KEGG   ORTHOLOGY: K12703
Entry
K12703                      KO                                     

Name
novJ
Definition
novobiocin biosynthesis protein NovJ
Pathway
ko00401  Novobiocin biosynthesis
ko01100  Metabolic pathways
ko01110  Biosynthesis of secondary metabolites
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09110 Biosynthesis of other secondary metabolites
   00401 Novobiocin biosynthesis
    K12703  novJ; novobiocin biosynthesis protein NovJ
Other DBs
RN: R06753
Genes
NGV: CDO52_02190
AG: AAF67503(novJ) AAG29782(couJ) AAN65226(cloJ)
Reference
  Authors
Pacholec M, Hillson NJ, Walsh CT
  Title
NovJ/NovK catalyze benzylic oxidation of a beta-hydroxyl tyrosyl-S-pantetheinyl enzyme during aminocoumarin ring formation in novobiocin biosynthesis.
  Journal
Biochemistry 44:12819-26 (2005)
DOI:10.1021/bi051297m

KEGG   ORTHOLOGY: K12704
Entry
K12704                      KO                                     

Name
novK
Definition
novobiocin biosynthesis protein NovK
Pathway
ko00401  Novobiocin biosynthesis
ko01100  Metabolic pathways
ko01110  Biosynthesis of secondary metabolites
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09110 Biosynthesis of other secondary metabolites
   00401 Novobiocin biosynthesis
    K12704  novK; novobiocin biosynthesis protein NovK
Other DBs
RN: R06753
Genes
NGV: CDO52_02195
AG: AAF67504(novK) AAG29783(couK) AAN65227(cloK)
Reference
  Authors
Pacholec M, Hillson NJ, Walsh CT
  Title
NovJ/NovK catalyze benzylic oxidation of a beta-hydroxyl tyrosyl-S-pantetheinyl enzyme during aminocoumarin ring formation in novobiocin biosynthesis.
  Journal
Biochemistry 44:12819-26 (2005)
DOI:10.1021/bi051297m

KEGG   REACTION: R06753
Entry
R06753                      Reaction                               

Definition
beta-Hydroxy-L-tyrosyl-[pcp] <=> beta-Keto-L-tyrosyl-[pcp]
Equation
Comment
3-ketoacyl reductase, NovJ CloJ CouJ
reductase, NovK CloK CouK
Reaction class
RC01681  C12462_C12463
Pathway
rn00401  Novobiocin biosynthesis
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Orthology
K12703  novobiocin biosynthesis protein NovJ
K12704  novobiocin biosynthesis protein NovK

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