KEGG   ORTHOLOGY: K13234
Entry
K13234                      KO                                     

Name
CURS1_2
Definition
curcumin synthase [EC:2.3.1.217]
Pathway
ko00945  Stilbenoid, diarylheptanoid and gingerol biosynthesis
ko01110  Biosynthesis of secondary metabolites
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09110 Biosynthesis of other secondary metabolites
   00945 Stilbenoid, diarylheptanoid and gingerol biosynthesis
    K13234  CURS1_2; curcumin synthase
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01008 Polyketide biosynthesis proteins
    K13234  CURS1_2; curcumin synthase
Enzymes [BR:ko01000]
 2. Transferases
  2.3  Acyltransferases
   2.3.1  Transferring groups other than aminoacyl groups
    2.3.1.217  curcumin synthase
     K13234  CURS1_2; curcumin synthase
Polyketide biosynthesis proteins [BR:ko01008]
 Polyketide synthase (PKS)
  Type III PKS
   Plant type
    K13234  CURS1_2; curcumin synthase
Other DBs
RN: R08808 R08810
Genes
MUS: 103976634
AG: BAH56226(CURS1) BAH85780(CURS2)
Reference
  Authors
Katsuyama Y, Kita T, Funa N, Horinouchi S
  Title
Curcuminoid biosynthesis by two type III polyketide synthases in the herb Curcuma longa.
  Journal
J Biol Chem 284:11160-70 (2009)
DOI:10.1074/jbc.M900070200
  Sequence
Reference
  Authors
Katsuyama Y, Kita T, Horinouchi S
  Title
Identification and characterization of multiple curcumin synthases from the herb Curcuma longa.
  Journal
FEBS Lett 583:2799-803 (2009)
DOI:10.1016/j.febslet.2009.07.029
  Sequence

KEGG   ORTHOLOGY: K17211
Entry
K17211            Tight     KO                                     

Name
CURS3
Definition
curcumin/demethoxycurcumin synthase [EC:2.3.1.217 2.3.1.219]
Pathway
ko00945  Stilbenoid, diarylheptanoid and gingerol biosynthesis
ko01110  Biosynthesis of secondary metabolites
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09110 Biosynthesis of other secondary metabolites
   00945 Stilbenoid, diarylheptanoid and gingerol biosynthesis
    K17211  CURS3; curcumin/demethoxycurcumin synthase
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01008 Polyketide biosynthesis proteins
    K17211  CURS3; curcumin/demethoxycurcumin synthase
Enzymes [BR:ko01000]
 2. Transferases
  2.3  Acyltransferases
   2.3.1  Transferring groups other than aminoacyl groups
    2.3.1.217  curcumin synthase
     K17211  CURS3; curcumin/demethoxycurcumin synthase
    2.3.1.219  demethoxycurcumin synthase
     K17211  CURS3; curcumin/demethoxycurcumin synthase
Polyketide biosynthesis proteins [BR:ko01008]
 Polyketide synthase (PKS)
  Type III PKS
   Plant type
    K17211  CURS3; curcumin/demethoxycurcumin synthase
Other DBs
RN: R08807 R08808 R08809 R08810
Genes
AG: BAH85781(CURS3)
Reference
  Authors
Katsuyama Y, Kita T, Horinouchi S
  Title
Identification and characterization of multiple curcumin synthases from the herb Curcuma longa.
  Journal
FEBS Lett 583:2799-803 (2009)
DOI:10.1016/j.febslet.2009.07.029
  Sequence

KEGG   ENZYME: 2.3.1.217
Entry
EC 2.3.1.217                Enzyme                                 

Name
curcumin synthase;
CURS;
CURS1 (gene name);
CURS2 (gene name);
CURS3 (gene name)
Class
Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups
Sysname
feruloyl-CoA:feruloylacetyl-CoA feruloyltransferase (curcumin-forming)
Reaction(IUBMB)
feruloyl-CoA + feruloylacetyl-CoA + H2O = 2 CoA + curcumin + CO2 [RN:R08810]
Reaction(KEGG)
R08810;
(other) R08808
Substrate
feruloyl-CoA [CPD:C00406];
feruloylacetyl-CoA [CPD:C17741];
H2O [CPD:C00001]
Product
CoA [CPD:C00010];
curcumin [CPD:C10443];
CO2 [CPD:C00011]
Comment
A polyketide synthase from the plant Curcuma longa (turmeric). Three isoforms exist, CURS1, CURS2 and CURS3. While CURS1 and CURS2 prefer feruloyl-CoA as a starter substrate, CURS3 can accept 4-coumaroyl-CoA equally well [2] (see EC 2.3.1.219, demethoxycurcumin synthase).
History
EC 2.3.1.217 created 2013
Pathway
ec00945  Stilbenoid, diarylheptanoid and gingerol biosynthesis
ec01110  Biosynthesis of secondary metabolites
Orthology
K13234  curcumin synthase
K17211  curcumin/demethoxycurcumin synthase
Genes
MUS: 103976634
Reference
1  [PMID:19258320]
  Authors
Katsuyama Y, Kita T, Funa N, Horinouchi S.
  Title
Curcuminoid biosynthesis by two type III polyketide synthases in the herb Curcuma longa.
  Journal
J Biol Chem 284:11160-70 (2009)
DOI:10.1074/jbc.M900070200
  Sequence
Reference
2  [PMID:19622354]
  Authors
Katsuyama Y, Kita T, Horinouchi S
  Title
Identification and characterization of multiple curcumin synthases from the herb  Curcuma longa.
  Journal
FEBS Lett 583:2799-803 (2009)
DOI:10.1016/j.febslet.2009.07.029
  Sequence
Reference
3  [PMID:21148316]
  Authors
Katsuyama Y, Miyazono K, Tanokura M, Ohnishi Y, Horinouchi S
  Title
Structural and biochemical elucidation of mechanism for decarboxylative condensation of beta-keto acid by curcumin synthase.
  Journal
J Biol Chem 286:6659-68 (2011)
DOI:10.1074/jbc.M110.196279
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 2.3.1.217
IUBMB Enzyme Nomenclature: 2.3.1.217
ExPASy - ENZYME nomenclature database: 2.3.1.217
BRENDA, the Enzyme Database: 2.3.1.217

KEGG   REACTION: R08810
Entry
R08810                      Reaction                               

Name
feruloyl-CoA:feruloylacetyl-CoA feruloyltransferase (curcumin-forming)
Definition
Feruloyl-diketide-CoA + Feruloyl-CoA + H2O <=> Curcumin + 2 CoA + CO2
Equation
Comment
curcuminoid synthase (CURS)
Reaction class
RC00004  C00010_C00406  C00010_C17741
RC02970  C10443_C17741
Enzyme
Pathway
rn00945  Stilbenoid, diarylheptanoid and gingerol biosynthesis
rn01110  Biosynthesis of secondary metabolites
Orthology
K13234  curcumin synthase [EC:2.3.1.217]
K17211  curcumin/demethoxycurcumin synthase [EC:2.3.1.217 2.3.1.219]
Other DBs
RHEA: 34826

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