KEGG   ORTHOLOGY: K12908Help
Entry
K12908                      KO                                     

Name
phpF
Definition
phosphonoformate cytidylyltransferase [EC:2.7.7.93]
Pathway
ko00440  Phosphonate and phosphinate metabolism
ko01130  Biosynthesis of antibiotics
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09106 Metabolism of other amino acids
   00440 Phosphonate and phosphinate metabolism
    K12908  phpF; phosphonoformate cytidylyltransferase
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.7  Nucleotidyltransferases
    2.7.7.93  phosphonoformate cytidylyltransferase
     K12908  phpF; phosphonoformate cytidylyltransferase
BRITE hierarchy
Other DBs
RN: R08867
Genes
AG: AAU00081(phpF)
TaxonomyKoalaUniProt
Reference
  Authors
Blodgett JA, Thomas PM, Li G, Velasquez JE, van der Donk WA, Kelleher NL, Metcalf WW
  Title
Unusual transformations in the biosynthesis of the antibiotic phosphinothricin tripeptide.
  Journal
Nat Chem Biol 3:480-5 (2007)
DOI:10.1038/nchembio.2007.9
  Sequence
Reference
  Authors
Metcalf WW, van der Donk WA
  Title
Biosynthesis of phosphonic and phosphinic acid natural products.
  Journal
Annu Rev Biochem 78:65-94 (2009)
DOI:10.1146/annurev.biochem.78.091707.100215

KEGG   ENZYME: 2.7.7.93Help
Entry
EC 2.7.7.93                 Enzyme                                 

Name
phosphonoformate cytidylyltransferase;
phpF (gene name)
Class
Transferases;
Transferring phosphorus-containing groups;
Nucleotidyltransferases
BRITE hierarchy
Sysname
CTP:phosphonoformate cytidylyltransferase
Reaction(IUBMB)
CTP + phosphonoformate = CMP-5'-phosphonoformate + diphosphate [RN:R08867]
Reaction(KEGG)
Substrate
CTP [CPD:C00063];
phosphonoformate [CPD:C06456]
Product
CMP-5'-phosphonoformate [CPD:C17945];
diphosphate [CPD:C00013]
Comment
The enzyme, characterized from the bacterium Streptomyces viridochromogenes, participates in the biosynthesis of the herbicide antibiotic bialaphos. The enzyme from the bacterium Kitasatospora phosalacinea participates in the biosynthesis of the related compound phosalacine. Both compounds contain the nonproteinogenic amino acid L-phosphinothricin that acts as a potent inhibitor of EC 6.3.1.2, glutamine synthetase.
History
EC 2.7.7.93 created 2016
Pathway
ec00440  Phosphonate and phosphinate metabolism
ec01130  Biosynthesis of antibiotics
Orthology
K12908  phosphonoformate cytidylyltransferase
Reference
1  [PMID:17632514]
  Authors
Blodgett JA, Thomas PM, Li G, Velasquez JE, van der Donk WA, Kelleher NL, Metcalf WW
  Title
Unusual transformations in the biosynthesis of the antibiotic phosphinothricin tripeptide.
  Journal
Nat Chem Biol 3:480-5 (2007)
DOI:10.1038/nchembio.2007.9
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 2.7.7.93
IUBMB Enzyme Nomenclature: 2.7.7.93
ExPASy - ENZYME nomenclature database: 2.7.7.93
BRENDA, the Enzyme Database: 2.7.7.93

KEGG   REACTION: R08867Help
Entry
R08867                      Reaction                               

Name
CTP:phosphonoformate cytidylyltransferase
Definition
Phosphonoformate + CTP <=> Phosphonoformyl-CMP + Diphosphate
Equation
Comment
cytidylyltransferase
Reaction class
RC00002  C06456_C17945
Enzyme
Pathway
rn00440  Phosphonate and phosphinate metabolism
rn01130  Biosynthesis of antibiotics
Orthology
K12908  phosphonoformate cytidylyltransferase [EC:2.7.7.93]
Other DBs
RHEA: 49431

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