KEGG ORTHOLOGY: K12380

ORTHOLOGY: K12380

Entry

K12380                      KO

Symbol

RASA3

Name

Ras GTPase-activating protein 3

Pathway

map04013

MAPK signaling pathway - fly

map04014

Ras signaling pathway

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04013 MAPK signaling pathway - fly
    K12380  RASA3; Ras GTPase-activating protein 3
   04014 Ras signaling pathway
    K12380  RASA3; Ras GTPase-activating protein 3

Other DBs

GO:

0005096

Genes

HSA:	22821(RASA3)

PTR:	452684(RASA3)

PPS:	100994258(RASA3)

GGO:	101144659(RASA3)

PON:	100433201(RASA3) 100444490 103892305 112131386 129047449

PPYG:

129011835(RASA3) 129015281 129016291

NLE:	100580920(RASA3)

HMH:	116467595(RASA3)

SSYN:

129464080(RASA3)

MCC:	698964(RASA3)

MCF:	102136941(RASA3)

MTHB:

126940824

MNI:	105485231(RASA3)

CSAB:

103214860(RASA3)

CATY:

105584971(RASA3)

PANU:

101001054(RASA3)

TGE:	112610932(RASA3)

MLEU:

105539231(RASA3)

RBB:	108521837(RASA3)

TFN:	117063459(RASA3)

PTEH:

111546378(RASA3)

CANG:

105517766

CJC:	100415408(RASA3)

SBQ:	101052668(RASA3)

CIMI:

108296307(RASA3)

ANAN:

105729772(RASA3)

CSYR:

103251136(RASA3)

MMUR:

105871894(RASA3)

LCAT:

123648831(RASA3)

PCOQ:

105824410(RASA3)

OGA:	100966719(RASA3)

MMU:	19414(Rasa3)

MCAL:

110300114(Rasa3)

MPAH:

110336325(Rasa3)

RNO:	29372(Rasa3)

MCOC:

116068941(Rasa3)

ANU:	117721626(Rasa3)

ASYL:

127668681(Rasa3)

MUN:	110562003(Rasa3)

CGE:	100752063(Rasa3)

MAUA:

101839234(Rasa3)

PROB:

127220284(Rasa3)

PLEU:

114701235(Rasa3)

MORG:

121462389(Rasa3)

MFOT:

126498206

AAMP:

119811869(Rasa3)

HGL:	101724956(Rasa3)

CPOC:

100725242(Rasa3)

CCAN:

109686940(Rasa3)

DORD:

105990416(Rasa3)

DSP:	122122890(Rasa3)

PLOP:

125348083(Rasa3)

NCAR:

124984840

MMMA:

107140726(Rasa3)

ITI:	101959321(Rasa3)

OPI:	101522520(RASA3)

TUP:	102474171(RASA3)

GVR:	103593937(RASA3)

CFA:	476998(RASA3)

CLUD:

112656134(RASA3)

VVP:

112927441

VLG:	121476868(RASA3)

NPO:	129516412(RASA3)

AML:	100478760(RASA3)

UMR:	103657515(RASA3)

UAH:	113247558(RASA3)

UAR:	123776711(RASA3)

ELK:

111147054

LLV:

125094874

MPUF:

101689092(RASA3)

MNP:	132002746(RASA3)

MLK:	131813960(RASA3)

NVS:	122907269(RASA3)

ORO:	101371150(RASA3)

EJU:	114196600(RASA3)

ZCA:	113919793(RASA3)

MLX:	118009210(RASA3)

NSU:	110585806(RASA3)

LWW:	102733684(RASA3)

FCA:	101092578(RASA3)

PYU:	121037664(RASA3)

PCOO:

112860726(RASA3)

PBG:	122485206(RASA3)

PVIV:

125160473(RASA3)

LRUF:

124514021

LGF:	123600644(RASA3)

AJU:

106986714

PTG:	102969989(RASA3)

PPAD:

109264019(RASA3)

PUC:

125933989

PLEZ:

122215508(RASA3)

HHV:	120223463(RASA3)

BTA:	282532(RASA3)

BOM:	102277090(RASA3)

BIU:	109567109(RASA3)

BBUB:

102403004(RASA3)

BBIS:

104982194(RASA3)

CHX:	102177991(RASA3)

OAS:	101121434(RASA3)

BTAX:

128057501(RASA3)

CSUM:

138089176(RASA3)

ODA:	120883392(RASA3)

CCAD:

122447064(RASA3)

MREE:

136144098(RASA3)

OVR:	110124265(RASA3)

MBEZ:

129556536(RASA3)

SSC:	100519683(RASA3)

CFR:	102520968(RASA3)

CBAI:

105066874(RASA3)

CDK:	105095495(RASA3)

VPC:	102527450(RASA3)

BACU:

102999080(RASA3)

BMUS:

118884176(RASA3)

LVE:	103070877(RASA3)

OOR:	101274765(RASA3)

LALB:

132508946(RASA3)

DLE:	111176354(RASA3)

PCAD:

102979451(RASA3)

PSIU:

116743227(RASA3)

NASI:

112404616(RASA3)

ECB:	100069263(RASA3)

EPZ:	103549646(RASA3)

EAI:	106848192(RASA3)

MYB:	102260354(RASA3)

MYD:	102761515(RASA3)

MMYO:

118659638(RASA3)

MLF:	102431629(RASA3)

MDT:	132228576(RASA3)

MYUM:

139006053(RASA3)

PKL:	118729135(RASA3)

EFUS:

103288206(RASA3)

MNA:	107536956(RASA3)

DRO:	112321496(RASA3)

SHON:

118984267(RASA3)

AJM:	119034598(RASA3)

PDIC:

114508674(RASA3)

PHAS:

123807596(RASA3)

MMF:	118622619(RASA3)

PPAM:

129064766(RASA3)

HAI:	109383917(RASA3)

RFQ:	117021458(RASA3)

PALE:

102880496(RASA3)

PGIG:

120615607(RASA3)

PVP:	105305102(RASA3)

RAY:	107514353(RASA3)

MJV:	108399967(RASA3)

TOD:	119259693(RASA3)

SARA:

101544222(RASA3)

SFUM:

130037838(RASA3)

SETR:

126015557(RASA3)

LAV:	100657369(RASA3)

TMU:

101361309

ETF:	101649919(RASA3)

DNM:

101415925

MDO:	100021209(RASA3)

SHR:	100918630(RASA3)

AFZ:

127553503

PCW:	110193390(RASA3)

TVP:	118847945(RASA3)

PBRV:

138165746(RASA3)

OAA:	100085335(RASA3)

TACU:

119941552(RASA3)

GGA:	418736(RASA3)

PCOC:

116236497(RASA3)

MGP:	100547617(RASA3)

CJO:	107306402(RASA3)

TPAI:

128071736(RASA3)

LMUT:

125701027(RASA3)

NMEL:

110407167(RASA3)

APLA:

101792776(RASA3)

ACYG:

106046433(RASA3)

CATA:

118257502(RASA3)

AFUL:

116490289(RASA3)

TGU:	100222817(RASA3)

LSR:	110478769(RASA3)

SCAN:

103812389(RASA3)

PMOA:

120504634(RASA3)

OTC:	121343187(RASA3)

PRUF:

121352624(RASA3)

ATRC:

139591727(RASA3)

GFR:	102032050(RASA3)

FAB:	101812794(RASA3)

OMA:	130255544(RASA3)

PHI:	102111125(RASA3)

PMAJ:

107209894(RASA3)

CCAE:

111922704(RASA3)

CCW:	104686101(RASA3)

CBRC:

103617549(RASA3)

ACOE:

138105089(RASA3)

ETL:	114057868(RASA3)

ZAB:	102074834(RASA3)

ZLE:	135446166(RASA3)

SVG:	106858436(RASA3)

MMEA:

130572188(RASA3)

HRT:	120748486(RASA3)

SATI:

136357998(RASA3)

CCIC:

134041330(RASA3)

FPG:	101924193(RASA3)

FCH:	102051312(RASA3)

CCRI:

104166670(RASA3)

NNT:	104409163(RASA3)

SHAB:

115602513(RASA3)

ACUN:

113481432(RASA3)

TALA:

104363143(RASA3)

ACHC:

115334610(RASA3)

HALD:

104317997(RASA3)

HLE:	104836892(RASA3)

AGEN:

126052854

HHAR:

128135319(RASA3)

GCL:

127023988

CSTI:

104553958(RASA3)

LDI:	104350466(RASA3)

MNB:	103775480(RASA3)

DPUB:

104298634(RASA3)

PPUS:

135175494(RASA3)

AVIT:

104280490(RASA3)

BRHI:

104491981(RASA3)

EGZ:	104126356(RASA3)

NNI:	104019362(RASA3)

PCRI:

104034563(RASA3)

PCAO:

104047205(RASA3)

PADL:

103918851(RASA3)

AFOR:

103896268(RASA3)

FGA:	104081685(RASA3)

GSTE:

104262327(RASA3)

CLV:	102093309(RASA3)

MUI:	104537877(RASA3)

PGUU:

104470376(RASA3)

CMAC:

104485954(RASA3)

CUCA:

104056623(RASA3)

TEO:	104375939(RASA3)

BREG:

104643106(RASA3)

OHA:	104332100(RASA3)

ACAR:

104526404(RASA3)

CPEA:

104388966(RASA3)

CVF:	104292710(RASA3)

RTD:	128905380(RASA3)

CRID:

134517158(RASA3)

AAM:	106494051(RASA3)

AROW:

112960839(RASA3)

NPD:	112953611(RASA3)

TGT:	104568016(RASA3)

DNE:	112981372(RASA3)

SCAM:

104138054(RASA3)

ASN:	102375662(RASA3)

AMJ:	106736944(RASA3)

CPOO:

109306283(RASA3)

GGN:	109302812(RASA3)

PSS:	102458209(RASA3)

CMY:	102942091(RASA3)

CCAY:

125639366(RASA3)

DCC:	119850341(RASA3)

CPIC:

101940925(RASA3)

TST:	117870764(RASA3)

CABI:

116823337(RASA3)

MRV:	120407001(RASA3)

ACS:	100560638(rasa3)

ASAO:

132771529(RASA3)

PVT:	110074113(RASA3)

SUND:

121926606(RASA3)

PMUR:

107287912(RASA3)

CTIG:

120310584(RASA3)

TSR:	106539170 106544060(RASA3)

PGUT:

117666531(RASA3)

APRI:

131199557(RASA3)

PTEX:

113440827(RASA3)

NSS:	113411603(RASA3)

VKO:	123022694(RASA3)

PMUA:

114596438(RASA3)

PRAF:

128411834(RASA3)

ZVI:	118084834(RASA3)

HCG:	128350770(RASA3)

GJA:	107110916(RASA3)

STOW:

125430579(RASA3)

EMC:	129326524(RASA3)

XLA:	108709718(rasa3.S) 446637(rasa3.L)

XTR:	100144662(rasa3)

NPR:	108792288(RASA3)

RTEM:

120926454(RASA3)

BBUF:

120995707(RASA3)

BGAR:

122932096(RASA3)

PWL:	138250140(RASA3)

MUO:	115469145(RASA3)

GSH:	117362555(RASA3)

DRE:	100318936(rasa3)

SRX:	107748330(rasa3)

SANH:

107665824(rasa3) 107694463

SGH:	107571979 107574389(rasa3)

CAUA:

113044680 113083742(rasa3)

CGIB:

127948894 127974672

PTET:

122349922(rasa3)

LROH:

127169605(rasa3)

OMC:	131540414(rasa3)

PPRM:

120459064(rasa3)

RKG:	130078596(rasa3)

MAMB:

125273004(rasa3)

CIDE:

127517541

CERY:

137033138(rasa3)

MASI:

127443428 127445112

TROS:

130552777(rasa3)

TDW:	130413677(rasa3)

MANU:

129445151(rasa3)

PDAB:

135735609(rasa3)

IPU:

108258926

IFU:	128601769(rasa3)

PHYP:

113537310(rasa3)

SMEO:

124378637(rasa3)

TFD:	113648912(rasa3)

TVC:	132839325(rasa3)

CGAR:

128506589(rasa3)

NGRA:

132866082(rasa3)

TRN:	134328528(rasa3)

AMEX:

103031558(rasa3)

CMAO:

118798026(rasa3)

EEE:	113576980(rasa3)

CHAR:

105896531(rasa3)

SPIL:

134071598(rasa3)

TRU:	101061959(rasa3)

TFS:	130514105(rasa3)

TNG:	GSTEN00012211G001 GSTEN00017931G001

LCO:	104922522(rasa3)

NCC:	104958972(rasa3)

TBEN:

117471514(rasa3)

CGOB:

115027719(rasa3)

PGEO:

117466362(rasa3)

GACU:

117548246(rasa3)

EMAC:

134862986(rasa3)

ELY:	117258786(rasa3)

EFO:	125901852(rasa3)

PLEP:

121947518(rasa3)

SLUC:

116034000(rasa3)

ECRA:

117949409(rasa3)

ESP:	116699678(rasa3)

PFLV:

114558973(rasa3)

GAT:	120835072(rasa3)

PPUG:

119229660(rasa3)

AFB:	129102978(rasa3)

CLUM:

117747491(rasa3)

PSWI:

130192407(rasa3)

CANA:

137787393(rasa3)

CVE:	137887401(rasa3)

MSAM:

119890254(rasa3)

SCHU:

122875890(rasa3)

CUD:	121510543(rasa3)

SPUL:

138588136(rasa3)

LMIX:

132972743(rasa3)

ALAT:

119018336(rasa3)

ASTR:

137593133(rasa3)

MZE:	101481601(rasa3)

ONL:	100690286(rasa3)

OAU:	116312227(rasa3)

OLA:	101174253(rasa3)

OML:	112160332(rasa3)

CSAI:

133460886(rasa3)

XMA:	102219837(rasa3)

XCO:	114143289(rasa3)

XHE:	116719242(rasa3)

PRET:

103461964(rasa3)

PFOR:

103139379(rasa3)

PLAI:

106955605(rasa3)

PMEI:

106930423(rasa3)

GAF:

122820791

PPRL:

129369571(rasa3)

CVG:	107103567(rasa3)

CTUL:

119782764(rasa3)

GMU:	124867049(rasa3)

NFU:	107381620(rasa3)

KMR:	108228212(rasa3)

ALIM:

106513977(rasa3) 106534498

NWH:

119425459

EJA:	138212798(rasa3)

BFRE:

138620507(rasa3)

MCEP:

125005209(rasa3)

CSEM:

103378931(rasa3)

POV:	109625126(rasa3)

SSEN:

122772845(rasa3)

SSOE:

131459494(rasa3)

HHIP:

117752843(rasa3)

HSP:	118108642(rasa3)

PPLT:

128438863(rasa3)

SMAU:

118302257(rasa3)

LCF:

108888018

SDU:	111238332(rasa3)

SLAL:

111668309(rasa3)

XGL:	120791594(rasa3)

HCQ:	109519688(rasa3)

SSCV:

125967204(rasa3)

SBIA:

133498340(rasa3)

PEE:	133399075(rasa3)

PTAO:

133472428(rasa3)

BPEC:

110173025(rasa3)

MALB:

109964309(rasa3)

BSPL:

114852372(rasa3)

SJO:	128363414(rasa3)

SSCO:

133977739(rasa3)

GMH:	115558729(rasa3)

SASA:

106592024

OMY:	110511434(rasa3)

OGO:

124030034

OKI:	116361900 116362656

OKE:	127928880(rasa3)

OCLA:

139372431 139412752

CCLU:

121562820(rasa3)

ELS:	105020110(rasa3)

SFM:	108938234(rasa3)

PKI:	111845437 111854982 111855822(rasa3)

AANG:

118214242(rasa3)

AROT:

135240876(rasa3)

CCOG:

133116608(rasa3)

LOC:	102692914(rasa3)

PSPA:

121320890 121327904

ARUT:

117405760 117407386

PSEX:

120523390(rasa3)

LCM:	102356491(RASA3)

CMK:	103177559(rasa3)

RTP:	109937258(rasa3)

CPLA:

122550476(rasa3)

HOC:	132816370(rasa3)

LERI:

129697900(rasa3)

BFO:

BBEL:

CIN:

SPU:

LPIC:

AJJ:

APLC:

ARUN:

AAMU:

AFIL:

AJC:

PFLL:

DME:	Dmel_CG6721(RasGAP1)

DER:

6546009

DSE:

6605110

DSI:	Dsimw501_GD12887(Dsim_GD12887)

DYA:	Dyak_GE20296

DAN:

DSR:

DPO:

DPE:

DMN:

DWI:

DGR:

DMO:	Dmoj_GI13821

DNV:

108652086

DHE:

111599801

DVI:	6624101(RasGAP1)

CCAT:

BOD:

BDR:

RZE:

AOQ:

ALUD:

TDA:	119663536 119668105

MDE:

SCAC:

LCQ:

LSQ:

CVJ:	135954432(RasGAP1)

GFS:

ECOE:

CLON:

HIS:

AGA:

ACOZ:

AARA:

AMER:

ASTE:

AMAP:

AFUN:

AMOU:

AALI:

ACOS:

AAG:

AALB:

ASUA:

CQU:	CpipJ_CPIJ015188

CPII:

CNS:

BCOO:

LLL:

PPAP:

AME:

ACER:

ALAB:

ADR:

AFLR:

BIM:

BBIF:

BVK:

BVAN:

BHUN:

BTER:

BAFF:

BPYO:

BPAS:

FVI:

CCAL:

OBB:

OLG:

MGEN:

NMEA:

CGIG:

SOC:

MPHA:

AEC:

ACEP:

PBAR:

VEM:

COBS:

139109588(Rasgap1)

TLN:	139810150(Rasgap1)

HST:

DQU:

CFO:

FEX:

PMEC:

138933009(Rasgap1)

LHU:	105675697(RasGAP1)

PGC:

OBO:

PCF:

PFUC:

VPS:

VCRB:

VVE:

LHT:

LBD:

MDL:

CGLO:

FAS:

DAM:

AGIF:

CINS:

VCAN:

CCIN:

AROA:

TCA:	655526(Gap1)

TMOL:

138130525(RasGAP1)

DPA:

109537326

ESIM:

136412121(RasGAP1)

EFOR:

136340938(RasGAP1)

SOY:

AGRG:

ATD:

CSET:

HAXR:

AGB:

LDC:

DVV:

NVL:

APLN:

PPYR:

OTU:

BMOR:

BMAN:

MSEX:

DPL:	KGM_204270

BANY:

MJU:

NIQ:

VCD:

MCIX:

PMAC:

PPOT:

PXU:

BPHI:

137929478(RasGAP1)

PRAP:

PBX:

PNAP:

CCRC:

AAGE:

HAW:

HZE:

TNL:

SLIU:

OFU:

ONU:

ATRA:

GMW:

PGW:

LGLY:

CSTB:

CFEL:

CCRN:

API:

DNX:

AGS:

RMD:

ACOO:

DVT:

BTAB:

DCI:

CLEC:

HHAL:

106685156(RasGAP1)

NLU:	111044036 120355775

MQU:

128991883

PHU:	Phum_PHUM303870

FOC:

TPAL:

ZNE:

CSEC:

SGRE:

BROR:

IEL:

HAMR:

139700919(RasGAP1)

PVM:

PJA:

PCHN:

PMOO:

HAME:

PCLA:

123774544(RasGAP1)

CQD:	128699690(RasGAP1)

PTRU:

123504490

ESN:

126997528

MNZ:

135206036

MRJ:	136826866(RasGAP1)

HAZT:

PPOI:

ISC:

DSV:

RSAN:

RMP:

VDE:

VJA:

DPTE:

DFR:

CSCU:

CVS:	136976258(RasGAP1)

LPOL:

106470236

PMEO:

129593600

CEL:	CELE_T24C12.2(gap-1)

CBR:	CBG_14068(Cbr-gap-1)

CRQ:	GCK72_023985

NAI:	NECAME_01934

BMY:	BM_BM5984(Bma-gap-1)

LOA:	LOAG_17173

TSP:

Tsp_11981

LGI:	LOTGIDRAFT_170855

PVUL:

PCAN:

LSAX:

BGT:

GAE:

HRF:

HRJ:

HASI:

HCRA:

MYI:

PMAX:

AIRR:

MCAF:

MMER:

RPHI:

DPOL:

MAEA:

OBI:

OSN:

LJP:

LAK:

LLON:

NVE:

EPA:

ADF:

AMIL:

MCAZ:

MFOO:

PDAM:

SPIS:

TAD:	TRIADDRAFT_63821

AQU:

100631838

MBR:	MONBRDRAFT_33470

SRE:	PTSG_07380

DDI:	DDB_G0278483(ngap)

DPP:	DICPUDRAFT_160044

DFA:	DFA_05512(ngap)

» show all

Reference

PMID:16431904

Authors

Kupzig S, Deaconescu D, Bouyoucef D, Walker SA, Liu Q, Polte CL, Daumke O, Ishizaki T, Lockyer PJ, Wittinghofer A, Cullen PJ

Title

GAP1 family members constitute bifunctional Ras and Rap GTPase-activating proteins.

Journal

J Biol Chem 281:9891-900 (2006)
DOI:10.1074/jbc.M512802200

Reference

PMID:1547500

Authors

Gaul U, Mardon G, Rubin GM

Title

A putative Ras GTPase activating protein acts as a negative regulator of signaling by the Sevenless receptor tyrosine kinase.

Journal

Cell 68:1007-19 (1992)
DOI:10.1016/0092-8674(92)90073-L

Sequence

[dme:Dmel_CG6721]

All links

Ontology (1)   
   GO (1)   
Gene (615)   
   MGENES (238)   
   RefGene (370)   
   OC (7)   
All databases (616)   

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