10960
SPHT: K426_15955
HTQ: FRZ44_22350(aruI)
HADH: FRZ61_24760(aruI)
BTS: Btus_2445
TMR: Tmar_0213
MOY: CVS54_03500(aruI)
KRH: KRH_21370
KVR: CIB50_0000905(aruI)
MPH: MLP_52890
PSIM: KR76_17655
TCU: Tcur_0450
NML: Namu_2951
GOB: Gobs_3087
AMQ: AMETH_5699(ilvB)
AMYY: YIM_01385(aruI1)
PDX: Psed_4489
CWO: Cwoe_4926
TRO: trd_0363
TLI: Tlie_1792
MOX: DAMO_0156
 » show all
Reference
1  [PMID:237915]
  Authors
Vanderbilt AS, Gaby NS, Rodwell VW.
  Title
Intermediates and enzymes between alpha-ketoarginine and gamma-guanidinobutyrate in the L-arginine catabolic pathway of Pseudomonas putida.
  Journal
J Biol Chem 250:5322-9 (1975)
Other DBs
ExplorEnz - The Enzyme Database: 4.1.1.75
IUBMB Enzyme Nomenclature: 4.1.1.75
ExPASy - ENZYME nomenclature database: 4.1.1.75
BRENDA, the Enzyme Database: 4.1.1.75
CAS: 56831-67-5

KEGG   REACTION: R03178
Entry
R03178                      Reaction                               

Name
2-oxo-5-Guanidinopentanoate carboxy-lyase
Definition
5-Guanidino-2-oxopentanoate <=> 4-Guanidinobutanal + CO2
Equation
Reaction class
RC00506  C02647_C03771
Enzyme
Pathway
rn00330  Arginine and proline metabolism
rn01100  Metabolic pathways
Orthology
K12253  5-guanidino-2-oxopentanoate decarboxylase [EC:4.1.1.75]
Other DBs
RHEA: 11343

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