KEGG   ORTHOLOGY: K12349
Entry
K12349                      KO                                     

Name
ASAH2
Definition
neutral ceramidase [EC:3.5.1.23]
Pathway
ko00600  Sphingolipid metabolism
ko01100  Metabolic pathways
ko04071  Sphingolipid signaling pathway
Module
M00099  Sphingosine biosynthesis
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09103 Lipid metabolism
   00600 Sphingolipid metabolism
    K12349  ASAH2; neutral ceramidase
 09130 Environmental Information Processing
  09132 Signal transduction
   04071 Sphingolipid signaling pathway
    K12349  ASAH2; neutral ceramidase
Enzymes [BR:ko01000]
 3. Hydrolases
  3.5  Acting on carbon-nitrogen bonds, other than peptide bonds
   3.5.1  In linear amides
    3.5.1.23  ceramidase
     K12349  ASAH2; neutral ceramidase
Other DBs
RN: R01494 R06518 R06528
GO: 0017040
Genes
HSA: 56624(ASAH2)
PTR: 450461
PPS: 100985247(ASAH2)
GGO: 101146782
PON: 100437539
NLE: 100599629(ASAH2)
MCC: 703913(ASAH2)
MCF: 102125051(ASAH2)
CSAB: 103216197(ASAH2)
RRO: 104675174
RBB: 108527549
CJC: 100390425(ASAH2)
SBQ: 101042224(ASAH2)
MMU: 54447(Asah2)
MCAL: 110285496(Asah2)
MPAH: 110328611(Asah2)
RNO: 114104(Asah2)
CGE: 100765841(Asah2)
NGI: 103731327(Asah2)
HGL: 101709668(Asah2)
CCAN: 109681824(Asah2)
OCU: 100357673(ASAH2)
TUP: 102487994(ASAH2)
CFA: 486461(ASAH2)
VVP: 112931971(ASAH2)
AML: 100471748(ASAH2)
UMR: 103661994(ASAH2)
UAH: 113259272(ASAH2)
ORO: 101371027(ASAH2)
ELK: 111145321
FCA: 101097670(ASAH2)
PTG: 102956747(ASAH2)
PPAD: 109255388(ASAH2)
AJU: 106980970(ASAH2)
BTA: 100336736(ASAH2)
BOM: 102269704(ASAH2) 102280046(ASAH2B)
BIU: 109578966(ASAH2)
BBUB: 102400616
CHX: 102183481(ASAH2)
OAS: 101121732(ASAH2)
SSC: 100157065(ASAH2)
CFR: 102509981
CDK: 105105273(ASAH2)
BACU: 103014205(ASAH2B)
LVE: 103073009(ASAH2B)
OOR: 101280545(ASAH2)
DLE: 111172537(ASAH2)
PCAD: 102979782(ASAH2)
ECB: 100071829(ASAH2)
EPZ: 103549842(ASAH2)
MYB: 102263955(ASAH2)
MYD: 102752227(ASAH2)
MNA: 107543278(ASAH2)
HAI: 109387522(ASAH2)
DRO: 112307346(ASAH2)
PALE: 102881257(ASAH2)
RAY: 107515497(ASAH2)
MJV: 108396673(ASAH2)
LAV: 100660560(ASAH2)
TMU: 101345677
MDO: 100022761(ASAH2)
SHR: 100928486(ASAH2)
PCW: 110199946(ASAH2)
OAA: 100075060
GGA: 423679(ASAH2)
MGP: 100540641
CJO: 107315615
NMEL: 110390502(ASAH2)
APLA: 101802423
ACYG: 106034302(ASAH2)
TGU: 100219353
LSR: 110474005(ASAH2)
SCAN: 103814224
GFR: 102041139(ASAH2)
FAB: 101808147(ASAH2)
PHI: 102109084(ASAH2)
PMAJ: 107206528(ASAH2)
CCAE: 111931637
CCW: 104695104
ETL: 114071322
FPG: 101922478(ASAH2)
FCH: 102054876(ASAH2)
CLV: 102098837
EGZ: 104125150(ASAH2)
NNI: 104013570
ACUN: 113481916
PADL: 103924283(ASAH2)
AAM: 106489032(ASAH2)
ASN: 102387682(ASAH2)
AMJ: 102561354(ASAH2)
PSS: 102460189(ASAH2)
CMY: 102945456(ASAH2B)
CPIC: 101947675(ASAH2)
ACS: 100552754(asah2)
PVT: 110084120(ASAH2)
PBI: 103060263
PMUR: 107293836(ASAH2)
PMUA: 114597303(ASAH2)
GJA: 107121645(ASAH2)
XLA: 108695739 108696963(asah2.L)
XTR: 100170585(asah2) 100494440
DRE: 493602(asah2)
SRX: 107708874 107739760(asah2)
SANH: 107653956(asah2)
SGH: 107598655(asah2)
CCAR: 109087245(asah2)
IPU: 108274155(asah2)
PHYP: 113527129(asah2)
EEE: 113577019(asah2)
TRU: 101072604
LCO: 104936727(asah2)
NCC: 104950330
MZE: 101482863(asah2)
ONL: 100698150(asah2)
OLA: 101165218(asah2)
XMA: 102227444(asah2)
XCO: 114152384(asah2)
PRET: 103482088
CVG: 107101341(asah2)
NFU: 107387510(asah2)
KMR: 108229571
ALIM: 106528220
AOCE: 111581012(asah2)
CSEM: 103382244(asah2)
POV: 109645044(asah2)
LCF: 108886127(asah2)
SDU: 111219686(asah2)
SLAL: 111655115(asah2)
HCQ: 109518534(asah2)
BPEC: 110166065(asah2)
MALB: 109969663(asah2)
SASA: 106589395(asah2)
OTW: 112224282(asah2)
SALP: 111967784(asah2)
ELS: 105006219
SFM: 108939518(asah2)
PKI: 111853654
LCM: 102355598(ASAH2)
CMK: 103180876
RTP: 109915825(asah2)
BFO: 118412025
DME: Dmel_CG1471(CDase)
DER: 6555347
DSE: 6612869
DSI: Dsimw501_GD21520(Dsim_GD21520)
DYA: Dyak_GE10878(Dyak_CDase)
DAN: 6505553
DSR: 110186443
DPE: 6594781
DMN: 108157355
DWI: 6651536
DAZ: 108621350
DNV: 108656826
DHE: 111592492
DVI: 6629503
MDE: 101895904
LCQ: 111675553
AME: 409628
BIM: 100747808
BTER: 100648282
CCAL: 108632899
OBB: 114877963
MPHA: 105833238
AEC: 105154112
ACEP: 105617928
VEM: 105564653
HST: 105181292
DQU: 106745072
CFO: 105251318
LHU: 105675031
PGC: 109864261
OBO: 105283617
PCF: 106793706
NVI: 100122600
CSOL: 105362634
MDL: 103571765
DPA: 109539809
NVL: 108565492
API: 100165996
DNX: 107167451
RMD: 113558557
BTAB: 109043949
CLEC: 106665047
ZNE: 110829192
PVM: 113819214
DPTE: 113791892
PTEP: 107456282
PCAN: 112556276
CRG: 105347438
MYI: 110446450
SHX: MS3_10036
EGL: EGR_06583
AQU: 100635163
LJA: Lj0g3v0208009.1(Lj0g3v0208009.1) Lj0g3v0212329.1(Lj0g3v0212329.1) Lj0g3v0212329.2(Lj0g3v0212329.2) Lj2g3v3336140.1(Lj2g3v3336140.1) Lj6g3v0635260.1(Lj6g3v0635260.1) Lj6g3v0635260.2(Lj6g3v0635260.2)
SLY: 101251446
SOT: 102606157
BVG: 104900023
SOE: 110778561
NNU: 104593520
OSA: 4326680
DOSA: Os01t0624000-01(Os01g0624000)
OBR: 102715249
BDI: 100837567
ATS: 109766002(LOC109766002) 109766004(LOC109766004) 109785808(LOC109785808)
ZMA: 100279713(cl24314_1)
APRO: F751_1851
MIS: MICPUN_58114(CDASE)
NTE: NEUTE1DRAFT131682(NEUTE1DRAFT_131682) NEUTE1DRAFT76518(NEUTE1DRAFT_76518)
MBE: MBM_05062
ANI: AN4245.2
ANG: ANI_1_1412164(An18g05500)
ABE: ARB_01232
TVE: TRV_01275
PTE: PTT_13176
TASA: A1Q1_08013
ABP: AGABI1DRAFT112961(AGABI1DRAFT_112961)
ABV: AGABI2DRAFT192931(AGABI2DRAFT_192931)
DDI: DDB_G0268374(dcd2B) DDB_G0293538(dcd2A)
DFA: DFA_00049 DFA_02907(dcd2A)
SMIN: v1.2.026056.t1(symbB.v1.2.026056.t1) v1.2.026056.t2(symbB.v1.2.026056.t2)
PAE: PA0845
PAEV: N297_872(dcd2A)
PAEI: N296_872(dcd2A)
PAEP: PA1S_22220
PAEM: U769_21590
PAEL: T223_22855
PAEG: AI22_11720
PAEC: M802_868(dcd2A)
PAEO: M801_872(dcd2A)
AGU: AS4_07000
MARJ: MARI_05780
ADI: B5T_02488
APAC: S7S_07645
AXE: P40_12080
DOL: Dole_2360
DAL: Dalk_5268
ADE: Adeh_4207
MXA: MXAN_0613
MMED: Mame_05229
CAK: Caul_0966
CSE: Cseg_0466
MALG: MALG_04831
SPHI: TS85_13035
SECH: B18_15870
AAY: WYH_00341
STH: STH1938
MTU: Rv0669c
MRA: MRA_0679
MTUR: CFBS_0704
MTD: UDA_0669c
MTUC: J113_04760
MTUE: J114_03575
MTUH: I917_04770
MTUL: TBHG_00664
MTUT: HKBT1_0704
MTUU: HKBT2_0705
MBB: BCG_0718c
MBT: JTY_0688
MBX: BCGT_0460
MAF: MAF_06780
MMI: MMAR_0997
MHAD: B586_03915
MMIN: MMIN_36350
MHIB: MHIB_14690
ASD: AS9A_2567
CJK: jk1103(asa)
CRD: CRES_1191(asa)
CVA: CVAR_1079
CTER: A606_04245
COA: DR71_2081
NFA: NFA_6470
RER: RER_07640
REY: O5Y_03715
REQ: REQ_06850
GBR: Gbro_2003
GOR: KTR9_1931
TPR: Tpau_2570
SGR: SGR_6570
SGB: WQO_02270
SALS: SLNWT_0663
SFI: SFUL_684
SPRI: SPRI_6615
ARM: ART_1274
BCV: Bcav_3339
SRO: Sros_3082
SEN: SACE_3165
AOI: AORI_3695
AMYY: YIM_27880
AORI: SD37_18970
SESP: BN6_43580
ALO: CRK61939
ACTN: L083_4617
AFS: AFR_19975
CAI: Caci_0673
RUL: UC8_18550
SUS: Acid_2075
GBA: J421_5535
PHE: Phep_0355
CHU: CHU_3456
DFE: Dfer_4491
LBY: Lbys_0455
FLM: MY04_3197
TMAR: MARIT_2033
TGA: TGAM_0395
 » show all
Reference
  Authors
Osawa Y, Uchinami H, Bielawski J, Schwabe RF, Hannun YA, Brenner DA
  Title
Roles for C16-ceramide and sphingosine 1-phosphate in regulating hepatocyte apoptosis in response to tumor necrosis factor-alpha.
  Journal
J Biol Chem 280:27879-87 (2005)
DOI:10.1074/jbc.M503002200
  Sequence
[hsa:56624]

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