KEGG   ORTHOLOGY: K12502
Entry
K12502                      KO                                     

Name
VTE3, APG1
Definition
MPBQ/MSBQ methyltransferase [EC:2.1.1.295]
Pathway
ko00130  Ubiquinone and other terpenoid-quinone biosynthesis
ko01100  Metabolic pathways
ko01110  Biosynthesis of secondary metabolites
Module
M00112  Tocopherol/tocotorienol biosynthesis
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09108 Metabolism of cofactors and vitamins
   00130 Ubiquinone and other terpenoid-quinone biosynthesis
    K12502  VTE3, APG1; MPBQ/MSBQ methyltransferase
Enzymes [BR:ko01000]
 2. Transferases
  2.1  Transferring one-carbon groups
   2.1.1  Methyltransferases
    2.1.1.295  2-methyl-6-phytyl-1,4-hydroquinone methyltransferase
     K12502  VTE3, APG1; MPBQ/MSBQ methyltransferase
Other DBs
RN: R07501 R10709 R10710
GO: 0051741 0051742
Genes
ATH: AT3G63410(APG1)
ALY: 9312789
CRB: 17887229
CSAT: 104699535 104699536 104748980 104788679 104788680
EUS: EUTSA_v10006087mg
BRP: 103830388
BNA: 106353332 106410579
BOE: 106300824
RSZ: 108818362
THJ: 104801966 104823034
CPAP: 110823242
EGR: 104427271
LJA: Lj5g3v1014830.1(Lj5g3v1014830.1) Lj5g3v1208090.1(Lj5g3v1208090.1)
ADU: 107473483
AIP: 107624907
CSV: 101218864
CMO: 103491265
MCHA: 111015269
SIND: 105163320
OEU: 111375743
BVG: 104894575
DOSA: Os07t0179300-00(Os07g0179300) Os12t0615400-01(Os12g0615400)
OBR: 102717119
ATS: 109753840(LOC109753840) 109759333(LOC109759333) 109759692(LOC109759692)
ZMA: 100284931
SITA: 101777009
PDA: 103716169
EGU: 105055609
MUS: 103975699
DCT: 110110033
PEQ: 110024315
AOF: 109833025
ATR: 18429566
CRE: CHLREDRAFT_129760(VTE3)
 » show all
Reference
  Authors
Cheng Z, Sattler S, Maeda H, Sakuragi Y, Bryant DA, DellaPenna D
  Title
Highly divergent methyltransferases catalyze a conserved reaction in tocopherol and plastoquinone synthesis in cyanobacteria and photosynthetic eukaryotes.
  Journal
Plant Cell 15:2343-56 (2003)
DOI:10.1105/tpc.013656
  Sequence
[ath:AT3G63410]

KEGG   ORTHOLOGY: K18534
Entry
K18534                      KO                                     

Name
K18534
Definition
MPBQ/MSBQ methyltransferase [EC:2.1.1.295]
Pathway
ko00130  Ubiquinone and other terpenoid-quinone biosynthesis
ko01100  Metabolic pathways
ko01110  Biosynthesis of secondary metabolites
Module
M00112  Tocopherol/tocotorienol biosynthesis
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09108 Metabolism of cofactors and vitamins
   00130 Ubiquinone and other terpenoid-quinone biosynthesis
    K18534  K18534; MPBQ/MSBQ methyltransferase
Enzymes [BR:ko01000]
 2. Transferases
  2.1  Transferring one-carbon groups
   2.1.1  Methyltransferases
    2.1.1.295  2-methyl-6-phytyl-1,4-hydroquinone methyltransferase
     K18534  K18534; MPBQ/MSBQ methyltransferase
Other DBs
RN: R07501 R10709 R10710
GO: 0051741 0051742
Genes
CRE: CHLREDRAFT_157804
VCN: VOLCADRAFT_105494
MNG: MNEG_2018
CSL: COCSUDRAFT_58884
CVR: CHLNCDRAFT_37067
APRO: F751_0698
OLU: OSTLU_10269 OSTLU_3898
OTA: OT_ostta02g04440 OT_ostta07g04670
BPG: Bathy08g00510 Bathy17g02220
MIS: MICPUN_61308 MICPUN_75700
FCY: FRACYDRAFT_277748(VTE3)
LEZ: GLE_2516
LEM: LEN_2498
DKO: I596_3178
CPS: CPS_3306
MHUA: MCHK_3250
MEX: Mext_2411
META: Y590_11650
BVR: BVIR_651
NDA: Ndas_0265
NAL: B005_3131
STRR: EKD16_04910(rebM4)
AMI: Amir_0228
ALO: CRK61372
SYN: sll0418
SYY: SYNGTS_1914(sll0418)
SYT: SYNGTI_1913(sll0418)
SYS: SYNPCCN_1912(sll0418)
SYQ: SYNPCCP_1912(sll0418)
SYJ: D082_05990(erg6)
SYC: syc0927_c
SYW: SYNW2141
SYG: sync_0378
CYA: CYA_0166
CYB: CYB_0976
SYNR: KR49_10590
SYND: KR52_00850
TEL: tll1726
THN: NK55_05270(vte3)
LET: O77CONTIG1_03739(rebM_3)
PMA: Pro_1661
PMM: PMM1505
PMT: PMT_1785
PRC: EW14_1844
PRM: EW15_2010
AMR: AM1_4828
CYT: cce_2731
TER: Tery_2173
ANA: all2121
AVA: Ava_1078
ANB: ANA_C11801(adpE)
CALH: IJ00_04090
DOU: BMF77_03807(eryG_2)
CEO: ETSB_0305
FMR: Fuma_01242(rebM)
SUS: Acid_6131
CBAL: M667_01525
CBAT: M666_01530
IAL: IALB_0840
NJA: NSJP_3545
THA: TAM4_1741
THS: TES1_1284
TEU: TEU_11385
MBN: Mboo_1437
MPD: MCP_0823
MEZ: Mtc_1963
RCI: LRC129
 » show all
Reference
  Authors
Shintani DK, Cheng Z, DellaPenna D
  Title
The role of 2-methyl-6-phytylbenzoquinone methyltransferase in determining tocopherol composition in Synechocystis sp. PCC6803.
  Journal
FEBS Lett 511:1-5 (2002)
DOI:10.1016/S0014-5793(01)03223-9
  Sequence
[syn:sll0418]

KEGG   ENZYME: 2.1.1.295
Entry
EC 2.1.1.295                Enzyme                                 

Name
2-methyl-6-phytyl-1,4-hydroquinone methyltransferase;
VTE3 (gene name);
2-methyl-6-solanyl-1,4-hydroquinone methyltransferase;
MPBQ/MSBQ methyltransferase;
MPBQ/MSBQ MT
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
Sysname
S-adenosyl-L-methionine:2-methyl-6-phytyl-1,4-benzoquinol C-3-methyltransferase
Reaction(IUBMB)
(1) S-adenosyl-L-methionine + 2-methyl-6-phytylbenzene-1,4-diol = S-adenosyl-L-homocysteine + 2,3-dimethyl-6-phytylbenzene-1,4-diol [RN:R07501];
(2) S-adenosyl-L-methionine + 2-methyl-6-all-trans-nonaprenylbenzene-1,4-diol = S-adenosyl-L-homocysteine + plastoquinol [RN:R10709];
(3) S-adenosyl-L-methionine + 6-geranylgeranyl-2-methylbenzene-1,4-diol = S-adenosyl-L-homocysteine + 6-geranylgeranyl-2,3-dimethylbenzene-1,4-diol [RN:R10710]
Reaction(KEGG)
Substrate
S-adenosyl-L-methionine [CPD:C00019];
2-methyl-6-phytylbenzene-1,4-diol [CPD:C15882];
2-methyl-6-all-trans-nonaprenylbenzene-1,4-diol [CPD:C17570];
6-geranylgeranyl-2-methylbenzene-1,4-diol [CPD:C20737]
Product
plastoquinol [CPD:C16695]
Comment
Involved in the biosynthesis of plastoquinol, as well as vitamin E (tocopherols and tocotrienols).
History
EC 2.1.1.295 created 2014
Pathway
ec00130  Ubiquinone and other terpenoid-quinone biosynthesis
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K12502  MPBQ/MSBQ methyltransferase
K18534  MPBQ/MSBQ methyltransferase
Genes
ATH: AT3G63410(APG1)
ALY: 9312789
CRB: 17887229
CSAT: 104699535 104699536 104748980 104788679 104788680
EUS: EUTSA_v10006087mg
BRP: 103830388
BNA: 106353332 106410579
BOE: 106300824
RSZ: 108818362
THJ: 104801966 104823034
CPAP: 110823242
EGR: 104427271
LJA: Lj5g3v1014830.1(Lj5g3v1014830.1) Lj5g3v1208090.1(Lj5g3v1208090.1)
ADU: 107473483
AIP: 107624907
CSV: 101218864
CMO: 103491265
MCHA: 111015269
SIND: 105163320
OEU: 111375743
BVG: 104894575
DOSA: Os07t0179300-00(Os07g0179300) Os12t0615400-01(Os12g0615400)
OBR: 102717119
ATS: 109753840(LOC109753840) 109759333(LOC109759333) 109759692(LOC109759692)
ZMA: 100284931
SITA: 101777009
PDA: 103716169
EGU: 105055609
MUS: 103975699
DCT: 110110033
PEQ: 110024315
AOF: 109833025
ATR: 18429566
MNG: MNEG_2018
APRO: F751_0698
FCY: FRACYDRAFT_277748(VTE3)
LEZ: GLE_2516
LEM: LEN_2498
DKO: I596_3178
CPS: CPS_3306
MHUA: MCHK_3250
MEX: Mext_2411
META: Y590_11650
BVR: BVIR_651
NDA: Ndas_0265
NAL: B005_3131
STRR: EKD16_04910(rebM4)
AMI: Amir_0228
ALO: CRK61372
SYN: sll0418
SYY: SYNGTS_1914(sll0418)
SYT: SYNGTI_1913(sll0418)
SYS: SYNPCCN_1912(sll0418)
SYQ: SYNPCCP_1912(sll0418)
SYJ: D082_05990(erg6)
SYC: syc0927_c
SYW: SYNW2141
SYG: sync_0378
CYA: CYA_0166
CYB: CYB_0976
SYNR: KR49_10590
SYND: KR52_00850
TEL: tll1726
THN: NK55_05270(vte3)
LET: O77CONTIG1_03739(rebM_3)
PMA: Pro_1661
PMM: PMM1505
PMT: PMT_1785
PRC: EW14_1844
PRM: EW15_2010
AMR: AM1_4828
CYT: cce_2731
TER: Tery_2173
ANA: all2121
AVA: Ava_1078
ANB: ANA_C11801(adpE)
CALH: IJ00_04090
DOU: BMF77_03807(eryG_2)
CEO: ETSB_0305
FMR: Fuma_01242(rebM)
SUS: Acid_6131
CBAL: M667_01525
CBAT: M666_01530
IAL: IALB_0840
NJA: NSJP_3545
THA: TAM4_1741
THS: TES1_1284
TEU: TEU_11385
MBN: Mboo_1437
MPD: MCP_0823
MEZ: Mtc_1963
RCI: LRC129
 » show all
Reference
1  [PMID:11821038]
  Authors
Shintani DK, Cheng Z, DellaPenna D
  Title
The role of 2-methyl-6-phytylbenzoquinone methyltransferase in determining tocopherol composition in Synechocystis sp. PCC6803.
  Journal
FEBS Lett 511:1-5 (2002)
DOI:10.1016/S0014-5793(01)03223-9
  Sequence
[syn:sll0418]
Reference
2  [PMID:14508009]
  Authors
Cheng Z, Sattler S, Maeda H, Sakuragi Y, Bryant DA, DellaPenna D.
  Title
Highly divergent methyltransferases catalyze a conserved reaction in tocopherol and plastoquinone synthesis in cyanobacteria and photosynthetic eukaryotes.
  Journal
Plant Cell 15:2343-56 (2003)
DOI:10.1105/tpc.013656
  Sequence
Reference
3  [PMID:14630966]
  Authors
Van Eenennaam AL, Lincoln K, Durrett TP, Valentin HE, Shewmaker CK, Thorne GM, Jiang J, Baszis SR, Levering CK, Aasen ED, Hao M, Stein JC, Norris SR, Last RL
  Title
Engineering vitamin E content: from Arabidopsis mutant to soy oil.
  Journal
Plant Cell 15:3007-19 (2003)
DOI:10.1105/tpc.015875
  Sequence
[ath:AT3G63410] [ana:all2121]
Other DBs
ExplorEnz - The Enzyme Database: 2.1.1.295
IUBMB Enzyme Nomenclature: 2.1.1.295
ExPASy - ENZYME nomenclature database: 2.1.1.295
BRENDA, the Enzyme Database: 2.1.1.295

KEGG   REACTION: R10710
Entry
R10710                      Reaction                               

Name
S-adenosyl-L-methionine:6-geranylgeranyl-2-methylbenzene-1,4-diol C3-methyltransferase
Definition
S-Adenosyl-L-methionine + 6-Geranylgeranyl-2-methylbenzene-1,4-diol <=> S-Adenosyl-L-homocysteine + 6-Geranylgeranyl-2,3-dimethylbenzene-1,4-diol
Equation
Reaction class
RC00003  C00019_C00021
RC01662  C20737_C20738
Enzyme
Pathway
rn00130  Ubiquinone and other terpenoid-quinone biosynthesis
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Module
M00112  Tocopherol/tocotorienol biosynthesis
Orthology
K12502  MPBQ/MSBQ methyltransferase [EC:2.1.1.295]
K18534  MPBQ/MSBQ methyltransferase [EC:2.1.1.295]
Other DBs
RHEA: 38010

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