KEGG   ORTHOLOGY: K12644
Entry
K12644                      KO                                     

Name
E2.3.1.159
Definition
acridone synthase [EC:2.3.1.159]
Pathway
ko01058  Acridone alkaloid biosynthesis
ko01110  Biosynthesis of secondary metabolites
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09110 Biosynthesis of other secondary metabolites
   01058 Acridone alkaloid biosynthesis
    K12644  E2.3.1.159; acridone synthase
Enzymes [BR:ko01000]
 2. Transferases
  2.3  Acyltransferases
   2.3.1  Transferring groups other than aminoacyl groups
    2.3.1.159  acridone synthase
     K12644  E2.3.1.159; acridone synthase
Other DBs
RN: R07250
GO: 0050635
Genes
CIT: 102611283 102618836 102619137
CIC: CICLE_v10025804mg CICLE_v10025807mg
AG: CAC14058(ACS2)
Reference
  Authors
Lukacin R, Springob K, Urbanke C, Ernwein C, Schroder G, Schroder J, Matern U.
  Title
Native acridone synthases I and II from Ruta graveolens L. form homodimers
  Journal
FEBS Lett 448:135-40 (1999)
DOI:10.1016/S0014-5793(99)00355-5
  Sequence

KEGG   ENZYME: 2.3.1.159
Entry
EC 2.3.1.159                Enzyme                                 

Name
acridone synthase
Class
Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups
Sysname
malonyl-CoA:N-methylanthraniloyl-CoA malonyltransferase (cyclizing)
Reaction(IUBMB)
3 malonyl-CoA + N-methylanthraniloyl-CoA = 4 CoA + 1,3-dihydroxy-N-methylacridone + 3 CO2 [RN:R07250]
Reaction(KEGG)
R07250
Substrate
malonyl-CoA [CPD:C00083];
N-methylanthraniloyl-CoA [CPD:C12092]
Product
CoA [CPD:C00010];
1,3-dihydroxy-N-methylacridone [CPD:C12093];
CO2 [CPD:C00011]
Comment
Belongs to a superfamily of plant polyketide synthases. Has many similarities to chalcone and stilbene synthases (see reaction synthesis)
History
EC 2.3.1.159 created 2002
Pathway
ec01058  Acridone alkaloid biosynthesis
ec01110  Biosynthesis of secondary metabolites
Orthology
K12644  acridone synthase
Genes
CIT: 102611283 102618836 102619137
CIC: CICLE_v10025804mg CICLE_v10025807mg
Reference
1  [PMID:8148006]
  Authors
Baumert A, Maier W, Groger D, Deutzmann R.
  Title
Purification and properties of acridone synthase from cell suspension cultures of Ruta graveolens L.
  Journal
Z Naturforsch [C] 49:26-32 (1994)
DOI:10.1515/znc-1994-1-205
Reference
2
  Authors
Maier, W., Baumert, A., Schumann, B., Furukawa, H. and Groger, D.
  Title
Synthesis of 1,3-dihydroxy-N-methylacridone and its conversion to rutacridone by cell-free extracts of Ruta-graveolens cell cultures.
  Journal
Phytochemistry 32:691-698 (1993)
Reference
3  [PMID:10217426]
  Authors
Lukacin R, Springob K, Urbanke C, Ernwein C, Schroder G, Schroder J, Matern U.
  Title
Native acridone synthases I and II from Ruta graveolens L. form homodimers.
  Journal
FEBS Lett 448:135-40 (1999)
DOI:10.1016/S0014-5793(99)00355-5
  Sequence
Reference
4  [PMID:9747538]
  Authors
Junghanns KT, Kneusel RE, Groger D, Matern U.
  Title
Differential regulation and distribution of acridone synthase in Ruta graveolens.
  Journal
Phytochemistry 49:403-11 (1998)
DOI:10.1016/S0031-9422(98)00104-6
Other DBs
ExplorEnz - The Enzyme Database: 2.3.1.159
IUBMB Enzyme Nomenclature: 2.3.1.159
ExPASy - ENZYME nomenclature database: 2.3.1.159
BRENDA, the Enzyme Database: 2.3.1.159
CAS: 99085-53-7

KEGG   REACTION: R07250
Entry
R07250                      Reaction                               

Name
malonyl-CoA:N-methylanthraniloyl-CoA malonyltransferase (cyclizing)
Definition
3 Malonyl-CoA + N-Methylanthraniloyl-CoA <=> 4 CoA + 1,3-Dihydroxy-N-methylacridone + 3 CO2 + H2O
Equation
3 C00083 + C12092 <=> 4 C00010 + C12093 + 3 C00011 + C00001
Reaction class
RC00004  C00010_C00083  C00010_C12092
RC02952  C12092_C12093
Enzyme
Pathway
rn01058  Acridone alkaloid biosynthesis
rn01110  Biosynthesis of secondary metabolites
Orthology
K12644  acridone synthase [EC:2.3.1.159]
Other DBs
RHEA: 22227

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