KEGG   ORTHOLOGY: K12420
Entry
K12420                      KO                                     

Name
actIII, oxyJ, snoaD, aknA
Definition
ketoreductase [EC:1.1.1.-]
Pathway
ko00253  Tetracycline biosynthesis
ko01056  Biosynthesis of type II polyketide backbone
ko01100  Metabolic pathways
ko01110  Biosynthesis of secondary metabolites
Module
M00778  Type II polyketide backbone biosynthesis, acyl-CoA + malonyl-CoA => polyketide
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   01056 Biosynthesis of type II polyketide backbone
    K12420  actIII, oxyJ, snoaD, aknA; ketoreductase
   00253 Tetracycline biosynthesis
    K12420  actIII, oxyJ, snoaD, aknA; ketoreductase
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01004 Lipid biosynthesis proteins
    K12420  actIII, oxyJ, snoaD, aknA; ketoreductase
   01008 Polyketide biosynthesis proteins
    K12420  actIII, oxyJ, snoaD, aknA; ketoreductase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.-  
     K12420  actIII, oxyJ, snoaD, aknA; ketoreductase
Lipid biosynthesis proteins [BR:ko01004]
 Polyketide synthase
  Component type
   K12420  actIII, oxyJ, snoaD, aknA; ketoreductase
Polyketide biosynthesis proteins [BR:ko01008]
 Polyketide synthase (PKS)
  Type II PKS
   C7-C12 cyclized polyketide type
    Octaketide PKS
     K12420  actIII, oxyJ, snoaD, aknA; ketoreductase
Other DBs
RN: R06642 R09262 R09263 R09264
Genes
PLU: plu4194
PLUM: A4R40_20800
PTT: VY86_11235
HOE: IMCC20628_03245
AMIH: CO731_05562(actIII_2)
SIX: BSY16_4353
EAD: OV14_a0977
EAH: FA04_32435
NEO: CYG48_14430
OAH: DR92_4240
PAMN: pAMV3p0416
SWI: Swit_0826
SPHD: HY78_22565
MANA: MAMMFC1_01617(actIII)
MSAL: DSM43276_02535(actIII)
SCO: SCO5086(actIII)
SFA: Sfla_5324
SBH: SBI_06852
SVE: SVEN_5983
SALS: SLNWT_5124
STRP: F750_1299
SFI: SFUL_4005
SLV: SLIV_12955(actIII)
STRE: GZL_p00217
SLD: T261_6833
SAMB: SAM23877_0193(alpD) SAM23877_7480(alpD)
SRW: TUE45_01316(actIII_1) TUE45_01559(actIII_2)
STRD: NI25_18970
SLAU: SLA_3116
SALJ: SMD11_0674(actIII) SMD11_1159(actIII) SMD11_6047(actIII)
SLX: SLAV_40230(actIII2) SLAV_40505(actIII3)
SGE: DWG14_07357(actIII_2)
LMOI: VV02_05830
NCA: Noca_0796
TFU: Tfu_1221
TCU: Tcur_2793
AORI: SD37_09340
SESP: BN6_54890(fabG7)
KAL: KALB_7825
MIL: ML5_4411
CWO: Cwoe_3117
AG: AAA65204(dpsE) AAF70104(aknA) AAZ78333(oxyJ) CAA12013(snoaD)
 » show all
Reference
PMID:2469622
  Authors
Hallam SE, Malpartida F, Hopwood DA
  Title
Nucleotide sequence, transcription and deduced function of a gene involved in polyketide antibiotic synthesis in Streptomyces coelicolor.
  Journal
Gene 74:305-20 (1988)
DOI:10.1016/0378-1119(88)90165-5
  Sequence
[sco:SCO5086]
Reference
  Authors
Korman TP, Hill JA, Vu TN, Tsai SC
  Title
Structural analysis of actinorhodin polyketide ketoreductase: cofactor binding and substrate specificity.
  Journal
Biochemistry 43:14529-38 (2004)
DOI:10.1021/bi048133a
Reference
  Authors
Zhang W, Ames BD, Tsai SC, Tang Y
  Title
Engineered biosynthesis of a novel amidated polyketide, using the malonamyl-specific initiation module from the oxytetracycline polyketide synthase.
  Journal
Appl Environ Microbiol 72:2573-80 (2006)
DOI:10.1128/AEM.72.4.2573-2580.2006
  Sequence
Reference
  Authors
Pickens LB, Tang Y
  Title
Oxytetracycline biosynthesis.
  Journal
J Biol Chem 285:27509-15 (2010)
DOI:10.1074/jbc.R110.130419
Reference
PMID:8668120
  Authors
Ylihonko K, Tuikkanen J, Jussila S, Cong L, Mantsala P
  Title
A gene cluster involved in nogalamycin biosynthesis from Streptomyces nogalater: sequence analysis and complementation of early-block mutations in the anthracycline pathway.
  Journal
Mol Gen Genet 251:113-20 (1996)
DOI:10.1007/BF02172908
  Sequence
Reference
  Authors
Raty K, Kantola J, Hautala A, Hakala J, Ylihonko K, Mantsala P
  Title
Cloning and characterization of Streptomyces galilaeus aclacinomycins polyketide synthase (PKS) cluster.
  Journal
Gene 293:115-22 (2002)
DOI:10.1016/S0378-1119(02)00699-6
  Sequence

KEGG   REACTION: R09263
Entry
R09263                      Reaction                               

Definition
7,9,12-Decaketide intermediate 1 + NADPH + H+ <=> 7,9,12-Decaketide intermediate 2 + NADP+
Equation
Comment
ketoreductase, SnoaD
Reaction class
RC00001  C00005_C00006
RC00144  C18330_C18331
Enzyme
1.1.1.-
Pathway
rn01056  Biosynthesis of type II polyketide backbone
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Module
M00778  Type II polyketide backbone biosynthesis, acyl-CoA + malonyl-CoA => polyketide
Orthology
K12420  ketoreductase [EC:1.1.1.-]

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