KEGG   ORTHOLOGY: K12977
Entry
K12977                      KO                                     

Name
lpxE
Definition
lipid A 1-phosphatase [EC:3.1.3.-]
Pathway
ko00540  Lipopolysaccharide biosynthesis
ko01100  Metabolic pathways
Module
M00867  KDO2-lipid A modification pathway
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09107 Glycan biosynthesis and metabolism
   00540 Lipopolysaccharide biosynthesis
    K12977  lpxE; lipid A 1-phosphatase
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01005 Lipopolysaccharide biosynthesis proteins
    K12977  lpxE; lipid A 1-phosphatase
Enzymes [BR:ko01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.3  Phosphoric-monoester hydrolases
    3.1.3.-  
     K12977  lpxE; lipid A 1-phosphatase
Lipopolysaccharide biosynthesis proteins [BR:ko01005]
 Lipid A
  K12977  lpxE; lipid A 1-phosphatase
Other DBs
RN: R12201
COG: COG0671
Genes
MOS: AXE82_08695
BAV: BAV0467
HPY: HP0021
HEO: C694_00100
HPJ: jhp_0019
HPA: HPAG1_0021
HPS: HPSH_00110
HHP: HPSH112_00100
HHQ: HPSH169_00100
HHR: HPSH417_00095
HPG: HPG27_20
HPL: HPB8_1604(lpxE)
HPZ: HPKB_0024
HPD: KHP_0019
HEY: MWE_0025
HPYR: K747_08630
HPYI: K750_00075
HPYU: K751_07655
HPYM: K749_05745
HEB: U063_0024
HEZ: U064_0024
HAC: Hac_1687
HCE: HCW_00260
HCM: HCD_00160
 » show all
Reference
  Authors
Tran AX, Whittimore JD, Wyrick PB, McGrath SC, Cotter RJ, Trent MS
  Title
The lipid A 1-phosphatase of Helicobacter pylori is required for resistance to the antimicrobial peptide polymyxin.
  Journal
J Bacteriol 188:4531-41 (2006)
DOI:10.1128/JB.00146-06
  Sequence
[hpy:HP0021]

KEGG   REACTION: R12201
Entry
R12201                      Reaction                               

Name
hexa-acylated-KDO2-lipid-A phosphohydrolase
Definition
H. pylori KDO2-lipid A + H2O <=> 1-Dephospho-KDO2-lipid A + Orthophosphate
Equation
Enzyme
3.1.3.-
Pathway
rn00540  Lipopolysaccharide biosynthesis
rn01100  Metabolic pathways
Module
M00867  KDO2-lipid A modification pathway
Orthology
K12977  lipid A 1-phosphatase [EC:3.1.3.-]

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