KEGG   ORTHOLOGY: K13231
Entry
K13231            Tight     KO                                     

Name
STS
Definition
pinosylvin synthase [EC:2.3.1.146]
Pathway
ko00945  Stilbenoid, diarylheptanoid and gingerol biosynthesis
ko01110  Biosynthesis of secondary metabolites
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09110 Biosynthesis of other secondary metabolites
   00945 Stilbenoid, diarylheptanoid and gingerol biosynthesis
    K13231  STS; pinosylvin synthase
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01008 Polyketide biosynthesis proteins
    K13231  STS; pinosylvin synthase
Enzymes [BR:ko01000]
 2. Transferases
  2.3  Acyltransferases
   2.3.1  Transferring groups other than aminoacyl groups
    2.3.1.146  pinosylvin synthase
     K13231  STS; pinosylvin synthase
Polyketide biosynthesis proteins [BR:ko01008]
 Polyketide synthase (PKS)
  Type III PKS
   Plant type
    K13231  STS; pinosylvin synthase
Other DBs
RN: R02505
GO: 0050198
Genes
AG: CAA87012(STS1) CAA87013(STS2)
Reference
PMID:7698342
  Authors
Raiber S, Schroder G, Schroder J
  Title
Molecular and enzymatic characterization of two stilbene synthases from Eastern white pine (Pinus strobus). A single Arg/His difference determines the activity and the pH dependence of the enzymes.
  Journal
FEBS Lett 361:299-302 (1995)
DOI:10.1016/0014-5793(95)00199-J
  Sequence

KEGG   ENZYME: 2.3.1.146
Entry
EC 2.3.1.146                Enzyme                                 

Name
pinosylvin synthase;
stilbene synthase (ambiguous);
pine stilbene synthase (ambiguous)
Class
Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups
Sysname
malonyl-CoA:cinnamoyl-CoA malonyltransferase (cyclizing)
Reaction(IUBMB)
3 malonyl-CoA + cinnamoyl-CoA = 4 CoA + pinosylvin + 4 CO2 [RN:R02505]
Reaction(KEGG)
R02505
Substrate
malonyl-CoA [CPD:C00083];
cinnamoyl-CoA [CPD:C00540]
Product
CoA [CPD:C00010];
pinosylvin [CPD:C01745];
CO2 [CPD:C00011]
Comment
Not identical with EC 2.3.1.74 (naringenin-chalcone synthase) or EC 2.3.1.95 (trihydroxystilbene synthase).
History
EC 2.3.1.146 created 1992
Pathway
ec00945  Stilbenoid, diarylheptanoid and gingerol biosynthesis
ec01110  Biosynthesis of secondary metabolites
Orthology
K13231  pinosylvin synthase
Reference
1
  Authors
Gehlert, R., Schoppner, A. and Kindl, H.
  Title
Stilbene synthase from seedlings of Pinus sylvestris - purification and induction in response to fungal infection.
  Journal
Mol Plant-Microbe Interaction 3:444-449 (1990)
Other DBs
ExplorEnz - The Enzyme Database: 2.3.1.146
IUBMB Enzyme Nomenclature: 2.3.1.146
ExPASy - ENZYME nomenclature database: 2.3.1.146
BRENDA, the Enzyme Database: 2.3.1.146
CAS: 72994-49-1

KEGG   REACTION: R02505
Entry
R02505                      Reaction                               

Name
Malonyl-CoA:cinnamoyl-CoA malonyltransferase (cyclizing)
Definition
3 Malonyl-CoA + Cinnamoyl-CoA <=> 4 CoA + Pinosylvin + 4 CO2
Equation
3 C00083 + C00540 <=> 4 C00010 + C01745 + 4 C00011
Comment
multi-step reaction
Reaction class
RC00004  C00010_C00083  C00010_C00540
RC02855  C00540_C01745
Enzyme
Pathway
rn00945  Stilbenoid, diarylheptanoid and gingerol biosynthesis
rn01110  Biosynthesis of secondary metabolites
Orthology
K13231  pinosylvin synthase [EC:2.3.1.146]
Other DBs
RHEA: 12555

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