KEGG   ORTHOLOGY: K12348
Entry
K12348                      KO                                     

Name
ASAH1
Definition
acid ceramidase [EC:3.5.1.23]
Pathway
ko00600  Sphingolipid metabolism
ko01100  Metabolic pathways
ko04071  Sphingolipid signaling pathway
ko04142  Lysosome
Module
M00099  Sphingosine biosynthesis
Disease
H00138  Farber lipogranulomatosis
H00423  Sphingolipidosis
H00424  Defects in the degradation of sphingomyelin
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09103 Lipid metabolism
   00600 Sphingolipid metabolism
    K12348  ASAH1; acid ceramidase
 09130 Environmental Information Processing
  09132 Signal transduction
   04071 Sphingolipid signaling pathway
    K12348  ASAH1; acid ceramidase
 09140 Cellular Processes
  09141 Transport and catabolism
   04142 Lysosome
    K12348  ASAH1; acid ceramidase
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors
    K12348  ASAH1; acid ceramidase
  09183 Protein families: signaling and cellular processes
   04147 Exosome
    K12348  ASAH1; acid ceramidase
Enzymes [BR:ko01000]
 3. Hydrolases
  3.5  Acting on carbon-nitrogen bonds, other than peptide bonds
   3.5.1  In linear amides
    3.5.1.23  ceramidase
     K12348  ASAH1; acid ceramidase
Peptidases and inhibitors [BR:ko01002]
 Cysteine peptidases
  Family C89
   K12348  ASAH1; acid ceramidase
Exosome [BR:ko04147]
 Exosomal proteins
  Exosomal proteins of other body fluids (saliva and urine)
   K12348  ASAH1; acid ceramidase
Other DBs
RN: R01494 R06518 R06528
GO: 0017040
Genes
HSA: 427(ASAH1)
PTR: 464022(ASAH1)
PPS: 100991999(ASAH1)
GGO: 101149522
PON: 100171626(ASAH1)
NLE: 100579536(ASAH1)
MCC: 703699(ASAH1)
MCF: 102118393(ASAH1)
CSAB: 103215400(ASAH1)
RRO: 104655223(ASAH1)
RBB: 108526474(ASAH1)
CJC: 100409902(ASAH1)
SBQ: 101044863(ASAH1)
MMU: 11886(Asah1)
MCAL: 110299751(Asah1)
MPAH: 110336346(Asah1)
RNO: 84431(Asah1)
MUN: 110558780(Asah1)
CGE: 100771068(Asah1)
NGI: 103748255(Asah1)
HGL: 101724913(Asah1)
CCAN: 109692105(Asah1)
OCU: 100338209(ASAH1)
TUP: 102490603(ASAH1)
CFA: 482897(ASAH1)
VVP: 112908911(ASAH1)
AML: 100471625(ASAH1)
UMR: 103681376(ASAH1)
UAH: 113262148(ASAH1)
ORO: 101384361(ASAH1)
ELK: 111144609
FCA: 101082231(ASAH1)
PTG: 102969154(ASAH1)
PPAD: 109277196(ASAH1)
AJU: 106988336(ASAH1)
BTA: 510620(ASAH1)
BOM: 102285015(ASAH1)
BIU: 109553501(ASAH1)
BBUB: 102414906(ASAH1)
CHX: 102169733(ASAH1)
OAS: 101117904(ASAH1)
SSC: 100512932(ASAH1)
CFR: 102503963(ASAH1)
CDK: 105102375(ASAH1)
BACU: 103004383(ASAH1)
LVE: 103084758(ASAH1)
OOR: 101276356(ASAH1)
DLE: 111173434(ASAH1)
PCAD: 102977037(ASAH1)
EPZ: 103556309(ASAH1)
EAI: 106828200(ASAH1)
MYB: 102261355(ASAH1)
MYD: 102772524(ASAH1)
MNA: 107534040(ASAH1)
HAI: 109394586(ASAH1)
DRO: 112306675(ASAH1)
PALE: 102884758(ASAH1)
RAY: 107502652(ASAH1)
MJV: 108396511(ASAH1)
LAV: 100658494(ASAH1)
TMU: 101359387
MDO: 100021204(ASAH1)
SHR: 100927628(ASAH1)
PCW: 110201225(ASAH1)
OAA: 100093499(ASAH1)
GGA: 422727(ASAH1)
MGP: 100550236(ASAH1)
CJO: 107313735(ASAH1)
NMEL: 110397955(ASAH1)
APLA: 101801719(ASAH1)
ACYG: 106035211(ASAH1)
TGU: 100223185(ASAH1)
LSR: 110474653(ASAH1)
SCAN: 103826204(ASAH1)
GFR: 102045042(ASAH1)
FAB: 101806040(ASAH1)
PHI: 102108790(ASAH1)
PMAJ: 107203488(ASAH1)
CCAE: 111928436(ASAH1)
CCW: 104690859(ASAH1)
ETL: 114064485(ASAH1)
FPG: 101917300(ASAH1)
FCH: 102045851(ASAH1)
CLV: 102098583(ASAH1)
EGZ: 104129441(ASAH1)
NNI: 104020838(ASAH1)
ACUN: 113479231(ASAH1)
PADL: 103926331(ASAH1)
AAM: 106490075(ASAH1)
ASN: 102383990(ASAH1)
AMJ: 102566045(ASAH1)
PSS: 102444687(ASAH1)
CMY: 102930137(ASAH1)
CPIC: 101944232(ASAH1)
ACS: 100565312(asah1)
PVT: 110077885(ASAH1)
PBI: 103052913(ASAH1)
PMUR: 107301677(ASAH1)
TSR: 106554883(ASAH1)
PMUA: 114603838(ASAH1)
GJA: 107108734(ASAH1)
XLA: 447327(asah1.L)
XTR: 100485700(asah1)
NPR: 108785692(ASAH1)
DRE: 393549(asah1b) 450068(asah1a)
IPU: 108260777(asah1) 108269357(ASAH1)
PHYP: 113528763 113547387(asah1)
AMEX: 103026123(asah1) 103040700
TRU: 101065149(asah1)
LCO: 104936951(asah1)
NCC: 104967119(asah1)
MZE: 101476420(asah1)
ONL: 100703085(asah1)
OLA: 101161703(asah1)
XMA: 102231620(asah1)
XCO: 114144122(asah1)
PRET: 103461639(asah1)
CVG: 107090456(asah1)
NFU: 107373323(asah1)
KMR: 108233727(asah1)
ALIM: 106525838(asah1)
AOCE: 111580238(asah1)
CSEM: 103384334(asah1)
POV: 109639561(asah1)
SDU: 111216721(asah1)
SLAL: 111663285(asah1)
HCQ: 109511169(asah1)
BPEC: 110167588(asah1)
MALB: 109972118(asah1)
ELS: 105022854(asah1)
SFM: 108924408(asah1)
PKI: 111853589(asah1)
LCM: 102355600(ASAH1)
CMK: 103178195(asah1)
RTP: 109929941(asah1)
CIN: 100179893
SKO: 102808956
BTAB: 109038589
FCD: 110859289
CSCU: 111623012
CEL: CELE_F27E5.1(asah-2) CELE_K11D2.2(asah-1)
CBR: CBG00863 CBG15381(Cbr-asah-1) CBG15382
TSP: Tsp_09460
CRG: 105334663
MYI: 110457570
OBI: 106876330
NVE: 5506073
EPA: 110240322
ADF: 107356522
AMIL: 114955375
DFA: DFA_06303
SMIN: v1.2.005120.t1(symbB.v1.2.005120.t1) v1.2.007250.t1(symbB.v1.2.007250.t1) v1.2.025307.t1(symbB.v1.2.025307.t1) v1.2.029508.t1(symbB.v1.2.029508.t1)
WIN: WPG_1505
 » show all
Reference
PMID:8955159
  Authors
Koch J, Gartner S, Li CM, Quintern LE, Bernardo K, Levran O, Schnabel D, Desnick RJ, Schuchman EH, Sandhoff K
  Title
Molecular cloning and characterization of a full-length complementary DNA encoding human acid ceramidase. Identification Of the first molecular lesion causing Farber disease.
  Journal
J Biol Chem 271:33110-5 (1996)
DOI:10.1074/jbc.271.51.33110
  Sequence
[hsa:427]

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