KEGG ORTHOLOGY: K12655

ORTHOLOGY: K12655

Entry

K12655                      KO

Symbol

OTUD5, DUBA

Name

OTU domain-containing protein 5 [EC:3.4.19.12]

Pathway

map04622

RIG-I-like receptor signaling pathway

Disease

H02460

Neurodevelopmental disorder with dysmorphic facies and skeletal anomalies

H02715

Neurodevelopmental disorder with defects of ubiquitin-proteasome system

Brite

KEGG Orthology (KO) [BR:ko00001]
09150 Organismal Systems
  09151 Immune system
   04622 RIG-I-like receptor signaling pathway
    K12655  OTUD5, DUBA; OTU domain-containing protein 5
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors
    K12655  OTUD5, DUBA; OTU domain-containing protein 5
  09182 Protein families: genetic information processing
   04121 Ubiquitin system
    K12655  OTUD5, DUBA; OTU domain-containing protein 5
Enzymes [BR:ko01000]
3. Hydrolases
  3.4  Acting on peptide bonds (peptidases)
   3.4.19  Omega peptidases
    3.4.19.12  ubiquitinyl hydrolase 1
     K12655  OTUD5, DUBA; OTU domain-containing protein 5
Peptidases and inhibitors [BR:ko01002]
Cysteine peptidases
  Family C85
   K12655  OTUD5, DUBA; OTU domain-containing protein 5
Ubiquitin system [BR:ko04121]
Deubiquitinating enzyme (DUB)
  Ubiquitin-specific proteases (UBPs)
   OTU
    K12655  OTUD5, DUBA; OTU domain-containing protein 5

Other DBs

GO:

0004843

Genes

HSA:	55593(OTUD5)

PTR:	737927(OTUD5)

PPS:	100983014(OTUD5)

GGO:	109025157(OTUD5)

PON:	100460247(OTUD5)

PPYG:

129024684(OTUD5)

NLE:	100603722(OTUD5)

HMH:	116811672(OTUD5)

SSYN:

129475779(OTUD5)

MCC:	711927(OTUD5)

MCF:	101925979(OTUD5)

MTHB:

126945572

MNI:	105493915(OTUD5)

CSAB:

103231950(OTUD5)

CATY:

105573119(OTUD5)

PANU:

101011092(OTUD5)

TGE:	112615436(OTUD5)

MLEU:

105547712(OTUD5)

RRO:	104661801(OTUD5)

RBB:	108539569(OTUD5)

TFN:	117077489(OTUD5)

PTEH:

111535710(OTUD5)

CANG:

105515002(OTUD5)

CJC:	100414386(OTUD5) 103792421

SBQ:	101030159(OTUD5)

CIMI:

108300910(OTUD5)

ANAN:

105730395(OTUD5)

CSYR:

103268706(OTUD5)

MMUR:

105856372(OTUD5)

LCAT:

123628378(OTUD5)

PCOQ:

105816829(OTUD5)

OGA:	100951211 100959586(OTUD5)

MMU:	54644(Otud5)

MCAL:

110286868(Otud5)

MPAH:

110313635(Otud5)

RNO:	363452(Otud5)

MCOC:

116103855(Otud5)

ANU:	117694230(Otud5)

MUN:	110561979(Otud5)

CGE:	100761947(Otud5)

MAUA:

101833971(Otud5)

PROB:

127218650(Otud5)

PLEU:

114701297(Otud5)

MORG:

121442593 121442674

MFOT:

126512813

AAMP:

119804630(Otud5)

NGI:	103741657(Otud5)

HGL:	101712863(Otud5)

CPOC:

100732793(Otud5)

CCAN:

109692145(Otud5)

DORD:

105997834(Otud5)

DSP:	122098777(Otud5)

PLOP:

125343306(Otud5)

NCAR:

124971808

MMMA:

107159815(Otud5)

OCU:

100346051

OPI:	101536258(OTUD5)

TUP:	102488642(OTUD5)

GVR:	103589441(OTUD5)

CFA:	480911(OTUD5)

CLUD:

112673128(OTUD5)

VVP:	112907295(OTUD5)

VLG:	121482901(OTUD5)

NPO:	129517710(OTUD5)

AML:	100471183(OTUD5)

UMR:	103663009(OTUD5)

UAH:	113265937(OTUD5)

UAR:	123797171(OTUD5)

ELK:

111150454

LLV:

125091269

MPUF:

101680775(OTUD5)

MNP:	132006749(OTUD5)

MLK:	131822166(OTUD5)

NVS:	122896302(OTUD5)

ORO:	101383748(OTUD5)

EJU:	114216718(OTUD5)

ZCA:	113930932(OTUD5)

MLX:	118010183(OTUD5)

NSU:	110571239(OTUD5)

LWW:	102737800(OTUD5)

FCA:	101098283(OTUD5)

PYU:	121025942(OTUD5)

PCOO:

112871165(OTUD5)

PBG:	122476853(OTUD5)

PVIV:

125157241(OTUD5)

LRUF:

124509524

PTG:	102970821(OTUD5)

PPAD:

109248079(OTUD5)

PUC:

125931664

AJU:

106989013

HHV:	120221016(OTUD5)

BTA:	539145(OTUD5)

BOM:	102267549(OTUD5)

BIU:	109554878(OTUD5)

BBUB:

102406730(OTUD5)

BBIS:

105002112(OTUD5)

CHX:	102171046(OTUD5)

OAS:	101106912(OTUD5)

BTAX:

128069865(OTUD5)

ODA:	120882109(OTUD5)

CCAD:

122434431(OTUD5)

MBEZ:

129564271(OTUD5)

SSC:	100624053(OTUD5)

CFR:	102505955(OTUD5)

CBAI:

105079403(OTUD5)

CDK:	105103299(OTUD5)

VPC:	102536927(OTUD5)

BACU:

103008744(OTUD5)

BMUS:

118888658(OTUD5) 118900908

LVE:	103077060(OTUD5)

OOR:	101286145(OTUD5)

DLE:	111169517(OTUD5)

PCAD:

102982979 102995031(OTUD5)

PSIU:

116747403(OTUD5)

NASI:

112415997(OTUD5)

ECB:	100062519(OTUD5)

EPZ:	103544600(OTUD5)

EAI:	106826966(OTUD5)

MYB:	102256182(OTUD5)

MYD:	102766719(OTUD5)

MMYO:

118654564(OTUD5)

MLF:	102429931(OTUD5)

MDT:	132223930(OTUD5)

PKL:	118731762(OTUD5)

EFUS:

103301292(OTUD5)

MNA:	107541400(OTUD5)

DRO:	112322374(OTUD5)

SHON:

118998331(OTUD5)

AJM:	119059696(OTUD5)

PDIC:

114504549(OTUD5)

PHAS:

123832761(OTUD5)

MMF:	118635686(OTUD5)

PPAM:

129065211(OTUD5)

HAI:	109374807(OTUD5)

RFQ:	117023284(OTUD5)

PALE:

102886038(OTUD5)

PGIG:

120587080(OTUD5)

PVP:	105310000(OTUD5)

RAY:	107515015(OTUD5)

MJV:	108404033(OTUD5)

TOD:	119245673(OTUD5)

SARA:

101545136(OTUD5)

SETR:

125999197(OTUD5) 126015670 126019144

LAV:	100663167(OTUD5)

TMU:

101345366

ETF:	101639040(OTUD5) 101651626

DNM:	101418350(OTUD5)

GAS:	123253361 123256626

SHR:	100919370(OTUD5)

AFZ:	127542337 127542740

PCW:	110201061(OTUD5)

TVP:	118833292(OTUD5) 118833342 118836471

OAA:	100076519(OTUD5)

GGA:	100858279(OTUD5)

PCOC:

116240918(OTUD5)

MGP:	104917157(OTUD5)

CJO:	107307193(OTUD5)

ACYG:

136787445(OTUD5)

LSR:

110482836

PMOA:

120507313

GFR:

102033409

PHI:	102100157(OTUD5)

ZLE:	135460243(OTUD5)

SVG:	106864520(OTUD5)

SHAB:

115602853(OTUD5)

AGEN:

126035208

NNI:	104019303(OTUD5)

CUCA:

104059715(OTUD5)

RTD:	128903163(OTUD5)

ASN:	102381335(OTUD5)

AMJ:	102565678(OTUD5)

CMY:	114021827(OTUD5)

CCAY:

125628242(OTUD5)

DCC:	119847049(OTUD5)

CPIC:

101933647(OTUD5)

MRV:	120388187(OTUD5)

ACS:	100564214(otud5)

ASAO:

132767808(OTUD5)

PVT:	110081169(OTUD5)

SUND:

121921423(OTUD5)

PBI:	103063397(OTUD5)

PMUR:

107286570(OTUD5)

CTIG:

120299538(OTUD5)

TSR:	106550978(OTUD5)

PGUT:

117675436(OTUD5)

APRI:

131192587(OTUD5)

PTEX:

113443248(OTUD5)

NSS:	113417768(OTUD5)

VKO:	123030020(OTUD5)

PMUA:

114587350(OTUD5)

PRAF:

128404582(OTUD5)

ZVI:	118097652(OTUD5)

HCG:	128345862(OTUD5)

GJA:	107116228(OTUD5)

STOW:

125429399(OTUD5)

EMC:	129346387(OTUD5)

XLA:	380010(otud5.S) 494714(otud5.L)

XTR:	448134(otud5)

NPR:	108789236(OTUD5)

RTEM:

120913918(OTUD5)

BBUF:

121009443(OTUD5)

BGAR:

122946694(OTUD5)

MUO:	115463473(OTUD5)

GSH:	117349426(OTUD5)

DRE:	445146(otud5b) 555459(otud5a)

SRX:	107727782 107734530 107743098 107749459

SANH:

107653422 107674365 107685670 107691361

SGH:	107581953 107584889 107597702 107601748

CCAR:

109074770 109074784 109090131 109110909

CAUA:

113074151 113095902 113107004 113111140

CGIB:

127963703 127968654 128018942 128022293

PTET:

122350836(otud5a) 122354442(otud5b)

LROH:

127169445(otud5a) 127173137(otud5b)

OMC:	131545311(otud5a) 131549444(otud5b)

PPRM:

120475286(otud5a) 120480695(otud5b)

RKG:	130085609(otud5b) 130099557(otud5a)

MAMB:

125256943(otud5b) 125279281(otud5a)

CIDE:

127517307 127522237

CERY:

137021070(otud5b) 137026862(otud5a)

MASI:

127415036 127424613 127426201 127427590

TROS:

130567992(otud5a) 130571167(otud5b)

TDW:	130410272(otud5b) 130440402(otud5a)

MANU:

129413991(otud5a) 129427365(otud5b)

IPU:	108265847(otud5a)

IFU:	128608158(otud5a)

PHYP:

113535109(otud5)

SMEO:

124400159(otud5a)

TFD:	113645611(otud5a)

TVC:	132854206(otud5a)

TRN:	134317856(otud5a)

AMEX:

103035418(otud5a)

CMAO:

118799761(otud5b) 118813797(otud5a)

EEE:	113573008 113585824

CHAR:

105904175(otud5b) 122131021(otud5a)

TRU:	101065412(otud5)

TFS:	130529723(otud5a)

TNG:	GSTEN00004051G001

LCO:	104935396(otud5)

TBEN:

117483829(otud5a)

PGEO:

117449529(otud5a)

GACU:

117533541(otud5a)

EMAC:

134868678(otud5a)

ELY:	117258485(otud5a)

EFO:	125892446(otud5a)

SLUC:

116045458(otud5a)

PFLV:

114559090(otud5)

GAT:	120829161(otud5a)

PPUG:

119222849(otud5a)

AFB:	129100322(otud5a)

CLUM:

117733042(otud5a)

PSWI:

130199024(otud5a)

MSAM:

119905534(otud5a)

SCHU:

122882659(otud5a)

CUD:	121517829(otud5a)

MZE:	101483153(otud5)

ONL:	100696797(otud5)

OAU:	116335425(otud5a)

OLA:	101172716(otud5)

OML:	112140837(otud5a)

CSAI:

133456946(otud5a)

XMA:	102220653(otud5)

XHE:	116719053(otud5)

PRET:

103460511(otud5)

PFOR:

103130517(otud5)

PLAI:

106942188(otud5)

PMEI:

106931487(otud5)

GAF:	122844220(otud5a)

PPRL:

129357623 129357731

CVG:	107101775(otud5)

CTUL:

119773990(otud5a)

GMU:	124873454(otud5a)

NFU:	107397277(otud5)

KMR:	108251658(otud5a)

ALIM:

106533698(otud5)

NWH:	119417792(otud5a)

AOCE:

111563459(otud5)

MCEP:

125009098(otud5a)

POV:	109646208(otud5)

SSEN:

122777772(otud5a)

HHIP:

117764305(otud5a)

HSP:	118110857(otud5a)

PPLT:

128442426(otud5a)

SMAU:

118317133(otud5a)

LCF:	108879508(otud5a)

SDU:	111235443(otud5)

SLAL:

111669626(otud5)

XGL:	120803554(otud5a)

HCQ:	109510417(otud5)

SSCV:

125988053

SBIA:

133510216(otud5a)

PEE:	133406606(otud5a)

PTAO:

133484699(otud5a)

BPEC:

110157991(otud5)

MALB:

109968614(otud5)

BSPL:

114858859(otud5a)

SJO:	128357837(otud5a)

SASA:

100380792(otud5) 106571839

STRU:

115168569(otud5)

OTW:	112222344(otud5a)

OMY:	110492580(otud5a)

OGO:	124045553(otud5a)

ONE:	115101968(otud5)

OKI:	109869152(otud5)

OKE:	118359558(otud5a)

SALP:

111966062 112069766(otud5)

SNH:	120059534 120061413(otud5a)

CCLU:

121538633 121546063(otud5a)

ELS:	105030716(otud5)

SFM:	108918201 108934835(otud5)

PKI:	111851625(otud5) 111857095

AANG:

118207672(otud5a)

LOC:	102694193(otud5)

PSPA:

121328770

ARUT:

117404184(otud5a)

PSEX:

120543169(otud5a)

LCM:	102348849(OTUD5)

LERI:

129715155

PMRN:

116947596(OTUD5)

LRJ:	133351633(OTUD5)

BFO:

BBEL:

CIN:

SCLV:

SPU:

APLC:

ARUN:

AJC:

SKO:

DME:	Dmel_CG6091(Duba)

DER:

6544724

DSE:

6605301

DSI:	Dsimw501_GD12791(Dsim_GD12791)

DYA:	Dyak_GE20197

DAN:

DSR:

DPO:

DPE:

DMN:

DWI:	111519749 6638977

DGR:

6558128

DMO:	Dmoj_GI11590

DAZ:

108613166

DNV:

108650963

DHE:	111592807 115483768

DVI:

CCAT:

BOD:

BDR:

RZE:	108365178 108369215

AOQ:

TDA:

MDE:

SCAC:

LCQ:

LSQ:	119610449 119614042

GFS:

ECOE:

CLON:

HIS:

AGA:

ACOZ:

AARA:

AMER:

ASTE:

AFUN:

AMOU:

AALI:

AAG:

AALB:

ASUA:

CQU:	CpipJ_CPIJ002852

CPII:

CNS:

BCOO:

AME:

ACER:

ALAB:

ADR:

AFLR:

BIM:

BBIF:

BVK:

BVAN:

BTER:

BAFF:

BPYO:

BPAS:

FVI:

CCAL:

OBB:

OLG:

MGEN:

NMEA:

CGIG:

SOC:

MPHA:

AEC:

ACEP:

PBAR:

VEM:

HST:

DQU:

CFO:

FEX:

LHU:

PGC:

OBO:

PCF:

PFUC:

VPS:

VCRB:

VVE:

NVI:

CSOL:

TPRE:

LHT:

CCIN:

DSM:

NPT:

NFB:

NLO:

NVG:

AROA:

TCA:

DPA:

SOY:

AGRG:

ATD:

CSET:

AGB:

LDC:

DVV:

NVL:

PPYR:

OTU:

CCRN:

API:

DNX:

AGS:

RMD:

ACOO:

DVT:

BTAB:

CLEC:

HHAL:

106680069(Duba)

NLU:	111049015 120350034

HVI:

124368697

MQU:	128998205 128998229

FOC:

TPAL:

ZNE:

CSEC:

SGRE:

IEL:

FCD:	110841591 110862934

DPX:	DAPPUDRAFT_302835

DMK:

116919748

DPZ:

124341741

PVM:	113817922 113827726

PJA:

PCHN:

PMOO:

HAME:

PCLA:

CQD:	128698034 128698036

PTRU:

ESN:

MNZ:

HAZT:

EAF:

LSM:

TCF:

PPOI:

DSV:

RSAN:

RMP:

VDE:

VJA:

TUT:

DPTE:

CSCU:

CVS:	136989875(Duba)

PTEP:

ABRU:

UDV:

SDM:

LPOL:

PMEO:

CEL:	CELE_B0546.2(otub-4)

CBR:

CBG_21043

CRQ:	GCK72_015918

NAI:	NECAME_16672

BMY:	BM_BM1848(Bma-otub-4)

LOA:	LOAG_06778

TSP:

Tsp_04017

HRO:	HELRODRAFT_68163

LGI:	LOTGIDRAFT_53774

PVUL:

PCAN:

BGT:

GAE:

HRF:

HRJ:

CRG:

CANU:

CVN:	111109453 111109747

OED:

MYI:

PMAX:

MCAF:

MMER:

RPHI:

DPOL:

MAEA:

OBI:

OSN:

LJP:

LAK:	106159802 106178400

SMM:	Smp_093950

SHX:	MS3_00009836(OTUD5)

OVI:	T265_02606

LLON:

135491408

NVE:	5497545 5499325 5516290

EPA:

ATEN:

ADF:

AMIL:

PDAM:

SPIS:

DGT:

XEN:

HMG:

HSY:

RES:

ATH:	AT2G27350(OTLD1)

ALY:

9316976

CRB:

17889224

CSAT:

104752644 104786993 109124417

EUS:	EUTSA_v10001965mg

BRP:	103829662 103864777

BNA:	106396422 106424331 106446755

BOE:	106336714 106342829

RSZ:

108813290

THJ:	104800519 104826435

CPAP:

110806860

CIT:

102626053

CIC:	CICLE_v10030048mg

PVY:	116118037 116144144

MINC:

123208825 123225993

TCC:

18590276

GRA:	105762038 105799235

GHI:	107889186 107891534

GAB:	108453462 108457028

HSYR:

120116337 120129499 120142226 120144138 120167893

DZI:	111284811 111303819

EGR:

104433960

GMX:	100780250 100809162

GSJ:	114375827 114379973

PVU:	PHAVU_011G096000g

VRA:

VAR:

VUN:

VUM:

CCAJ:

APRC:

MTR:

TPRA:

CAM:

PSAT:

VVO:

LJA:

ADU:	107462049 127741166

AIP:

107612593

AHF:	112706930 112773234

LANG:

109325590 109359657

PCIN:

129313641 129315687

QSA:	O6P43_000491 O6P43_028552

FVE:

RCN:

PPER:

PMUM:

PAVI:

PDUL:

MDM:	103424922 103436110

MSYL:

126589820 126615575

PXB:	103963856 103966383

ZJU:

MNT:

CSAV:

CSV:

CMO:

BHJ:

MCHA:

CMAX:

CMOS:

CPEP:

RCU:

MEAN:

JCU:

HBR:	110640117 110640118 110663116

MESC:

110613410 110626535

POP:	18098067 7478574

PEU:	105112429 105138864

PALZ:

JRE:

CILL:

CAVE:

QSU:

QLO:

TWL:	119990439 120002359

VVI:

100246727

VRI:

117916083

SLY:	101253195 101264788

SPEN:

107004674 107023456

SOT:	102597381 102601554

SSTN:

125844094 125872067

SDUL:

129898959 129902238

CANN:

107847672 107875665

LBB:	132600612 132604070

NTA:	107784311 107784988 107802061 107811581

NSY:	104235107 104237015

NTO:	104091529 104102873

NAU:	109238221 109240490

INI:

ITR:

SIND:

OEU:

EGT:

SSPL:

121741884 121743305 121788815

SMIL:

131021423 131021778

SHIS:

125189057 125189489

APAN:

127239250

HAN:	110898126 110908731

ECAD:

LSV:

CCAV:

DCR:

CSIN:

RVL:

AEW:	130767938 130770581

BVG:

104899827

SOE:

110798816

CQI:	110683601 110688138

ATRI:

MOF:

NNU:

MING:

TSS:	122653245 122658501

PSOM:

OSA:

OBR:

OGL:

BDI:

ATS:

TDC:	119355100 119364226

TAES:

123045416 123053248 123189160

TUA:

LPER:

LRD:

SBI:

ZMA:	100285430 103164604

MFLO:

SITA:

SVS:

PVIR:

PHAI:

PDA:	103699095 103703112 120103934

EGU:	105052100 109505501

MUS:	103968367 103976528

ZOF:	122018898 122021321 122023354 122024843

DCT:

PEQ:

AOF:

MSIN:

NCOL:

ATR:

SMO:	SELMODRAFT_428669 SELMODRAFT_43495 SELMODRAFT_63572

PPP:

112284790

CCP:	CHC_T00000160001

MBR:	MONBRDRAFT_6817

DDI:	DDB_G0285907

DPP:	DICPUDRAFT_10519

DFA:

DFA_07171

ACAN:

ACA1_074920 ACA1_301120

CPV:

cgd6_2750

CHO:	Chro.60317

TET:	TTHERM_00419820 TTHERM_00817280

PTM:	GSPATT00002346001 GSPATT00006808001

FCY:	FRACYDRAFT_137471

PIF:	PITG_10931

PSOJ:

PHYSODRAFT_481518

SPAR:

SPRG_14827 SPRG_16510

GTT:	GUITHDRAFT_108248

» show all

Reference

PMID:24659992

Authors

Radjacommare R, Usharani R, Kuo CH, Fu H

Title

Distinct phylogenetic relationships and biochemical properties of Arabidopsis ovarian tumor-related deubiquitinases support their functional differentiation.

Journal

Front Plant Sci 5:84 (2014)
DOI:10.3389/fpls.2014.00084

Sequence

[ath:AT2G27350]

Reference

PMID:17991829

Authors

Kayagaki N, Phung Q, Chan S, Chaudhari R, Quan C, O'Rourke KM, Eby M, Pietras E, Cheng G, Bazan JF, Zhang Z, Arnott D, Dixit VM

Title

DUBA: a deubiquitinase that regulates type I interferon production.

Journal

Science 318:1628-32 (2007)
DOI:10.1126/science.1145918

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   KEGG ENZYME (1)   
Gene (3261)   
   KEGG GENES (842)   
   KEGG MGENES (334)   
   RefGene (2063)   
   OC (22)   
Literature (2)   
   PubMed (2)   
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