KEGG   ORTHOLOGY: K12901
Entry
K12901            Tight     KO                                     

Name
fomC
Definition
phosphonoacetaldehyde reductase
Pathway
ko00440  Phosphonate and phosphinate metabolism
ko00998  Biosynthesis of various secondary metabolites - part 2
ko01100  Metabolic pathways
ko01110  Biosynthesis of secondary metabolites
Module
M00903  Fosfomycin biosynthesis, phosphoenolpyruvate => fosfomycin
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09106 Metabolism of other amino acids
   00440 Phosphonate and phosphinate metabolism
    K12901  fomC; phosphonoacetaldehyde reductase
  09110 Biosynthesis of other secondary metabolites
   00998 Biosynthesis of various secondary metabolites - part 2
    K12901  fomC; phosphonoacetaldehyde reductase
Other DBs
RN: R08861
Genes
AG: BAA32497(fomC)
Reference
  Authors
Metcalf WW, van der Donk WA
  Title
Biosynthesis of phosphonic and phosphinic acid natural products.
  Journal
Annu Rev Biochem 78:65-94 (2009)
DOI:10.1146/annurev.biochem.78.091707.100215
Reference
  Authors
Woodyer RD, Shao Z, Thomas PM, Kelleher NL, Blodgett JA, Metcalf WW, van der Donk WA, Zhao H
  Title
Heterologous production of fosfomycin and identification of the minimal biosynthetic gene cluster.
  Journal
Chem Biol 13:1171-82 (2006)
DOI:10.1016/j.chembiol.2006.09.007

KEGG   REACTION: R08861
Entry
R08861                      Reaction                               

Definition
Phosphonoacetaldehyde + NADPH + H+ <=> 2-Hydroxyethylphosphonate + NADP+
Equation
Comment
PnAA reductase
Reaction class
RC00001  C00005_C00006
RC00087  C03167_C06451
Pathway
rn00440  Phosphonate and phosphinate metabolism
rn00998  Biosynthesis of various secondary metabolites - part 2
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Module
M00903  Fosfomycin biosynthesis, phosphoenolpyruvate => fosfomycin
Orthology
K12901  phosphonoacetaldehyde reductase

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