KEGG   ORTHOLOGY: K12692
Entry
K12692            Tight     KO                                     
Symbol
H6H
Name
hyoscyamine (6S)-dioxygenase / 6beta-hydroxyhyoscyamine epoxidase [EC:1.14.11.11 1.14.20.13]
Pathway
map00960  Tropane, piperidine and pyridine alkaloid biosynthesis
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
Reaction
R03737  (6S)-6beta-hydroxyhyoscyamine,2-oxoglutarate:oxygen oxidoreductase (epoxide-forming)
R03812  L-hyoscyamine,2-oxoglytarate:oxygen oxidoreductase ((6S)-hydroxylating)
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09110 Biosynthesis of other secondary metabolites
   00960 Tropane, piperidine and pyridine alkaloid biosynthesis
    K12692  H6H; hyoscyamine (6S)-dioxygenase / 6beta-hydroxyhyoscyamine epoxidase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.11  With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor
    1.14.11.11  hyoscyamine (6S)-dioxygenase
     K12692  H6H; hyoscyamine (6S)-dioxygenase / 6beta-hydroxyhyoscyamine epoxidase
   1.14.20  With 2-oxoglutarate as one donor, and the other dehydrogenated
    1.14.20.13  6beta-hydroxyhyoscyamine epoxidase
     K12692  H6H; hyoscyamine (6S)-dioxygenase / 6beta-hydroxyhyoscyamine epoxidase
Other DBs
GO: 0047998 0047594
Genes
AG: BAA05630(H6H) BAA78340(H6H)
Reference
PMID:8066129
  Authors
Kanegae T, Kajiya H, Amano Y, Hashimoto T, Yamada Y
  Title
Species-dependent expression of the hyoscyamine 6 beta-hydroxylase gene in the pericycle.
  Journal
Plant Physiol 105:483-90 (1994)
DOI:10.1104/pp.105.2.483
  Sequence
[ag:BAA05630]
Reference
PMID:8354403
  Authors
Hashimoto T, Matsuda J, Yamada Y
  Title
Two-step epoxidation of hyoscyamine to scopolamine is catalyzed by bifunctional hyoscyamine 6 beta-hydroxylase.
  Journal
FEBS Lett 329:35-9 (1993)
DOI:10.1016/0014-5793(93)80187-y

  All links  
Ontology (4)   
   KEGG BRITE (2)   
   GO (2)   
Pathway (6)   
   KEGG PATHWAY (6)   
Chemical reaction (6)   
   KEGG ENZYME (2)   
   KEGG REACTION (2)   
   KEGG RCLASS (2)   
Gene (2)   
   KEGG GENES (2)   
Literature (2)   
   PubMed (2)   
All databases (20)   

Download RDF
DBGET integrated database retrieval system