KEGG   ORTHOLOGY: K12420Help
Entry
K12420                      KO                                     

Name
actIII, oxyJ, snoaD, aknA
Definition
ketoreductase [EC:1.1.1.-]
Pathway
ko00253  Tetracycline biosynthesis
ko01056  Biosynthesis of type II polyketide backbone
ko01100  Metabolic pathways
ko01130  Biosynthesis of antibiotics
Module
M00778  Type II polyketide backbone biosynthesis, acyl-CoA + malonyl-CoA => polyketide
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   01056 Biosynthesis of type II polyketide backbone
    K12420  actIII, oxyJ, snoaD, aknA; ketoreductase
   00253 Tetracycline biosynthesis
    K12420  actIII, oxyJ, snoaD, aknA; ketoreductase
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01004 Lipid biosynthesis proteins
    K12420  actIII, oxyJ, snoaD, aknA; ketoreductase
   01008 Polyketide biosynthesis proteins
    K12420  actIII, oxyJ, snoaD, aknA; ketoreductase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.-  
     K12420  actIII, oxyJ, snoaD, aknA; ketoreductase
Lipid biosynthesis proteins [BR:ko01004]
 Polyketide synthase
  Component type
   K12420  actIII, oxyJ, snoaD, aknA; ketoreductase
Polyketide biosynthesis proteins [BR:ko01008]
 Polyketide synthase (PKS)
  Type II PKS
   C7-C12 cyclized polyketide type
    Octaketide PKS
     K12420  actIII, oxyJ, snoaD, aknA; ketoreductase
BRITE hierarchy
Other DBs
RN: R06642 R09262 R09263 R09264
Genes
PLU: plu4194
PLUM: A4R40_20800
PTT: VY86_11235
HOE: IMCC20628_03245
ABF: AMK58_25505
MANA: MAMMFC1_01617(actIII)
MSAO: MYCSP_12660
MSAL: DSM43276_02535(actIII)
NBR: O3I_007460
NNO: NONO_c10780
NTP: CRH09_08635
SCO: SCO5086(actIII)
SSX: SACTE_6349
SFA: Sfla_5324
SBH: SBI_06852
SVE: SVEN_5983
SDV: BN159_2469 BN159_2517
SALS: SLNWT_5124
STRP: F750_1299
SFI: SFUL_4005
SCI: B446_13340
SALU: DC74_6593
SALL: SAZ_34285
SLV: SLIV_12955(actIII)
SVT: SVTN_18785 SVTN_28610
STRE: GZL_p00217
SCW: TU94_31820
SLD: T261_6833
SXI: SXIM_35690
STRC: AA958_30270
SAMB: SAM23877_0193(alpD) SAM23877_7480(alpD)
SPRI: SPRI_0200 SPRI_0260 SPRI_7093 SPRI_7153
SCZ: ABE83_16230
SCX: AS200_01420
SRW: TUE45_01316(actIII_1) TUE45_01559(actIII_2)
STRF: ASR50_01285 ASR50_34160
SPAV: Spa2297_32765
SGS: AVL59_46175
SLS: SLINC_6892
STRD: NI25_18970
SPUN: BFF78_19360
SLAU: SLA_3116
SALJ: SMD11_0674(actIII) SMD11_1159(actIII) SMD11_6047(actIII)
SLX: SLAV_40230(actIII2) SLAV_40505(actIII3)
SNZ: DC008_13165
SGE: DWG14_07357(actIII_2)
KAB: B7C62_31020
KAU: B6264_18570
LMOI: VV02_05830
TFU: Tfu_1221
TCU: Tcur_2793
FRA: Francci3_4103 Francci3_4146
FRI: FraEuI1c_1326
PSEQ: AD006_29990
PECQ: AD017_31260
PHH: AFB00_31110
SESP: BN6_54890(fabG7)
KAL: KALB_7825
LED: BBK82_02525
PMAD: BAY61_07695
STP: Strop_2194
MAU: Micau_4010
MIL: ML5_4411
AMS: AMIS_50680
CAI: Caci_3549 Caci_6493
CEP: Cri9333_4738
CSG: Cylst_0020
AG: AAA65204(dpsE) AAF70104(aknA) AAZ78333(oxyJ) CAA12013(snoaD)
 » show all
TaxonomyKoalaUniProt
Reference
PMID:2469622
  Authors
Hallam SE, Malpartida F, Hopwood DA
  Title
Nucleotide sequence, transcription and deduced function of a gene involved in polyketide antibiotic synthesis in Streptomyces coelicolor.
  Journal
Gene 74:305-20 (1988)
DOI:10.1016/0378-1119(88)90165-5
  Sequence
[sco:SCO5086]
Reference
  Authors
Korman TP, Hill JA, Vu TN, Tsai SC
  Title
Structural analysis of actinorhodin polyketide ketoreductase: cofactor binding and substrate specificity.
  Journal
Biochemistry 43:14529-38 (2004)
DOI:10.1021/bi048133a
Reference
  Authors
Zhang W, Ames BD, Tsai SC, Tang Y
  Title
Engineered biosynthesis of a novel amidated polyketide, using the malonamyl-specific initiation module from the oxytetracycline polyketide synthase.
  Journal
Appl Environ Microbiol 72:2573-80 (2006)
DOI:10.1128/AEM.72.4.2573-2580.2006
  Sequence
Reference
  Authors
Pickens LB, Tang Y
  Title
Oxytetracycline biosynthesis.
  Journal
J Biol Chem 285:27509-15 (2010)
DOI:10.1074/jbc.R110.130419
Reference
PMID:8668120
  Authors
Ylihonko K, Tuikkanen J, Jussila S, Cong L, Mantsala P
  Title
A gene cluster involved in nogalamycin biosynthesis from Streptomyces nogalater: sequence analysis and complementation of early-block mutations in the anthracycline pathway.
  Journal
Mol Gen Genet 251:113-20 (1996)
DOI:10.1007/BF02172908
  Sequence
Reference
  Authors
Raty K, Kantola J, Hautala A, Hakala J, Ylihonko K, Mantsala P
  Title
Cloning and characterization of Streptomyces galilaeus aclacinomycins polyketide synthase (PKS) cluster.
  Journal
Gene 293:115-22 (2002)
DOI:10.1016/S0378-1119(02)00699-6
  Sequence

  All links  
Ontology (4)   
   KEGG BRITE (4)   
Pathway (9)   
   KEGG PATHWAY (8)   
   KEGG MODULE (1)   
Chemical reaction (6)   
   KEGG REACTION (4)   
   KEGG RCLASS (2)   
Gene (101)   
   KEGG GENES (84)   
   KEGG MGENES (12)   
   RefGene (4)   
   OC (1)   
Protein sequence (74)   
   UniProt (73)   
   SWISS-PROT (1)   
Literature (6)   
   PubMed (6)   
All databases (200)   

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KEGG   REACTION: R06642Help
Entry
R06642                      Reaction                               

Definition
18-Carbamoyl-3,5,7,9,11,13,15,17-octaoxooctadecanoyl-[acp] + NADPH + H+ <=> C-9 Reduced nonaketamide + NADP+
Equation
Comment
ketoreductase, OxyJ (otcY2-1)
Reaction class
RC00001  C00005_C00006
RC00029  C12441_C12442
Enzyme
1.1.1.-
Pathway
rn00253  Tetracycline biosynthesis
rn01056  Biosynthesis of type II polyketide backbone
rn01100  Metabolic pathways
rn01130  Biosynthesis of antibiotics
Module
M00778  Type II polyketide backbone biosynthesis, acyl-CoA + malonyl-CoA => polyketide
Orthology
K12420  ketoreductase [EC:1.1.1.-]

  All links  
Ontology (1)   
   KEGG BRITE (1)   
Pathway (9)   
   KEGG PATHWAY (8)   
   KEGG MODULE (1)   
Chemical substance (5)   
   KEGG COMPOUND (5)   
Chemical reaction (2)   
   KEGG RCLASS (2)   
Gene (85)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (84)   
All databases (102)   

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