KEGG   ORTHOLOGY: K12618
Entry
K12618                      KO                                     

Name
XRN1, SEP1, KEM1
Definition
5'-3' exoribonuclease 1 [EC:3.1.13.-]
Pathway
ko03008  Ribosome biogenesis in eukaryotes
ko03018  RNA degradation
Brite
KEGG Orthology (KO) [BR:ko00001]
 09120 Genetic Information Processing
  09122 Translation
   03008 Ribosome biogenesis in eukaryotes
    K12618  XRN1, SEP1, KEM1; 5'-3' exoribonuclease 1
  09123 Folding, sorting and degradation
   03018 RNA degradation
    K12618  XRN1, SEP1, KEM1; 5'-3' exoribonuclease 1
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03019 Messenger RNA biogenesis
    K12618  XRN1, SEP1, KEM1; 5'-3' exoribonuclease 1
   03009 Ribosome biogenesis
    K12618  XRN1, SEP1, KEM1; 5'-3' exoribonuclease 1
   03016 Transfer RNA biogenesis
    K12618  XRN1, SEP1, KEM1; 5'-3' exoribonuclease 1
   03036 Chromosome and associated proteins
    K12618  XRN1, SEP1, KEM1; 5'-3' exoribonuclease 1
Enzymes [BR:ko01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.13  Exoribonucleases producing 5'-phosphomonoesters
    3.1.13.-  
     K12618  XRN1, SEP1, KEM1; 5'-3' exoribonuclease 1
Messenger RNA biogenesis [BR:ko03019]
 Eukaryotic type
  mRNA surveillance and transport factors
   mRNA cycle factors
    Common to processing body (P body) and stress granule
     K12618  XRN1, SEP1, KEM1; 5'-3' exoribonuclease 1
  mRNA degradation factors
   5'-3' decay
    5' exonucleases
     K12618  XRN1, SEP1, KEM1; 5'-3' exoribonuclease 1
Ribosome biogenesis [BR:ko03009]
 Eukaryotic type
  Pre-60S particles
   RNases
    K12618  XRN1, SEP1, KEM1; 5'-3' exoribonuclease 1
Transfer RNA biogenesis [BR:ko03016]
 Eukaryotic type
  tRNA degradation factors
   Rapid tRNA decay (RTD) pathway factors
    K12618  XRN1, SEP1, KEM1; 5'-3' exoribonuclease 1
Chromosome and associated proteins [BR:ko03036]
 Eukaryotic type
  Gene silencing
   piRNA pathway
    K12618  XRN1, SEP1, KEM1; 5'-3' exoribonuclease 1
Genes
HSA: 54464(XRN1)
PTR: 460744(XRN1)
PPS: 100975490(XRN1)
GGO: 101147797(XRN1)
PON: 100449590(XRN1)
NLE: 100597889(XRN1)
MCC: 714497(XRN1)
MCF: 101926618(XRN1)
CSAB: 103241558(XRN1)
RRO: 104682193(XRN1)
RBB: 108535875(XRN1)
CJC: 100412678(XRN1)
SBQ: 101043520(XRN1)
MMU: 24127(Xrn1)
MCAL: 110302417(Xrn1)
MPAH: 110327930(Xrn1)
RNO: 300944(Xrn1)
CGE: 100760243(Xrn1)
NGI: 103752522(Xrn1)
HGL: 101701152(Xrn1)
OCU: 100351589(XRN1)
TUP: 102482614(XRN1)
CFA: 477100(XRN1)
VVP: 112934964(XRN1)
AML: 100464646(XRN1)
UMR: 103678392(XRN1)
UAH: 113254016(XRN1)
ORO: 101369891(XRN1)
ELK: 111147901
FCA: 101097088(XRN1)
PTG: 102948561(XRN1)
PPAD: 109260339(XRN1)
AJU: 106982266(XRN1)
BTA: 540834(XRN1)
BOM: 102268763(XRN1)
BIU: 109559563(XRN1)
BBUB: 102412468(XRN1)
CHX: 102178771(XRN1)
OAS: 101106821(XRN1)
SSC: 100515927(XRN1)
CFR: 102511588(XRN1)
CDK: 105086327(XRN1)
BACU: 103016273(XRN1)
LVE: 103082255(XRN1)
OOR: 101275029(XRN1)
DLE: 111179267(XRN1)
PCAD: 102983142(XRN1)
ECB: 100051335(XRN1)
EPZ: 103541058(XRN1)
EAI: 106838126(XRN1)
MYB: 102249234(XRN1)
MYD: 102768117(XRN1)
MNA: 107537977(XRN1)
HAI: 109390466(XRN1)
PALE: 102889090(XRN1)
RAY: 107500836
MJV: 108397426(XRN1)
LAV: 100661562(XRN1)
TMU: 101341941
MDO: 100013672(XRN1)
SHR: 100934609(XRN1)
PCW: 110197215(XRN1)
OAA: 100077938(XRN1)
GGA: 424778(XRN1)
MGP: 100542331(XRN1)
CJO: 107318069(XRN1)
NMEL: 110397591(XRN1)
APLA: 101794979
ACYG: 106036229(XRN1)
TGU: 100232132(XRN1)
LSR: 110473939(XRN1)
SCAN: 103815415(XRN1)
GFR: 102032070(XRN1)
FAB: 101808622(XRN1)
PHI: 102109729(XRN1)
PMAJ: 107208804(XRN1)
CCAE: 111933509(XRN1)
CCW: 104693453(XRN1)
ETL: 114069633(XRN1)
FPG: 101913095(XRN1)
FCH: 102053827(XRN1)
CLV: 102097760(XRN1)
EGZ: 104127112(XRN1)
NNI: 104016386(XRN1)
ACUN: 113483398(XRN1)
PADL: 103917881(XRN1)
AAM: 106485908(XRN1)
ASN: 102380424(XRN1)
AMJ: 102558616(XRN1)
PSS: 102459789(XRN1)
CPIC: 101931509(XRN1)
ACS: 100562142(xrn1)
PVT: 110078451(XRN1)
PBI: 103066866(XRN1)
PMUR: 107292035(XRN1)
TSR: 106539914(XRN1)
PMUA: 114597838(XRN1)
GJA: 107112361(XRN1)
XLA: 108717067(xrn1.L) 108718136(xrn1.S)
XTR: 733797(xrn1)
NPR: 108786347(XRN1)
DRE: 394008(xrn1)
SANH: 107677707(xrn1) 107700493
CCAR: 109110725
IPU: 108280294(xrn1)
AMEX: 103022720(xrn1)
EEE: 113590777(xrn1)
TRU: 101074214(xrn1)
LCO: 104929169(xrn1)
MZE: 101463778(xrn1)
ONL: 100691398(xrn1)
OLA: 101169885(xrn1)
XMA: 102228523(xrn1)
XCO: 114146609(xrn1)
PRET: 103478843(xrn1)
CVG: 107101793(xrn1)
NFU: 107395421(xrn1)
KMR: 108238650(xrn1)
ALIM: 106514920(xrn1)
AOCE: 111562863(xrn1)
CSEM: 103396659(xrn1)
POV: 109643207(xrn1)
LCF: 108896664(xrn1)
SDU: 111223795(xrn1)
SLAL: 111652960(xrn1)
HCQ: 109515519(xrn1)
BPEC: 110170407(xrn1)
OTW: 112226368 112260391(xrn1)
SALP: 111956514
ELS: 105018288(xrn1)
SFM: 108926832(xrn1)
LCM: 102350811(XRN1)
CMK: 103178358(xrn1)
RTP: 109934425(xrn1)
CIN: 100175420
SPU: 578630
APLC: 110984281
SKO: 100369596
DME: Dmel_CG3291(pcm)
DER: 6550391
DSE: 6614992
DSI: Dsimw501_GD27168(Dsim_GD27168)
DAN: 6503195
DSR: 110180082
DPE: 6597663
DMN: 108157502
DWI: 6652837
DAZ: 108618031
DNV: 108655614
DHE: 111598418
DVI: 6634679
MDE: 101894071
LCQ: 111680632
AAG: 5571065
AME: 409993
BIM: 100742741
BTER: 100649909
CCAL: 108625725
OBB: 114879716
SOC: 105204713
MPHA: 105830537
AEC: 105154516
ACEP: 105621109
PBAR: 105430804
VEM: 105563097
HST: 105190279
DQU: 106741804
CFO: 105251517
LHU: 105674583
PGC: 109860415
OBO: 105277307
PCF: 106790418
CSOL: 105365383
MDL: 103571248
TCA: 663618(XRN1)
DPA: 109540773
NVL: 108563534
BMOR: 101746591
BMAN: 114250593
PMAC: 106721332
PRAP: 110997731
HAW: 110374975
TNL: 113502334
API: 100163356
DNX: 107167875
AGS: 114121792
RMD: 113548120
BTAB: 109044785
CLEC: 106667311
ZNE: 110830323
FCD: 110842333
PVM: 113800050
TUT: 107368142
DPTE: 113797584
PTEP: 107451429
CEL: CELE_Y39G8C.1(xrn-1)
CBR: CBG20837(Cbr-xrn-1)
PCAN: 112556540
CRG: 105340192
MYI: 110442937
OBI: 106881569
LAK: 106168392
SHX: MS3_08894
NVE: 5514203
AMIL: 114971157
PDAM: 113684377
SPIS: 111332903
DGT: 114518166
AQU: 100632707
APRO: F751_4693
SCE: YGL173C(XRN1)
ERC: Ecym_8383
KMX: KLMA_40274(XRN1)
NCS: NCAS_0C04170(NCAS0C04170)
NDI: NDAI_0G03520(NDAI0G03520)
TPF: TPHA_0H00510(TPHA0H00510)
TBL: TBLA_0G02750(TBLA0G02750)
TDL: TDEL_0F01070(TDEL0F01070)
KAF: KAFR_0C03080(KAFR0C03080)
CAL: CAALFM_C113420CA(KEM1)
SLB: AWJ20_379(XRN1)
NCR: NCU06678
NTE: NEUTE1DRAFT127448(NEUTE1DRAFT_127448)
MGR: MGG_12403
SSCK: SPSK_04815
MAW: MAC_05995
MAJ: MAA_09154
CMT: CCM_03184
MBE: MBM_06945
ANI: AN8185.2
ANG: ANI_1_654084(An09g05290)
ABE: ARB_06879
TVE: TRV_05959
PTE: PTT_07733
SPO: SPAC17A5.14(exo2)
CNE: CNE03620
CNB: CNBE3620
TASA: A1Q1_03823
ABV: AGABI2DRAFT184268(AGABI2DRAFT_184268)
MGL: MGL_4024
MRT: MRET_4129
DDI: DDB_G0276137(xrn1)
DFA: DFA_11745(xrn1)
CPV: cgd6_2080
SPAR: SPRG_14369
 » show all
Reference
  Authors
Chernyakov I, Whipple JM, Kotelawala L, Grayhack EJ, Phizicky EM
  Title
Degradation of several hypomodified mature tRNA species in Saccharomyces cerevisiae is mediated by Met22 and the 5'-3' exonucleases Rat1 and Xrn1.
  Journal
Genes Dev 22:1369-80 (2008)
DOI:10.1101/gad.1654308
  Sequence
[sce:YGL173C]
Reference
  Authors
Mullen TE, Marzluff WF
  Title
Degradation of histone mRNA requires oligouridylation followed by decapping and simultaneous degradation of the mRNA both 5' to 3' and 3' to 5'.
  Journal
Genes Dev 22:50-65 (2008)
DOI:10.1101/gad.1622708
  Sequence
[hsa:54464]

KEGG   ORTHOLOGY: K12619
Entry
K12619                      KO                                     

Name
XRN2, RAT1
Definition
5'-3' exoribonuclease 2 [EC:3.1.13.-]
Pathway
ko03008  Ribosome biogenesis in eukaryotes
ko03018  RNA degradation
Brite
KEGG Orthology (KO) [BR:ko00001]
 09120 Genetic Information Processing
  09122 Translation
   03008 Ribosome biogenesis in eukaryotes
    K12619  XRN2, RAT1; 5'-3' exoribonuclease 2
  09123 Folding, sorting and degradation
   03018 RNA degradation
    K12619  XRN2, RAT1; 5'-3' exoribonuclease 2
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03021 Transcription machinery
    K12619  XRN2, RAT1; 5'-3' exoribonuclease 2
   03019 Messenger RNA biogenesis
    K12619  XRN2, RAT1; 5'-3' exoribonuclease 2
   03009 Ribosome biogenesis
    K12619  XRN2, RAT1; 5'-3' exoribonuclease 2
   03016 Transfer RNA biogenesis
    K12619  XRN2, RAT1; 5'-3' exoribonuclease 2
Enzymes [BR:ko01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.13  Exoribonucleases producing 5'-phosphomonoesters
    3.1.13.-  
     K12619  XRN2, RAT1; 5'-3' exoribonuclease 2
Transcription machinery [BR:ko03021]
 Eukaryotic type
  RNA polymerase II system
   Other transcription-related factors
    Transcription termination factor
     K12619  XRN2, RAT1; 5'-3' exoribonuclease 2
Messenger RNA biogenesis [BR:ko03019]
 Eukaryotic type
  mRNA degradation factors
   5'-3' decay
    5' exonucleases
     K12619  XRN2, RAT1; 5'-3' exoribonuclease 2
Ribosome biogenesis [BR:ko03009]
 Eukaryotic type
  Pre-60S particles
   RNases
    K12619  XRN2, RAT1; 5'-3' exoribonuclease 2
Transfer RNA biogenesis [BR:ko03016]
 Eukaryotic type
  tRNA degradation factors
   Rapid tRNA decay (RTD) pathway factors
    K12619  XRN2, RAT1; 5'-3' exoribonuclease 2
Genes
HSA: 22803(XRN2)
PTR: 458131(XRN2)
PPS: 100981151(XRN2)
GGO: 101139932(XRN2)
PON: 100173960(XRN2)
NLE: 100593111(XRN2)
MCC: 700934(XRN2)
MCF: 102134671(XRN2)
CSAB: 103215286(XRN2)
RRO: 104666944(XRN2)
RBB: 108536432(XRN2)
CJC: 100388181(XRN2)
SBQ: 101047908(XRN2)
MMU: 24128(Xrn2)
MCAL: 110310241(Xrn2)
MPAH: 110318322(Xrn2)
RNO: 362229(Xrn2)
MUN: 110553976(Xrn2)
CGE: 100770311(Xrn2)
NGI: 103740603(Xrn2)
HGL: 101697198(Xrn2)
CCAN: 109699816(Xrn2)
OCU: 100353161(XRN2)
TUP: 102490729(XRN2)
CFA: 477133(XRN2)
VVP: 112922703(XRN2)
AML: 100468930(XRN2)
UMR: 103677852(XRN2)
UAH: 113246784(XRN2)
ORO: 101381649(XRN2)
ELK: 111141389
FCA: 101084699(XRN2)
PTG: 102950740(XRN2)
PPAD: 109274657(XRN2)
AJU: 106984730(XRN2)
BTA: 517417(XRN2)
BOM: 102273486(XRN2)
BIU: 109568047(XRN2)
BBUB: 102410632(XRN2)
CHX: 102171526(XRN2)
OAS: 101102410(XRN2)
SSC: 100517201(XRN2)
CFR: 102504615(XRN2)
CDK: 105101564(XRN2)
BACU: 103000607(XRN2)
LVE: 103072390(XRN2)
OOR: 101282901(XRN2)
DLE: 111185048(XRN2)
PCAD: 102981997(XRN2)
ECB: 100050094(XRN2)
EPZ: 103563461(XRN2)
EAI: 106840312(XRN2)
MYB: 102263305(XRN2)
MYD: 102759792(XRN2)
MNA: 107536325(XRN2)
HAI: 109373916(XRN2)
DRO: 112304193(XRN2)
PALE: 102893608(XRN2)
RAY: 107500776(XRN2)
LAV: 100654986(XRN2)
TMU: 101354926
MDO: 100031372(XRN2)
SHR: 100926971(XRN2)
PCW: 110208731(XRN2)
OAA: 100074900(XRN2)
GGA: 421236(XRN2)
CJO: 107310734(XRN2)
NMEL: 110395808(XRN2)
APLA: 101794687(XRN2)
ACYG: 106042287(XRN2)
TGU: 100225776(XRN2)
LSR: 110474346(XRN2)
SCAN: 103819264(XRN2)
GFR: 102043356(XRN2)
FAB: 101816872(XRN2)
PHI: 102108757(XRN2)
PMAJ: 107201361(XRN2)
CCAE: 111926373(XRN2)
CCW: 104691474(XRN2)
ETL: 114067804(XRN2)
FPG: 101919651(XRN2)
FCH: 102053601(XRN2)
CLV: 102093706(XRN2)
EGZ: 104133448(XRN2)
NNI: 104022453(XRN2)
ACUN: 113478504(XRN2)
PADL: 103922061(XRN2)
AAM: 106499579(XRN2)
ASN: 102374361(XRN2)
AMJ: 102558593(XRN2)
PSS: 102452295(XRN2)
CMY: 102941188(XRN2)
CPIC: 101947639(XRN2)
ACS: 100562943(xrn2)
PVT: 110077452(XRN2)
PBI: 103063230(XRN2)
PMUR: 107297762(XRN2)
TSR: 106552193(XRN2)
PMUA: 114601202(XRN2)
GJA: 107106120(XRN2)
XLA: 100049102(xrn2.L) 108716605
XTR: 733834(xrn2)
NPR: 108804761(XRN2)
DRE: 321940(xrn2)
SRX: 107719412 107745894(xrn2)
IPU: 108257946(xrn2)
PHYP: 113531933(xrn2)
AMEX: 103036099(xrn2)
EEE: 113571690(xrn2)
TRU: 101080068(xrn2)
LCO: 104939755(xrn2)
MZE: 101473736(xrn2)
ONL: 100696623(xrn2)
OLA: 101163131(xrn2)
XMA: 102222739(xrn2)
XCO: 114158956(xrn2)
PRET: 103457049(xrn2)
CVG: 107098172(xrn2)
NFU: 107378188(xrn2)
ALIM: 106524235(xrn2)
AOCE: 111582655(xrn2)
CSEM: 103381319(xrn2)
LCF: 108872468(xrn2)
SDU: 111216427(xrn2)
SLAL: 111645237(xrn2)
HCQ: 109516769(xrn2)
MALB: 109971310(xrn2)
SASA: 106571262
OTW: 112250005
SALP: 111954157
ELS: 105017831(xrn2)
LCM: 102366306(XRN2)
CMK: 103181691(xrn2)
CIN: 100177034
SPU: 590369
SKO: 100376752(XRN2)
DME: Dmel_CG10354(Rat1)
DER: 6542584
DSI: Dsimw501_GD23438(Dsim_GD23438)
DSR: 110185682
DPE: 113565487
DMN: 108161907
DHE: 111600864
MDE: 101894988
AAG: 5578992
AME: 408840
BIM: 100745013
BTER: 100644887
CCAL: 108627054
OBB: 114872943
SOC: 105205191
MPHA: 105833546
AEC: 105149991
ACEP: 105621236
PBAR: 105428363
VEM: 105569456
HST: 105184218
DQU: 106740771
CFO: 105249372
LHU: 105677838
PGC: 109857581
OBO: 105286335
NVI: 100117393
TCA: 662556
BMOR: 101746473
BMAN: 114248413
PRAP: 111003936
TNL: 113504793
PXY: 105381915
API: 100159621
DNX: 107171441
AGS: 114128954
RMD: 113552326
FCD: 110844059
CEL: CELE_Y48B6A.3(xrn-2)
CBR: CBG20900(Cbr-xrn-2)
BMY: Bm1_49855
TSP: Tsp_08094
CRG: 105345357
OBI: 106869156
NVE: 116604541
EPA: 110245011
AMIL: 114975336
DGT: 114531593
HMG: 100205936
AQU: 100640875
ATH: AT1G75660(XRN3) AT5G42540(XRN2)
ALY: 9299844
RCN: 112169420
PPER: 18792164
PAVI: 110771075
MDM: 103450393
PXB: 103927935
QSU: 112002385
INI: 109170026
SIND: 105166022
DOSA: Os01t0872700-01(Os01g0872700)
OBR: 102710165
BDI: 100835512
ATS: 109748677(LOC109748677)
SBI: 8085812
ZMA: 103649964
SITA: 101753124
PDA: 103720841
EGU: 105035524
MUS: 103993606
DCT: 110098478
PEQ: 110038885
AOF: 109825184
OLU: OSTLU_526
SCE: YOR048C(RAT1)
ERC: Ecym_5486
KMX: KLMA_20373(RAT1)
NCS: NCAS_0G00590(NCAS0G00590)
NDI: NDAI_0F00680(NDAI0F00680)
TPF: TPHA_0J01240(TPHA0J01240)
TBL: TBLA_0A09480(TBLA0A09480)
TDL: TDEL_0B02780(TDEL0B02780)
KAF: KAFR_0C06110(KAFR0C06110)
CAL: CAALFM_C401080WA(RAT1)
SLB: AWJ20_5114(RAT1)
NCR: NCU01643
MGR: MGG_11426
SSCK: SPSK_01409
MAW: MAC_09299
MAJ: MAA_02697
CMT: CCM_07458
BFU: BCIN_13g04510(Bcrat1)
MBE: MBM_07364
ANI: AN0707.2
ANG: ANI_1_968074(An08g06790)
ABE: ARB_05228
TVE: TRV_02267
PTE: PTT_07622
SPO: SPAC26A3.12c(dhp1)
CNE: CNF01810
CNB: CNBF2890
MGL: MGL_2332
MRT: MRET_0181
EHI: EHI_080270(293.t00010) EHI_093360(22.t00005) EHI_128220 EHI_132400(297.t00006) EHI_133330(5.t00013)
TAN: TA08085
TPV: TP04_0369
BBO: BBOV_II002230(18.m06180)
CPV: cgd8_2250
 » show all
Reference
  Authors
Fang F, Phillips S, Butler JS
  Title
Rat1p and Rai1p function with the nuclear exosome in the processing and degradation of rRNA precursors.
  Journal
RNA 11:1571-8 (2005)
DOI:10.1261/rna.2900205
  Sequence
[sce:YOR048C]
Reference
  Authors
Kim M, Krogan NJ, Vasiljeva L, Rando OJ, Nedea E, Greenblatt JF, Buratowski S
  Title
The yeast Rat1 exonuclease promotes transcription termination by RNA polymerase II.
  Journal
Nature 432:517-22 (2004)
DOI:10.1038/nature03041
  Sequence
[sce:YOR048C]

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