KEGG   ORTHOLOGY: K12701Help
Entry
K12701                      KO                                     

Name
novH
Definition
novobiocin biosynthesis protein NovH
Pathway
ko00401  Novobiocin biosynthesis
ko01100  Metabolic pathways
ko01130  Biosynthesis of antibiotics
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09110 Biosynthesis of other secondary metabolites
   00401 Novobiocin biosynthesis
    K12701  novH; novobiocin biosynthesis protein NovH
BRITE hierarchy
Other DBs
RN: R06751
Genes
NGV: CDO52_02180
AG: AAF67501(novH) AAG29780(couH) AAN65224(cloH)
TaxonomyKoalaUniProt
Reference
  Authors
Steffensky M, Muhlenweg A, Wang ZX, Li SM, Heide L
  Title
Identification of the novobiocin biosynthetic gene cluster of Streptomyces spheroides NCIB 11891.
  Journal
Antimicrob Agents Chemother 44:1214-22 (2000)
DOI:10.1128/AAC.44.5.1214-1222.2000
  Sequence

KEGG   REACTION: R06751Help
Entry
R06751                      Reaction                               

Definition
L-Tyrosine + Peptidyl-carrier protein + ATP <=> L-Tyrosyl-[pcp] + AMP + Diphosphate
Equation
Comment
peptide synthetase, NovH CloH CouH
Peptidyl-carrier protein is pcp domain of the enzyme itself [KO:K12701].
Reaction class
RC00039  C12461_C21097
RC00137  C00082_C12461
Pathway
rn00401  Novobiocin biosynthesis
rn01100  Metabolic pathways
rn01130  Biosynthesis of antibiotics
Orthology
K12701  novobiocin biosynthesis protein NovH

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