KEGG ORTHOLOGY: K12654

ORTHOLOGY: K12654

Entry

K12654                      KO

Symbol

STING1, TMEM173, MITA

Name

stimulator of interferon genes protein

Pathway

map04621

NOD-like receptor signaling pathway

map04622

RIG-I-like receptor signaling pathway

map04623

Cytosolic DNA-sensing pathway

map05131

Shigellosis

map05163

Human cytomegalovirus infection

map05168

Herpes simplex virus 1 infection

map05170

Human immunodeficiency virus 1 infection

map05171

Coronavirus disease - COVID-19

Disease

H01746

STING-associated vasculopathy with onset in infancy

Brite

KEGG Orthology (KO) [BR:ko00001]
09150 Organismal Systems
  09151 Immune system
   04621 NOD-like receptor signaling pathway
    K12654  STING1, TMEM173, MITA; stimulator of interferon genes protein
   04622 RIG-I-like receptor signaling pathway
    K12654  STING1, TMEM173, MITA; stimulator of interferon genes protein
   04623 Cytosolic DNA-sensing pathway
    K12654  STING1, TMEM173, MITA; stimulator of interferon genes protein
09160 Human Diseases
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    K12654  STING1, TMEM173, MITA; stimulator of interferon genes protein
   05171 Coronavirus disease - COVID-19
    K12654  STING1, TMEM173, MITA; stimulator of interferon genes protein
   05168 Herpes simplex virus 1 infection
    K12654  STING1, TMEM173, MITA; stimulator of interferon genes protein
   05163 Human cytomegalovirus infection
    K12654  STING1, TMEM173, MITA; stimulator of interferon genes protein
  09171 Infectious disease: bacterial
   05131 Shigellosis
    K12654  STING1, TMEM173, MITA; stimulator of interferon genes protein
09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking
    K12654  STING1, TMEM173, MITA; stimulator of interferon genes protein
Membrane trafficking [BR:ko04131]
Autophagy
  Xenophagy
   Other xenophagy associated proteins
    K12654  STING1, TMEM173, MITA; stimulator of interferon genes protein

Genes

HSA:	340061(STING1)

PTR:	462107(STING1)

PPS:	100981835(STING1)

GGO:	101133875(STING1)

PON:	100459760(STING1)

PPYG:

129037060(STING1)

NLE:	105737525(STING1)

HMH:	116471574(STING1)

SSYN:

129486313(STING1)

MCC:	694353(TMEM173)

MCF:	102142250(STING1)

MTHB:

126957321

MNI:	105467057(TMEM173)

CSAB:

103244640(TMEM173)

CATY:

105599864(TMEM173)

PANU:

100997804(STING1)

TGE:	112626617(TMEM173)

MLEU:

105551820(TMEM173)

RRO:	104681744(STING1)

RBB:	108544077(TMEM173)

TFN:	117065778(STING1)

PTEH:

111528436 113224863

CANG:

105506995(TMEM173)

CJC:	100403981(STING1)

SBQ:	101032869(TMEM173)

CIMI:

108310070(STING1)

ANAN:

105731315(STING1)

CSYR:

103249555(TMEM173)

MMUR:

105862625(TMEM173)

LCAT:

123637842(STING1)

PCOQ:

105812006(TMEM173)

OGA:	100960636(TMEM173)

MMU:	72512(Sting1)

MCAL:

110284821(Tmem173)

MPAH:

110333201(Tmem173)

RNO:	498840(Sting1)

MCOC:

116087002(Sting1)

ANU:	117719568(Sting1)

CGE:	100758381(Sting1)

MAUA:

101834236(Sting1)

PROB:

127235167(Sting1)

PLEU:

114705142(Sting1)

MORG:

121443011 121453596

MFOT:

126497042 126497170

AAMP:

119814740(Sting1)

NGI:	103743083(Tmem173)

HGL:	101722845(Tmem173)

CPOC:

100732510(Tmem173)

CCAN:

109689178(Tmem173)

DORD:

105988598(Tmem173)

DSP:	122118148(Sting1)

PLOP:

125339891(Sting1)

NCAR:

124986514

MMMA:

107141583(Sting1)

OCU:	100349135(STING1)

OPI:	101520424(STING1)

TUP:	102488712(TMEM173)

GVR:	103584100 103587190(TMEM173)

CFA:	606815(STING1)

CLUD:

112658963(STING1)

VVP:	112933944(TMEM173)

VLG:	121497271(STING1)

NPO:	129513336(STING1)

AML:	100473848(STING1)

UMR:	103663769(STING1)

UAH:	113261804(STING1)

UAR:	123790287(STING1)

ELK:

111141242

LLV:

125099664

MPUF:

101691280(TMEM173)

MNP:	132028569(STING1) 132028570

MLK:	131832121(STING1)

NVS:	122890962(STING1)

ORO:	101384140(TMEM173)

EJU:	114209443(TMEM173)

ZCA:	113929903(STING1)

MLX:	118016696(STING1)

NSU:	110591049(STING1)

LWW:	102733154(STING1)

FCA:	101090737(STING1)

PYU:	121010787(STING1)

PCOO:

112861316(TMEM173)

PBG:	122479110(STING1)

PVIV:

125161717(STING1)

LRUF:

124516287

PTG:	102949177(TMEM173)

PPAD:

109252151(TMEM173)

PUC:

125935570

AJU:	106967746(STING1)

HHV:	120245611(STING1)

BTA:	533661(STING1)

BOM:	102280504(TMEM173)

BIU:	109562082(TMEM173)

BBUB:

102416177(STING1)

BBIS:

104996188(TMEM173)

CHX:	102171058(STING1)

OAS:	101116050(STING1)

BTAX:

128050274(STING1)

ODA:	120863586(STING1)

CCAD:

122439844(STING1)

MBEZ:

129558440(STING1)

SSC:	100217389(TMEM173)

CFR:	102506411(STING1)

CBAI:

105082187(TMEM173)

CDK:	105098117(STING1)

VPC:	102528957(STING1)

BACU:

102999049(TMEM173)

BMUS:

118892150(STING1)

LVE:	103072143(TMEM173)

OOR:	101275872(STING1)

DLE:	111182516(STING1)

PCAD:

114483846(STING1)

PSIU:

116752236(STING1)

NASI:

112404461(TMEM173)

ECB:	100062046(TMEM173)

EPZ:	103548002(TMEM173)

EAI:	106839235(STING1)

MYB:	102241202(TMEM173)

MYD:	102754009(TMEM173)

MMYO:

118659024(STING1)

MLF:	102434781(TMEM173)

MDT:	132235717(STING1)

PKL:	118711644(STING1)

EFUS:

103286123(STING1)

MNA:	107530112(TMEM173)

DRO:	112318146(TMEM173)

SHON:

118997793(STING1)

AJM:	119050990(STING1)

PDIC:

114509793(STING1)

PHAS:

123811122(STING1)

MMF:	118616346(STING1)

PPAM:

129066421(STING1)

HAI:	109393185(TMEM173)

RFQ:	117016402(STING1)

PALE:

102888203(TMEM173)

PGIG:

120581381(STING1)

PVP:	105306956(TMEM173)

RAY:	107521573(TMEM173)

MJV:	108405108(STING1)

TOD:	119242720(STING1)

SARA:

101548317(TMEM173)

SETR:

126027042(STING1)

LAV:	100670392(TMEM173)

TMU:

101342770

ETF:	101649228(STING1)

DNM:	101434300(TMEM173)

MDO:	100025682(TMEM173)

GAS:	123235645(STING1)

SHR:	100932153(STING1)

AFZ:

127549981

PCW:	110220899(TMEM173)

TVP:	118840916(STING1)

OAA:	100088829(STING1)

GGA:	768990(TMEM173)

PCOC:

116237731(STING1)

MGP:	104913212(STING1)

CJO:	107320413(STING1)

TPAI:

128081366(STING1)

LMUT:

125700077(STING1)

NMEL:

110405146(TMEM173)

APLA:

101799156(STING1)

ACYG:

106049651(STING1)

CATA:

118254441(STING1)

AFUL:

116495055(STING1)

TGU:	100218078(STING1)

LSR:	110471342(STING1)

SCAN:

103817453(TMEM173)

PMOA:

120498576(STING1)

OTC:	121332374(STING1)

PRUF:

121364642(STING1)

GFR:	102032619(TMEM173)

FAB:	101815614(TMEM173)

OMA:	130258650(STING1)

PHI:	102108692(TMEM173)

PMAJ:

107210608(STING1)

CCAE:

111935667(TMEM173)

CCW:	104693558(STING1)

CBRC:

103624899(TMEM173)

ETL:	114059797(TMEM173)

ZAB:	102074615(TMEM173)

ZLE:	135453663(STING1)

ACHL:

103802751(TMEM173)

SVG:	106860017(TMEM173)

MMEA:

130580293(STING1)

HRT:	120759271(STING1)

SATI:

136367378(STING1)

FPG:	101922549(TMEM173)

FCH:	102053394(TMEM173)

CCRI:

104166716(TMEM173)

NNT:	104401859(TMEM173)

SHAB:

115615641(STING1)

ACUN:

113485185(TMEM173)

TALA:

104362646(STING1)

ACHC:

115334319(STING1)

HALD:

104323445(TMEM173)

HLE:	104830827(TMEM173)

AGEN:

126050815

GCL:

127022010

CSTI:

104549682(TMEM173)

LDI:	104346674(TMEM173)

MNB:	103776319(TMEM173)

DPUB:

104298349(TMEM173)

AVIT:

104267529(TMEM173)

BRHI:

104495235(TMEM173)

EGZ:	104131967(TMEM173)

NNI:	104022143(TMEM173)

PCRI:

104029600(TMEM173)

PCAO:

104053742(TMEM173)

PADL:

103921594(TMEM173)

AFOR:

103899581(TMEM173)

FGA:	104073799(TMEM173)

GSTE:

104255986(TMEM173)

CLV:	102090573(TMEM173)

MUI:	104533350(TMEM173)

PGUU:

104464809(TMEM173)

PLET:

104616437(TMEM173)

EHS:	104514204(TMEM173)

CMAC:

104480932(TMEM173)

CUCA:

104054847(STING1)

TEO:	104372666(TMEM173)

BREG:

104642929(TMEM173)

OHA:	104328277(TMEM173)

ACAR:

104525604(TMEM173)

CPEA:

104398240(TMEM173)

CVF:	104291456(TMEM173)

RTD:	128916266(STING1)

AAM:	106494309(TMEM173)

AROW:

112967099(TMEM173)

NPD:	112944344(TMEM173)

TGT:	104573081(TMEM173)

DNE:	112986299(TMEM173)

SCAM:

104150480(TMEM173)

ASN:	102373608(TMEM173)

AMJ:	102571375(TMEM173)

PSS:	102454007(TMEM173)

CMY:	102932364(STING1)

CCAY:

125641391(STING1)

DCC:	119860452(STING1)

CPIC:

101952355(STING1)

TST:	117881870(STING1)

CABI:

116823245(STING1)

MRV:	120369684(STING1)

ACS:	100564513(tmem173)

ASAO:

132774232(STING1)

PVT:	110077447(TMEM173)

SUND:

121928901(STING1)

PMUA:

114601175(TMEM173)

PRAF:

128416863(STING1)

ZVI:	118079382(STING1)

HCG:	128324788(STING1)

GJA:

107107713

STOW:

125443679(STING1)

EMC:	129333581(STING1)

XLA:	108712650(sting1.S)

XTR:	100127621(sting1)

NPR:	108798433(TMEM173)

RTEM:

120932424(STING1)

BBUF:

121009420(STING1)

BGAR:

122928262(STING1)

MUO:	115476611(TMEM173)

GSH:	117351645(STING1)

DRE:	101243556(sting1)

SRX:

107731712

SANH:

107660166 107680289

SGH:	107559268 107579047

CCAR:

109091093 109097113

CAUA:

113057687 113076544 113114474

CGIB:

127971011 128027033

PTET:

122357461(sting1)

LROH:

127175904(sting1)

OMC:	131553470(sting1)

PPRM:

120460622(sting1)

RKG:	130084762(sting1)

MAMB:

125259388(sting1)

CIDE:

127494683

CERY:

137017711(sting1)

MASI:

127412724

TROS:

130563658(sting1)

TDW:	130438003(sting1)

MANU:

129421748(sting1)

IPU:	108274684(sting1)

IFU:	128618397(sting1)

PHYP:

113529992(tmem173)

SMEO:

124392354(sting1)

TFD:	113654971(sting1)

TVC:	132856862(sting1)

TRN:	134319432(sting1)

AMEX:

103043645(sting1)

CMAO:

118801446(sting1)

EEE:	113581725(tmem173)

CHAR:

105897430(sting1)

LCO:	104920568(tmem173)

TBEN:

117475202(sting1)

CGOB:

115015094(tmem173)

PGEO:

117454095(sting1)

GACU:

117534702(sting1)

EMAC:

134860052(sting1)

ELY:	117260693(sting1)

EFO:	125894272(sting1)

PLEP:

121947981(sting1)

SLUC:

116036524(sting1)

ECRA:

117952059(sting1)

PFLV:

114562667(tmem173)

GAT:	120817637(sting1)

PPUG:

119210607(sting1)

AFB:	129089690(sting1)

CLUM:

117737361(sting1)

MSAM:

119888294(sting1)

SCHU:

122879820(sting1)

CUD:	121516827(sting1)

ALAT:

119008127(sting1)

MZE:	101472581(tmem173)

ONL:	100697006(tmem173)

OAU:	116329439(sting1)

OLA:	101160004(tmem173)

OML:	112153054(sting1)

CSAI:

133447668(sting1)

XMA:	102235680(tmem173)

XCO:	114139734(tmem173)

XHE:	116714932(sting1)

PRET:

103471059(tmem173)

PFOR:

103139865(tmem173)

PLAI:

106952395(tmem173)

PMEI:

106910062(tmem173)

GAF:	122837240(sting1)

PPRL:

129362626(sting1)

CVG:	107082384(tmem173)

CTUL:

119778429(sting1)

GMU:	124859846(sting1)

NFU:

107380073

KMR:	108237966(sting1)

ALIM:

106534723(tmem173)

NWH:	119408315(sting1)

AOCE:

111567610(tmem173)

MCEP:

125008176(sting1)

POV:	109626281(tmem173)

SSEN:

122778177(sting1)

HHIP:

117769597(sting1)

HSP:	118112807(sting1)

PPLT:

128445482(sting1)

SMAU:

118319655(sting1)

LCF:	108878651(sting1)

SDU:	111226663(tmem173)

SLAL:

111646434(tmem173)

XGL:	120784894(sting1)

BPEC:

110153938(tmem173)

MALB:

109957474(tmem173)

BSPL:

114864860(sting1)

SJO:	128363381(sting1)

SASA:

106612120(tmem173)

STRU:

115169157 115205559

OTW:	112221185 112255958

OMY:	110487764 110504688

OGO:

124011318

ONE:

115122470

OKI:	109879782 109910196

OKE:	118372926 118381455

SALP:

111965530 111967243

SNH:	120046931 120062057

CCLU:

121558729(sting1)

ELS:	105026749(tmem173)

SFM:	108922973(tmem173)

PKI:	111852992(tmem173)

AANG:

118222610(sting1)

LOC:	102691936(tmem173)

PSPA:

121297385(sting1)

ARUT:

117413138(sting1) 117431195

LCM:	102363630(TMEM173)

CMK:	103186966(sting1)

RTP:	109930370(sting1)

CPLA:

122556674(sting1)

HOC:	132823069(sting1)

LERI:

129701715(sting1)

PMRN:

116950884(STING1)

LRJ:	133354413(STING1)

BFO:

BBEL:

SKO:

DPO:

DPE:

DMN:

DWI:

DMO:	Dmoj_GI18829

DAZ:

DNV:

DHE:

LCQ:

BIM:

BTER:

SOC:

MPHA:

AEC:

ACEP:

PBAR:

VEM:

HST:

DQU:

CFO:	105255316 105258298

FEX:

115238926

LHU:	105678393(Sting)

PGC:

OBO:

NVI:

TPRE:

DSM:

NPT:

NFB:

NLO:

NVG:

TCA:

DPA:

AGRG:

ATD:

NVL:

OTU:

BMOR:

BMAN:

BANY:

MJU:

PMAC:

PPOT:

PXU:

PRAP:

ZCE:

LSIN:

AAGE:

HAW:	110380251 110380253

HZE:	124638953 124638991

TNL:	113503665 113503863

SLIU:

ATRA:

GMW:

LGLY:

MQU:

ZNE:

BROR:

DPX:	DAPPUDRAFT_229490

DMK:	116915814 123470044

PVM:

PJA:

PCHN:

PPOI:

DSV:

RSAN:

RMP:	119174089 119174091

CSCU:

111617947 111617948 111624909

CVS:	136971111 136971832

ABRU:

SDM:

LPOL:

PCAN:

HRF:

CRG:	105329774 105330678 105332933 105344520

CANU:

128156740 128180493 128182267 128183617

CVN:	111124607 111124608 111124610 111125472

OED:

125679350

MMER:

123554287 123554299

LAK:

106181941

NVE:	116616001 5506676

EPA:	110242126 110242127 110242128 110242139 110245547 110245548

ATEN:

116292638 116303443

ADF:	107333219 107333220 107333225

AMIL:

114961089 114974498 114974499 114974504

PDAM:

113674075 113677076 113677077 113677097 113680320

SPIS:

111321938 111325159 111325160 111325161 111325162 111325163 111325177 111325185 111325205

DGT:	114516230 114517439 114522631 114523399 114525607 114525662 114529951 114529958 114529983 114531716

XEN:	124441193 124441375 124441376 124442520 124453196 124453439

HMG:	101236704 101241765

HSY:	130644488 130644491

RES:	135684519 135688698

» show all

Reference

PMID:18724357

Authors

Ishikawa H, Barber GN

Title

STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling.

Journal

Nature 455:674-8 (2008)
DOI:10.1038/nature07317

Reference

PMID:18559423

Authors

Jin L, Waterman PM, Jonscher KR, Short CM, Reisdorph NA, Cambier JC

Title

MPYS, a novel membrane tetraspanner, is associated with major histocompatibility complex class II and mediates transduction of apoptotic signals.

Journal

Mol Cell Biol 28:5014-26 (2008)
DOI:10.1128/MCB.00640-08

Sequence

[mmu:72512]

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Ontology (2)   
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   KEGG PATHWAY (16)   
Disease (1)   
   KEGG DISEASE (1)   
Gene (599)   
   KEGG GENES (552)   
   KEGG MGENES (11)   
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