KEGG   ORTHOLOGY: K12909Help
Entry
K12909                      KO                                     

Name
phpI
Definition
carboxyvinyl-carboxyphosphonate phosphorylmutase [EC:2.7.8.23]
Pathway
ko00440  Phosphonate and phosphinate metabolism
ko01130  Biosynthesis of antibiotics
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09106 Metabolism of other amino acids
   00440 Phosphonate and phosphinate metabolism
    K12909  phpI; carboxyvinyl-carboxyphosphonate phosphorylmutase
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.8  Transferases for other substituted phosphate groups
    2.7.8.23  carboxyvinyl-carboxyphosphonate phosphorylmutase
     K12909  phpI; carboxyvinyl-carboxyphosphonate phosphorylmutase
BRITE hierarchy
Other DBs
RN: R05165 R08868 R08869
COG: COG2513
GO: 0008807
Genes
AG: AAU00084(phpI) CAA48139(bcpA)
TaxonomyKoalaUniProt
Reference
  Authors
Blodgett JA, Thomas PM, Li G, Velasquez JE, van der Donk WA, Kelleher NL, Metcalf WW
  Title
Unusual transformations in the biosynthesis of the antibiotic phosphinothricin tripeptide.
  Journal
Nat Chem Biol 3:480-5 (2007)
DOI:10.1038/nchembio.2007.9
  Sequence
Reference
  Authors
Metcalf WW, van der Donk WA
  Title
Biosynthesis of phosphonic and phosphinic acid natural products.
  Journal
Annu Rev Biochem 78:65-94 (2009)
DOI:10.1146/annurev.biochem.78.091707.100215
Reference
PMID:1330557
  Authors
Pollack SJ, Freeman S, Pompliano DL, Knowles JR
  Title
Cloning, overexpression and mechanistic studies of carboxyphosphonoenolpyruvate mutase from Streptomyces hygroscopicus.
  Journal
Eur J Biochem 209:735-43 (1992)
DOI:10.1111/j.1432-1033.1992.tb17342.x
  Sequence

KEGG   ENZYME: 2.7.8.23Help
Entry
EC 2.7.8.23                 Enzyme                                 

Name
carboxyvinyl-carboxyphosphonate phosphorylmutase
Class
Transferases;
Transferring phosphorus-containing groups;
Transferases for other substituted phosphate groups
BRITE hierarchy
Sysname
1-carboxyvinyl carboxyphosphonate phosphorylmutase (decarboxylating)
Reaction(IUBMB)
1-carboxyvinyl carboxyphosphonate = 3-(hydroxyphosphinoyl)pyruvate + CO2 [RN:R05165]
Reaction(KEGG)
R05165;
(other) R08868 R08869
Show
Substrate
1-carboxyvinyl carboxyphosphonate [CPD:C06367]
Product
3-(hydroxyphosphinoyl)pyruvate;
CO2 [CPD:C00011]
Comment
Catalyses the transfer and decarboxylation of the carboxy(hydroxy)phosphoryl group, HOOC-P(O)(OH)- (phosphoryl being a 3-valent group), in the formation of an unusual C-P bond that is involved in the biosynthesis of the antibiotic bialaphos.
History
EC 2.7.8.23 created 1999
Pathway
ec00440  Phosphonate and phosphinate metabolism
ec01130  Biosynthesis of antibiotics
Orthology
K12909  carboxyvinyl-carboxyphosphonate phosphorylmutase
Reference
1  [PMID:1330557]
  Authors
Pollack SJ, Freeman S, Pompliano DL, Knowles JR.
  Title
Cloning, overexpression and mechanistic studies of carboxyphosphonoenolpyruvate mutase from Streptomyces hygroscopicus.
  Journal
Eur J Biochem 209:735-43 (1992)
DOI:10.1111/j.1432-1033.1992.tb17342.x
  Sequence
Reference
2  [PMID:3611020]
  Authors
Anzai H, Murakami T, Imai S, Satoh A, Nagaoka K, Thompson CJ.
  Title
Transcriptional regulation of bialaphos biosynthesis in Streptomyces hygroscopicus.
  Journal
J Bacteriol 169:3482-8 (1987)
DOI:10.1128/JB.169.8.3482-3488.1987
Other DBs
ExplorEnz - The Enzyme Database: 2.7.8.23
IUBMB Enzyme Nomenclature: 2.7.8.23
ExPASy - ENZYME nomenclature database: 2.7.8.23
BRENDA, the Enzyme Database: 2.7.8.23
CAS: 122799-57-9

KEGG   REACTION: R05165Help
Entry
R05165                      Reaction                               

Name
1-Carboxyvinyl carboxyphosphonate phosphorylmutase (decarboxylating)
Definition
1-Carboxyvinyl carboxyphosphonate <=> 3-(Hydrohydroxyphosphoryl)pyruvate + CO2
Equation
Comment
two-step reaction (see R08868+R08869)
Reaction class
RC02775  C06367_C06368
Enzyme
Pathway
rn00440  Phosphonate and phosphinate metabolism
rn01130  Biosynthesis of antibiotics
Orthology
K12909  carboxyvinyl-carboxyphosphonate phosphorylmutase [EC:2.7.8.23]
Other DBs
RHEA: 14048

DBGET integrated database retrieval system