KEGG ORTHOLOGY: K12647

ORTHOLOGY: K12647

Entry

K12647                      KO

Symbol

IFIH1, MDA5

Name

interferon-induced helicase C domain-containing protein 1 [EC:5.6.2.6]

Pathway

map04622

RIG-I-like receptor signaling pathway

map05161

Hepatitis B

map05162

Measles

map05164

Influenza A

map05168

Herpes simplex virus 1 infection

map05171

Coronavirus disease - COVID-19

Disease

H00290

Aicardi-Goutieres syndrome

H00408

Type 1 diabetes mellitus

H01571

Singleton-Merten syndrome

H02525

Disorders of innate immunity

Brite

KEGG Orthology (KO) [BR:ko00001]
09150 Organismal Systems
  09151 Immune system
   04622 RIG-I-like receptor signaling pathway
    K12647  IFIH1, MDA5; interferon-induced helicase C domain-containing protein 1
09160 Human Diseases
  09172 Infectious disease: viral
   05161 Hepatitis B
    K12647  IFIH1, MDA5; interferon-induced helicase C domain-containing protein 1
   05171 Coronavirus disease - COVID-19
    K12647  IFIH1, MDA5; interferon-induced helicase C domain-containing protein 1
   05164 Influenza A
    K12647  IFIH1, MDA5; interferon-induced helicase C domain-containing protein 1
   05162 Measles
    K12647  IFIH1, MDA5; interferon-induced helicase C domain-containing protein 1
   05168 Herpes simplex virus 1 infection
    K12647  IFIH1, MDA5; interferon-induced helicase C domain-containing protein 1
09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04054 Pattern recognition receptors
    K12647  IFIH1, MDA5; interferon-induced helicase C domain-containing protein 1
Enzymes [BR:ko01000]
5. Isomerases
  5.6  Isomerases altering macromolecular conformation
   5.6.2  Enzymes altering nucleic acid conformation
    5.6.2.6  RNA 3'-5' helicase
     K12647  IFIH1, MDA5; interferon-induced helicase C domain-containing protein 1
Pattern recognition receptors [BR:ko04054]
Cytoplasmic pattern recognition receptors
  RIG-I-like receptors
   K12647  IFIH1, MDA5; interferon-induced helicase C domain-containing protein 1

Other DBs

GO:

0034458

Genes

HSA:	64135(IFIH1)

PTR:	459692(IFIH1)

PPS:	100981559(IFIH1)

GGO:	101142588(IFIH1)

PON:	100438807(IFIH1)

PPYG:

129031310(IFIH1)

NLE:	100597651(IFIH1)

HMH:	116810736(IFIH1)

SSYN:

129489421(IFIH1)

MCC:	702024(IFIH1)

MCF:	102135560(IFIH1)

MTHB:

126932955

MNI:	105483341(IFIH1)

CSAB:

103217190(IFIH1)

CATY:

105576049(IFIH1)

PANU:

101024962(IFIH1)

TGE:	112636165(IFIH1)

MLEU:

105547413(IFIH1)

RRO:	104661275(IFIH1)

RBB:	108541427(IFIH1)

TFN:	117094941(IFIH1)

PTEH:

111546062(IFIH1)

CANG:

105515310(IFIH1)

CJC:	100392317(IFIH1)

SBQ:	101040725(IFIH1)

CIMI:

108317486(IFIH1)

ANAN:

105708892(IFIH1)

CSYR:

103256184(IFIH1)

MMUR:

105868961(IFIH1)

LCAT:

123643203(IFIH1)

PCOQ:

105819577(IFIH1)

OGA:	100958514(IFIH1)

MMU:	71586(Ifih1)

MCAL:

110289518(Ifih1)

MPAH:

110318467(Ifih1)

RNO:	499801(Ifih1)

MCOC:

116090232(Ifih1)

ANU:	117702567(Ifih1)

MUN:	110548643(Ifih1)

CGE:	100767593(Ifih1)

MAUA:

101844185(Ifih1)

PROB:

127222475(Ifih1)

PLEU:

114690408(Ifih1)

MORG:

121433247(Ifih1)

MFOT:

126488761

AAMP:

119819080(Ifih1)

NGI:	103744095(Ifih1)

HGL:	101721395(Ifih1)

CPOC:

100717607(Ifih1)

CCAN:

109701161(Ifih1)

DORD:

105995788(Ifih1)

DSP:	122124962(Ifih1)

PLOP:

125350614(Ifih1)

NCAR:

124980157

MMMA:

107136888(Ifih1)

OCU:

100343560

OPI:	101522167(IFIH1)

TUP:	102476561(IFIH1)

GVR:	103598330(IFIH1)

CFA:	488371(IFIH1)

CLUD:

112674675(IFIH1)

VVP:	112916461(IFIH1)

VLG:	121501636(IFIH1)

NPO:	129498533(IFIH1)

AML:	100467176(IFIH1)

UMR:	103659509(IFIH1)

UAH:	113250835(IFIH1)

UAR:	123781312(IFIH1)

ELK:

111140996

LLV:

125095477

MPUF:

101675562(IFIH1)

MNP:	132013791(IFIH1)

MLK:	131827162(IFIH1)

NVS:	122902538(IFIH1)

ORO:	101381886(IFIH1)

EJU:	114216530(IFIH1)

ZCA:	113920745(IFIH1)

MLX:	118012394(IFIH1)

NSU:	110591963(IFIH1)

LWW:

102744424

FCA:	101099233(IFIH1)

PYU:	121030621(IFIH1)

PCOO:

112848925(IFIH1)

PBG:	122481388(IFIH1)

PVIV:

125171890(IFIH1)

LRUF:

124514967

PTG:	102970672(IFIH1)

PPAD:

109272005(IFIH1)

PUC:

125911583

AJU:

106984839

HHV:	120246112(IFIH1)

BTA:	535490(IFIH1)

BOM:	102266380(IFIH1)

BIU:	109567061(IFIH1)

BBUB:

102410252(IFIH1)

BBIS:

105002385(IFIH1)

CHX:	102183188(IFIH1)

OAS:	101106234(IFIH1)

BTAX:

128043437(IFIH1)

ODA:	120854856(IFIH1)

CCAD:

122453719(IFIH1)

MBEZ:

129537680(IFIH1)

SSC:	100101927(IFIH1)

CFR:	102520863(IFIH1)

CBAI:

105081951(IFIH1)

CDK:	105093686(IFIH1)

VPC:	102543498(IFIH1)

BACU:

103014106(IFIH1)

BMUS:

118898539(IFIH1)

LVE:	103086848(IFIH1)

OOR:	101271323(IFIH1)

DLE:	111172800(IFIH1)

PCAD:

102994692(IFIH1)

PSIU:

116756928(IFIH1)

NASI:

112393613(IFIH1)

ECB:	100061257(IFIH1)

EPZ:	103554416(IFIH1)

EAI:	106843229(IFIH1)

MYB:	102241185(IFIH1)

MYD:	102760067(IFIH1)

MMYO:

118661739(IFIH1)

MLF:	102424242(IFIH1)

MDT:	132238589(IFIH1)

PKL:	118709529(IFIH1)

EFUS:

103283368(IFIH1)

MNA:	107525248(IFIH1)

DRO:	112322284(IFIH1)

SHON:

118985776(IFIH1)

AJM:	119045642(IFIH1)

PDIC:

114495299(IFIH1)

PHAS:

123813652(IFIH1)

MMF:	118625298(IFIH1)

PPAM:

129061636(IFIH1)

HAI:	109379834(IFIH1)

RFQ:	117026306(IFIH1)

PALE:

102888688(IFIH1)

PGIG:

120597132(IFIH1)

PVP:	105291001(IFIH1)

RAY:	107511736(IFIH1)

MJV:	108398082(IFIH1)

TOD:	119255876(IFIH1)

SARA:

101559134(IFIH1)

SETR:

126009035(IFIH1)

LAV:	100675913(IFIH1)

TMU:

101341398

ETF:	101649079(IFIH1)

DNM:	101415870(IFIH1)

MDO:	100022390(IFIH1)

GAS:	123241463(IFIH1)

SHR:	100915060(IFIH1)

AFZ:

127554612

PCW:	110220730(IFIH1)

TVP:	118838191(IFIH1)

OAA:	100082294(IFIH1)

GGA:	424185(IFIH1)

PCOC:

116232915(IFIH1)

MGP:	100545639(IFIH1)

CJO:	107316932(IFIH1)

TPAI:

128076945(IFIH1)

LMUT:

125697191(IFIH1)

NMEL:

110399598(IFIH1)

APLA:

101800076(IFIH1)

ACYG:

106029824(IFIH1)

CATA:

118260733(IFIH1)

AFUL:

116490944(IFIH1)

TGU:	100225529(IFIH1)

LSR:	110469640(IFIH1)

SCAN:

103814392(IFIH1)

PMOA:

120497672(IFIH1)

OTC:	121335426(IFIH1)

PRUF:

121356520(IFIH1)

GFR:	102040357(IFIH1)

FAB:	101809185(IFIH1)

OMA:	130255673(IFIH1)

PHI:	102107885(IFIH1)

PMAJ:

107207576(IFIH1)

CCAE:

111931733(IFIH1)

CCW:	104693924(IFIH1)

CBRC:

103625573(IFIH1)

ETL:	114073731(IFIH1)

ZAB:	102073005(IFIH1)

ZLE:	135450419(IFIH1)

ACHL:

103803442(IFIH1)

SVG:	106855901(IFIH1)

MMEA:

130574424(IFIH1)

HRT:	120755001(IFIH1)

SATI:

136363552(IFIH1)

FPG:	101916011(IFIH1)

FCH:	102051096(IFIH1)

CCRI:

104154788(IFIH1)

NNT:	104399417(IFIH1)

SHAB:

115608507(IFIH1)

ACUN:

113482120(IFIH1)

TALA:

104368200(IFIH1)

ACHC:

115342625(IFIH1)

HALD:

104310812(IFIH1)

HLE:	104831774(IFIH1)

AGEN:

126050092

GCL:

127018359

CSTI:

104550683(IFIH1)

LDI:	104343943(IFIH1)

MNB:	103776330(IFIH1)

DPUB:

104300872(IFIH1)

AVIT:

104270792(IFIH1)

BRHI:

104489613(IFIH1)

EGZ:	104128023(IFIH1)

NNI:	104009962(IFIH1)

PCRI:

104024348(IFIH1)

PCAO:

104042610(IFIH1)

PADL:

103918138(IFIH1)

AFOR:

103895343(IFIH1)

FGA:	104077798(IFIH1)

GSTE:

104264360(IFIH1)

CLV:	102091175(IFIH1)

MUI:	104533342(IFIH1)

PGUU:

104463330(IFIH1)

PLET:

104627824(IFIH1)

EHS:	104503108(IFIH1)

CMAC:

104477472(IFIH1)

CUCA:

104054524(IFIH1)

TEO:

104381144

OHA:	104329005(IFIH1)

ACAR:

104518380(IFIH1)

CPEA:

104387518(IFIH1)

CVF:	104294922(IFIH1)

RTD:	128912404(IFIH1)

AAM:	106499314(IFIH1)

AROW:

112972046(IFIH1)

NPD:	112957953(IFIH1)

TGT:	104581227(IFIH1)

DNE:	112979912(IFIH1)

SCAM:

104144923(IFIH1)

ASN:	102384738(IFIH1)

AMJ:	102560357(IFIH1)

CPOO:

109323084(IFIH1)

GGN:	109301604(IFIH1)

PSS:	102443714(IFIH1)

CMY:	102943181(IFIH1)

CCAY:

125645189(IFIH1)

DCC:	119863698(IFIH1)

CPIC:

101937263(IFIH1)

TST:	117885133(IFIH1)

CABI:

116838412(IFIH1)

MRV:	120374928(IFIH1)

ACS:	100553529(ifih1)

ASAO:

132776357(IFIH1)

PVT:	110089482(IFIH1)

PBI:	103050994(IFIH1)

PMUR:

107285523

CTIG:

120312269(IFIH1)

TSR:	106539326(IFIH1)

PGUT:

117670839(IFIH1)

APRI:

131202555(IFIH1)

PTEX:

113434120(IFIH1)

NSS:	113416479 113416534

VKO:	123017039(IFIH1)

PMUA:

114605687(IFIH1)

PRAF:

128423313(IFIH1)

ZVI:	118093458(IFIH1)

HCG:	128340308(IFIH1)

GJA:	107123061(IFIH1)

STOW:

125426697(IFIH1)

EMC:	129325086(IFIH1)

XLA:	108701345(ifih1.L)

XTR:	100488298(ifih1)

NPR:	108787198(IFIH1)

RTEM:

120944068(IFIH1)

BBUF:

121007367(IFIH1)

BGAR:

122944887(IFIH1)

MUO:	115474382(IFIH1)

GSH:	117361482(IFIH1)

DRE:	565759(ifih1)

SRX:	107722900 107730588

SANH:

107674760(ifih1)

SGH:	107561563 107563828

CCAR:

109072590 109096478

CAUA:

113108248(ifih1)

CGIB:

127964540

PTET:

122351578(ifih1)

LROH:

127171214(ifih1)

OMC:	131547109(ifih1)

PPRM:

120487156(ifih1)

MAMB:

125270759(ifih1)

CIDE:

127518530

CERY:

137035425(ifih1)

MASI:

127447638

TROS:

130555924(ifih1)

TDW:	130427168(ifih1)

MANU:

129452427(ifih1)

IPU:	101154683(ifih1)

IFU:	128608941(ifih1)

PHYP:

113526113(ifih1)

SMEO:

124383090(ifih1)

TFD:	113654392(ifih1)

TVC:	132850270(ifih1)

TRN:	134324212(ifih1)

AMEX:

103026821(ifih1)

CMAO:

118806376(ifih1)

EEE:	113577523(ifih1)

CHAR:

105901604 105907943(ifih1)

TRU:	101076792(ifih1)

TFS:	130526856(ifih1)

TNG:	GSTEN00030578G001

LCO:	104920059(ifih1)

NCC:	104955305(ifih1)

TBEN:

117485767(ifih1)

CGOB:

115026421(ifih1)

PGEO:

117466415(ifih1)

GACU:

117556833(ifih1)

EMAC:

134867206(ifih1)

ELY:	117251370(ifih1)

EFO:	125899582(ifih1)

PLEP:

121948965(ifih1)

SLUC:

116049100(ifih1)

ECRA:

117953458(ifih1)

ESP:	116698016(ifih1)

PFLV:

114563770(ifih1)

GAT:	120833526(ifih1)

PPUG:

119228451(ifih1)

AFB:	129104388(ifih1)

CLUM:

117750306(ifih1)

PSWI:

130201963(ifih1)

MSAM:

119904054(ifih1)

SCHU:

122885629(ifih1)

CUD:	121523003(ifih1)

ALAT:

119026164(ifih1)

MZE:	101476548(ifih1)

ONL:	100703536(ifih1)

OAU:	116322947(ifih1)

OLA:	101175445(ifih1)

OML:	112154928(ifih1)

CSAI:

133445972(ifih1)

XMA:	102237624(ifih1)

XCO:	114147627(ifih1)

XHE:	116723180(ifih1)

PRET:

103461699(ifih1)

PFOR:

103134368(ifih1)

PLAI:

106958456(ifih1)

PMEI:

106909697(ifih1)

GAF:	122839710(ifih1)

PPRL:

129361392(ifih1)

CVG:	107081995(ifih1)

CTUL:

119786417(ifih1)

GMU:	124871128(ifih1)

NFU:	107390069(ifih1)

KMR:	108240713(ifih1)

ALIM:

106512943(ifih1)

NWH:	119419122(ifih1)

AOCE:

111575744(ifih1)

MCEP:

125018153(ifih1)

CSEM:

103392158(ifih1)

POV:	109631067(ifih1)

SSEN:

122765186(ifih1)

HHIP:

117754863(ifih1)

HSP:	118119917(ifih1)

PPLT:

128455849(ifih1)

SMAU:

118320500(ifih1)

LCF:

108901049

SDU:	111218444(ifih1)

SLAL:

111654519(ifih1)

XGL:	120801167(ifih1)

HCQ:	109514801(ifih1)

SSCV:

125973546

SBIA:

133512270(ifih1)

PEE:	133410247(ifih1)

PTAO:

133487152(ifih1)

BPEC:

110163921(ifih1)

MALB:

109957114(ifih1)

BSPL:

114846712(ifih1)

SJO:	128367846(ifih1)

SASA:

106581804(ifih1)

STRU:

115156064(ifih1)

OTW:	112225192(ifih1)

OMY:	100499612(ifih1)

OGO:

124042636

ONE:	115144059(ifih1)

OKI:	109870672(ifih1)

OKE:

118386002

SALP:

111959481

SNH:

120064408

CCLU:

121552057(ifih1)

ELS:	105022448(ifih1)

SFM:	108927949(ifih1)

PKI:	111849610(ifih1)

AANG:

118223664(ifih1)

LOC:	102693765(ifih1)

PSPA:

121322264(ifih1)

ARUT:

117406696 117426630(ifih1)

PSEX:

120531778(ifih1)

LCM:	102365428(IFIH1)

CMK:	103176369(ifih1)

RTP:	109920310(ifih1)

CPLA:

122551634(ifih1)

HOC:	132817078(ifih1)

LERI:

129698833(ifih1)

PMRN:

116938885(IFIH1)

BFO:	118413652 118414539 118416634 118423656

BBEL:

109470177 109471579 109472097 109484316

SPU:	105441782 115917944 578749

LPIC:

129273703

APLC:

110981267 110982589

ARUN:

117300078

SKO:	100371629 100371781 100378083

LGI:	LOTGIDRAFT_142329

PCAN:

112564109

BGT:

106061293

GAE:

121384536

HRF:	124113416 124113418

HRJ:	124253088 124253224 124275605

CRG:	105319712 105322988

CANU:

128180956 128184294 128185239 128186135

CVN:	111100904 111104065 111134530 111134532

OED:

125657867

MYI:	110449340 110449350

PMAX:

117315910 117315911 117327156

MMER:

RPHI:

DPOL:

MAEA:

LJP:

LAK:	106166008 106177543 106177544 112041766

LLON:

135489108

NVE:	5516210 5516250 5519349

EPA:	110235254 110235281 110244727

ATEN:

116289777 116298607 116298609 116298618 116304018

ADF:

107355208

AMIL:

114970170 114977263

PDAM:

113668173 113668179 113680120

SPIS:

111335040 111343597 111343600

DGT:	114538050 114544017

XEN:	124443494 124443938

AQU:	100641581 105313428

» show all

Reference

PMID:11805321

Authors

Kang DC, Gopalkrishnan RV, Wu Q, Jankowsky E, Pyle AM, Fisher PB

Title

mda-5: An interferon-inducible putative RNA helicase with double-stranded RNA-dependent ATPase activity and melanoma growth-suppressive properties.

Journal

Proc Natl Acad Sci U S A 99:637-42 (2002)
DOI:10.1073/pnas.022637199

Sequence

[hsa:64135]

All links

Ontology (4)   
   KEGG BRITE (3)   
   GO (1)   
Pathway (12)   
   KEGG PATHWAY (12)   
Disease (4)   
   KEGG DISEASE (4)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Gene (841)   
   KEGG GENES (483)   
   KEGG MGENES (285)   
   RefGene (69)   
   OC (4)   
Literature (1)   
   PubMed (1)   
All databases (863)   

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