KEGG   ORTHOLOGY: K12254
Entry
K12254                      KO                                     

Name
kauB
Definition
4-guanidinobutyraldehyde dehydrogenase / NAD-dependent aldehyde dehydrogenase [EC:1.2.1.54 1.2.1.-]
Pathway
ko00330  Arginine and proline metabolism
ko01100  Metabolic pathways
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09105 Amino acid metabolism
   00330 Arginine and proline metabolism
    K12254  kauB; 4-guanidinobutyraldehyde dehydrogenase / NAD-dependent aldehyde dehydrogenase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.2  Acting on the aldehyde or oxo group of donors
   1.2.1  With NAD+ or NADP+ as acceptor
    1.2.1.54  gamma-guanidinobutyraldehyde dehydrogenase
     K12254  kauB; 4-guanidinobutyraldehyde dehydrogenase / NAD-dependent aldehyde dehydrogenase
    1.2.1.-  
     K12254  kauB; 4-guanidinobutyraldehyde dehydrogenase / NAD-dependent aldehyde dehydrogenase
Other DBs
RN: R02549 R03177
COG: COG1012
GO: 0047107
Genes
SLQ: M495_12010
XAL: XALC_2105
XSA: SB85_04725
XTN: FD63_11895
XHY: FZ025_01015
XTH: G4Q83_09765
SML: Smlt1571(aldH)
SMT: Smal_1330
BUJ: BurJV3_1321
SMZ: SMD_1402(aldH)
PSUW: WQ53_02590
PSD: DSC_07485
PAE: PA5312
PAEV: N297_5492
PAEI: N296_5492
PAU: PA14_70140(aldH)
PNC: NCGM2_6076(aldH)
PAEB: NCGM1900_6154(aldH)
PAEP: PA1S_28715
PAEM: U769_29220
PAEL: T223_29175
PAEG: AI22_05275
PAEC: M802_5490
PAEO: M801_5357
PMY: Pmen_0237
PMK: MDS_0290
PPSE: BN5_0159
PCQ: PcP3B5_54750(puuC_3) PcP3B5_60480(puuC_4)
PPU: PP_5278(kauB)
PPF: Pput_5188
PPI: YSA_04677
PPX: T1E_2789
PPUH: B479_26140
PPUT: L483_31550
PPUN: PP4_53430
PSB: Psyr_0227
PSYR: N018_00480
PVD: CFBP1590_0205(puuC)
PFL: PFL_6046
PPRC: PFLCHA0_c24080(puuC1) PFLCHA0_c60050(puuC4)
PFS: PFLU_5976(aldH)
PFB: VO64_2867
PEN: PSEEN5424(aldH)
PSA: PST_0046
PSTT: CH92_21230
PKC: PKB_5073(puuc3) PKB_5650(puuc5)
PSEC: CCOS191_5174(puuC3)
PANR: A7J50_5711
PSET: THL1_5607
PALL: UYA_01070
AVN: Avin_48030(aldH)
AVL: AvCA_48030(aldH)
AVD: AvCA6_48030(aldH)
ACX: Achr_37390(aldH)
FBL: Fbal_1146
SAGA: M5M_11425
MICC: AUP74_00575(puuC)
MICT: FIU95_19470(puuC)
HCO: LOKO_02562(puuC)
HBE: BEI_1148
AJP: AMJAP_2131(kauB)
RFO: REIFOR_00600(puuC)
ASA: ASA_4155
AVR: B565_3831
AMED: B224_5460
ASR: WL1483_1298(puuC)
ACAV: VI35_20215
AEL: NCTC12917_04090(puuC)
OCE: GU3_00195
BMK: DM80_3359
PLG: NCTC10937_00050(puuC_1)
HYF: DTO96_100783(puuC)
HYB: Q5W_22305
HPSE: HPF_00630(puuC)
CBAB: SMCB_2218
JAG: GJA_494
LCH: Lcho_1737
TIN: Tint_0186
RGE: RGE_26320(aldH)
PBH: AAW51_2992(puuC)
SIX: BSY16_55
ARA: Arad_8305(dhaL)
MET: M446_3859
RCP: RCAP_rcc02448(aldH2)
SECH: B18_09235
RCE: RC1_1452(puuC)
TXI: TH3_10790
SMAL: SMALA_7627
TBI: Tbis_1741
AMN: RAM_31850
AMM: AMES_6118(puuC)
AMZ: B737_6118(puuC)
 » show all
Reference
  Authors
Yang Z, Lu CD
  Title
Functional genomics enables identification of genes of the arginine transaminase pathway in Pseudomonas aeruginosa.
  Journal
J Bacteriol 189:3945-53 (2007)
DOI:10.1128/JB.00261-07
  Sequence
[pae:PA5312]
Reference
  Authors
Chou HT, Kwon DH, Hegazy M, Lu CD
  Title
Transcriptome analysis of agmatine and putrescine catabolism in Pseudomonas aeruginosa PAO1.
  Journal
J Bacteriol 190:1966-75 (2008)
DOI:10.1128/JB.01804-07

KEGG   ENZYME: 1.2.1.54
Entry
EC 1.2.1.54                 Enzyme                                 

Name
gamma-guanidinobutyraldehyde dehydrogenase;
alpha-guanidinobutyraldehyde dehydrogenase;
4-guanidinobutyraldehyde dehydrogenase;
GBAL dehydrogenase
Class
Oxidoreductases;
Acting on the aldehyde or oxo group of donors;
With NAD+ or NADP+ as acceptor
Sysname
4-guanidinobutanal:NAD+ 1-oxidoreductase
Reaction(IUBMB)
4-guanidinobutanal + NAD+ + H2O = 4-guanidinobutanoate + NADH + 2 H+ [RN:R03177]
Reaction(KEGG)
R03177
Substrate
4-guanidinobutanal [CPD:C02647];
NAD+ [CPD:C00003];
H2O [CPD:C00001]
Product
4-guanidinobutanoate [CPD:C01035];
NADH [CPD:C00004];
H+ [CPD:C00080]
Comment
Involved in the degradation of arginine in Pseudomonas putida (cf. EC 1.2.1.19 aminobutyraldehyde dehydrogenase).
History
EC 1.2.1.54 created 1989
Pathway
ec00330  Arginine and proline metabolism
ec01100  Metabolic pathways
Orthology
K12254  4-guanidinobutyraldehyde dehydrogenase / NAD-dependent aldehyde dehydrogenase
Genes
SLQ: M495_12010
XAL: XALC_2105
XSA: SB85_04725
XTN: FD63_11895
XHY: FZ025_01015
XTH: G4Q83_09765
SML: Smlt1571(aldH)
SMT: Smal_1330
BUJ: BurJV3_1321
SMZ: SMD_1402(aldH)
PSUW: WQ53_02590
PSD: DSC_07485
PAE: PA5312
PAEV: N297_5492
PAEI: N296_5492
PAU: PA14_70140(aldH)
PNC: NCGM2_6076(aldH)
PAEB: NCGM1900_6154(aldH)
PAEP: PA1S_28715
PAEM: U769_29220
PAEL: T223_29175
PAEG: AI22_05275
PAEC: M802_5490
PAEO: M801_5357
PMY: Pmen_0237
PMK: MDS_0290
PPSE: BN5_0159
PCQ: PcP3B5_54750(puuC_3) PcP3B5_60480(puuC_4)
PPU: PP_5278(kauB)
PPF: Pput_5188
PPI: YSA_04677
PPX: T1E_2789
PPUH: B479_26140
PPUT: L483_31550
PPUN: PP4_53430
PSB: Psyr_0227
PSYR: N018_00480
PVD: CFBP1590_0205(puuC)
PFL: PFL_6046
PPRC: PFLCHA0_c24080(puuC1) PFLCHA0_c60050(puuC4)
PFS: PFLU_5976(aldH)
PFB: VO64_2867
PEN: PSEEN5424(aldH)
PSA: PST_0046
PSTT: CH92_21230
PKC: PKB_5073(puuc3) PKB_5650(puuc5)
PSEC: CCOS191_5174(puuC3)
PANR: A7J50_5711
PSET: THL1_5607
PALL: UYA_01070
AVN: Avin_48030(aldH)
AVL: AvCA_48030(aldH)
AVD: AvCA6_48030(aldH)
ACX: Achr_37390(aldH)
FBL: Fbal_1146
SAGA: M5M_11425
MICC: AUP74_00575(puuC)
MICT: FIU95_19470(puuC)
HCO: LOKO_02562(puuC)
HBE: BEI_1148
AJP: AMJAP_2131(kauB)
RFO: REIFOR_00600(puuC)
ASA: ASA_4155
AVR: B565_3831
AMED: B224_5460
ASR: WL1483_1298(puuC)
ACAV: VI35_20215
AEL: NCTC12917_04090(puuC)
OCE: GU3_00195
BMK: DM80_3359
PLG: NCTC10937_00050(puuC_1)
HYF: DTO96_100783(puuC)
HYB: Q5W_22305
HPSE: HPF_00630(puuC)
CBAB: SMCB_2218
JAG: GJA_494
LCH: Lcho_1737
TIN: Tint_0186
RGE: RGE_26320(aldH)
PBH: AAW51_2992(puuC)
SIX: BSY16_55
ARA: Arad_8305(dhaL)
MET: M446_3859
RCP: RCAP_rcc02448(aldH2)
SECH: B18_09235
RCE: RC1_1452(puuC)
TXI: TH3_10790
SMAL: SMALA_7627
TBI: Tbis_1741
AMN: RAM_31850
AMM: AMES_6118(puuC)
AMZ: B737_6118(puuC)
 » show all
Reference
1
  Authors
Yorifuji, T., Koike, K., Sakurai, T. and Yokoyama, K.
  Title
4-Aminobutyraldehyde and 4-guanidinobutyraldehyde dehydrogenases for arginine degradation in Pseudomonas putida.
  Journal
Agric Biol Chem 50:2009-2016 (1986)
Other DBs
ExplorEnz - The Enzyme Database: 1.2.1.54
IUBMB Enzyme Nomenclature: 1.2.1.54
ExPASy - ENZYME nomenclature database: 1.2.1.54
BRENDA, the Enzyme Database: 1.2.1.54
CAS: 56831-75-5

KEGG   REACTION: R03177
Entry
R03177                      Reaction                               

Name
4-Guanidinobutanal:NAD+ 1-oxidoreductase
Definition
4-Guanidinobutanal + NAD+ + H2O <=> 4-Guanidinobutanoate + NADH + H+
Equation
Reaction class
RC00001  C00003_C00004
RC00080  C01035_C02647
Enzyme
Pathway
rn00330  Arginine and proline metabolism
rn01100  Metabolic pathways
Orthology
K12254  4-guanidinobutyraldehyde dehydrogenase / NAD-dependent aldehyde dehydrogenase [EC:1.2.1.54 1.2.1.-]
Other DBs
RHEA: 14384

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