KEGG   ORTHOLOGY: K13233
Entry
K13233                      KO                                     

Name
DCS
Definition
phenylpropanoylacetyl-CoA synthase [EC:2.3.1.218]
Pathway
ko00945  Stilbenoid, diarylheptanoid and gingerol biosynthesis
ko01110  Biosynthesis of secondary metabolites
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09110 Biosynthesis of other secondary metabolites
   00945 Stilbenoid, diarylheptanoid and gingerol biosynthesis
    K13233  DCS; phenylpropanoylacetyl-CoA synthase
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01008 Polyketide biosynthesis proteins
    K13233  DCS; phenylpropanoylacetyl-CoA synthase
Enzymes [BR:ko01000]
 2. Transferases
  2.3  Acyltransferases
   2.3.1  Transferring groups other than aminoacyl groups
    2.3.1.218  phenylpropanoylacetyl-CoA synthase
     K13233  DCS; phenylpropanoylacetyl-CoA synthase
Polyketide biosynthesis proteins [BR:ko01008]
 Polyketide synthase (PKS)
  Type III PKS
   Plant type
    K13233  DCS; phenylpropanoylacetyl-CoA synthase
Other DBs
RN: R08805 R08806
Genes
MUS: 103975557
AG: BAH56225(DCS)
Reference
  Authors
Katsuyama Y, Kita T, Funa N, Horinouchi S
  Title
Curcuminoid biosynthesis by two type III polyketide synthases in the herb Curcuma longa.
  Journal
J Biol Chem 284:11160-70 (2009)
DOI:10.1074/jbc.M900070200
  Sequence

KEGG   ENZYME: 2.3.1.218
Entry
EC 2.3.1.218                Enzyme                                 

Name
phenylpropanoylacetyl-CoA synthase;
phenylpropanoyl-diketide-CoA synthase;
DCS
Class
Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups
Sysname
phenylpropanoyl-CoA:malonyl-CoA phenylpropanoyl-transferase (decarboxylating)
Reaction(IUBMB)
(1) feruloyl-CoA + malonyl-CoA = feruloylacetyl-CoA + CO2 + CoA [RN:R08806];
(2) 4-coumaroyl-CoA + malonyl-CoA = (4-coumaroyl)acetyl-CoA + CO2 + CoA [RN:R08805]
Reaction(KEGG)
R08805 R08806
Substrate
feruloyl-CoA [CPD:C00406];
malonyl-CoA [CPD:C00083];
4-coumaroyl-CoA [CPD:C00223]
Product
feruloylacetyl-CoA [CPD:C17741];
CO2 [CPD:C00011];
CoA [CPD:C00010];
(4-coumaroyl)acetyl-CoA [CPD:C17740]
Comment
The enzyme has been characterized from the plant Curcuma longa (turmeric). It prefers feruloyl-CoA, and has no activity with cinnamoyl-CoA.
History
EC 2.3.1.218 created 2013
Pathway
ec00945  Stilbenoid, diarylheptanoid and gingerol biosynthesis
ec01110  Biosynthesis of secondary metabolites
Orthology
K13233  phenylpropanoylacetyl-CoA synthase
Genes
MUS: 103975557
Reference
1  [PMID:19258320]
  Authors
Katsuyama Y, Kita T, Funa N, Horinouchi S.
  Title
Curcuminoid biosynthesis by two type III polyketide synthases in the herb Curcuma longa.
  Journal
J Biol Chem 284:11160-70 (2009)
DOI:10.1074/jbc.M900070200
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 2.3.1.218
IUBMB Enzyme Nomenclature: 2.3.1.218
ExPASy - ENZYME nomenclature database: 2.3.1.218
BRENDA, the Enzyme Database: 2.3.1.218

KEGG   REACTION: R08805
Entry
R08805                      Reaction                               

Name
p-coumaroyl-CoA:malonyl-CoA C-coumaroyltransferase (decarboxylating)
Definition
p-Coumaroyl-CoA + Malonyl-CoA <=> p-Coumaroyl-diketide-CoA + CoA + CO2
Equation
Comment
diketide-CoA synthase (DCS)
Reaction class
RC00004  C00010_C00223
RC02955  C00223_C17740
Enzyme
Pathway
rn00945  Stilbenoid, diarylheptanoid and gingerol biosynthesis
rn01110  Biosynthesis of secondary metabolites
Orthology
K13233  phenylpropanoylacetyl-CoA synthase [EC:2.3.1.218]
Other DBs
RHEA: 22503

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