KEGG ORTHOLOGY: K12367

ORTHOLOGY: K12367

Entry

K12367                      KO

Symbol

DOCK2

Name

dedicator of cytokinesis protein 2

Pathway

map04062

Chemokine signaling pathway

Disease

H00093

Combined immunodeficiency

Brite

KEGG Orthology (KO) [BR:ko00001]
09150 Organismal Systems
  09151 Immune system
   04062 Chemokine signaling pathway
    K12367  DOCK2; dedicator of cytokinesis protein 2
09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking
    K12367  DOCK2; dedicator of cytokinesis protein 2
Membrane trafficking [BR:ko04131]
Others
  Rho GTPase associated proteins
   Rho guanine nucleotide exchange factors (GEFs)
    K12367  DOCK2; dedicator of cytokinesis protein 2

Other DBs

GO:	0005085 0005096

Genes

HSA:	1794(DOCK2)

PTR:	471731(DOCK2)

PPS:	100973015(DOCK2)

GGO:	101139420(DOCK2)

PON:	100456474(DOCK2)

PPYG:

129036364(DOCK2)

NLE:	100596090(DOCK2)

HMH:	116471833(DOCK2)

SSYN:

129486029(DOCK2)

MCC:	704061(DOCK2)

MCF:	107130111(DOCK2)

MTHB:

126957128

MNI:	105480844(DOCK2)

CSAB:

103244950(DOCK2)

CATY:

105581631(DOCK2)

PANU:

101019414(DOCK2)

TGE:	112626544(DOCK2)

MLEU:

105530931(DOCK2)

RRO:	104663613(DOCK2)

RBB:	108513615(DOCK2)

TFN:	117065431(DOCK2)

PTEH:

111547206(DOCK2)

CANG:

105515825(DOCK2)

CJC:	100397465(DOCK2)

SBQ:	101050901(DOCK2)

CIMI:

108317349(DOCK2)

ANAN:

105723137(DOCK2)

CSYR:

103263014

MMUR:

105880137(DOCK2)

LCAT:

123637974(DOCK2)

PCOQ:

105814635(DOCK2)

OGA:	100947188(DOCK2)

MMU:	94176(Dock2)

MCAL:

110304405(Dock2)

MPAH:

110331331(Dock2)

MCOC:

116076732(Dock2)

ANU:	117711181(Dock2)

MUN:	110545462(Dock2)

CGE:	100766266(Dock2)

MAUA:

101843588(Dock2)

PROB:

127219430(Dock2)

PLEU:

114710658(Dock2)

MORG:

121463761(Dock2)

MFOT:

126499473

AAMP:

119811683(Dock2)

HGL:	101707633(Dock2)

CPOC:

100714041(Dock2)

CCAN:

109686849(Dock2)

DORD:

DSP:

PLOP:

NCAR:

MMMA:

107147964(Dock2)

OCU:

100357300

OPI:	101528474(DOCK2)

TUP:	102472239(DOCK2)

CFA:	489128(DOCK2)

CLUD:

112651202(DOCK2)

VVP:

112926358

VLG:	121488108(DOCK2)

NPO:	129509971(DOCK2)

AML:

100465542

UMR:	103664785(DOCK2)

UAH:	113264075(DOCK2)

UAR:	123788581(DOCK2)

ELK:

111140871

LLV:

125099858

MPUF:

101678489(DOCK2)

MNP:	132027527(DOCK2)

MLK:	131831893(DOCK2)

NVS:	122892984(DOCK2)

ORO:	101383042(DOCK2)

EJU:	114208685(DOCK2)

ZCA:	113929141(DOCK2)

MLX:	118016576(DOCK2)

NSU:	110587923(DOCK2)

FCA:	101097544(DOCK2)

PYU:	121010716(DOCK2)

PCOO:

112860515(DOCK2)

PBG:	122492679(DOCK2)

PVIV:

125162379(DOCK2)

LRUF:

124520400

PTG:	102972543(DOCK2)

PPAD:

109267473(DOCK2)

PUC:

125934429

AJU:

106969263

HHV:	120234070(DOCK2)

BTA:	510083(DOCK2)

BOM:	102283435(DOCK2)

BIU:	109574918(DOCK2)

BBUB:

102389854(DOCK2)

BBIS:

104999107(DOCK2)

CHX:	102177564(DOCK2)

OAS:	101104011(DOCK2)

BTAX:

128066259(DOCK2)

ODA:	120879696(DOCK2)

CCAD:

122454347(DOCK2)

MBEZ:

129553133(DOCK2)

SSC:	100512021(DOCK2)

CFR:	102511337(DOCK2)

CBAI:

105082635(DOCK2)

CDK:	105089389(DOCK2)

VPC:	102537686(DOCK2)

BACU:

103011592(DOCK2)

BMUS:

118893440(DOCK2)

LVE:	103078799(DOCK2)

OOR:	101284407(DOCK2)

DLE:	111185489(DOCK2)

PCAD:

102994703(DOCK2)

PSIU:

116750967(DOCK2)

NASI:

112405061(DOCK2)

ECB:	100070446(DOCK2)

EPZ:	103559426(DOCK2)

EAI:	106837369(DOCK2)

MYB:	102241503(DOCK2)

MYD:	102756868(DOCK2)

MMYO:

118657842(DOCK2)

MLF:	102441351(DOCK2)

MDT:	132235947(DOCK2)

PKL:	118710918(DOCK2)

EFUS:

103291565(DOCK2)

MNA:	107537891(DOCK2)

DRO:	112319431(DOCK2)

SHON:

118994933(DOCK2)

AJM:	119036197(DOCK2)

PDIC:

114510283(DOCK2)

PHAS:

123806744(DOCK2)

MMF:	118615340(DOCK2)

PPAM:

129066490(DOCK2)

HAI:	109379373(DOCK2)

RFQ:	117016732(DOCK2)

PALE:

102890291(DOCK2)

PGIG:

120613599(DOCK2)

PVP:	105289940(DOCK2)

RAY:	107518467(DOCK2)

MJV:	108396111(DOCK2)

TOD:	119236765(DOCK2)

SARA:

101550515(DOCK2)

SETR:

126011896(DOCK2)

LAV:	100655974(DOCK2)

TMU:

101357939

ETF:	101656937(DOCK2)

DNM:	101431675(DOCK2)

MDO:	100030952(DOCK2)

GAS:	123233792(DOCK2)

SHR:	100921385(DOCK2)

AFZ:

127550187

PCW:	110212317(DOCK2)

TVP:	118841783(DOCK2)

OAA:	100077856(DOCK2)

GGA:	427612(DOCK2) 429518(DOCK2L)

PCOC:

116225614 116231983(DOCK2)

MGP:	100539674(DOCK2) 100541844

CJO:	107306830 107320251(DOCK2)

TPAI:

128071999 128081532(DOCK2)

LMUT:

125692664 125700023(DOCK2)

NMEL:

110390922 110405556(DOCK2)

APLA:

101802192(DOCK2) 101803899

ACYG:

106034371(DOCK2) 106043193

CATA:

118256223(DOCK2) 118260608

AFUL:

116488954 116494733(DOCK2)

TGU:	100227341 100231624(DOCK2)

LSR:	110468737 110471339(DOCK2)

SCAN:

103817226(DOCK2) 103823113

PMOA:

120498672(DOCK2) 120509036

OTC:	121332270(DOCK2) 121335159

PRUF:

121364597(DOCK2) 121364684

GFR:	102042659 102044813(DOCK2)

FAB:	101806235 101816594(DOCK2)

OMA:	130252082 130258648(DOCK2)

PHI:	102100339 102108751(DOCK2)

PMAJ:

107203409 107210604(DOCK2)

CCAE:

111929154 111935731(DOCK2)

CCW:	104690947 104693530(DOCK2)

CBRC:

103621141 103624882(DOCK2)

ETL:	114059793 114068871

ZAB:	102073768(DOCK2)

ZLE:	135447182 135453538(DOCK2)

ACHL:

103801464(DOCK2)

SVG:	106853112 106860028(DOCK2)

MMEA:

130575445 130580899(DOCK2)

HRT:	120752684 120759366(DOCK2)

SATI:

136360318 136367387(DOCK2)

FPG:	101911287 101915777(DOCK2)

FCH:	102050732 102055998(DOCK2)

NNT:	104410941(DOCK2)

SHAB:

115603587 115615504(DOCK2)

ACUN:

113485253(DOCK2) 113490508

TALA:

104369059(DOCK2) 116962489

ACHC:

115334233(DOCK2) 115338038

HLE:	104832339 104839035(DOCK2)

AGEN:

126050890 126052025

GCL:	127015486 127022153

DPUB:

104299046(DOCK2)

EGZ:	104135691(DOCK2)

NNI:	104014139 104016586(DOCK2)

PADL:

103918757(DOCK2) 103922174

AFOR:

103902155 103904280(DOCK2)

CLV:	102085717 102087155(DOCK2)

MUI:

104548300

EHS:	104510121(DOCK2)

CUCA:

104056873 104062457(DOCK2)

TEO:	104376664(DOCK2)

OHA:	104332172(DOCK2)

ACAR:

104527894(DOCK2)

CPEA:

104392532(DOCK2) 104398129

CVF:	104282637(DOCK2) 104294208

RTD:	128910374 128916047(DOCK2)

AAM:	106493556(DOCK2)

AROW:

112963878(DOCK2) 112978208

NPD:	112944281(DOCK2) 112954038

TGT:	104566300(DOCK2) 104575977

DNE:	112982216(DOCK2) 112994540

SCAM:

104154074(DOCK2)

ASN:	102377683 102384798(DOCK2)

AMJ:	102573430(DOCK2) 102574301

CPOO:

109309845(DOCK2) 109324490

GGN:	109290133(DOCK2)

PSS:	102457670(DOCK2)

CMY:	102930173(DOCK2) 102937744

CCAY:

125635193 125641478(DOCK2)

DCC:	119854624 119860258(DOCK2)

CPIC:

101936905(DOCK2) 101941224

TST:	117878454 117881690(DOCK2)

CABI:

116838461(DOCK2)

MRV:	120369956(DOCK2) 120406127

ACS:	100558131(dock2)

ASAO:

132768782(DOCK2)

PVT:	110072295(DOCK2)

SUND:

121923281(DOCK2)

PBI:

103064376

PMUR:

107285851(DOCK2)

CTIG:

120312456(DOCK2)

PGUT:

117657912(DOCK2)

APRI:

131190539(DOCK2)

PTEX:

113433540(DOCK2)

NSS:	113426203(DOCK2)

VKO:	123035490(DOCK2)

PMUA:

114590896(DOCK2)

PRAF:

128407750(DOCK2)

ZVI:	118076508(DOCK2)

HCG:	128344563(DOCK2)

GJA:	107125973(DOCK2)

STOW:

125428311(DOCK2)

EMC:	129328150(DOCK2)

XLA:	108710913(dock2.L)

XTR:	100497849(dock2)

NPR:	108788549(DOCK2)

RTEM:

120932352(DOCK2)

BBUF:

121009584(DOCK2)

BGAR:

122928241(DOCK2)

MUO:

115461208

GSH:	117351652(DOCK2) 117365127

SRX:

107750047

SANH:

107654652 107677012

SGH:	107552325(dock2)

CAUA:

CGIB:

PTET:

LROH:

OMC:

PPRM:

MAMB:

CIDE:

CERY:

137024038(dock2-like)

MASI:

TROS:

TDW:

MANU:

IPU:

IFU:

PHYP:

113529552(dock2)

SMEO:

TFD:

TVC:

TRN:

AMEX:

CMAO:

EEE:	113577131(dock2)

CHAR:

105903231

TRU:	101068169(dock2)

TFS:

130531158

LCO:	104933610(dock2)

TBEN:

117485498

CGOB:

115014336(dock2)

PGEO:

GACU:

EMAC:

ELY:

EFO:

PLEP:

SLUC:

ECRA:

ESP:	116696814(dock2)

PFLV:

114562504(dock2)

GAT:

PPUG:

AFB:

CLUM:

PSWI:

MSAM:

SCHU:

CUD:

ALAT:

MZE:	101476504(dock2)

ONL:	100712098(dock2)

OAU:

116335174

OLA:	101168874(dock2)

OML:

112153224

CSAI:

133447008

XMA:	102236684(dock2)

XCO:	114139346(dock2)

XHE:	116714512(dock2)

PRET:

103471338(dock2)

PFOR:

103147450(dock2)

PLAI:

106941964(dock2)

PMEI:

106926402(dock2)

GAF:

122836636

PPRL:

129362977

CVG:	107096704(dock2)

CTUL:

119796527

GMU:

124860244

NFU:	107376550(dock2)

KMR:

108243080

ALIM:

106516737(dock2)

NWH:

119408457

AOCE:

111575946(dock2)

MCEP:

125008053

CSEM:

103390941(dock2)

POV:	109628663(dock2)

SSEN:

HHIP:

HSP:

PPLT:

SMAU:

LCF:

SDU:	111232389(dock2)

SLAL:

111662793(dock2)

XGL:

120785038

HCQ:	109524347(dock2)

SSCV:

SBIA:

PEE:

PTAO:

BPEC:

110162300(dock2)

MALB:

109957552(dock2)

BSPL:

SJO:

SASA:

STRU:

OTW:	112220473 112238187

OMY:	110488657 110504415

OGO:	123993286 124011625

ONE:

115130563

OKI:	109864674(dock2) 109881350

OKE:	118374637 118384019

SALP:

111964784

SNH:	120048179(dock2) 120062377

CCLU:

121532851 121544127

ELS:	105025225(dock2)

SFM:	108925426(dock2)

PKI:	111859859(dock2)

AANG:

118223163

LOC:

102698393

PSPA:

121297270 121324489 121327399

ARUT:

117403985 117413226 117973525 117973667(dock2)

PSEX:

120542177

LCM:	102347512(DOCK2)

CMK:	103177303 103188103

RTP:

109937103

CPLA:

122553785 122556798

HOC:	132823334 132824791

LERI:

SCLV:

CPII:

IEL:

PTRU:

DFR:

Reference

PMID:11518968

Authors

Fukui Y, Hashimoto O, Sanui T, Oono T, Koga H, Abe M, Inayoshi A, Noda M, Oike M, Shirai T, Sasazuki T

Title

Haematopoietic cell-specific CDM family protein DOCK2 is essential for lymphocyte migration.

Journal

Nature 412:826-31 (2001)
DOI:10.1038/35090591

Sequence

[mmu:94176]

Reference

PMID:12829596

Authors

Sanui T, Inayoshi A, Noda M, Iwata E, Stein JV, Sasazuki T, Fukui Y

Title

DOCK2 regulates Rac activation and cytoskeletal reorganization through interaction with ELMO1.

Journal

Blood 102:2948-50 (2003)
DOI:10.1182/blood-2003-01-0173

All links

Ontology (4)   
   KEGG BRITE (2)   
   GO (2)   
Pathway (2)   
   KEGG PATHWAY (2)   
Disease (1)   
   KEGG DISEASE (1)   
Gene (1364)   
   KEGG GENES (461)   
   KEGG MGENES (428)   
   RefGene (467)   
   OC (8)   
Literature (2)   
   PubMed (2)   
All databases (1373)   

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