KEGG   ORTHOLOGY: K13034
Entry
K13034                      KO                                     

Name
ATCYSC1
Definition
L-3-cyanoalanine synthase/ cysteine synthase [EC:2.5.1.47 4.4.1.9]
Pathway
ko00270  Cysteine and methionine metabolism
ko00460  Cyanoamino acid metabolism
ko00920  Sulfur metabolism
ko01100  Metabolic pathways
ko01110  Biosynthesis of secondary metabolites
ko01120  Microbial metabolism in diverse environments
ko01200  Carbon metabolism
ko01230  Biosynthesis of amino acids
Module
M00021  Cysteine biosynthesis, serine => cysteine
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09102 Energy metabolism
   00920 Sulfur metabolism
    K13034  ATCYSC1; L-3-cyanoalanine synthase/ cysteine synthase
  09105 Amino acid metabolism
   00270 Cysteine and methionine metabolism
    K13034  ATCYSC1; L-3-cyanoalanine synthase/ cysteine synthase
  09106 Metabolism of other amino acids
   00460 Cyanoamino acid metabolism
    K13034  ATCYSC1; L-3-cyanoalanine synthase/ cysteine synthase
Enzymes [BR:ko01000]
 2. Transferases
  2.5  Transferring alkyl or aryl groups, other than methyl groups
   2.5.1  Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
    2.5.1.47  cysteine synthase
     K13034  ATCYSC1; L-3-cyanoalanine synthase/ cysteine synthase
 4. Lyases
  4.4  Carbon-sulfur lyases
   4.4.1  Carbon-sulfur lyases (only sub-subclass identified to date)
    4.4.1.9  L-3-cyanoalanine synthase
     K13034  ATCYSC1; L-3-cyanoalanine synthase/ cysteine synthase
Other DBs
RN: R00897 R02846 R03524 R03601 R04859
GO: 0004124 0050017
Genes
ATH: AT3G61440(CYSC1)
ALY: 9312681 9319720
CRB: 17886219
CSAT: 104699755 104747140 104749184 104788433
EUS: EUTSA_v10006044mg
BRP: 103841966 103862824
BNA: 106393304 106396803 106415606 106415702 106415710 106444997
BOE: 106311835 106336914 106338498
RSZ: 108855811 108863440
THJ: 104802038 104817302
CPAP: 110820910
CIT: 102609716
TCC: 18614120
DZI: 111304748
EGR: 104443429
GMX: 100101899(OAS-TL3) 100806420
VRA: 106759445
VAR: 108329722
VUN: 114186237
CCAJ: 109802499
CAM: 101512608
LJA: Lj1g3v2682510.1(Lj1g3v2682510.1)
FVE: 101292050
PPER: 18786519
PMUM: 103342779
PAVI: 110751794
ZJU: 107404050
CSV: 101220896
CMO: 103497706
MCHA: 111024353
CMAX: 111499275
CMOS: 111460401
CPEP: 111807524
JCU: 105642966
JRE: 109021531
VVI: 100255091
SOT: 102601315(PCAS-2) 102604154(PCAS-1)
CANN: 107839203
SIND: 105172766
OEU: 111390009
LSV: 111902665
CCAV: 112526366
DCR: 108210215
BVG: 104887240
SOE: 110789773
NNU: 104610634
PSOM: 113274742
OSA: 4335048
DOSA: Os04t0165700-01(Os04g0165700)
OBR: 102715851
BDI: 100835065
ATS: 109731680(LOC109731680)
SBI: 8066013
ZMA: 100216722
SITA: 101779131
PDA: 103715474
EGU: 105043037
MUS: 103985756
DCT: 110097663
PEQ: 110025102
AOF: 109837549
ATR: 18422839
 » show all
Reference
  Authors
Hatzfeld Y, Maruyama A, Schmidt A, Noji M, Ishizawa K, Saito K
  Title
beta-Cyanoalanine synthase is a mitochondrial cysteine synthase-like protein in spinach and Arabidopsis.
  Journal
Plant Physiol 123:1163-71 (2000)
DOI:10.1104/pp.123.3.1163
  Sequence
[ath:AT3G61440]

KEGG   ENZYME: 4.4.1.9
Entry
EC 4.4.1.9                  Enzyme                                 

Name
L-3-cyanoalanine synthase;
beta-cyanoalanine synthase;
beta-cyanoalanine synthetase;
beta-cyano-L-alanine synthase;
L-cysteine hydrogen-sulfide-lyase (adding HCN)
Class
Lyases;
Carbon-sulfur lyases;
Carbon-sulfur lyases (only sub-subclass identified to date)
Sysname
L-cysteine hydrogen-sulfide-lyase (adding hydrogen cyanide; L-3-cyanoalanine-forming)
Reaction(IUBMB)
L-cysteine + hydrogen cyanide = L-3-cyanoalanine + hydrogen sulfide [RN:R03524]
Reaction(KEGG)
R03524;
(other) R02846
Substrate
L-cysteine [CPD:C00097];
hydrogen cyanide [CPD:C01326]
Product
L-3-cyanoalanine [CPD:C02512];
hydrogen sulfide [CPD:C00283]
Comment
Contains pyridoxal phospate.
History
EC 4.4.1.9 created 1972, deleted 1976, reinstated 1978
Pathway
ec00460  Cyanoamino acid metabolism
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K13034  L-3-cyanoalanine synthase/ cysteine synthase
Genes
ATH: AT3G61440(CYSC1)
ALY: 9312681 9319720
CRB: 17886219
CSAT: 104699755 104747140 104749184 104788433
EUS: EUTSA_v10006044mg
BRP: 103841966 103862824
BNA: 106393304 106396803 106415606 106415702 106415710 106444997
BOE: 106311835 106336914 106338498
RSZ: 108855811 108863440
THJ: 104802038 104817302
CPAP: 110820910
CIT: 102609716
TCC: 18614120
DZI: 111304748
EGR: 104443429
GMX: 100101899(OAS-TL3) 100806420
VRA: 106759445
VAR: 108329722
VUN: 114186237
CCAJ: 109802499
CAM: 101512608
LJA: Lj1g3v2682510.1(Lj1g3v2682510.1)
FVE: 101292050
PPER: 18786519
PMUM: 103342779
PAVI: 110751794
ZJU: 107404050
CSV: 101220896
CMO: 103497706
MCHA: 111024353
CMAX: 111499275
CMOS: 111460401
CPEP: 111807524
JCU: 105642966
JRE: 109021531
VVI: 100255091
SOT: 102601315(PCAS-2) 102604154(PCAS-1)
CANN: 107839203
SIND: 105172766
OEU: 111390009
LSV: 111902665
CCAV: 112526366
DCR: 108210215
BVG: 104887240
SOE: 110789773
NNU: 104610634
PSOM: 113274742
OSA: 4335048
DOSA: Os04t0165700-01(Os04g0165700)
OBR: 102715851
BDI: 100835065
ATS: 109731680(LOC109731680)
SBI: 8066013
ZMA: 100216722
SITA: 101779131
PDA: 103715474
EGU: 105043037
MUS: 103985756
DCT: 110097663
PEQ: 110025102
AOF: 109837549
ATR: 18422839
 » show all
Reference
1  [PMID:1055433]
  Authors
Akopyan TN, Braunstein AE, Goryachenkova EV.
  Title
Beta-cyanoalanine synthase: purification and characterization.
  Journal
Proc Natl Acad Sci U S A 72:1617-21 (1975)
DOI:10.1073/pnas.72.4.1617
Reference
2  [PMID:5001194]
  Authors
Castric PA, Conn EE.
  Title
Formation of  -cyanoalanine by O-acetylserine sulfhydrylase.
  Journal
J Bacteriol 108:132-6 (1971)
DOI:10.1128/JB.108.1.132-136.1971
Reference
3
  Authors
Hendrickson, H.R.
  Title
The beta-cyanoalanine synthase of blue lupine.
  Journal
Fed Proc 27:593 (1968)
Reference
4  [PMID:5769995]
  Authors
Hendrickson HR, Conn EE.
  Title
Cyanide metabolism in higher plants. IV. Purification and properties of the beta-cyanolanine synthase of blue lupine.
  Journal
J Biol Chem 244:2632-40 (1969)
Other DBs
ExplorEnz - The Enzyme Database: 4.4.1.9
IUBMB Enzyme Nomenclature: 4.4.1.9
ExPASy - ENZYME nomenclature database: 4.4.1.9
BRENDA, the Enzyme Database: 4.4.1.9
CAS: 9059-53-4

KEGG   REACTION: R03524
Entry
R03524                      Reaction                               

Name
L-cysteine hydrogen-sulfide-lyase (adding HCN)
Definition
L-Cysteine + Hydrogen cyanide <=> Hydrogen sulfide + 3-Cyano-L-alanine
Equation
Reaction class
RC00793  C00097_C02512
RC02814  C00097_C00283
Enzyme
Pathway
rn00460  Cyanoamino acid metabolism
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Orthology
K13034  L-3-cyanoalanine synthase/ cysteine synthase [EC:2.5.1.47 4.4.1.9]
Other DBs
RHEA: 17824

DBGET integrated database retrieval system