KEGG   ORTHOLOGY: K12743
Entry
K12743                      KO                                     
Symbol
PCBAB
Name
N-(5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valine synthase [EC:6.3.2.26]
Pathway
map00311  Penicillin and cephalosporin biosynthesis
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
Module
M00672  Penicillin biosynthesis, aminoadipate + cycteine + valine => penicillin
M00673  Cephamycin C biosynthesis, aminoadipate + cycteine + valine => cephamycin C
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09110 Biosynthesis of other secondary metabolites
   00311 Penicillin and cephalosporin biosynthesis
    K12743  PCBAB; N-(5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valine synthase
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01008 Polyketide biosynthesis proteins
    K12743  PCBAB; N-(5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valine synthase
Enzymes [BR:ko01000]
 6. Ligases
  6.3  Forming carbon-nitrogen bonds
   6.3.2  Acid-D-amino-acid ligases (peptide synthases)
    6.3.2.26  N-(5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valine synthase
     K12743  PCBAB; N-(5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valine synthase
Polyketide biosynthesis proteins [BR:ko01008]
 Nonribosomal peptide synthetase (NRPS)
  Linear NRPS
   ACV synthetase
    K12743  PCBAB; N-(5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valine synthase
Other DBs
RN: R04870
GO: 0050564
Genes
BCOO: 119075341
ANI: AN2621.2
AOR: AO090038000543
AFV: AFLA_009029
APUU: APUU_12364S
ABE: ARB_02226
TVE: TRV_00553
SCT: SCAT_5684(pcbAB)
SCY: SCATT_56840
SCLF: BB341_07790
AMYY: YIM_39185(srfAA)
 » show all
Reference
PMID:2061333
  Authors
MacCabe AP, van Liempt H, Palissa H, Unkles SE, Riach MB, Pfeifer E, von Dohren H, Kinghorn JR
  Title
Delta-(L-alpha-aminoadipyl)-L-cysteinyl-D-valine synthetase from Aspergillus nidulans. Molecular characterization of the acvA gene encoding the first enzyme of the penicillin biosynthetic pathway.
  Journal
J Biol Chem 266:12646-54 (1991)
DOI:10.1016/S0021-9258(18)98948-9
  Sequence
[ani:AN2621.2]

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