KEGG   ORTHOLOGY: K13042
Entry
K13042                      KO                                     

Name
bsmB
Definition
dimethylglycine N-methyltransferase [EC:2.1.1.161]
Pathway
ko00260  Glycine, serine and threonine metabolism
ko01100  Metabolic pathways
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09105 Amino acid metabolism
   00260 Glycine, serine and threonine metabolism
    K13042  bsmB; dimethylglycine N-methyltransferase
Enzymes [BR:ko01000]
 2. Transferases
  2.1  Transferring one-carbon groups
   2.1.1  Methyltransferases
    2.1.1.161  dimethylglycine N-methyltransferase
     K13042  bsmB; dimethylglycine N-methyltransferase
Other DBs
RN: R07244
GO: 0052729
Genes
SYW: SYNW1913(sdmt)
SYX: SynWH7803_0360
SYNR: KR49_11735
SYNW: SynWH8103_02186(gbmt2)
PMT: PMT_0551
PMF: P9303_17021
Reference
  Authors
Lu WD, Chi ZM, Su CD
  Title
Identification of glycine betaine as compatible solute in Synechococcus sp. WH8102 and characterization of its N-methyltransferase genes involved in betaine synthesis.
  Journal
Arch Microbiol 186:495-506 (2006)
DOI:10.1007/s00203-006-0167-8
  Sequence
[syw:SYNW1913]

KEGG   ENZYME: 2.1.1.161
Entry
EC 2.1.1.161                Enzyme                                 

Name
dimethylglycine N-methyltransferase;
BsmB;
DMT
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
Sysname
S-adenosyl-L-methionine:N,N-dimethylglycine N-methyltransferase (betaine-forming)
Reaction(IUBMB)
S-adenosyl-L-methionine + N,N-dimethylglycine = S-adenosyl-L-homocysteine + betaine [RN:R07244]
Reaction(KEGG)
R07244
Substrate
S-adenosyl-L-methionine [CPD:C00019];
N,N-dimethylglycine [CPD:C01026]
Product
S-adenosyl-L-homocysteine [CPD:C00021];
betaine [CPD:C00719]
Comment
This enzyme, from the marine cyanobacterium Synechococcus sp. WH8102, differs from EC 2.1.1.157, sarcosine/dimethylglycine N-methyltransferase in that it cannot use sarcosine as an alternative substrate [1]. Betaine is a 'compatible solute' that enables cyanobacteria to cope with osmotic stress by maintaining a positive cellular turgor.
History
EC 2.1.1.161 created 2007
Pathway
ec00260  Glycine, serine and threonine metabolism
ec01100  Metabolic pathways
Orthology
K13042  dimethylglycine N-methyltransferase
Genes
SYW: SYNW1913(sdmt)
SYX: SynWH7803_0360
SYNR: KR49_11735
SYNW: SynWH8103_02186(gbmt2)
PMT: PMT_0551
PMF: P9303_17021
Reference
1  [PMID:17019606]
  Authors
Lu WD, Chi ZM, Su CD.
  Title
Identification of glycine betaine as compatible solute in Synechococcus sp. WH8102 and characterization of its N-methyltransferase genes involved in betaine synthesis.
  Journal
Arch Microbiol 186:495-506 (2006)
DOI:10.1007/s00203-006-0167-8
  Sequence
[syw:SYNW1913]
Other DBs
ExplorEnz - The Enzyme Database: 2.1.1.161
IUBMB Enzyme Nomenclature: 2.1.1.161
ExPASy - ENZYME nomenclature database: 2.1.1.161
BRENDA, the Enzyme Database: 2.1.1.161

KEGG   REACTION: R07244
Entry
R07244                      Reaction                               

Name
S-adenosyl-L-methionine:N,N-dimethylglycine N-methyltransferase
Definition
S-Adenosyl-L-methionine + N,N-Dimethylglycine <=> S-Adenosyl-L-homocysteine + Betaine
Equation
Reaction class
RC00003  C00019_C00021
RC00496  C00719_C01026
Enzyme
2.1.1.157       2.1.1.161       2.1.1.162
Pathway
rn00260  Glycine, serine and threonine metabolism
rn01100  Metabolic pathways
Orthology
K13042  dimethylglycine N-methyltransferase [EC:2.1.1.161]
Other DBs
RHEA: 10075

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