KEGG   ORTHOLOGY: K12311
Entry
K12311                      KO                                     
Symbol
MAN2B1, LAMAN
Name
lysosomal alpha-mannosidase [EC:3.2.1.24]
Pathway
map00511  Other glycan degradation
map04142  Lysosome
Disease
H00139  alpha-Mannosidosis
H00422  Glycoproteinoses
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09107 Glycan biosynthesis and metabolism
   00511 Other glycan degradation
    K12311  MAN2B1, LAMAN; lysosomal alpha-mannosidase
 09140 Cellular Processes
  09141 Transport and catabolism
   04142 Lysosome
    K12311  MAN2B1, LAMAN; lysosomal alpha-mannosidase
Enzymes [BR:ko01000]
 3. Hydrolases
  3.2  Glycosylases
   3.2.1  Glycosidases, i.e. enzymes that hydrolyse O- and S-glycosyl compounds
    3.2.1.24  alpha-mannosidase
     K12311  MAN2B1, LAMAN; lysosomal alpha-mannosidase
Other DBs
RN: R08717 R08718
GO: 0004559
CAZy: GH38
Genes
HSA: 4125(MAN2B1)
PTR: 455745(MAN2B1)
PPS: 100977668(MAN2B1)
GGO: 101136007(MAN2B1)
PON: 100174476(MAN2B1)
NLE: 100598622(MAN2B1)
MCC: 716173(MAN2B1)
MCF: 102137710(MAN2B1)
CSAB: 103233978(MAN2B1)
CATY: 105571296(MAN2B1)
PANU: 100999431(MAN2B1)
TGE: 112612024(MAN2B1)
RRO: 104661102(MAN2B1)
RBB: 108539608(MAN2B1)
TFN: 117075666(MAN2B1)
PTEH: 111523839(MAN2B1)
CJC: 100395073(MAN2B1)
SBQ: 101050078(MAN2B1)
CSYR: 103250460(MAN2B1)
MMUR: 105885518(MAN2B1)
LCAT: 123637103(MAN2B1)
OGA: 100955271(MAN2B1)
MMU: 17159(Man2b1)
MCAL: 110299925(Man2b1)
MPAH: 110337426(Man2b1)
RNO: 361378(Man2b1)
MCOC: 116069755(Man2b1)
MUN: 110552994
CGE: 100766505(Man2b1)
MAUA: 110339551(Man2b1) 110339630
PLEU: 114687637(Man2b1)
MORG: 121446964(Man2b1)
AAMP: 119802278(Man2b1)
NGI: 103751895(Man2b1)
HGL: 101705792(Man2b1)
CPOC: 100718205(Man2b1)
CCAN: 109681246(Man2b1) 109685194
DORD: 105999103 105999216(Man2b1)
DSP: 122100236(Man2b1) 122119714
NCAR: 124969157
OPI: 101531130 101535240(MAN2B1)
TUP: 102483853(MAN2B1)
CFA: 484932(MAN2B1)
VVP: 112908075(MAN2B1)
VLG: 121495332(MAN2B1)
AML: 100470947(MAN2B1)
UMR: 103682159(MAN2B1)
UAH: 113247191(MAN2B1)
UAR: 123777730(MAN2B1)
ELK: 111162426
LLV: 125084305
MPUF: 101674984(MAN2B1)
ORO: 101367441(MAN2B1)
EJU: 114197695(MAN2B1)
ZCA: 113918390(MAN2B1)
MLX: 118005098(MAN2B1)
FCA: 493697(MAN2B1)
PYU: 121014027(MAN2B1)
PBG: 122486918(MAN2B1)
PTG: 102971102(MAN2B1)
PPAD: 109253930(MAN2B1)
AJU: 106985939(MAN2B1)
HHV: 120245274(MAN2B1)
BTA: 282272(MAN2B1)
BOM: 102269568(MAN2B1)
BIU: 109561547(MAN2B1)
BBUB: 102397437(MAN2B1)
CHX: 102183410(MAN2B1)
OAS: 101102146(MAN2B1)
ODA: 120864030(MAN2B1)
CCAD: 122440484(MAN2B1)
SSC: 100518647(MAN2B1)
CFR: 102508436(MAN2B1)
CBAI: 105068346(MAN2B1)
CDK: 105104070(MAN2B1)
VPC: 102531532(MAN2B1)
BACU: 102999783(MAN2B1)
LVE: 103088076(MAN2B1)
OOR: 101285368(MAN2B1)
DLE: 111166628(MAN2B1)
PCAD: 102988126
PSIU: 116751394(MAN2B1)
ECB: 100064359(MAN2B1)
EAI: 106826920(MAN2B1)
MYB: 102255151(MAN2B1)
MYD: 102755574(MAN2B1)
MMYO: 118652615(MAN2B1)
MNA: 107541549(MAN2B1)
PKL: 118710397(MAN2B1)
HAI: 109394253(MAN2B1)
DRO: 112301548(MAN2B1)
SHON: 118984144(MAN2B1)
AJM: 119049641(MAN2B1)
PDIC: 114503002(MAN2B1)
PHAS: 123828467(MAN2B1)
MMF: 118615631(MAN2B1)
RFQ: 117038281(MAN2B1)
PALE: 102898106(MAN2B1)
PGIG: 120618549(MAN2B1)
PVP: 105307155(MAN2B1)
RAY: 107519445(MAN2B1)
MJV: 108389546
TOD: 119240990(MAN2B1)
SARA: 101555929(MAN2B1)
LAV: 100658867(MAN2B1)
MDO: 100010377(MAN2B1)
GAS: 123242474(MAN2B1)
SHR: 100930413(MAN2B1)
PCW: 110214156(MAN2B1)
OAA: 103170598(MAN2B1)
PCOC: 116243082(MAN2B1)
CJO: 107307162(MAN2B1)
LSR: 110481532(MAN2B1)
PMOA: 120505347(MAN2B1)
OTC: 121339167(MAN2B1)
PRUF: 121363737(MAN2B1)
PHI: 102101310(MAN2B1)
ETL: 114071214(MAN2B1)
NNI: 104009709(MAN2B1)
ACHC: 115337956(MAN2B1)
AAM: 106498060(MAN2B1)
AROW: 112962292(MAN2B1)
NPD: 112957581(MAN2B1)
DNE: 112997244(MAN2B1)
ASN: 102376538(MAN2B1)
AMJ: 102562074(MAN2B1)
PSS: 102446502(MAN2B1)
CMY: 102934391(MAN2B1)
CPIC: 101942520(MAN2B1)
TST: 117888619(MAN2B1)
CABI: 116817752(MAN2B1)
MRV: 120391037(MAN2B1)
ACS: 100557773(man2b1)
PVT: 110082637(MAN2B1)
SUND: 121921054(MAN2B1)
PBI: 103064652(MAN2B1)
PMUR: 107286892(MAN2B1)
TSR: 106547262(MAN2B1)
PGUT: 117658791(MAN2B1)
VKO: 123035467(MAN2B1)
PMUA: 114590817(MAN2B1)
ZVI: 118079992(MAN2B1)
GJA: 107114373(MAN2B1)
STOW: 125429660(MAN2B1)
XLA: 108711713(man2b1.L)
XTR: 779924(man2b1)
NPR: 108794969(MAN2B1)
RTEM: 120933374(MAN2B1)
BBUF: 120986466(MAN2B1)
DRE: 541519(man2b1)
SRX: 107737232(man2b1) 107751149
SGH: 107556324 107571451(man2b1)
CAUA: 113055377(man2b1)
PPRM: 120480245(man2b1)
MAMB: 125257150(man2b1)
IPU: 108259485(man2b1)
PHYP: 113524272(man2b1)
SMEO: 124379734(man2b1)
TFD: 113647037(man2b1)
AMEX: 103033201(man2b1) 111188897
EEE: 113589666(man2b1)
TRU: 101073393(man2b1)
LCO: 104925274(man2b1)
CGOB: 115005506(man2b1)
ELY: 117255795(man2b1)
SLUC: 116042549(man2b1)
ECRA: 117961843(man2b1)
PFLV: 114546537(man2b1)
GAT: 120815094(man2b1)
PPUG: 119217876(man2b1)
MSAM: 119898586(man2b1)
CUD: 121508883(man2b1)
ALAT: 119024353(man2b1)
MZE: 101487837(man2b1) 112434922
ONL: 100710610(man2b1)
OAU: 116326125(man2b1)
OLA: 101168422(man2b1)
OML: 112141688(man2b1)
XMA: 102232163(man2b1)
XCO: 114145277(man2b1)
XHE: 116720465(man2b1)
PRET: 103480745(man2b1)
PFOR: 103136455(man2b1)
PLAI: 106957745(man2b1)
PMEI: 106923345(man2b1)
GAF: 122830349(man2b1)
CVG: 107084261(man2b1)
CTUL: 119786999(man2b1)
GMU: 124868456(man2b1)
NFU: 107391285(man2b1)
KMR: 108240322(man2b1)
ALIM: 106527227(man2b1)
NWH: 119422414(man2b1)
AOCE: 111569836(man2b1)
CSEM: 103383445
POV: 109640173(man2b1)
SSEN: 122760879(man2b1)
HHIP: 117754574(man2b1)
HSP: 118098336(man2b1)
LCF: 108880838(man2b1)
SDU: 111235904(man2b1)
SLAL: 111657943(man2b1)
XGL: 120799945(man2b1)
HCQ: 109511053(man2b1)
BPEC: 110172144(man2b1)
MALB: 109970346(man2b1)
BSPL: 114851038(man2b1)
SASA: 101448032(man2b1) 106590633
OTW: 112217216(man2b1)
OGO: 124018621(man2b1) 124018633
SALP: 112078491(man2b1)
ELS: 105012090(man2b1)
SFM: 108927502(man2b1)
PKI: 111845292(man2b1)
AANG: 118221182(man2b1)
LOC: 102694089(man2b1)
PSPA: 121304558(man2b1)
ARUT: 117401938(man2b1)
LCM: 102355373(MAN2B1)
RTP: 109916012(man2b1)
CIN: 100176799
SCLV: 120328114
APLC: 110975939
SKO: 100373155
DME: Dmel_CG5322(LManI) Dmel_CG6206(LManII) Dmel_CG9463(LManIII) Dmel_CG9465(LManIV) Dmel_CG9466(LManV) Dmel_CG9468(LManVI)
DSI: Dsimw501_GD22254(Dsim_GD22254) Dsimw501_GD22379(Dsim_GD22379) Dsimw501_GD22380(Dsim_GD22380) Dsimw501_GD22381(Dsim_GD22381) Dsimw501_GD22383(Dsim_GD22383) Dsimw501_GD23708(Dsim_GD23708)
DAZ: 108610905
AME: 552249
ACER: 107996108
ALAB: 122720039
BIM: 100743817
BBIF: 117204147
BVK: 117235663
BVAN: 117159570
BTER: 100651034
BPYO: 122566868
CCAL: 108622870
OBB: 114872696
MGEN: 117220507
NMEA: 116427224
CGIG: 122401836
SOC: 105208102
MPHA: 105837315
AEC: 105154650
ACEP: 105622460
PBAR: 105432214
VEM: 105564677
HST: 105190275
DQU: 106751241
CFO: 105250629
FEX: 115245488
LHU: 105672298
PGC: 109858269
OBO: 105285665
PCF: 106789636
PFUC: 122513457
VPS: 122636941
NVI: 100120019
CSOL: 105362560
TPRE: 106654401
CGLO: 123270380
AGIF: 122848060
CCIN: 107264999
CSET: 123310708
HHAL: 106681251
FOC: 113202060
TPAL: 117649128
ZNE: 110837258
CSEC: 111868816
FCD: 110842868
PVM: 113827618
PJA: 122261523
PCHN: 125036596
HAME: 121877354
PCLA: 123760011
PTRU: 123512081
HAZT: 108665826
CEL: CELE_F55D10.1(aman-1)
CBR: CBG_14532(Cbr-aman-1)
BMY: BM_BM4424(Bma-aman-1)
LAK: 106168249
NVE: 5509115
ATEN: 116289045
AMIL: 114957267
PDAM: 113678650
SPIS: 111329016
HMG: 100212242
BOE: 106332583
DCR: 108225642
TDC: 119350249
DDI: DDB_G0292206(manA)
DFA: DFA_00378(manA) DFA_02102 DFA_10499(manF) DFA_11726(manC)
SMIN: v1.2.017760.t1(symbB.v1.2.017760.t1)
 » show all
Reference
  Authors
Venkatesan M, Kuntz DA, Rose DR
  Title
Human lysosomal alpha-mannosidases exhibit different inhibition and metal binding properties.
  Journal
Protein Sci 18:2242-51 (2009)
DOI:10.1002/pro.235
  Sequence
[hsa:4125]

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