KEGG ORTHOLOGY: K12406

ORTHOLOGY: K12406

Entry

K12406                      KO

Symbol

PKLR

Name

pyruvate kinase isozymes R/L [EC:2.7.1.40]

Pathway

map00010

Glycolysis / Gluconeogenesis

map00620

Pyruvate metabolism

map01100

Metabolic pathways

map01110

Biosynthesis of secondary metabolites

map01200

Carbon metabolism

map01230

Biosynthesis of amino acids

map04910

Insulin signaling pathway

map04930

Type II diabetes mellitus

map04932

Non-alcoholic fatty liver disease

map04950

Maturity onset diabetes of the young

Module

M00001

Glycolysis (Embden-Meyerhof pathway), glucose => pyruvate

M00002

Glycolysis, core module involving three-carbon compounds

Reaction

R00200

ATP:pyruvate 2-O-phosphotransferase

R00430

GTP:pyruvate 2-O-phosphotransferase

R01138

dATP:pyruvate 2-O-phosphotransferase

R01858

dGTP:pyruvate 2-O-phosphotransferase

R02320

NTP:pyruvate O2-phosphotransferase

Disease

H01096

Pyruvate kinase deficiency

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09101 Carbohydrate metabolism
   00010 Glycolysis / Gluconeogenesis
    K12406  PKLR; pyruvate kinase isozymes R/L
   00620 Pyruvate metabolism
    K12406  PKLR; pyruvate kinase isozymes R/L
09150 Organismal Systems
  09152 Endocrine system
   04910 Insulin signaling pathway
    K12406  PKLR; pyruvate kinase isozymes R/L
09160 Human Diseases
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    K12406  PKLR; pyruvate kinase isozymes R/L
   04950 Maturity onset diabetes of the young
    K12406  PKLR; pyruvate kinase isozymes R/L
   04932 Non-alcoholic fatty liver disease
    K12406  PKLR; pyruvate kinase isozymes R/L
09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04147 Exosome
    K12406  PKLR; pyruvate kinase isozymes R/L
Enzymes [BR:ko01000]
2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.1  Phosphotransferases with an alcohol group as acceptor
    2.7.1.40  pyruvate kinase
     K12406  PKLR; pyruvate kinase isozymes R/L
Exosome [BR:ko04147]
Exosomal proteins
  Exosomal proteins of other body fluids (saliva and urine)
   K12406  PKLR; pyruvate kinase isozymes R/L

Other DBs

GO:

0004743

Genes

HSA:	5313(PKLR)

PTR:	469513(PKLR)

PPS:	100980055(PKLR)

GGO:	101129346(PKLR)

PON:	100435140(PKLR)

PPYG:

129017990(PKLR)

NLE:	100579676(PKLR)

HMH:	116469318(PKLR)

SSYN:

134734397(PKLR)

MCC:	719152(PKLR)

MCF:	102116429(PKLR)

MTHB:

126933640

MNI:	105498012(PKLR)

CSAB:

103223883(PKLR)

CATY:

105593532(PKLR)

PANU:

101016119(PKLR)

TGE:	112622336(PKLR)

MLEU:

105544854(PKLR)

RRO:	104659593(PKLR)

RBB:	108526846(PKLR)

TFN:	117074608(PKLR)

PTEH:

111543761(PKLR)

CANG:

105502037(PKLR)

CJC:	100391903(PKLR)

SBQ:	101040510(PKLR)

CIMI:

108297158(PKLR)

ANAN:

105715486(PKLR)

CSYR:

103262621(PKLR)

MMUR:

105873168(PKLR)

LCAT:

123634068(PKLR)

PCOQ:

105821897(PKLR)

OGA:	100955995(PKLR)

MMU:	18770(Pklr)

MCAL:

110290727(Pklr)

MPAH:

110320360(Pklr)

RNO:	24651(Pklr)

MCOC:

116093152(Pklr)

ANU:	117707155(Pklr)

MUN:	110544999(Pklr)

CGE:	100755461(Pklr)

MAUA:

101831687(Pklr)

PROB:

127232814(Pklr)

PLEU:

114707930(Pklr)

MORG:

121450778(Pklr)

MFOT:

126486482

AAMP:

119801202(Pklr)

NGI:	103750858(Pklr)

HGL:	101701016(Pklr)

CPOC:

100716756(Pklr)

CCAN:

109687970(Pklr)

DORD:

105984991(Pklr)

DSP:	122109603(Pklr)

PLOP:

125359210(Pklr)

NCAR:

124962400

MMMA:

107156718(Pklr)

OCU:

100355056

OPI:	101534803(PKLR)

TUP:	102488414(PKLR)

GVR:	103596182(PKLR)

CFA:	490425(PKLR)

CLUD:

112648931(PKLR)

VVP:	112918921(PKLR)

VLG:	121488418(PKLR)

NPO:	129509043(PKLR)

AML:	100474752(PKLR)

UMR:	103668697(PKLR)

UAH:	113245274(PKLR)

UAR:	123783411(PKLR)

ELK:

111138942

LLV:

125086191

MPUF:

101671035(PKLR)

MNP:	132025896(PKLR)

MLK:	131814944(PKLR)

NVS:	122918258(PKLR)

ORO:	101364399(PKLR)

EJU:	114198647(PKLR)

ZCA:	113932065(PKLR)

MLX:	118013609(PKLR)

NSU:	110573558(PKLR)

LWW:	102741679(PKLR)

FCA:	101088459(PKLR)

PYU:	121015639(PKLR)

PCOO:

112851705(PKLR)

PBG:	122476589(PKLR)

PVIV:

125155372(PKLR)

LRUF:

124521891

PTG:	102971027(PKLR)

PPAD:

109256357(PKLR)

PUC:

125925711

AJU:

106981518

HHV:	120244657(PKLR)

BTA:	539579(PKLR)

BOM:	102273144(PKLR)

BIU:	109553613(PKLR)

BBUB:

102393826(PKLR)

BBIS:

104987400(PKLR)

CHX:	102187548(PKLR)

OAS:	780515(PKLR)

BTAX:

128044425(PKLR)

ODA:	120855736(PKLR)

CCAD:

122432517(PKLR)

MBEZ:

129541555(PKLR)

SSC:	100738344(PKLR)

CFR:	102522070(PKLR)

CBAI:

105068153(PKLR)

CDK:	105088819(PKLR)

VPC:	102542351(PKLR)

BACU:

103019356(PKLR)

BMUS:

118884027(PKLR)

LVE:	103089176(PKLR)

OOR:	101290268(PKLR)

DLE:	111166979(PKLR)

PCAD:

102982777(PKLR)

PSIU:

116754609(PKLR)

NASI:

112401742(PKLR)

ECB:	100063608(PKLR)

EPZ:	103552837(PKLR)

EAI:	106828491(PKLR)

MYB:	102255792(PKLR)

MYD:	102762600(PKLR)

MMYO:

118673208(PKLR)

MLF:	102422910(PKLR)

MDT:	132220719(PKLR)

PKL:	118721629(PKLR)

EFUS:

103298891(PKLR)

MNA:	107543786(PKLR)

DRO:	112315575(PKLR)

SHON:

118990152(PKLR)

AJM:	119039718(PKLR)

PDIC:

114488856(PKLR)

PHAS:

123804602(PKLR)

MMF:	118637241(PKLR)

PPAM:

129062152(PKLR)

HAI:	109393365(PKLR)

RFQ:	117014390(PKLR)

PALE:

102888780(PKLR)

PGIG:

120592122(PKLR)

PVP:	105296362(PKLR)

RAY:	107521461(PKLR)

MJV:	108407272(PKLR)

TOD:	119235279(PKLR)

SARA:

101558377(PKLR)

SETR:

126020141(PKLR)

LAV:	100659553(PKLR)

TMU:

101350675

ETF:	101638962(PKLR)

DNM:	101436765(PKLR)

MDO:	100022269(PKLR)

GAS:	123247777(PKLR)

SHR:	100930790(PKLR)

AFZ:

127559819

PCW:	110211952(PKLR)

TVP:	118847675(PKLR)

OAA:	114808131(PKLR)

ASN:	102373250(PKLR)

AMJ:	102572085(PKLR)

CPOO:

109324807(PKLR)

GGN:	109305098(PKLR)

CMY:	102942996(PKLR)

CCAY:

125625873(PKLR)

DCC:	119847784(PKLR)

CPIC:

101940854(PKLR)

CABI:

116817240(PKLR)

MRV:	120390465(PKLR)

ASAO:

132764239 132764243

PVT:	110081059(PKLR)

PBI:	103060723(PKLR)

PMUR:

107297021(PKLR)

CTIG:

120317061(PKLR)

TSR:

106544312

APRI:

131186382(PKLR)

VKO:	123032632(PKLR)

PMUA:

114586554(PKLR)

PRAF:

128403782(PKLR)

ZVI:	118075917(PKLR)

HCG:	128337174(PKLR)

GJA:	107119573(PKLR)

STOW:

125436554

EMC:	129339682(PKLR)

XLA:	108700448(pklr.S) 398967(pklr.L)

XTR:	100380137(pklr)

NPR:	108794239(PKLR)

RTEM:

120920890(PKLR)

MUO:	115457530(PKLR)

GSH:	117350192(PKLR)

LCM:	102364735(PKLR)

LJP:

135462633

» show all

Reference

PMID:3126495

Authors

Tani K, Fujii H, Nagata S, Miwa S

Title

Human liver type pyruvate kinase: complete amino acid sequence and the expression in mammalian cells.

Journal

Proc Natl Acad Sci U S A 85:1792-5 (1988)
DOI:10.1073/pnas.85.6.1792

Sequence

[hsa:5313]

Reference

PMID:1896471

Authors

Kanno H, Fujii H, Hirono A, Miwa S

Title

cDNA cloning of human R-type pyruvate kinase and identification of a single amino acid substitution (Thr384----Met) affecting enzymatic stability in a pyruvate kinase variant (PK Tokyo) associated with hereditary hemolytic anemia.

Journal

Proc Natl Acad Sci U S A 88:8218-21 (1991)
DOI:10.1073/pnas.88.18.8218

Sequence

[hsa:5313]

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